GREMLIN Database
Q97XI5 - Uncharacterized protein
UniProt: Q97XI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (266)
Sequences: 6402 (5824)
Seq/√Len: 357.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_I13_N2.8031.00
107_I110_L2.3291.00
65_V68_L2.3191.00
100_V103_H2.2081.00
184_V187_H2.1901.00
79_I82_L2.1901.00
72_V75_Q2.1831.00
86_V89_Q2.1821.00
121_V124_Q2.1801.00
135_V138_Q2.1781.00
149_V152_H2.1321.00
156_I159_L2.0831.00
78_A83_Q2.0081.00
187_H191_I1.9661.00
142_I145_L1.9491.00
17_I20_L1.9191.00
162_A167_Q1.9071.00
242_N245_D1.8951.00
44_I47_L1.8931.00
54_H58_I1.8741.00
99_E104_G1.8661.00
128_I131_L1.8501.00
198_Q201_L1.8431.00
51_I54_H1.8191.00
37_L40_N1.8081.00
170_V173_Q1.7731.00
205_L208_F1.7481.00
114_V117_L1.7421.00
113_A116_S1.7311.00
32_I36_K1.6971.00
73_K76_G1.6931.00
80_V83_Q1.6751.00
191_I194_L1.6751.00
9_E14_P1.6691.00
95_S99_E1.6491.00
93_I96_L1.6381.00
197_S202_S1.6321.00
58_I61_L1.6241.00
177_I180_L1.6131.00
81_S85_T1.6071.00
237_R241_G1.5771.00
43_S48_Q1.5421.00
29_K32_I1.5351.00
163_V166_L1.5221.00
228_L231_H1.5201.00
30_D34_I1.4901.00
234_D239_K1.4751.00
44_I48_Q1.4651.00
16_L21_A1.4621.00
78_A81_S1.4591.00
60_S64_A1.4581.00
55_G59_V1.4541.00
57_A62_Q1.4441.00
104_G108_V1.4411.00
155_A160_Q1.4271.00
31_E34_I1.4161.00
59_V62_Q1.4121.00
144_S148_E1.4091.00
137_K141_A1.3941.00
125_G129_V1.3911.00
46_A50_A1.3831.00
39_E43_S1.3711.00
200_R204_E1.3681.00
205_L209_T1.3631.00
98_E102_R1.3471.00
22_D26_E1.3471.00
226_K230_L1.3441.00
64_A67_S1.3411.00
202_S206_G1.3241.00
38_E41_T1.3241.00
45_Q48_Q1.3211.00
163_V167_Q1.3021.00
176_A179_S1.3001.00
179_S183_E1.2961.00
191_I195_A1.2941.00
70_E74_R1.2901.00
124_Q128_I1.2881.00
162_A165_S1.2841.00
176_A181_Q1.2811.00
102_R106_A1.2691.00
106_A109_S1.2671.00
150_K154_D1.2611.00
221_L224_Y1.2581.00
116_S120_E1.2541.00
40_N44_I1.2451.00
94_V97_Q1.2421.00
165_S169_E1.2401.00
19_A23_K1.2401.00
29_K34_I1.2321.00
49_E53_R1.2181.00
235_P238_V1.2171.00
36_K41_T1.2161.00
212_A216_L1.2121.00
142_I146_Q1.2101.00
89_Q93_I1.2081.00
196_K200_R1.2011.00
123_R127_A1.1981.00
16_L19_A1.1961.00
133_K137_K1.1921.00
64_A69_Q1.1911.00
254_R257_E1.1901.00
115_K118_Q1.1821.00
112_E116_S1.1781.00
212_A215_G1.1761.00
54_H57_A1.1761.00
72_V76_G1.1741.00
127_A132_Q1.1691.00
141_A144_S1.1611.00
113_A118_Q1.1541.00
43_S46_A1.1521.00
122_K125_G1.1491.00
99_E102_R1.1461.00
197_S200_R1.1411.00
17_I24_V1.1371.00
207_S211_R1.1341.00
139_G143_V1.1331.00
21_A25_Y1.1331.00
227_S231_H1.1251.00
141_A146_Q1.1231.00
9_E13_N1.1201.00
192_L195_A1.1191.00
91_E95_S1.1191.00
92_A95_S1.1171.00
36_K39_E1.1131.00
157_V161_E1.1121.00
57_A60_S1.1111.00
38_E42_K1.1021.00
236_K240_H1.1011.00
92_A97_Q1.0991.00
89_Q92_A1.0981.00
129_V132_Q1.0941.00
240_H244_V1.0841.00
101_K105_D1.0811.00
119_E123_R1.0771.00
97_Q101_K1.0731.00
