GREMLIN Database
Q97XI7 - Second ORF in transposon ISC1078
UniProt: Q97XI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (163)
Sequences: 1956 (1477)
Seq/√Len: 115.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_S109_V3.1951.00
75_P107_N2.9061.00
24_E141_K2.8521.00
78_N99_M2.7591.00
57_G64_G2.6821.00
56_G137_W2.6231.00
74_K77_L2.5161.00
79_S108_E2.4511.00
98_V123_L2.4431.00
21_I97_I2.3701.00
111_E115_E2.3601.00
27_V51_R2.3221.00
112_F116_N2.2711.00
87_R116_N2.2031.00
99_M113_L1.9801.00
162_F165_S1.9411.00
138_A142_K1.9351.00
68_S156_M1.9311.00
75_P79_S1.8651.00
152_F156_M1.8121.00
25_S51_R1.7091.00
96_V121_V1.7021.00
80_K84_L1.6961.00
143_R162_F1.6711.00
26_Y159_A1.6561.00
58_I170_V1.6521.00
79_S107_N1.6231.00
140_L162_F1.6121.00
14_R17_Y1.5841.00
79_S112_F1.5711.00
27_V49_R1.5481.00
58_I136_P1.5311.00
103_R106_G1.5141.00
26_Y54_V1.4961.00
139_V143_R1.4751.00
146_S149_Y1.4651.00
56_G133_A1.4631.00
25_S30_I1.4311.00
156_M160_T1.4171.00
113_L120_F1.4021.00
106_G110_R1.3861.00
26_Y144_L1.3831.00
85_Y88_K1.3791.00
21_I78_N1.3591.00
168_K171_N1.3501.00
73_K103_R1.3501.00
154_T157_W1.3301.00
157_W161_R1.3221.00
75_P108_E1.3071.00
59_T62_K1.3061.00
45_V48_K1.2951.00
135_G138_A1.2870.99
20_H58_I1.2710.99
140_L166_I1.2650.99
99_M122_Y1.2590.99
161_R165_S1.2530.99
94_K119_E1.2440.99
99_M120_F1.2330.99
150_T154_T1.2270.99
79_S83_I1.2240.99
21_I55_V1.2070.99
149_Y154_T1.2050.99
135_G176_S1.1970.99
131_S134_E1.1930.99
173_L176_S1.1920.99
172_D175_Y1.1570.99
160_T164_R1.1380.99
108_E111_E1.1290.99
54_V159_A1.1270.99
151_D154_T1.1190.99
26_Y141_K1.1180.99
75_P109_V1.0970.98
161_R164_R1.0900.98
24_E29_Y1.0830.98
74_K104_I1.0820.98
35_G41_G1.0760.98
83_I112_F1.0710.98
83_I115_E1.0680.98
106_G122_Y1.0660.98
171_N175_Y1.0610.98
78_N129_D1.0490.98
170_V173_L1.0480.98
22_F102_A1.0460.98
25_S53_A1.0360.98
25_S104_I1.0240.97
38_K41_G1.0190.97
107_N110_R1.0150.97
27_V31_N1.0010.97
24_E159_A0.9990.97
101_N106_G0.9980.97
98_V131_S0.9960.97
17_Y94_K0.9800.97
162_F166_I0.9630.96
73_K77_L0.9580.96
82_I112_F0.9580.96
100_D105_H0.9490.96
60_I174_T0.9480.96
147_K158_D0.9470.96
132_P174_T0.9450.96
78_N81_D0.9410.96
73_K104_I0.9370.96
37_M42_G0.9360.96
76_S80_K0.9030.95
76_S108_E0.9020.95
69_Y77_L0.9000.95
78_N82_I0.8970.95
105_H141_K0.8920.94
153_E169_R0.8830.94
65_I89_V0.8830.94
52_F68_S0.8810.94
48_K51_R0.8780.94
169_R172_D0.8740.94
21_I99_M0.8730.94
167_S171_N0.8710.94
23_D105_H0.8700.94
170_V174_T0.8670.93
20_H98_V0.8570.93
143_R165_S0.8510.93
134_E173_L0.8490.93
111_E114_E0.8450.93
37_M41_G0.8440.93
110_R122_Y0.8430.93
152_F155_L0.8390.92
113_L118_V0.8310.92
110_R114_E0.8300.92
78_N97_I0.8280.92
17_Y96_V0.8260.92
32_K36_W0.8240.92
158_D162_F0.8220.92
