Q97XJ9 - SULSO - GREMLIN Contacts

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Q97XJ9 - dTDP-Glucose 4,6-dehydratase (RfbB-2)

UniProt:	Q97XJ9	Sequences: MNRVQLSQRSSPIFPQPAQVAPTRLKQGTEEFLREKYFSEDRVNYLEADLAKSRLNFAGLVVFSCFICSSPPSYIQTFLQKFSSSQLFLYFIHLVFLREKRDSHTDVDRSIYKPQDFVSTNVFGTVNVLEAARRYNFKYVHISTDEVYGEECSDENSSVNPSSPYSASKASADLFVKSYIKTYNVEAIIVRPSNNYGPRQFPEKFIPKAIIRTILGIYVPIYGNGEQERDWIYVEDTARVIFDLIRSAEWRGEVYNIPGGYRVKNIQLIRLLERVIKKEIKVKYVSDRPGHDRRYCMINTKLNYTTTPLEEGLRKTYDWYANNNWWWSSLVNDEFFKSDEPWRPYEDKKY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	350 (290)
Sequences:	47101 (32715)
Seq/√Len:	1921.1

ECOLI - RMLB1 GM4D RMLB2 GALE HLDD FCL YBJS RMLD YFCH YEEZ QOR2 ARNA YRAR
BACSU - YTCB RMLB GALE YFNG SPSK YFHF YTBQ YWNB EPSC YHFK YESF YHEG
HALSA - Q9HSV1 Q9HSU9 Q9HRD1 Q9HS50 Q9HML4 Q9HSE7 Q9HNV3 Q9HSQ3 Q9HPF1 Q9HR86
SULSO - Q97XJ9 Q97XG1 Q7LXE8 Q97VN5 Q7LXG5 Q980W1 Q97UM3 Q7LX44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_T	51_A	3.202	1.00
271_L	310_E	3.163	1.00
23_T	48_A	2.743	1.00
240_V	257_I	2.657	1.00
40_E	239_R	2.621	1.00
119_S	123_F	2.545	1.00
275_V	314_R	2.445	1.00
95_V	245_I	2.445	1.00
85_S	134_R	2.374	1.00
113_K	116_D	2.317	1.00
308_P	311_E	2.216	1.00
40_E	242_F	2.197	1.00
142_I	241_I	2.197	1.00
274_R	310_E	2.191	1.00
52_K	77_T	2.149	1.00
77_T	83_S	2.091	1.00
138_K	186_E	2.058	1.00
239_R	306_T	2.050	1.00
192_P	241_I	2.001	1.00
266_I	270_R	1.998	1.00
253_E	301_K	1.990	1.00
97_L	245_I	1.977	1.00
23_T	50_L	1.938	1.00
40_E	45_Y	1.934	1.00
235_E	315_K	1.913	1.00
239_R	243_D	1.910	1.00
190_V	244_L	1.908	1.00
271_L	274_R	1.894	1.00
98_R	141_H	1.881	1.00
50_L	93_H	1.881	1.00
264_K	267_Q	1.878	1.00
50_L	75_I	1.857	1.00
50_L	73_S	1.828	1.00
176_V	187_A	1.823	1.00
27_Q	98_R	1.821	1.00
85_S	131_A	1.814	1.00
196_Y	312_G	1.779	1.00
25_L	93_H	1.752	1.00
211_I	215_L	1.741	1.00
45_Y	246_R	1.741	1.00
26_K	38_F	1.737	1.00
37_Y	97_L	1.684	1.00
37_Y	238_A	1.681	1.00
126_V	175_F	1.679	1.00
80_Q	119_S	1.670	1.00
233_Y	315_K	1.668	1.00
48_A	73_S	1.660	1.00
218_Y	283_K	1.654	1.00
170_A	174_L	1.634	1.00
37_Y	99_E	1.629	1.00
82_F	130_E	1.622	1.00
125_T	172_A	1.586	1.00
45_Y	242_F	1.568	1.00
220_P	283_K	1.560	1.00
123_F	126_V	1.545	1.00
126_V	130_E	1.543	1.00
40_E	43_V	1.537	1.00
24_R	47_E	1.532	1.00
