GREMLIN Database
Q97XI6 - Second ORF in transposon ISC1395
UniProt: Q97XI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (146)
Sequences: 2020 (1481)
Seq/√Len: 122.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_A87_Y3.7911.00
57_S85_N3.4481.00
56_N59_I3.2191.00
61_A88_V2.9171.00
60_F77_L2.5831.00
38_S46_P2.5681.00
4_T75_L2.4271.00
90_S94_Q2.4191.00
10_H32_K2.4121.00
77_L92_A2.3901.00
117_K121_R2.1811.00
37_A116_W2.1501.00
76_I102_L2.1071.00
7_S120_K2.0971.00
143_L146_R2.0901.00
50_F137_E2.0541.00
91_V95_L1.9881.00
118_D122_W1.9301.00
74_V100_L1.9061.00
20_G26_V1.8981.00
138_E142_Y1.7691.00
9_I35_V1.7671.00
86_A90_S1.7291.00
119_L143_L1.6221.00
130_E135_S1.6171.00
61_A85_N1.6041.00
9_I140_F1.5841.00
40_P43_D1.5601.00
21_L24_V1.5371.00
68_R71_G1.5311.00
23_N26_V1.5051.00
55_V82_F1.4691.00
137_E141_Y1.4491.00
142_Y146_R1.4441.00
135_S138_E1.4431.00
8_G13_P1.4301.00
143_L147_E1.4191.00
37_A112_I1.4131.00
64_L91_V1.3821.00
133_L137_E1.3751.00
119_L147_E1.3711.00
52_Y137_E1.3671.00
55_V59_I1.3411.00
81_K84_K1.3411.00
57_S61_A1.3231.00
85_N88_V1.3071.00
65_R91_V1.3031.00
77_L99_L1.2701.00
139_E143_L1.2601.00
79_N84_K1.2480.99
84_K89_F1.2390.99
141_Y145_L1.2360.99
77_L101_F1.2320.99
8_G32_K1.2320.99
40_P73_I1.1970.99
134_D146_R1.1960.99
4_T60_F1.1830.99
7_S35_V1.1720.99
92_A97_I1.1560.99
57_S88_V1.1470.99
61_A91_V1.1190.99
79_N104_P1.1010.99
10_H14_S1.0960.99
40_P44_G1.0850.99
92_A99_L1.0850.99
8_G82_F1.0850.99
130_E139_E1.0840.99
20_G23_N1.0740.98
58_E87_Y1.0710.98
15_K19_L1.0590.98
39_I115_V1.0410.98
61_A65_R1.0400.98
114_L117_K1.0400.98
15_K21_L1.0210.98
84_K101_F1.0180.98
18_R23_N1.0180.98
10_H30_S1.0130.98
48_F51_T1.0020.98
34_N80_A0.9960.97
102_L110_N0.9940.97
76_I105_Y0.9930.97
70_S73_I0.9780.97
57_S87_Y0.9680.97
3_F42_F0.9600.97
4_T36_L0.9580.97
9_I123_V0.9550.97
71_G94_Q0.9520.97
132_T135_S0.9460.97
51_T55_V0.9320.96
122_W143_L0.9250.96
110_N113_E0.9230.96
90_S93_S0.9150.96
17_R23_N0.9090.96
64_L92_A0.9080.96
16_V19_L0.9060.96
55_V81_K0.8880.95
77_L102_L0.8870.95
123_V126_Y0.8870.95
89_F93_S0.8860.95
38_S66_L0.8820.95
73_I97_I0.8730.95
80_A116_W0.8710.95
124_N131_Y0.8620.94
137_E140_F0.8610.94
142_Y149_S0.8440.94
131_Y135_S0.8420.93
6_E83_H0.8360.93
4_T77_L0.8330.93
120_K124_N0.8330.93
22_Y71_G0.8070.92
115_V147_E0.8040.92
75_L92_A0.7990.92
8_G12_D0.7830.91
123_V130_E0.7700.90
29_P33_L0.7540.89
134_D150_Q0.7510.89
126_Y143_L0.7430.88
