GREMLIN Database
Q97XJ9 - dTDP-Glucose 4,6-dehydratase (RfbB-2)
UniProt: Q97XJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (290)
Sequences: 47101 (32715)
Seq/√Len: 1921.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_T51_A3.2021.00
271_L310_E3.1631.00
23_T48_A2.7431.00
240_V257_I2.6571.00
40_E239_R2.6211.00
119_S123_F2.5451.00
275_V314_R2.4451.00
95_V245_I2.4451.00
85_S134_R2.3741.00
113_K116_D2.3171.00
308_P311_E2.2161.00
40_E242_F2.1971.00
142_I241_I2.1971.00
274_R310_E2.1911.00
52_K77_T2.1491.00
77_T83_S2.0911.00
138_K186_E2.0581.00
239_R306_T2.0501.00
192_P241_I2.0011.00
266_I270_R1.9981.00
253_E301_K1.9901.00
97_L245_I1.9771.00
23_T50_L1.9381.00
40_E45_Y1.9341.00
235_E315_K1.9131.00
239_R243_D1.9101.00
190_V244_L1.9081.00
271_L274_R1.8941.00
98_R141_H1.8811.00
50_L93_H1.8811.00
264_K267_Q1.8781.00
50_L75_I1.8571.00
50_L73_S1.8281.00
176_V187_A1.8231.00
27_Q98_R1.8211.00
85_S131_A1.8141.00
196_Y312_G1.7791.00
25_L93_H1.7521.00
211_I215_L1.7411.00
45_Y246_R1.7411.00
26_K38_F1.7371.00
37_Y97_L1.6841.00
37_Y238_A1.6811.00
126_V175_F1.6791.00
80_Q119_S1.6701.00
233_Y315_K1.6681.00
48_A73_S1.6601.00
218_Y283_K1.6541.00
170_A174_L1.6341.00
37_Y99_E1.6291.00
82_F130_E1.6221.00
125_T172_A1.5861.00
45_Y242_F1.5681.00
220_P283_K1.5601.00
123_F126_V1.5451.00
126_V130_E1.5431.00
40_E43_V1.5371.00
24_R47_E1.5321.00
55_L74_Y1.5181.00
318_D322_N1.5131.00
243_D247_S1.5081.00
242_F246_R1.5011.00
307_T315_K1.4991.00
314_R318_D1.4801.00
133_R183_Y1.4751.00
82_F127_N1.4611.00
271_L275_V1.4551.00
86_Q90_Y1.4531.00
154_D157_S1.4411.00
266_I284_Y1.4081.00
85_S135_Y1.4031.00
82_F85_S1.3911.00
228_E262_R1.3871.00
138_K188_I1.3851.00
39_S199_R1.3821.00
143_S147_V1.3801.00
141_H172_A1.3751.00
159_V170_A1.3731.00
40_E238_A1.3661.00
38_F51_A1.3651.00
99_E142_I1.3601.00
83_S86_Q1.3581.00
233_Y312_G1.3571.00
29_T38_F1.3561.00
33_L195_N1.3471.00
115_Q119_S1.3451.00
118_V171_S1.3431.00
96_F132_A1.3361.00
97_L241_I1.3291.00
174_L177_K1.3091.00
192_P237_T1.2981.00
155_E301_K1.2941.00
212_R217_I1.2891.00
23_T94_L1.2881.00
267_Q270_R1.2831.00
232_I237_T1.2811.00
311_E315_K1.2731.00
180_I187_A1.2561.00
311_E314_R1.2511.00
40_E235_E1.2441.00
142_I192_P1.2421.00
190_V241_I1.2381.00
47_E246_R1.2271.00
51_A72_P1.2271.00
89_L135_Y1.2251.00
307_T311_E1.2221.00
177_K189_I1.2221.00
98_R125_T1.2101.00
132_A139_Y1.2071.00
226_E264_K1.2051.00
79_L124_G1.2051.00
130_E133_R1.2031.00
234_V238_A1.2011.00
24_R41_D1.1991.00
270_R273_E1.1821.00
121_N168_S1.1801.00
141_H189_I1.1781.00
165_Y169_K1.1671.00
25_L52_K1.1651.00
230_D260_G1.1591.00
226_E266_I1.1551.00
128_V139_Y1.1541.00
36_K235_E1.1531.00
130_E134_R1.1501.00
129_L179_Y1.1481.00
263_V309_L1.1481.00
273_E279_E1.1401.00
88_F96_F1.1351.00
148_Y256_N1.1321.00
233_Y307_T1.1261.00
41_D242_F1.1201.00
75_I90_Y1.1151.00
86_Q89_L1.1091.00
167_A171_S1.1031.00
42_R71_P1.1021.00
191_R254_V1.0951.00
193_S297_M1.0871.00
186_E251_R1.0801.00
102_D120_T1.0731.00
141_H176_V1.0701.00
109_R113_K1.0681.00
35_E199_R1.0681.00
42_R72_P1.0671.00
310_E314_R1.0641.00
139_Y176_V1.0601.00
276_I317_Y1.0601.00