55_L	74_Y	1.518	1.00
318_D	322_N	1.513	1.00
243_D	247_S	1.508	1.00
242_F	246_R	1.501	1.00
307_T	315_K	1.499	1.00
314_R	318_D	1.480	1.00
133_R	183_Y	1.475	1.00
82_F	127_N	1.461	1.00
271_L	275_V	1.455	1.00
86_Q	90_Y	1.453	1.00
154_D	157_S	1.441	1.00
266_I	284_Y	1.408	1.00
85_S	135_Y	1.403	1.00
82_F	85_S	1.391	1.00
228_E	262_R	1.387	1.00
138_K	188_I	1.385	1.00
39_S	199_R	1.382	1.00
143_S	147_V	1.380	1.00
141_H	172_A	1.375	1.00
159_V	170_A	1.373	1.00
40_E	238_A	1.366	1.00
38_F	51_A	1.365	1.00
99_E	142_I	1.360	1.00
83_S	86_Q	1.358	1.00
233_Y	312_G	1.357	1.00
29_T	38_F	1.356	1.00
33_L	195_N	1.347	1.00
115_Q	119_S	1.345	1.00
118_V	171_S	1.343	1.00
96_F	132_A	1.336	1.00
97_L	241_I	1.329	1.00
174_L	177_K	1.309	1.00
192_P	237_T	1.298	1.00
155_E	301_K	1.294	1.00
212_R	217_I	1.289	1.00
23_T	94_L	1.288	1.00
267_Q	270_R	1.283	1.00
232_I	237_T	1.281	1.00
311_E	315_K	1.273	1.00
180_I	187_A	1.256	1.00
311_E	314_R	1.251	1.00
40_E	235_E	1.244	1.00
142_I	192_P	1.242	1.00
190_V	241_I	1.238	1.00
47_E	246_R	1.227	1.00
51_A	72_P	1.227	1.00
89_L	135_Y	1.225	1.00
307_T	311_E	1.222	1.00
177_K	189_I	1.222	1.00
98_R	125_T	1.210	1.00
132_A	139_Y	1.207	1.00
226_E	264_K	1.205	1.00
79_L	124_G	1.205	1.00
130_E	133_R	1.203	1.00
234_V	238_A	1.201	1.00
24_R	41_D	1.199	1.00
270_R	273_E	1.182	1.00
121_N	168_S	1.180	1.00
141_H	189_I	1.178	1.00
165_Y	169_K	1.167	1.00
25_L	52_K	1.165	1.00
230_D	260_G	1.159	1.00
226_E	266_I	1.155	1.00
128_V	139_Y	1.154	1.00
36_K	235_E	1.153	1.00
130_E	134_R	1.150	1.00
129_L	179_Y	1.148	1.00
263_V	309_L	1.148	1.00
273_E	279_E	1.140	1.00
88_F	96_F	1.135	1.00
148_Y	256_N	1.132	1.00
233_Y	307_T	1.126	1.00
41_D	242_F	1.120	1.00
75_I	90_Y	1.115	1.00
86_Q	89_L	1.109	1.00
167_A	171_S	1.103	1.00
42_R	71_P	1.102	1.00
191_R	254_V	1.095	1.00
193_S	297_M	1.087	1.00
186_E	251_R	1.080	1.00
102_D	120_T	1.073	1.00
141_H	176_V	1.070	1.00
109_R	113_K	1.068	1.00
35_E	199_R	1.068	1.00
42_R	72_P	1.067	1.00
310_E	314_R	1.064	1.00
139_Y	176_V	1.060	1.00
276_I	317_Y	1.060	1.00
131_A	135_Y	1.056	1.00
175_F	178_S	1.052	1.00
132_A	137_F	1.043	1.00
52_K	83_S	1.040	1.00
129_L	139_Y	1.036	1.00
88_F	93_H	1.036	1.00
30_E	53_S	1.035	1.00
65_C	68_C	1.033	1.00
218_Y	281_K	1.033	1.00
131_A	134_R	1.032	1.00
262_R	294_R	1.028	1.00
275_V	310_E	1.026	1.00