114_V118_Q1.0721.00
127_A130_S1.0621.00
85_T88_K1.0611.00
85_T90_G1.0611.00
148_E153_G1.0591.00
76_G80_V1.0591.00
158_S162_A1.0571.00
63_E67_S1.0551.00
14_P18_S1.0491.00
83_Q87_E1.0481.00
195_A199_K1.0481.00
105_D109_S1.0451.00
183_E188_S1.0361.00
204_E207_S1.0301.00
13_N16_L1.0211.00
134_T139_G1.0191.00
236_K239_K1.0151.00
234_D237_R1.0151.00
111_Q115_K1.0111.00
241_G246_T1.0101.00
52_K56_D1.0101.00
193_R197_S1.0071.00
183_E186_K1.0061.00
77_E81_S1.0061.00
143_V146_Q1.0041.00
243_I247_V1.0021.00
209_T213_G1.0011.00
69_Q73_K1.0001.00
186_K190_A1.0001.00
187_H190_A0.9951.00
88_K92_A0.9901.00
164_K167_Q0.9881.00
160_Q164_K0.9851.00
148_E151_R0.9821.00
151_R155_A0.9801.00
15_Q19_A0.9791.00
74_R78_A0.9771.00
130_S134_T0.9751.00
138_Q142_I0.9751.00
75_Q78_A0.9721.00
22_D25_Y0.9721.00
18_S21_A0.9711.00
101_K104_G0.9671.00
245_D248_G0.9671.00
50_A55_G0.9641.00
68_L72_V0.9621.00
56_D59_V0.9621.00
13_N17_I0.9581.00
146_Q150_K0.9551.00
120_E125_G0.9541.00
35_R39_E0.9501.00
59_V63_E0.9411.00
129_V133_K0.9391.00
225_K229_E0.9391.00
42_K46_A0.9391.00
93_I97_Q0.9291.00
222_K226_K0.9291.00
172_R176_A0.9281.00
78_A82_L0.9181.00
190_A195_A0.9171.00
210_S214_K0.9131.00
161_E165_S0.9131.00
120_E124_Q0.9061.00
12_K16_L0.9041.00
182_E186_K0.9021.00
45_Q49_E0.9021.00
71_E75_Q0.8921.00
241_G245_D0.8891.00
9_E12_K0.8871.00
67_S71_E0.8851.00
169_E174_G0.8821.00
63_E66_K0.8801.00
268_Y271_E0.8751.00
134_T137_K0.8701.00
80_V84_K0.8671.00
58_I62_Q0.8641.00
136_E139_G0.8601.00
66_K69_Q0.8591.00
140_E144_S0.8561.00
77_E80_V0.8551.00
100_V104_G0.8551.00
164_K168_E0.8521.00
198_Q202_S0.8511.00
147_E150_K0.8501.00
52_K55_G0.8501.00
252_K255_S0.8501.00
152_H155_A0.8441.00
221_L225_K0.8441.00
48_Q52_K0.8431.00
152_H156_I0.8401.00
110_L114_V0.8391.00
84_K88_K0.8351.00
109_S113_A0.8351.00
103_H107_I0.8291.00
87_E90_G0.8251.00
126_E130_S0.8231.00
143_V147_E0.8231.00
18_S22_D0.8231.00
11_L14_P0.8201.00
184_V188_S0.8201.00
147_E151_R0.8191.00
62_Q66_K0.8161.00
37_L41_T0.8131.00
86_V90_G0.8091.00
203_I207_S0.8081.00
87_E91_E0.8071.00
162_A166_L0.8031.00
50_A54_H0.8001.00
30_D33_V0.8001.00
173_Q177_I0.8001.00
253_G257_E0.7971.00
214_K218_R0.7961.00
231_H234_D0.7891.00
128_I132_Q0.7861.00
167_Q171_K0.7851.00
239_K243_I0.7841.00
156_I160_Q0.7841.00
118_Q122_K0.7831.00
159_L163_V0.7781.00
75_Q79_I0.7771.00
269_V273_K0.7771.00
11_L15_Q0.7761.00
71_E76_G0.7741.00
136_E140_E0.7721.00
122_K126_E0.7711.00
169_E172_R0.7711.00
31_E35_R0.7671.00
49_E52_K0.7661.00
213_G217_E0.7651.00
174_G178_V0.7631.00
131_L135_V0.7611.00
98_E101_K0.7611.00
107_I111_Q0.7611.00
230_L234_D0.7601.00
66_K70_E0.7571.00
192_L196_K0.7541.00
199_K202_S0.7521.00
271_E275_F0.7501.00
261_Y264_N0.7491.00
132_Q136_E0.7481.00
260_F263_T0.7471.00
142_I149_V0.7461.00
53_R57_A0.7451.00
262_E266_Y0.7451.00
227_S230_L0.7451.00
