GREMLIN Database
Q97XI4 - Uncharacterized protein
UniProt: Q97XI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (198)
Sequences: 2014 (1095)
Seq/√Len: 77.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_E199_K4.7221.00
99_F102_A3.4301.00
130_F136_V3.1861.00
14_L137_F2.9971.00
174_Q193_D2.9711.00
15_K71_E2.9641.00
23_A67_Y2.7961.00
91_G167_E2.7171.00
155_L200_V2.6131.00
85_I92_I2.5561.00
33_A73_Y2.5031.00
154_R195_E2.4471.00
152_G197_P2.3701.00
86_Q135_N2.3521.00
84_Q135_N2.3471.00
92_I164_A2.2161.00
89_G133_T2.1651.00
146_E201_W2.1341.00
91_G129_K2.0911.00
82_I100_L2.0511.00
94_A138_L2.0201.00
166_E199_K1.9651.00
53_K109_D1.9551.00
169_M197_P1.9401.00
43_T65_E1.9121.00
149_L153_E1.8491.00
162_L165_F1.8421.00
187_E190_F1.8301.00
16_V24_I1.8071.00
41_K67_Y1.7891.00
84_Q137_F1.7431.00
149_L197_P1.7411.00
107_N131_R1.7161.00
23_A65_E1.6851.00
127_L165_F1.6771.00
94_A130_F1.6731.00
148_Y199_K1.6561.00
169_M194_I1.6521.00
94_A98_S1.6431.00
91_G131_R1.6421.00
92_I201_W1.6371.00
170_R195_E1.6321.00
90_N166_E1.6301.00
185_S190_F1.6131.00
38_V72_V1.6051.00
156_Q193_D1.5981.00
13_Y32_I1.5730.99
37_S68_G1.5660.99
140_A163_M1.5580.99
17_M71_E1.5510.99
26_V74_L1.5410.99
154_R193_D1.5270.99
153_E197_P1.5220.99
9_K81_P1.5070.99
150_D197_P1.5020.99
18_L72_V1.4710.99
12_Q81_P1.4650.99
19_G69_P1.4440.99
109_D129_K1.4340.99
59_G158_E1.4230.99
17_M69_P1.4120.99
108_Y130_F1.3650.99
23_A104_N1.3330.98
115_L119_W1.3310.98
165_F171_Y1.3280.98
185_S188_G1.3130.98
172_G193_D1.2910.98
20_E68_G1.2790.98
81_P143_G1.2640.98
66_L72_V1.2590.97
13_Y204_T1.2390.97
83_V140_A1.2350.97
182_I189_L1.2240.97
111_T129_K1.2160.97
144_L201_W1.2100.97
41_K65_E1.2050.97
82_I137_F1.2040.97
162_L171_Y1.1800.96
37_S69_P1.1750.96
10_D81_P1.1720.96
26_V66_L1.1610.96
106_V130_F1.1480.96
38_V66_L1.1410.96
87_L136_V1.1300.95
25_Y102_A1.1300.95
31_M158_E1.1280.95
185_S189_L1.1160.95
15_K73_Y1.0960.94
13_Y33_A1.0840.94
34_K156_Q1.0720.94
158_E187_E1.0680.94
35_Q71_E1.0590.93
74_L101_C1.0470.93
88_Q133_T1.0470.93
57_T128_A1.0320.92
16_V74_L1.0210.92
102_A106_V1.0170.92
140_A144_L1.0030.91
32_I75_S0.9860.91
37_S70_G0.9770.90
50_G107_N0.9660.90
157_V202_L0.9600.89
147_R202_L0.9590.89
46_G52_L0.9560.89
92_I136_V0.9510.89
24_I74_L0.9480.89
75_S100_L0.9440.89
14_L82_I0.9350.88
52_L55_E0.9340.88
152_G169_M0.9320.88
40_M176_V0.9300.88
179_I183_L0.9270.88
87_L133_T0.9190.87
85_I138_L0.9140.87
27_D62_F0.9020.86
90_N133_T0.8980.86
87_L90_N0.8810.85
106_V168_G0.8790.85
174_Q177_G0.8790.85
12_Q204_T0.8670.84
36_S154_R0.8610.84
27_D139_H0.8510.83
112_L165_F0.8480.83
127_L171_Y0.8480.83
118_G125_I0.8430.82
25_Y43_T0.8370.82
131_R167_E0.8330.81
175_R178_G0.8280.81
149_L169_M0.8270.81
93_L111_T0.8220.81
40_M64_T0.8160.80
133_T150_D0.8140.80
103_E135_N0.8140.80
10_D143_G0.8040.79
19_G22_E0.8000.79
175_R182_I0.7960.78
36_S70_G0.7960.78
93_L165_F0.7900.78
44_M61_F0.7850.77
105_G133_T0.7830.77
143_G204_T0.7820.77
149_L154_R0.7810.77
111_T171_Y0.7790.77
177_G181_S0.7790.77
90_N167_E0.7750.77
194_I202_L0.7740.76
35_Q70_G0.7690.76
176_V181_S0.7670.76
180_K184_F0.7630.75
166_E169_M0.7580.75
38_V91_G0.7580.75
147_R155_L0.7570.75
49_F52_L0.7550.75
166_E201_W0.7540.75
117_V172_G0.7520.74
93_L127_L0.7370.73
