GREMLIN Database
Q97XJ2 - Second ORF in transposon ISC1058
UniProt: Q97XJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (180)
Sequences: 286 (169)
Seq/√Len: 12.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_S171_R3.0800.97
9_D12_T2.6890.93
61_F108_Y2.6580.93
40_I177_V2.4170.89
158_G161_W2.4140.88
133_H137_R2.3880.88
66_I167_F2.3340.87
42_T60_K2.3220.86
44_T47_Q2.3120.86
124_P128_A2.3090.86
109_D136_R2.2570.85
80_V177_V2.1650.82
40_I80_V2.0740.79
46_G125_K2.0400.78
65_E87_S1.9650.75
131_K134_L1.9530.75
106_K125_K1.9420.74
147_G151_W1.8640.71
58_D62_L1.7630.67
136_R151_W1.7530.66
166_L169_V1.7510.66
11_S16_R1.7510.66
43_N60_K1.7460.66
157_Y164_E1.7390.66
109_D151_W1.7330.65
155_K158_G1.7200.65
9_D120_V1.7100.64
124_P139_A1.6900.63
166_L170_K1.6760.63
73_F166_L1.6480.61
44_T75_V1.6320.61
12_T15_E1.6280.60
32_E70_N1.6160.60
32_E45_G1.5940.59
157_Y160_R1.5730.58
130_T140_V1.5680.57
14_W66_I1.5650.57
113_V131_K1.5640.57
34_I70_N1.5630.57
41_S47_Q1.5450.56
64_I124_P1.5140.55
11_S150_R1.5110.54
170_K177_V1.4850.53
13_I93_K1.4780.53
10_Y14_W1.4310.50
41_S109_D1.4290.50
36_D39_G1.4230.50
37_A87_S1.4230.50
45_G49_I1.4140.49
120_V139_A1.3700.47
60_K83_N1.3590.47
68_M162_R1.3540.46
49_I162_R1.3520.46
22_I27_A1.3460.46
51_A56_T1.3370.46
106_K109_D1.3360.45
149_D152_R1.3220.45
170_K173_F1.3030.44
48_Y65_E1.3010.44
33_V76_I1.2870.43
160_R164_E1.2790.43
152_R158_G1.2640.42
127_N137_R1.2560.41
68_M163_V1.2400.41
124_P143_F1.2400.41
69_D107_T1.2380.41
67_V71_N1.2270.40
131_K158_G1.2240.40
50_V56_T1.2030.39
179_Q182_L1.1970.38
84_E143_F1.1750.37
108_Y123_P1.1690.37
44_T53_W1.1450.36
165_S182_L1.1440.36
88_A119_E1.1440.36
165_S168_S1.1420.36
102_F113_V1.1380.36
33_V67_V1.1300.35
35_A60_K1.1120.34
51_A57_R1.1120.34
6_T10_Y1.1040.34
44_T62_L1.0970.34
92_V156_G1.0940.34
38_T64_I1.0780.33
61_F65_E1.0780.33
87_S91_T1.0760.33
4_I30_E1.0700.33
3_I153_E1.0690.32
16_R151_W1.0640.32
18_R22_I1.0520.32
169_V173_F1.0520.32
102_F120_V1.0510.32
61_F87_S1.0490.32
99_G114_Y1.0440.31
55_K176_S1.0390.31
55_K75_V1.0370.31
44_T58_D1.0200.30
131_K167_F1.0100.30
43_N57_R1.0010.29
9_D127_N0.9990.29
138_K141_R0.9930.29
90_K126_K0.9920.29
8_L14_W0.9850.29
5_P31_L0.9760.28
149_D155_K0.9690.28
173_F178_R0.9550.28
41_S53_W0.9540.28
7_S12_T0.9430.27
7_S15_E0.9380.27
37_A91_T0.9330.27
82_S85_V0.9320.27
42_T64_I0.9220.26
4_I18_R0.9130.26
20_M115_K0.9110.26
5_P11_S0.9110.26
25_P133_H0.9050.26
16_R136_R0.9050.26
68_M73_F0.9030.25
13_I37_A0.9030.25
101_K182_L0.9020.25
104_E108_Y0.9010.25
115_K118_V0.8980.25
49_I103_Y0.8950.25
63_K87_S0.8920.25
166_L179_Q0.8890.25
153_E171_R0.8770.24
52_K115_K0.8750.24
126_K129_S0.8740.24
53_W61_F0.8720.24
77_N118_V0.8690.24
4_I27_A0.8660.24
41_S44_T0.8540.24
66_I86_E0.8530.24
69_D151_W0.8500.23
120_V175_E0.8490.23
114_Y123_P0.8470.23
6_T18_R0.8400.23
44_T167_F0.8380.23
31_L163_V0.8310.23
59_S180_V0.8300.23
162_R166_L0.8270.23
12_T24_F0.8240.22
