Q97XI3 - SULSO - GREMLIN Contacts

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Q97XI3 - Potassium channel protein, putative

UniProt:	Q97XI3	Sequences: MNKERVWNRIIIPLLENLVAPYSVVRRIYVQIILLGVAVLINAVVFITYQHLDWISAIYAGVNVVTTVGLYSPNIYQMPSNEKIILTLTIILAVGLYTSIVQSIIATLISRSTWNDVKARWRGKHMKGHTILIGNGSELLSAVRRLNRLSIDYIVLTTSKDIADKIKGDNVILGDPKDDNTLLSAGVKEAKNAIVMLEDDMEALLVTLKLQKLNPPLQVIVAIRDDSLRDLFNTAGADLVISREDIIGRIAASAAVSTNIAGLIFPERSGDMIIGIFHVTKKRRIKDLPDGVVPLAIIRGNRIDPFFTKETELNIGEQLVVLGNPSTFREVKELLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (296)
Sequences:	3104 (2459)
Seq/√Len:	142.9

ECOLI - KCH
BACSU - YUGO
HALSA - Q9HRN5 Q9HP16
SULSO - Q97XI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_A	210_L	5.171	1.00
299_R	317_E	4.302	1.00
193_A	217_L	3.966	1.00
132_L	143_V	3.725	1.00
127_K	189_E	3.701	1.00
186_G	189_E	3.552	1.00
211_Q	219_V	3.381	1.00
183_L	188_K	3.239	1.00
297_I	311_T	3.191	1.00
67_T	71_Y	2.954	1.00
279_V	313_L	2.829	1.00
207_T	237_A	2.775	1.00
284_R	287_D	2.724	1.00
128_G	191_K	2.710	1.00
56_S	83_K	2.579	1.00
268_R	272_M	2.421	1.00
211_Q	238_D	2.375	1.00
174_G	181_T	2.249	1.00
267_E	272_M	2.188	1.00
313_L	319_L	2.111	1.00
71_Y	74_N	2.092	1.00
172_I	185_A	2.083	1.00
299_R	311_T	2.077	1.00
285_I	289_P	2.070	1.00
203_A	221_V	2.039	1.00
195_V	203_A	2.036	1.00
299_R	314_N	2.033	1.00
64_V	70_L	1.947	1.00
47_I	54_W	1.943	1.00
70_L	74_N	1.942	1.00
79_P	82_E	1.934	1.00
156_L	181_T	1.910	1.00
130_T	192_N	1.878	1.00
286_K	310_E	1.856	1.00
197_L	206_V	1.849	1.00
156_L	185_A	1.802	1.00
35_L	39_V	1.772	1.00
39_V	46_F	1.751	1.00
64_V	68_V	1.747	1.00
74_N	77_Q	1.720	1.00
267_E	271_D	1.685	1.00
214_N	217_L	1.684	1.00
285_I	288_L	1.655	1.00
46_F	86_L	1.621	1.00
81_N	84_I	1.610	1.00
187_V	210_L	1.585	1.00
68_V	71_Y	1.576	1.00
111_R	114_W	1.524	1.00
60_A	74_N	1.522	1.00
45_V	49_Y	1.515	1.00
87_T	91_I	1.503	1.00
324_N	327_T	1.501	1.00
130_T	146_L	1.496	1.00
218_Q	238_D	1.496	1.00
39_V	43_A	1.495	1.00
64_V	67_T	1.491	1.00
160_K	173_L	1.478	1.00
136_G	139_L	1.472	1.00
131_I	187_V	1.471	1.00
187_V	214_N	1.468	1.00
296_A	320_V	1.434	1.00
156_L	172_I	1.430	1.00
74_N	79_P	1.427	1.00
67_T	70_L	1.407	1.00
44_V	48_T	1.392	1.00
129_H	190_A	1.378	1.00
74_N	82_E	1.377	1.00
43_A	47_I	1.371	1.00
86_L	91_I	1.369	1.00
63_N	90_I	1.362	1.00
160_K	164_D	1.358	1.00
279_V	283_R	1.357	1.00
269_S	272_M	1.353	1.00
53_D	56_S	1.353	1.00
57_A	61_G	1.317	1.00
42_N	45_V	1.308	1.00