131_A135_Y1.0561.00
175_F178_S1.0521.00
132_A137_F1.0431.00
52_K83_S1.0401.00
129_L139_Y1.0361.00
88_F93_H1.0361.00
30_E53_S1.0351.00
65_C68_C1.0331.00
218_Y281_K1.0331.00
131_A134_R1.0321.00
262_R294_R1.0281.00
275_V310_E1.0261.00
79_L100_K1.0251.00
243_D246_R1.0241.00
177_K254_V1.0211.00
275_V317_Y1.0201.00
315_K318_D1.0171.00
24_R95_V1.0131.00
235_E307_T1.0111.00
75_I87_L0.9961.00
220_P285_V0.9951.00
39_S43_V0.9861.00
99_E241_I0.9841.00
85_S89_L0.9781.00
23_T93_H0.9771.00
178_S182_T0.9741.00
258_P297_M0.9731.00
263_V267_Q0.9711.00
52_K84_S0.9661.00
177_K181_K0.9661.00
83_S87_L0.9651.00
273_E278_K0.9571.00
123_F127_N0.9531.00
318_D321_A0.9511.00
228_E294_R0.9471.00
84_S131_A0.9451.00
129_L176_V0.9431.00
27_Q128_V0.9381.00
173_D191_R0.9371.00
188_I244_L0.9361.00
82_F134_R0.9361.00
236_D259_G0.9361.00
153_S157_S0.9321.00
195_N237_T0.9251.00
90_Y93_H0.9221.00
52_K87_L0.9181.00
122_V171_S0.9181.00
154_D298_I0.9171.00
120_T124_G0.9151.00
88_F131_A0.9151.00
54_R78_F0.9131.00
88_F135_Y0.9131.00
24_R97_L0.9131.00
133_R185_V0.9121.00
208_K212_R0.9061.00
189_I254_V0.9011.00
243_D302_L0.8971.00
177_K187_A0.8951.00
156_N301_K0.8881.00
205_F209_A0.8781.00
37_Y41_D0.8741.00
225_G266_I0.8731.00
240_V304_Y0.8721.00
118_V122_V0.8711.00
38_F49_D0.8691.00
228_E264_K0.8671.00
125_T176_V0.8631.00
239_R307_T0.8621.00
55_L76_Q0.8571.00
32_F197_G0.8571.00
179_Y183_Y0.8531.00
36_K39_S0.8501.00
130_E179_Y0.8451.00
80_Q120_T0.8411.00
36_K234_V0.8381.00
32_F234_V0.8361.00
195_N232_I0.8351.00
24_R245_I0.8351.00
191_R256_N0.8331.00
307_T312_G0.8311.00
42_R49_D0.8271.00
145_D193_S0.8271.00
198_P315_K0.8261.00
292_D295_Y0.8251.00
275_V318_D0.8241.00
53_S74_Y0.8231.00
167_A174_L0.8191.00
239_R242_F0.8151.00
98_R128_V0.8141.00
262_R296_C0.8141.00
275_V313_L0.8131.00
208_K211_I0.8111.00
140_V190_V0.8111.00
95_V138_K0.8091.00
267_Q271_L0.8031.00
243_D303_N0.8021.00
190_V257_I0.8021.00
204_K207_P0.7991.00
143_S173_D0.7991.00
261_Y308_P0.7991.00
244_L302_L0.7981.00
127_N131_A0.7981.00
27_Q100_K0.7941.00
174_L178_S0.7941.00
255_Y301_K0.7931.00
282_V285_V0.7911.00
56_N76_Q0.7881.00
260_G299_N0.7861.00
133_R179_Y0.7841.00
187_A252_G0.7841.00
233_Y236_D0.7831.00
127_N130_E0.7801.00
216_G278_K0.7781.00
118_V123_F0.7771.00
116_D119_S0.7771.00
196_Y233_Y0.7761.00
213_T273_E0.7741.00
116_D120_T0.7701.00
47_E94_L0.7631.00
55_L58_A0.7621.00
258_P299_N0.7611.00
211_I214_I0.7601.00
263_V268_L0.7571.00
271_L309_L0.7541.00
243_D304_Y0.7541.00
239_R304_Y0.7531.00
102_D116_D0.7531.00
36_K40_E0.7511.00
118_V168_S0.7501.00
147_V159_V0.7491.00
171_S174_L0.7441.00
270_R274_R0.7431.00
66_F69_S0.7221.00
88_F132_A0.7211.00
140_V241_I0.7201.00
279_E282_V0.7171.00
273_E280_I0.7161.00
102_D117_F0.7141.00
35_E39_S0.7111.00
36_K238_A0.7081.00
147_V173_D0.7081.00
117_F168_S0.7061.00
125_T129_L0.7041.00
172_A176_V0.7001.00
161_P166_S0.6981.00
171_S175_F0.6951.00
96_F128_V0.6951.00
56_N59_G0.6921.00
236_D239_R0.6911.00
37_Y241_I0.6881.00
291_H295_Y0.6881.00
114_P167_A0.6871.00
268_L309_L0.6861.00
210_I214_I0.6851.00
167_A178_S0.6851.00
23_T47_E0.6811.00
296_C299_N0.6801.00
129_L175_F0.6761.00