79_L	100_K	1.025	1.00
243_D	246_R	1.024	1.00
177_K	254_V	1.021	1.00
275_V	317_Y	1.020	1.00
315_K	318_D	1.017	1.00
24_R	95_V	1.013	1.00
235_E	307_T	1.011	1.00
75_I	87_L	0.996	1.00
220_P	285_V	0.995	1.00
39_S	43_V	0.986	1.00
99_E	241_I	0.984	1.00
85_S	89_L	0.978	1.00
23_T	93_H	0.977	1.00
178_S	182_T	0.974	1.00
258_P	297_M	0.973	1.00
263_V	267_Q	0.971	1.00
52_K	84_S	0.966	1.00
177_K	181_K	0.966	1.00
83_S	87_L	0.965	1.00
273_E	278_K	0.957	1.00
123_F	127_N	0.953	1.00
318_D	321_A	0.951	1.00
228_E	294_R	0.947	1.00
84_S	131_A	0.945	1.00
129_L	176_V	0.943	1.00
27_Q	128_V	0.938	1.00
173_D	191_R	0.937	1.00
188_I	244_L	0.936	1.00
82_F	134_R	0.936	1.00
236_D	259_G	0.936	1.00
153_S	157_S	0.932	1.00
195_N	237_T	0.925	1.00
90_Y	93_H	0.922	1.00
52_K	87_L	0.918	1.00
122_V	171_S	0.918	1.00
154_D	298_I	0.917	1.00
120_T	124_G	0.915	1.00
88_F	131_A	0.915	1.00
54_R	78_F	0.913	1.00
88_F	135_Y	0.913	1.00
24_R	97_L	0.913	1.00
133_R	185_V	0.912	1.00
208_K	212_R	0.906	1.00
189_I	254_V	0.901	1.00
243_D	302_L	0.897	1.00
177_K	187_A	0.895	1.00
156_N	301_K	0.888	1.00
205_F	209_A	0.878	1.00
37_Y	41_D	0.874	1.00
225_G	266_I	0.873	1.00
240_V	304_Y	0.872	1.00
118_V	122_V	0.871	1.00
38_F	49_D	0.869	1.00
228_E	264_K	0.867	1.00
125_T	176_V	0.863	1.00
239_R	307_T	0.862	1.00
55_L	76_Q	0.857	1.00
32_F	197_G	0.857	1.00
179_Y	183_Y	0.853	1.00
36_K	39_S	0.850	1.00
130_E	179_Y	0.845	1.00
80_Q	120_T	0.841	1.00
36_K	234_V	0.838	1.00
32_F	234_V	0.836	1.00
195_N	232_I	0.835	1.00
24_R	245_I	0.835	1.00
191_R	256_N	0.833	1.00
307_T	312_G	0.831	1.00
42_R	49_D	0.827	1.00
145_D	193_S	0.827	1.00
198_P	315_K	0.826	1.00
292_D	295_Y	0.825	1.00
275_V	318_D	0.824	1.00
53_S	74_Y	0.823	1.00
167_A	174_L	0.819	1.00
239_R	242_F	0.815	1.00
98_R	128_V	0.814	1.00
262_R	296_C	0.814	1.00
275_V	313_L	0.813	1.00
208_K	211_I	0.811	1.00
140_V	190_V	0.811	1.00
95_V	138_K	0.809	1.00
267_Q	271_L	0.803	1.00
243_D	303_N	0.802	1.00
190_V	257_I	0.802	1.00
204_K	207_P	0.799	1.00
143_S	173_D	0.799	1.00
261_Y	308_P	0.799	1.00
244_L	302_L	0.798	1.00
127_N	131_A	0.798	1.00
27_Q	100_K	0.794	1.00
174_L	178_S	0.794	1.00
255_Y	301_K	0.793	1.00
282_V	285_V	0.791	1.00
56_N	76_Q	0.788	1.00
260_G	299_N	0.786	1.00
133_R	179_Y	0.784	1.00
187_A	252_G	0.784	1.00
233_Y	236_D	0.783	1.00
127_N	130_E	0.780	1.00