210_L	217_L	1.291	1.00
199_D	202_E	1.287	1.00
59_Y	62_V	1.273	1.00
290_D	327_T	1.271	1.00
68_V	74_N	1.264	1.00
299_R	304_D	1.264	1.00
59_Y	63_N	1.262	1.00
35_L	46_F	1.262	1.00
276_I	318_Q	1.250	1.00
168_G	171_V	1.248	1.00
291_G	327_T	1.236	1.00
163_A	171_V	1.233	1.00
260_I	263_L	1.217	1.00
200_D	228_L	1.211	1.00
89_T	94_V	1.210	1.00
71_Y	77_Q	1.209	1.00
157_T	162_I	1.208	1.00
183_L	213_L	1.207	1.00
58_I	87_T	1.205	1.00
288_L	313_L	1.194	1.00
208_L	235_A	1.193	1.00
257_S	261_A	1.193	1.00
66_T	90_I	1.180	1.00
314_N	317_E	1.180	1.00
267_E	273_I	1.176	1.00
281_K	315_I	1.168	1.00
41_I	44_V	1.158	1.00
86_L	90_I	1.150	0.99
34_L	41_I	1.149	0.99
54_W	58_I	1.148	0.99
60_A	63_N	1.147	0.99
56_S	59_Y	1.137	0.99
67_T	74_N	1.134	0.99
285_I	294_P	1.128	0.99
286_K	309_K	1.126	0.99
60_A	86_L	1.122	0.99
38_A	42_N	1.120	0.99
91_I	95_G	1.120	0.99
90_I	94_V	1.106	0.99
31_Q	42_N	1.106	0.99
59_Y	64_V	1.102	0.99
257_S	260_I	1.101	0.99
71_Y	76_Y	1.091	0.99
90_I	95_G	1.090	0.99
187_V	193_A	1.085	0.99
74_N	83_K	1.085	0.99
39_V	47_I	1.082	0.99
162_I	165_K	1.072	0.99
55_I	87_T	1.068	0.99
126_M	170_N	1.063	0.99
142_A	194_I	1.063	0.99
295_L	322_L	1.061	0.99
158_T	175_D	1.059	0.99
130_T	191_K	1.051	0.99
115_N	118_K	1.047	0.99
35_L	47_I	1.043	0.99
69_G	74_N	1.043	0.99
180_N	183_L	1.043	0.99
76_Y	81_N	1.042	0.99
297_I	317_E	1.041	0.99
157_T	171_V	1.041	0.99
166_I	171_V	1.040	0.99
51_H	54_W	1.038	0.99
200_D	208_L	1.038	0.99
176_P	206_V	1.038	0.99
157_T	163_A	1.038	0.99
30_V	38_A	1.036	0.99
284_R	312_E	1.035	0.99
42_N	89_T	1.033	0.99
63_N	74_N	1.032	0.99
64_V	71_Y	1.031	0.99
59_Y	83_K	1.024	0.99
64_V	69_G	1.024	0.99
133_I	193_A	1.023	0.99
270_G	273_I	1.018	0.99
43_A	46_F	1.012	0.99
237_A	240_V	1.009	0.99
162_I	166_I	1.006	0.99
59_Y	86_L	0.998	0.99
76_Y	82_E	0.993	0.98
59_Y	67_T	0.990	0.98
42_N	46_F	0.990	0.98
70_L	75_I	0.983	0.98
219_V	238_D	0.980	0.98
154_I	172_I	0.980	0.98
163_A	166_I	0.978	0.98
67_T	79_P	0.976	0.98
223_I	232_F	0.973	0.98
98_T	102_Q	0.973	0.98
138_E	222_A	0.968	0.98
42_N	48_T	0.967	0.98
195_V	207_T	0.963	0.98
261_A	266_P	0.958	0.98
31_Q	43_A	0.957	0.98
43_A	48_T	0.957	0.98
94_V	98_T	0.957	0.98
132_L	155_V	0.956	0.98
42_N	47_I	0.954	0.98
81_N	85_I	0.954	0.98
284_R	289_P	0.953	0.98
36_G	48_T	0.951	0.98
28_I	31_Q	0.950	0.98
151_I	191_K	0.949	0.98
58_I	61_G	0.949	0.98
142_A	248_G	0.949	0.98
131_I	217_L	0.949	0.98
57_A	60_A	0.946	0.98
29_Y	32_I	0.938	0.98
