Q97XI4 - SULSO - GREMLIN Contacts

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Q97XI4 - Uncharacterized protein

UniProt:	Q97XI4	Sequences: MPQYEILGKDLQYLKVMLGEGEAIYVDAGHMIAKQSSVTMKTTMRGGFFGALKREITGGSFFVTELYGPGEVYLSGVFPGPIVQIQLQGNGILAESHSFLCAENGVNYDATLNKLSVGWLGGEGIFLAKFRGTGNVFLHAYGGLIERYLDPGERLQVEAAHLMAFEEGMRYGIQRVGGIKSILFSGEGLFFVDIEGPGKVWLHTLTVEQLAASLRPYLPQGQQGGPSFNIGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	232 (198)
Sequences:	2014 (1095)
Seq/√Len:	77.8

HALSA - Q9HPJ4 Q9HMA6 Q9HRV1
SULSO - Q97XI4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
146_E	199_K	4.722	1.00
99_F	102_A	3.430	1.00
130_F	136_V	3.186	1.00
14_L	137_F	2.997	1.00
174_Q	193_D	2.971	1.00
15_K	71_E	2.964	1.00
23_A	67_Y	2.796	1.00
91_G	167_E	2.717	1.00
155_L	200_V	2.613	1.00
85_I	92_I	2.556	1.00
33_A	73_Y	2.503	1.00
154_R	195_E	2.447	1.00
152_G	197_P	2.370	1.00
86_Q	135_N	2.352	1.00
84_Q	135_N	2.347	1.00
92_I	164_A	2.216	1.00
89_G	133_T	2.165	1.00
146_E	201_W	2.134	1.00
91_G	129_K	2.091	1.00
82_I	100_L	2.051	1.00
94_A	138_L	2.020	1.00
166_E	199_K	1.965	1.00
53_K	109_D	1.955	1.00
169_M	197_P	1.940	1.00
43_T	65_E	1.912	1.00
149_L	153_E	1.849	1.00
162_L	165_F	1.842	1.00
187_E	190_F	1.830	1.00
16_V	24_I	1.807	1.00
41_K	67_Y	1.789	1.00
84_Q	137_F	1.743	1.00
149_L	197_P	1.741	1.00
107_N	131_R	1.716	1.00
23_A	65_E	1.685	1.00
127_L	165_F	1.677	1.00
94_A	130_F	1.673	1.00
148_Y	199_K	1.656	1.00
169_M	194_I	1.652	1.00
94_A	98_S	1.643	1.00
91_G	131_R	1.642	1.00
92_I	201_W	1.637	1.00
170_R	195_E	1.632	1.00
90_N	166_E	1.630	1.00
185_S	190_F	1.613	1.00
38_V	72_V	1.605	1.00
156_Q	193_D	1.598	1.00
13_Y	32_I	1.573	0.99
37_S	68_G	1.566	0.99
140_A	163_M	1.558	0.99
17_M	71_E	1.551	0.99
26_V	74_L	1.541	0.99
154_R	193_D	1.527	0.99
153_E	197_P	1.522	0.99
9_K	81_P	1.507	0.99
150_D	197_P	1.502	0.99
18_L	72_V	1.471	0.99
12_Q	81_P	1.465	0.99
19_G	69_P	1.444	0.99
109_D	129_K	1.434	0.99
59_G	158_E	1.423	0.99
17_M	69_P	1.412	0.99
108_Y	130_F	1.365	0.99
23_A	104_N	1.333	0.98
115_L	119_W	1.331	0.98
165_F	171_Y	1.328	0.98
185_S	188_G	1.313	0.98
172_G	193_D	1.291	0.98
20_E	68_G	1.279	0.98
81_P	143_G	1.264	0.98
66_L	72_V	1.259	0.97
13_Y	204_T	1.239	0.97
83_V	140_A	1.235	0.97
182_I	189_L	1.224	0.97
111_T	129_K	1.216	0.97
144_L	201_W	1.210	0.97
41_K	65_E	1.205	0.97
82_I	137_F	1.204	0.97
162_L	171_Y	1.180	0.96
37_S	69_P	1.175	0.96
10_D	81_P	1.172	0.96
26_V	66_L	1.161	0.96
106_V	130_F	1.148	0.96
38_V	66_L	1.141	0.96
87_L	136_V	1.130	0.95
25_Y	102_A	1.130	0.95
31_M	158_E	1.128	0.95
185_S	189_L	1.116	0.95
15_K	73_Y	1.096	0.94
13_Y	33_A	1.084	0.94