229_E233_V0.7451.00
177_I181_Q0.7431.00
234_D238_V0.7411.00
175_E179_S0.7341.00
189_K193_R0.7311.00
91_E94_V0.7220.99
90_G94_V0.7180.99
235_P239_K0.7150.99
229_E232_G0.7080.99
204_E209_T0.7070.99
226_K229_E0.7050.99
34_I38_E0.7040.99
188_S191_I0.7040.99
120_E123_R0.6980.99
79_I83_Q0.6970.99
71_E74_R0.6960.99
194_L198_Q0.6940.99
138_Q141_A0.6930.99
156_I163_V0.6880.99
155_A158_S0.6870.99
255_S259_D0.6850.99
124_Q127_A0.6840.99
50_A53_R0.6830.99
206_G209_T0.6780.99
73_K77_E0.6770.99
223_L227_S0.6750.99
171_K174_G0.6750.99
247_V251_E0.6740.99
84_K87_E0.6730.99
244_V247_V0.6710.99
106_A111_Q0.6700.99
20_L24_V0.6700.99
56_D60_S0.6680.99
17_I21_A0.6660.99
110_L113_A0.6620.99
199_K203_I0.6620.99
244_V248_G0.6620.99
36_K40_N0.6610.99
237_R240_H0.6610.99
266_Y269_V0.6590.99
227_S232_G0.6560.99
215_G218_R0.6560.99
222_K225_K0.6550.99
267_I271_E0.6550.99
99_E103_H0.6520.99
178_V181_Q0.6520.99
178_V182_E0.6490.99
210_S213_G0.6470.99
182_E185_K0.6470.99
171_K175_E0.6380.99
55_G58_I0.6380.99
204_E208_F0.6370.99
261_Y265_D0.6360.99
256_F260_F0.6310.99
242_N246_T0.6310.99
96_L100_V0.6300.99
190_A193_R0.6300.99
265_D269_V0.6280.99
58_I65_V0.6220.98
51_I55_G0.6180.98
266_Y271_E0.6180.98
253_G260_F0.6140.98
92_A96_L0.6130.98
181_Q185_K0.6130.98
40_N43_S0.6130.98
149_V153_G0.6120.98
47_L51_I0.6120.98
103_H106_A0.6110.98
157_V160_Q0.6100.98
270_F273_K0.6090.98
260_F264_N0.6090.98
206_G210_S0.6090.98
131_L138_Q0.6090.98
185_K188_S0.6070.98
135_V139_G0.6000.98
235_P242_N0.5930.98
104_G107_I0.5880.98
41_T44_I0.5850.98
24_V27_K0.5820.98
68_L71_E0.5820.98
208_F211_R0.5810.98
166_L170_V0.5790.98
41_T45_Q0.5790.98
154_D158_S0.5780.98
94_V98_E0.5750.97
130_S133_K0.5740.97
231_H235_P0.5710.97
35_R38_E0.5670.97
121_V125_G0.5610.97
19_A22_D0.5590.97
44_I51_I0.5590.97
153_G157_V0.5550.97
69_Q72_V0.5540.97
255_S258_V0.5530.97
102_R105_D0.5510.97
150_K153_G0.5500.97
30_D37_L0.5420.96
263_T267_I0.5400.96
65_V69_Q0.5340.96
70_E73_K0.5330.96
163_V170_V0.5330.96
106_A110_L0.5320.96
23_K27_K0.5290.96
119_E122_K0.5240.96
85_T89_Q0.5180.95
10_I14_P0.5170.95
170_V174_G0.5150.95
185_K189_K0.5140.95
259_D262_E0.5140.95
180_L184_V0.5140.95
33_V36_K0.5140.95
240_H243_I0.5120.95
132_Q135_V0.5120.95
249_I252_K0.5110.95
140_E143_V0.5100.95
29_K33_V0.5080.95
10_I17_I0.5050.95
183_E187_H0.5020.95
108_V111_Q0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.2364 99.3 0.448 Contact Map
1c1gA 2 0.8576 99.1 0.499 Contact Map
2dfsA 2 0.3758 97 0.71 Contact Map
4linA 5 0.6909 97 0.71 Contact Map
4uxvA 1 0.9061 96.4 0.73 Contact Map
3o0zA 2 0.4727 96 0.739 Contact Map
2v71A 3 0.4848 95.9 0.741 Contact Map
3ojaB 1 0.3909 95.8 0.744 Contact Map
3na7A 1 0.7061 95.1 0.756 Contact Map
2efrA 2 0.4697 94.7 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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