70_L	77_Q	0.934	0.98
204_L	208_L	0.933	0.98
71_Y	75_I	0.929	0.98
117_V	120_R	0.928	0.98
38_A	43_A	0.920	0.97
142_A	146_L	0.918	0.97
68_V	90_I	0.913	0.97
59_Y	74_N	0.912	0.97
35_L	49_Y	0.911	0.97
197_L	202_E	0.910	0.97
91_I	94_V	0.906	0.97
142_A	147_N	0.902	0.97
29_Y	33_I	0.900	0.97
34_L	37_V	0.899	0.97
114_W	118_K	0.896	0.97
45_V	85_I	0.891	0.97
194_I	255_A	0.890	0.97
153_Y	169_D	0.889	0.97
77_Q	82_E	0.888	0.97
195_V	221_V	0.886	0.97
280_T	283_R	0.885	0.97
58_I	62_V	0.882	0.97
31_Q	45_V	0.880	0.97
136_G	222_A	0.878	0.97
279_V	282_K	0.876	0.97
276_I	280_T	0.875	0.97
31_Q	46_F	0.873	0.97
31_Q	38_A	0.868	0.96
263_L	266_P	0.865	0.96
102_Q	106_A	0.861	0.96
269_S	273_I	0.849	0.96
46_F	49_Y	0.840	0.96
135_N	140_L	0.837	0.96
133_I	217_L	0.833	0.95
226_D	245_D	0.831	0.95
300_G	314_N	0.820	0.95
268_R	273_I	0.820	0.95
277_F	283_R	0.817	0.95
143_V	153_Y	0.814	0.95
131_I	193_A	0.807	0.95
104_I	285_I	0.802	0.94
106_A	109_I	0.801	0.94
278_H	318_Q	0.801	0.94
67_T	83_K	0.798	0.94
142_A	196_M	0.796	0.94
205_L	228_L	0.795	0.94
146_L	149_L	0.790	0.94
183_L	186_G	0.783	0.94
115_N	119_A	0.782	0.94
197_L	222_A	0.780	0.94
52_L	57_A	0.777	0.93
31_Q	35_L	0.777	0.93
67_T	82_E	0.772	0.93
176_P	182_L	0.771	0.93
293_V	296_A	0.767	0.93
298_I	318_Q	0.767	0.93
32_I	40_L	0.765	0.93
78_M	82_E	0.764	0.93
207_T	219_V	0.763	0.93
196_M	222_A	0.760	0.93
232_F	236_G	0.759	0.93
71_Y	79_P	0.759	0.93
40_L	44_V	0.755	0.92
32_I	35_L	0.753	0.92
157_T	176_P	0.752	0.92
278_H	281_K	0.748	0.92
80_S	85_I	0.747	0.92
276_I	279_V	0.747	0.92
62_V	87_T	0.747	0.92
207_T	221_V	0.746	0.92
32_I	36_G	0.746	0.92
197_L	207_T	0.744	0.92
44_V	47_I	0.744	0.92
268_R	271_D	0.743	0.92
28_I	36_G	0.740	0.92
143_V	155_V	0.739	0.92
76_Y	79_P	0.739	0.92
229_R	233_N	0.738	0.92
200_D	223_I	0.737	0.92
58_I	64_V	0.736	0.91
166_I	169_D	0.735	0.91
49_Y	85_I	0.734	0.91
138_E	196_M	0.733	0.91
44_V	49_Y	0.733	0.91
304_D	311_T	0.727	0.91
64_V	74_N	0.720	0.91
257_S	263_L	0.718	0.90
231_L	234_T	0.715	0.90
70_L	82_E	0.715	0.90
139_L	222_A	0.713	0.90
133_I	176_P	0.706	0.90
78_M	81_N	0.706	0.90
152_D	187_V	0.705	0.90
254_A	261_A	0.705	0.90
297_I	304_D	0.704	0.90
38_A	46_F	0.701	0.89
39_V	49_Y	0.698	0.89
294_P	319_L	0.697	0.89
299_R	302_R	0.693	0.89
94_V	104_I	0.693	0.89
129_H	154_I	0.693	0.89
69_G	77_Q	0.691	0.89
94_V	97_Y	0.689	0.89
66_T	70_L	0.687	0.88
40_L	281_K	0.687	0.88
67_T	76_Y	0.684	0.88
57_A	63_N	0.681	0.88
52_L	60_A	0.681	0.88