34_K	156_Q	1.072	0.94
158_E	187_E	1.068	0.94
35_Q	71_E	1.059	0.93
74_L	101_C	1.047	0.93
88_Q	133_T	1.047	0.93
57_T	128_A	1.032	0.92
16_V	74_L	1.021	0.92
102_A	106_V	1.017	0.92
140_A	144_L	1.003	0.91
32_I	75_S	0.986	0.91
37_S	70_G	0.977	0.90
50_G	107_N	0.966	0.90
157_V	202_L	0.960	0.89
147_R	202_L	0.959	0.89
46_G	52_L	0.956	0.89
92_I	136_V	0.951	0.89
24_I	74_L	0.948	0.89
75_S	100_L	0.944	0.89
14_L	82_I	0.935	0.88
52_L	55_E	0.934	0.88
152_G	169_M	0.932	0.88
40_M	176_V	0.930	0.88
179_I	183_L	0.927	0.88
87_L	133_T	0.919	0.87
85_I	138_L	0.914	0.87
27_D	62_F	0.902	0.86
90_N	133_T	0.898	0.86
87_L	90_N	0.881	0.85
106_V	168_G	0.879	0.85
174_Q	177_G	0.879	0.85
12_Q	204_T	0.867	0.84
36_S	154_R	0.861	0.84
27_D	139_H	0.851	0.83
112_L	165_F	0.848	0.83
127_L	171_Y	0.848	0.83
118_G	125_I	0.843	0.82
25_Y	43_T	0.837	0.82
131_R	167_E	0.833	0.81
175_R	178_G	0.828	0.81
149_L	169_M	0.827	0.81
93_L	111_T	0.822	0.81
40_M	64_T	0.816	0.80
133_T	150_D	0.814	0.80
103_E	135_N	0.814	0.80
10_D	143_G	0.804	0.79
19_G	22_E	0.800	0.79
175_R	182_I	0.796	0.78
36_S	70_G	0.796	0.78
93_L	165_F	0.790	0.78
44_M	61_F	0.785	0.77
105_G	133_T	0.783	0.77
143_G	204_T	0.782	0.77
149_L	154_R	0.781	0.77
111_T	171_Y	0.779	0.77
177_G	181_S	0.779	0.77
90_N	167_E	0.775	0.77
194_I	202_L	0.774	0.76
35_Q	70_G	0.769	0.76
176_V	181_S	0.767	0.76
180_K	184_F	0.763	0.75
166_E	169_M	0.758	0.75
38_V	91_G	0.758	0.75
147_R	155_L	0.757	0.75
49_F	52_L	0.755	0.75
166_E	201_W	0.754	0.75
117_V	172_G	0.752	0.74
93_L	127_L	0.737	0.73
157_V	162_L	0.733	0.73
42_T	64_T	0.732	0.72
178_G	181_S	0.729	0.72
46_G	54_R	0.726	0.72
8_G	12_Q	0.725	0.72
129_K	167_E	0.724	0.72
83_V	146_E	0.718	0.71
179_I	182_I	0.713	0.70
28_A	42_T	0.712	0.70
114_K	117_V	0.710	0.70
27_D	60_S	0.706	0.70
36_S	68_G	0.688	0.68
150_D	153_E	0.685	0.67
58_G	122_G	0.678	0.67
157_V	194_I	0.674	0.66
102_A	108_Y	0.667	0.65
18_L	38_V	0.665	0.65
123_E	160_A	0.665	0.65
59_G	187_E	0.663	0.65
174_Q	195_E	0.659	0.64
45_R	65_E	0.657	0.64
151_P	154_R	0.656	0.64
76_G	141_Y	0.656	0.64
25_Y	65_E	0.654	0.64
95_E	127_L	0.653	0.64
55_E	109_D	0.650	0.63
163_M	201_W	0.650	0.63
159_A	192_V	0.648	0.63
51_A	121_G	0.647	0.63
87_L	91_G	0.646	0.63
25_Y	63_V	0.640	0.62
93_L	129_K	0.639	0.62
156_Q	174_Q	0.638	0.62
141_Y	206_T	0.637	0.62
24_I	69_P	0.637	0.62
23_A	115_L	0.632	0.61
142_G	203_H	0.630	0.61
159_A	185_S	0.626	0.60
25_Y	45_R	0.626	0.60
95_E	123_E	0.625	0.60
59_G	97_H	0.623	0.60
20_E	69_P	0.621	0.60
157_V	161_H	0.621	0.60
40_M	106_V	0.620	0.60
161_H	206_T	0.618	0.59
178_G	188_G	0.617	0.59
96_S	125_I	0.617	0.59
19_G	148_Y	0.613	0.59