216_G	278_K	0.778	1.00
118_V	123_F	0.777	1.00
116_D	119_S	0.777	1.00
196_Y	233_Y	0.776	1.00
213_T	273_E	0.774	1.00
116_D	120_T	0.770	1.00
47_E	94_L	0.763	1.00
55_L	58_A	0.762	1.00
258_P	299_N	0.761	1.00
211_I	214_I	0.760	1.00
263_V	268_L	0.757	1.00
271_L	309_L	0.754	1.00
243_D	304_Y	0.754	1.00
239_R	304_Y	0.753	1.00
102_D	116_D	0.753	1.00
36_K	40_E	0.751	1.00
118_V	168_S	0.750	1.00
147_V	159_V	0.749	1.00
171_S	174_L	0.744	1.00
270_R	274_R	0.743	1.00
66_F	69_S	0.722	1.00
88_F	132_A	0.721	1.00
140_V	241_I	0.720	1.00
279_E	282_V	0.717	1.00
273_E	280_I	0.716	1.00
102_D	117_F	0.714	1.00
35_E	39_S	0.711	1.00
36_K	238_A	0.708	1.00
147_V	173_D	0.708	1.00
117_F	168_S	0.706	1.00
125_T	129_L	0.704	1.00
172_A	176_V	0.700	1.00
161_P	166_S	0.698	1.00
171_S	175_F	0.695	1.00
96_F	128_V	0.695	1.00
56_N	59_G	0.692	1.00
236_D	239_R	0.691	1.00
37_Y	241_I	0.688	1.00
291_H	295_Y	0.688	1.00
114_P	167_A	0.687	1.00
268_L	309_L	0.686	1.00
210_I	214_I	0.685	1.00
167_A	178_S	0.685	1.00
23_T	47_E	0.681	1.00
296_C	299_N	0.680	1.00
129_L	175_F	0.676	1.00
190_V	240_V	0.676	1.00
236_D	307_T	0.675	1.00
248_A	251_R	0.675	1.00
33_L	237_T	0.672	1.00
317_Y	321_A	0.672	1.00
193_S	258_P	0.664	1.00
82_F	131_A	0.664	1.00
124_G	127_N	0.664	1.00
138_K	248_A	0.660	1.00
180_I	252_G	0.658	1.00
238_A	242_F	0.658	1.00
192_P	195_N	0.658	1.00
159_V	174_L	0.658	1.00
110_S	117_F	0.657	1.00
26_K	41_D	0.657	1.00
118_V	167_A	0.656	1.00
155_E	256_N	0.655	1.00
111_I	164_P	0.653	1.00
30_E	55_L	0.652	1.00
198_P	233_Y	0.648	1.00
224_N	284_Y	0.643	1.00
227_Q	265_N	0.640	1.00
50_L	90_Y	0.640	1.00
316_T	319_W	0.634	1.00
68_C	72_P	0.631	1.00
41_D	245_I	0.631	1.00
247_S	255_Y	0.631	1.00
25_L	87_L	0.630	1.00
273_E	276_I	0.629	1.00
210_I	317_Y	0.627	1.00
146_E	166_S	0.627	1.00
47_E	95_V	0.626	1.00
133_R	184_N	0.624	1.00
37_Y	242_F	0.623	1.00
75_I	83_S	0.622	1.00
140_V	245_I	0.621	1.00
109_R	112_Y	0.620	1.00
46_L	49_D	0.617	1.00
25_L	96_F	0.614	1.00
96_F	139_Y	0.613	1.00
163_S	166_S	0.611	1.00
178_S	181_K	0.611	1.00
81_K	84_S	0.609	1.00
39_S	235_E	0.608	1.00
189_I	252_G	0.608	1.00
36_K	199_R	0.608	1.00
84_S	127_N	0.607	1.00
230_D	259_G	0.605	1.00
194_N	229_R	0.604	1.00
210_I	272_L	0.603	1.00
175_F	179_Y	0.599	1.00
73_S	90_Y	0.597	1.00
263_V	271_L	0.597	1.00
273_E	282_V	0.596	1.00