153_E165_S0.8210.91
156_M161_R0.8180.91
15_E18_K0.8180.91
86_L97_I0.8130.91
149_Y158_D0.8060.91
90_I95_T0.7990.90
53_A102_A0.7790.89
56_G136_P0.7730.89
35_G42_G0.7720.89
99_M123_L0.7700.89
61_S67_F0.7690.89
163_L166_I0.7640.88
62_K170_V0.7630.88
28_S155_L0.7620.88
153_E158_D0.7560.88
16_G175_Y0.7500.87
56_G66_T0.7470.87
91_K116_N0.7360.86
135_G173_L0.7310.86
64_G89_V0.7280.86
16_G60_I0.7220.85
158_D161_R0.7170.85
26_Y140_L0.7150.85
71_T77_L0.7130.85
31_N148_I0.7120.84
74_K79_S0.7090.84
138_A141_K0.7080.84
20_H25_S0.7050.84
168_K175_Y0.7040.84
56_G134_E0.7040.84
101_N125_P0.6960.83
58_I132_P0.6940.83
101_N134_E0.6770.81
38_K116_N0.6760.81
44_K157_W0.6740.81
70_S156_M0.6700.81
136_P173_L0.6650.80
61_S171_N0.6650.80
73_K102_A0.6560.79
24_E54_V0.6550.79
20_H137_W0.6530.79
123_L131_S0.6490.79
21_I57_G0.6430.78
35_G38_K0.6390.78
21_I123_L0.6390.78
26_Y162_F0.6360.77
155_L159_A0.6310.77
50_K53_A0.6300.77
141_K145_Y0.6300.77
40_G128_P0.6270.76
99_M102_A0.6200.75
54_V66_T0.6190.75
85_Y89_V0.6180.75
51_R73_K0.6160.75
37_M69_Y0.6140.75
137_W170_V0.6130.75
32_K142_K0.6100.74
112_F115_E0.6080.74
45_V50_K0.6060.74
83_I87_R0.6060.74
90_I97_I0.6010.73
157_W164_R0.5930.72
150_T158_D0.5920.72
55_V99_M0.5880.72
125_P169_R0.5870.71
156_M159_A0.5870.71
161_R169_R0.5870.71
55_V123_L0.5840.71
63_E136_P0.5840.71
140_L156_M0.5820.71
75_P104_I0.5780.70
169_R175_Y0.5780.70
125_P156_M0.5760.70
24_E137_W0.5740.70
58_I63_E0.5690.69
112_F119_E0.5650.69
75_P103_R0.5640.68
134_E137_W0.5620.68
65_I84_L0.5600.68
109_V112_F0.5590.68
99_M125_P0.5570.67
126_Y141_K0.5570.67
81_D85_Y0.5560.67
73_K81_D0.5550.67
99_M109_V0.5540.67
44_K47_P0.5530.67
67_F80_K0.5520.67
91_K175_Y0.5490.66
45_V59_T0.5470.66
108_E122_Y0.5450.66
164_R175_Y0.5430.66
133_A137_W0.5390.65
154_T165_S0.5390.65
65_I118_V0.5390.65
94_K118_V0.5340.64
63_E137_W0.5330.64
29_Y36_W0.5330.64
73_K112_F0.5310.64
115_E153_E0.5290.64
93_E151_D0.5270.63
84_L112_F0.5250.63
28_S49_R0.5240.63
47_P73_K0.5200.62
28_S125_P0.5150.61
48_K104_I0.5140.61
87_R112_F0.5080.60
52_F140_L0.5080.60
53_A72_Y0.5070.60
98_V134_E0.5070.60
109_V122_Y0.5040.60
113_L116_N0.5040.60
23_D26_Y0.5010.59
62_K85_Y0.5010.59
131_S136_P0.5010.59
14_R18_K0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f2kA 1 0.8942 100 0.273 Contact Map
4mdaA 1 0.8942 100 0.295 Contact Map
4u7bA 2 1 100 0.44 Contact Map
4fcyA 4 0.9101 98.8 0.783 Contact Map
1c6vA 4 0.746 97.4 0.847 Contact Map
4fw1A 2 0.8413 97.3 0.85 Contact Map
4mq3A 1 0.672 97.1 0.854 Contact Map
3l3uA 2 0.7831 97.1 0.854 Contact Map
1cxqA 2 0.7354 96.6 0.864 Contact Map
2x78A 2 0.8042 96.6 0.864 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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