194_I	198_G	0.613	0.59
90_N	168_G	0.611	0.59
138_L	201_W	0.610	0.58
83_V	138_L	0.610	0.58
8_G	145_I	0.608	0.58
39_T	67_Y	0.607	0.58
110_A	130_F	0.604	0.58
76_G	139_H	0.601	0.57
31_M	100_L	0.600	0.57
130_F	138_L	0.598	0.57
51_A	107_N	0.598	0.57
94_A	136_V	0.598	0.57
25_Y	108_Y	0.596	0.57
64_T	127_L	0.595	0.57
50_G	53_K	0.594	0.56
110_A	178_G	0.592	0.56
106_V	136_V	0.589	0.56
104_N	179_I	0.589	0.56
45_R	51_A	0.586	0.55
114_K	170_R	0.585	0.55
101_C	136_V	0.585	0.55
132_G	196_G	0.584	0.55
37_S	153_E	0.583	0.55
42_T	184_F	0.582	0.55
164_A	194_I	0.581	0.55
26_V	30_H	0.579	0.55
140_A	164_A	0.578	0.54
35_Q	131_R	0.577	0.54
85_I	144_L	0.577	0.54
86_Q	90_N	0.574	0.54
32_I	165_F	0.570	0.53
30_H	158_E	0.570	0.53
9_K	68_G	0.567	0.53
156_Q	190_F	0.566	0.53
29_G	122_G	0.565	0.53
59_G	95_E	0.563	0.53
141_Y	204_T	0.558	0.52
15_K	83_V	0.557	0.52
95_E	128_A	0.557	0.52
109_D	131_R	0.555	0.51
95_E	159_A	0.553	0.51
149_L	152_G	0.552	0.51
125_I	190_F	0.552	0.51
182_I	185_S	0.552	0.51
25_Y	44_M	0.552	0.51
33_A	155_L	0.551	0.51
165_F	194_I	0.550	0.51
91_G	170_R	0.550	0.51
59_G	186_G	0.549	0.51
93_L	205_L	0.549	0.51
113_N	126_F	0.547	0.50
144_L	164_A	0.545	0.50
22_E	119_W	0.545	0.50
51_A	54_R	0.545	0.50
97_H	156_Q	0.540	0.50
42_T	185_S	0.539	0.49
162_L	192_V	0.538	0.49
70_G	147_R	0.537	0.49
94_A	207_V	0.534	0.49
76_G	205_L	0.532	0.49
176_V	208_E	0.531	0.48
105_G	121_G	0.529	0.48
143_G	201_W	0.529	0.48
151_P	197_P	0.528	0.48
113_N	121_G	0.525	0.48
53_K	56_I	0.523	0.47
103_E	106_V	0.520	0.47
37_S	91_G	0.520	0.47
162_L	194_I	0.519	0.47
172_G	195_E	0.519	0.47
112_L	118_G	0.515	0.46
141_Y	205_L	0.515	0.46
9_K	36_S	0.514	0.46
144_L	199_K	0.513	0.46
110_A	126_F	0.513	0.46
139_H	173_I	0.512	0.46
140_A	204_T	0.511	0.46
162_L	166_E	0.510	0.46
99_F	130_F	0.510	0.46
146_E	166_E	0.509	0.46
102_A	130_F	0.508	0.46
47_G	58_G	0.508	0.46
87_L	92_I	0.508	0.46
173_I	189_L	0.508	0.46
92_I	199_K	0.507	0.45
54_R	62_F	0.507	0.45
62_F	184_F	0.506	0.45
98_S	163_M	0.506	0.45
122_G	188_G	0.502	0.45
14_L	101_C	0.502	0.45
41_K	180_K	0.501	0.45
10_D	179_I	0.501	0.45
92_I	138_L	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pg6A	3	0.9009	100	0.178	Contact Map
1yoxA	3	0.9052	100	0.187	Contact Map
4qglA	1	0.25	15.4	0.959	Contact Map
2hc8A	1	0.4353	8	0.964	Contact Map
1cvrA	1	0.4009	7.9	0.964	Contact Map
3htnA	3	0.6034	4.9	0.967	Contact Map
2dlwA	1	0.4655	4.9	0.967	Contact Map
1hf2A	2	0.444	4.7	0.967	Contact Map
2kijA	1	0.431	4.5	0.968	Contact Map
4v02C	2	0.4483	3.8	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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