132_T145_L0.7430.88
3_F76_I0.7410.88
37_A48_F0.7270.87
15_K20_G0.7230.87
85_N89_F0.7230.87
126_Y139_E0.7200.87
3_F8_G0.7100.86
121_R125_T0.7060.86
117_K120_K0.7040.86
133_L136_M0.7030.85
68_R146_R0.6870.84
54_N131_Y0.6870.84
18_R21_L0.6860.84
34_N54_N0.6800.84
134_D139_E0.6770.83
89_F99_L0.6730.83
137_E142_Y0.6720.83
3_F39_I0.6670.82
104_P137_E0.6670.82
55_V80_A0.6590.82
105_Y120_K0.6570.81
80_A130_E0.6570.81
51_T59_I0.6550.81
91_V98_T0.6500.81
117_K136_M0.6500.81
30_S34_N0.6460.80
8_G15_K0.6410.80
56_N82_F0.6360.79
62_E65_R0.6340.79
87_Y90_S0.6340.79
18_R26_V0.6320.79
20_G24_V0.6290.79
9_I120_K0.6270.78
77_L88_V0.6250.78
63_F66_L0.6250.78
60_F84_K0.6240.78
49_M59_I0.6220.78
27_D30_S0.6220.78
59_I82_F0.6210.78
142_Y145_L0.6210.78
124_N127_Y0.6200.78
146_R150_Q0.6190.77
20_G25_P0.6170.77
82_F92_A0.6170.77
145_L149_S0.6150.77
11_H30_S0.6120.77
92_A95_L0.6100.76
112_I144_F0.6090.76
138_E145_L0.6090.76
125_T130_E0.6090.76
126_Y130_E0.6080.76
146_R149_S0.6020.75
9_I119_L0.5990.75
78_D83_H0.5970.75
39_I45_V0.5960.75
122_W125_T0.5880.74
36_L83_H0.5850.73
72_P95_L0.5810.73
2_F38_S0.5810.73
15_K121_R0.5810.73
46_P69_N0.5810.73
39_I63_F0.5760.72
11_H33_L0.5750.72
39_I46_P0.5730.72
97_I124_N0.5700.71
94_Q134_D0.5700.71
101_F106_S0.5650.71
124_N140_F0.5620.70
16_V21_L0.5610.70
43_D47_C0.5580.70
47_C97_I0.5480.69
136_M140_F0.5420.68
134_D141_Y0.5420.68
57_S86_A0.5410.68
3_F25_P0.5410.68
6_E9_I0.5400.67
49_M62_E0.5390.67
31_R133_L0.5380.67
89_F97_I0.5360.67
65_R68_R0.5350.67
91_V94_Q0.5340.67
136_M139_E0.5320.66
40_P46_P0.5300.66
15_K18_R0.5300.66
79_N82_F0.5290.66
22_Y25_P0.5290.66
5_D107_P0.5240.65
134_D138_E0.5230.65
126_Y142_Y0.5180.64
135_S146_R0.5180.64
102_L105_Y0.5170.64
10_H29_P0.5160.64
123_V143_L0.5140.64
119_L145_L0.5120.63
127_Y131_Y0.5110.63
31_R34_N0.5100.63
2_F62_E0.5090.63
71_G137_E0.5080.63
27_D147_E0.5070.63
8_G34_N0.5030.62
4_T102_L0.5020.62
45_V86_A0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f2kA 1 0.8805 100 0.245 Contact Map
4mdaA 1 0.8679 100 0.258 Contact Map
4u7bA 2 0.9811 100 0.399 Contact Map
4fcyA 4 0.9371 98.9 0.739 Contact Map
4fw1A 2 0.8742 97.9 0.809 Contact Map
4mq3A 1 0.7925 97.9 0.81 Contact Map
1c6vA 4 0.7799 97.8 0.812 Contact Map
3l3uA 2 0.8365 97.5 0.822 Contact Map
2x78A 2 0.8428 97.5 0.825 Contact Map
3hphA 3 0.8491 97.4 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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