190_V240_V0.6761.00
236_D307_T0.6751.00
248_A251_R0.6751.00
33_L237_T0.6721.00
317_Y321_A0.6721.00
193_S258_P0.6641.00
82_F131_A0.6641.00
124_G127_N0.6641.00
138_K248_A0.6601.00
180_I252_G0.6581.00
238_A242_F0.6581.00
192_P195_N0.6581.00
159_V174_L0.6581.00
110_S117_F0.6571.00
26_K41_D0.6571.00
118_V167_A0.6561.00
155_E256_N0.6551.00
111_I164_P0.6531.00
30_E55_L0.6521.00
198_P233_Y0.6481.00
224_N284_Y0.6431.00
227_Q265_N0.6401.00
50_L90_Y0.6401.00
316_T319_W0.6341.00
68_C72_P0.6311.00
41_D245_I0.6311.00
247_S255_Y0.6311.00
25_L87_L0.6301.00
273_E276_I0.6291.00
210_I317_Y0.6271.00
146_E166_S0.6271.00
47_E95_V0.6261.00
133_R184_N0.6241.00
37_Y242_F0.6231.00
75_I83_S0.6221.00
140_V245_I0.6211.00
109_R112_Y0.6201.00
46_L49_D0.6171.00
25_L96_F0.6141.00
96_F139_Y0.6131.00
163_S166_S0.6111.00
178_S181_K0.6111.00
81_K84_S0.6091.00
39_S235_E0.6081.00
189_I252_G0.6081.00
36_K199_R0.6081.00
84_S127_N0.6071.00
230_D259_G0.6051.00
194_N229_R0.6041.00
210_I272_L0.6031.00
175_F179_Y0.5991.00
73_S90_Y0.5971.00
263_V271_L0.5971.00
273_E282_V0.5961.00
132_A135_Y0.5941.00
95_V140_V0.5941.00
213_T272_L0.5881.00
176_V189_I0.5871.00
164_P167_A0.5871.00
213_T219_V0.5861.00
25_L88_F0.5821.00
198_P235_E0.5811.00
151_E157_S0.5801.00
212_R220_P0.5801.00
271_L313_L0.5791.00
88_F128_V0.5781.00
177_K180_I0.5761.00
78_F81_K0.5741.00
151_E294_R0.5731.00
269_I273_E0.5711.00
154_D300_T0.5701.00
51_A74_Y0.5661.00
283_K287_D0.5651.00
209_A269_I0.5651.00
292_D297_M0.5631.00
48_A71_P0.5631.00
159_V254_V0.5611.00
77_T87_L0.5601.00
294_R297_M0.5591.00
272_L313_L0.5581.00
99_E192_P0.5581.00
207_P211_I0.5571.00
161_P170_A0.5571.00
150_E293_R0.5561.00
38_F42_R0.5551.00
242_F245_I0.5541.00
283_K286_S0.5531.00
188_I255_Y0.5511.00
102_D121_N0.5501.00
115_Q126_V0.5471.00
206_I268_L0.5461.00
267_Q310_E0.5461.00
87_L93_H0.5451.00
65_C69_S0.5441.00
140_V244_L0.5441.00
101_R121_N0.5411.00
186_E248_A0.5371.00
150_E162_S0.5341.00
251_R255_Y0.5331.00
164_P168_S0.5321.00
50_L87_L0.5301.00
98_R139_Y0.5281.00
152_C155_E0.5271.00
210_I316_T0.5261.00
149_G160_N0.5251.00
97_L242_F0.5251.00
152_C298_I0.5251.00
179_Y185_V0.5251.00
168_S172_A0.5221.00
188_I247_S0.5211.00
25_L77_T0.5181.00
180_I186_E0.5171.00
80_Q116_D0.5171.00
214_I321_A0.5171.00
210_I276_I0.5161.00
205_F213_T0.5141.00
125_T141_H0.5141.00
288_R291_H0.5131.00
261_Y310_E0.5131.00
291_H294_R0.5121.00
167_A170_A0.5111.00
88_F137_F0.5081.00
41_D47_E0.5081.00
147_V191_R0.5081.00
144_T147_V0.5071.00
107_V110_S0.5061.00
69_S72_P0.5061.00
209_A219_V0.5041.00
180_I185_V0.5041.00
186_E249_E0.5001.00
108_D112_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.8971 100 0.306 Contact Map
3rufA 2 0.8914 100 0.311 Contact Map
1rpnA 4 0.8629 100 0.311 Contact Map
1oc2A 2 0.9171 100 0.313 Contact Map
1orrA 3 0.8543 100 0.319 Contact Map
1rkxA 3 0.9143 100 0.32 Contact Map
2hunA 2 0.9114 100 0.322 Contact Map
4wkgA 5 0.8857 100 0.323 Contact Map
2c20A 2 0.8571 100 0.324 Contact Map
2bllA 2 0.8457 100 0.326 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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