132_A	135_Y	0.594	1.00
95_V	140_V	0.594	1.00
213_T	272_L	0.588	1.00
176_V	189_I	0.587	1.00
164_P	167_A	0.587	1.00
213_T	219_V	0.586	1.00
25_L	88_F	0.582	1.00
198_P	235_E	0.581	1.00
151_E	157_S	0.580	1.00
212_R	220_P	0.580	1.00
271_L	313_L	0.579	1.00
88_F	128_V	0.578	1.00
177_K	180_I	0.576	1.00
78_F	81_K	0.574	1.00
151_E	294_R	0.573	1.00
269_I	273_E	0.571	1.00
154_D	300_T	0.570	1.00
51_A	74_Y	0.566	1.00
283_K	287_D	0.565	1.00
209_A	269_I	0.565	1.00
292_D	297_M	0.563	1.00
48_A	71_P	0.563	1.00
159_V	254_V	0.561	1.00
77_T	87_L	0.560	1.00
294_R	297_M	0.559	1.00
272_L	313_L	0.558	1.00
99_E	192_P	0.558	1.00
207_P	211_I	0.557	1.00
161_P	170_A	0.557	1.00
150_E	293_R	0.556	1.00
38_F	42_R	0.555	1.00
242_F	245_I	0.554	1.00
283_K	286_S	0.553	1.00
188_I	255_Y	0.551	1.00
102_D	121_N	0.550	1.00
115_Q	126_V	0.547	1.00
206_I	268_L	0.546	1.00
267_Q	310_E	0.546	1.00
87_L	93_H	0.545	1.00
65_C	69_S	0.544	1.00
140_V	244_L	0.544	1.00
101_R	121_N	0.541	1.00
186_E	248_A	0.537	1.00
150_E	162_S	0.534	1.00
251_R	255_Y	0.533	1.00
164_P	168_S	0.532	1.00
50_L	87_L	0.530	1.00
98_R	139_Y	0.528	1.00
152_C	155_E	0.527	1.00
210_I	316_T	0.526	1.00
149_G	160_N	0.525	1.00
97_L	242_F	0.525	1.00
152_C	298_I	0.525	1.00
179_Y	185_V	0.525	1.00
168_S	172_A	0.522	1.00
188_I	247_S	0.521	1.00
25_L	77_T	0.518	1.00
180_I	186_E	0.517	1.00
80_Q	116_D	0.517	1.00
214_I	321_A	0.517	1.00
210_I	276_I	0.516	1.00
205_F	213_T	0.514	1.00
125_T	141_H	0.514	1.00
288_R	291_H	0.513	1.00
261_Y	310_E	0.513	1.00
291_H	294_R	0.512	1.00
167_A	170_A	0.511	1.00
88_F	137_F	0.508	1.00
41_D	47_E	0.508	1.00
147_V	191_R	0.508	1.00
144_T	147_V	0.507	1.00
107_V	110_S	0.506	1.00
69_S	72_P	0.506	1.00
209_A	219_V	0.504	1.00
180_I	185_V	0.504	1.00
186_E	249_E	0.500	1.00
108_D	112_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sb8A	2	0.8971	100	0.306	Contact Map
3rufA	2	0.8914	100	0.311	Contact Map
1rpnA	4	0.8629	100	0.311	Contact Map
1oc2A	2	0.9171	100	0.313	Contact Map
1orrA	3	0.8543	100	0.319	Contact Map
1rkxA	3	0.9143	100	0.32	Contact Map
2hunA	2	0.9114	100	0.322	Contact Map
4wkgA	5	0.8857	100	0.323	Contact Map
2c20A	2	0.8571	100	0.324	Contact Map
2bllA	2	0.8457	100	0.326	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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