128_A140_V0.8210.22
16_R109_D0.8200.22
69_D121_V0.8190.22
38_T107_T0.8180.22
86_E89_V0.8180.22
32_E44_T0.8070.22
69_D125_K0.8050.22
89_V102_F0.8010.22
174_G177_V0.7990.22
13_I103_Y0.7980.22
76_I145_K0.7950.21
136_R147_G0.7920.21
92_V118_V0.7830.21
103_Y134_L0.7760.21
49_I56_T0.7750.21
55_K59_S0.7740.21
6_T12_T0.7730.21
23_T102_F0.7690.21
107_T125_K0.7610.20
74_N79_E0.7570.20
4_I21_N0.7550.20
14_W26_E0.7460.20
14_W17_V0.7440.20
41_S58_D0.7410.20
20_M25_P0.7400.20
163_V174_G0.7330.19
102_F118_V0.7270.19
110_A113_V0.7170.19
24_F28_S0.7140.19
34_I103_Y0.7110.19
109_D125_K0.7110.19
40_I132_R0.7080.19
46_G128_A0.7080.19
75_V118_V0.7060.19
145_K181_L0.7060.19
164_E174_G0.7030.18
7_S30_E0.7020.18
109_D147_G0.6990.18
41_S167_F0.6990.18
93_K98_K0.6970.18
10_Y64_I0.6960.18
119_E155_K0.6930.18
139_A144_R0.6880.18
86_E161_W0.6820.18
44_T109_D0.6780.18
35_A77_N0.6730.18
63_K81_T0.6690.17
94_D180_V0.6650.17
6_T13_I0.6630.17
58_D163_V0.6590.17
79_E86_E0.6550.17
51_A131_K0.6550.17
56_T126_K0.6550.17
136_R140_V0.6520.17
118_V162_R0.6470.17
65_E81_T0.6450.17
5_P170_K0.6400.17
23_T153_E0.6350.16
5_P17_V0.6350.16
37_A84_E0.6340.16
103_Y121_V0.6340.16
30_E73_F0.6330.16
35_A92_V0.6320.16
79_E133_H0.6320.16
3_I146_L0.6310.16
76_I99_G0.6270.16
88_A176_S0.6240.16
112_E141_R0.6220.16
67_V73_F0.6210.16
36_D123_P0.6190.16
11_S125_K0.6150.16
12_T73_F0.6140.16
20_M159_V0.6130.16
34_I168_S0.6110.16
83_N126_K0.6110.16
11_S85_V0.6090.16
62_L94_D0.6050.16
33_V99_G0.6010.15
151_W174_G0.5980.15
80_V142_E0.5980.15
31_L54_G0.5980.15
151_W164_E0.5960.15
25_P140_V0.5940.15
31_L156_G0.5920.15
7_S37_A0.5920.15
78_A103_Y0.5900.15
15_E53_W0.5860.15
120_V152_R0.5850.15
4_I10_Y0.5840.15
4_I100_K0.5810.15
46_G99_G0.5770.15
34_I118_V0.5760.15
51_A152_R0.5680.15
72_E158_G0.5660.15
119_E142_E0.5640.15
149_D153_E0.5640.15
37_A52_K0.5640.15
11_S100_K0.5610.14
111_N162_R0.5600.14
81_T95_L0.5600.14
45_G158_G0.5540.14
48_Y61_F0.5520.14
114_Y124_P0.5500.14
65_E91_T0.5480.14
61_F81_T0.5370.14
142_E146_L0.5330.14
124_P136_R0.5300.14
125_K131_K0.5300.14
53_W167_F0.5260.14
130_T141_R0.5240.14
32_E167_F0.5240.14
73_F169_V0.5230.14
80_V133_H0.5200.13
162_R165_S0.5200.13
51_A126_K0.5170.13
40_I175_E0.5170.13
10_Y133_H0.5140.13
34_I42_T0.5130.13
14_W75_V0.5130.13
19_N22_I0.5110.13
76_I171_R0.5110.13
5_P169_V0.5090.13
52_K140_V0.5080.13
42_T58_D0.5060.13
113_V158_G0.5040.13
75_V153_E0.5020.13
57_R158_G0.5010.13
61_F104_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9946 90.4 0.927 Contact Map
4fcyA 4 0.9402 23.2 0.957 Contact Map
1xccA 2 0.7663 8.5 0.965 Contact Map
1ityA 1 0.3478 7.5 0.966 Contact Map
2v2gA 2 0.6793 6.6 0.967 Contact Map
4fw1A 2 0.6141 5.2 0.968 Contact Map
3bk2A 2 0.75 5.1 0.968 Contact Map
1bcoA 1 0.6359 4.8 0.969 Contact Map
3optA 1 0.4783 4.5 0.969 Contact Map
4wesB 2 0.9185 4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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