157_V162_L0.7330.73
42_T64_T0.7320.72
178_G181_S0.7290.72
46_G54_R0.7260.72
8_G12_Q0.7250.72
129_K167_E0.7240.72
83_V146_E0.7180.71
179_I182_I0.7130.70
28_A42_T0.7120.70
114_K117_V0.7100.70
27_D60_S0.7060.70
36_S68_G0.6880.68
150_D153_E0.6850.67
58_G122_G0.6780.67
157_V194_I0.6740.66
102_A108_Y0.6670.65
18_L38_V0.6650.65
123_E160_A0.6650.65
59_G187_E0.6630.65
174_Q195_E0.6590.64
45_R65_E0.6570.64
151_P154_R0.6560.64
76_G141_Y0.6560.64
25_Y65_E0.6540.64
95_E127_L0.6530.64
55_E109_D0.6500.63
163_M201_W0.6500.63
159_A192_V0.6480.63
51_A121_G0.6470.63
87_L91_G0.6460.63
25_Y63_V0.6400.62
93_L129_K0.6390.62
156_Q174_Q0.6380.62
141_Y206_T0.6370.62
24_I69_P0.6370.62
23_A115_L0.6320.61
142_G203_H0.6300.61
159_A185_S0.6260.60
25_Y45_R0.6260.60
95_E123_E0.6250.60
59_G97_H0.6230.60
20_E69_P0.6210.60
157_V161_H0.6210.60
40_M106_V0.6200.60
161_H206_T0.6180.59
178_G188_G0.6170.59
96_S125_I0.6170.59
19_G148_Y0.6130.59
194_I198_G0.6130.59
90_N168_G0.6110.59
138_L201_W0.6100.58
83_V138_L0.6100.58
8_G145_I0.6080.58
39_T67_Y0.6070.58
110_A130_F0.6040.58
76_G139_H0.6010.57
31_M100_L0.6000.57
130_F138_L0.5980.57
51_A107_N0.5980.57
94_A136_V0.5980.57
25_Y108_Y0.5960.57
64_T127_L0.5950.57
50_G53_K0.5940.56
110_A178_G0.5920.56
106_V136_V0.5890.56
104_N179_I0.5890.56
45_R51_A0.5860.55
114_K170_R0.5850.55
101_C136_V0.5850.55
132_G196_G0.5840.55
37_S153_E0.5830.55
42_T184_F0.5820.55
164_A194_I0.5810.55
26_V30_H0.5790.55
140_A164_A0.5780.54
35_Q131_R0.5770.54
85_I144_L0.5770.54
86_Q90_N0.5740.54
32_I165_F0.5700.53
30_H158_E0.5700.53
9_K68_G0.5670.53
156_Q190_F0.5660.53
29_G122_G0.5650.53
59_G95_E0.5630.53
141_Y204_T0.5580.52
15_K83_V0.5570.52
95_E128_A0.5570.52
109_D131_R0.5550.51
95_E159_A0.5530.51
149_L152_G0.5520.51
125_I190_F0.5520.51
182_I185_S0.5520.51
25_Y44_M0.5520.51
33_A155_L0.5510.51
165_F194_I0.5500.51
91_G170_R0.5500.51
59_G186_G0.5490.51
93_L205_L0.5490.51
113_N126_F0.5470.50
144_L164_A0.5450.50
22_E119_W0.5450.50
51_A54_R0.5450.50
97_H156_Q0.5400.50
42_T185_S0.5390.49
162_L192_V0.5380.49
70_G147_R0.5370.49
94_A207_V0.5340.49
76_G205_L0.5320.49
176_V208_E0.5310.48
105_G121_G0.5290.48
143_G201_W0.5290.48
151_P197_P0.5280.48
113_N121_G0.5250.48
53_K56_I0.5230.47
103_E106_V0.5200.47
37_S91_G0.5200.47
162_L194_I0.5190.47
172_G195_E0.5190.47
112_L118_G0.5150.46
141_Y205_L0.5150.46
9_K36_S0.5140.46
144_L199_K0.5130.46
110_A126_F0.5130.46
139_H173_I0.5120.46
140_A204_T0.5110.46
162_L166_E0.5100.46
99_F130_F0.5100.46
146_E166_E0.5090.46
102_A130_F0.5080.46
47_G58_G0.5080.46
87_L92_I0.5080.46
173_I189_L0.5080.46
92_I199_K0.5070.45
54_R62_F0.5070.45
62_F184_F0.5060.45
98_S163_M0.5060.45
122_G188_G0.5020.45
14_L101_C0.5020.45
41_K180_K0.5010.45
10_D179_I0.5010.45
92_I138_L0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pg6A 3 0.9009 100 0.178 Contact Map
1yoxA 3 0.9052 100 0.187 Contact Map
4qglA 1 0.25 15.4 0.959 Contact Map
2hc8A 1 0.4353 8 0.964 Contact Map
1cvrA 1 0.4009 7.9 0.964 Contact Map
3htnA 3 0.6034 4.9 0.967 Contact Map
2dlwA 1 0.4655 4.9 0.967 Contact Map
1hf2A 2 0.444 4.7 0.967 Contact Map
2kijA 1 0.431 4.5 0.968 Contact Map
4v02C 2 0.4483 3.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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