63_N	71_Y	0.680	0.88
112_S	118_K	0.679	0.88
296_A	303_I	0.678	0.88
111_R	117_V	0.678	0.88
75_I	83_K	0.677	0.88
153_Y	161_D	0.675	0.88
223_I	240_V	0.675	0.88
100_I	277_F	0.675	0.88
74_N	81_N	0.674	0.87
221_V	237_A	0.673	0.87
157_T	166_I	0.669	0.87
95_G	98_T	0.669	0.87
103_S	106_A	0.666	0.87
193_A	288_L	0.665	0.87
136_G	142_A	0.664	0.87
60_A	76_Y	0.659	0.86
111_R	115_N	0.657	0.86
36_G	43_A	0.655	0.86
116_D	120_R	0.652	0.86
101_V	105_I	0.651	0.86
220_I	251_A	0.649	0.85
259_N	264_I	0.649	0.85
275_G	279_V	0.647	0.85
262_G	266_P	0.645	0.85
36_G	42_N	0.644	0.85
34_L	42_N	0.639	0.85
49_Y	81_N	0.638	0.84
129_H	185_A	0.637	0.84
118_K	122_R	0.632	0.84
103_S	107_T	0.628	0.84
204_L	232_F	0.628	0.84
55_I	80_S	0.627	0.83
112_S	119_A	0.627	0.83
39_V	44_V	0.626	0.83
83_K	200_D	0.624	0.83
51_H	60_A	0.623	0.83
94_V	101_V	0.623	0.83
55_I	59_Y	0.622	0.83
302_R	305_P	0.621	0.83
46_F	87_T	0.621	0.83
59_Y	70_L	0.621	0.83
131_I	190_A	0.619	0.83
162_I	294_P	0.618	0.83
30_V	34_L	0.618	0.83
282_K	315_I	0.615	0.82
241_I	316_G	0.615	0.82
140_L	144_R	0.614	0.82
87_T	90_I	0.614	0.82
34_L	38_A	0.613	0.82
65_V	205_L	0.613	0.82
136_G	157_T	0.611	0.82
135_N	139_L	0.610	0.82
28_I	32_I	0.610	0.82
267_E	278_H	0.609	0.82
100_I	104_I	0.609	0.82
276_I	320_V	0.608	0.82
32_I	42_N	0.606	0.81
312_E	316_G	0.606	0.81
155_V	169_D	0.606	0.81
146_L	192_N	0.605	0.81
34_L	46_F	0.600	0.81
139_L	143_V	0.594	0.80
66_T	71_Y	0.593	0.80
66_T	69_G	0.593	0.80
155_V	192_N	0.591	0.80
33_I	310_E	0.590	0.80
87_T	95_G	0.589	0.79
311_T	314_N	0.587	0.79
45_V	48_T	0.587	0.79
77_Q	83_K	0.586	0.79
32_I	48_T	0.584	0.79
36_G	40_L	0.584	0.79
260_I	268_R	0.583	0.79
228_L	231_L	0.582	0.79
77_Q	90_I	0.582	0.79
57_A	64_V	0.581	0.79
183_L	217_L	0.581	0.79
259_N	265_F	0.579	0.78
218_Q	239_L	0.578	0.78
37_V	48_T	0.578	0.78
207_T	232_F	0.577	0.78
36_G	41_I	0.577	0.78
95_G	99_S	0.577	0.78
80_S	83_K	0.576	0.78
62_V	67_T	0.574	0.78
66_T	91_I	0.574	0.78
133_I	206_V	0.573	0.78
37_V	47_I	0.572	0.78
187_V	217_L	0.569	0.77
76_Y	80_S	0.569	0.77
195_V	210_L	0.568	0.77
130_T	239_L	0.567	0.77
43_A	58_I	0.567	0.77
290_D	293_V	0.564	0.77
101_V	109_I	0.561	0.76
60_A	68_V	0.561	0.76
59_Y	66_T	0.560	0.76
35_L	40_L	0.559	0.76
35_L	54_W	0.558	0.76
139_L	176_P	0.557	0.76
209_K	231_L	0.557	0.76
176_P	198_E	0.556	0.76
205_L	231_L	0.549	0.75
82_E	85_I	0.548	0.74
82_E	90_I	0.548	0.74
259_N	262_G	0.547	0.74
132_L	232_F	0.546	0.74
52_L	76_Y	0.546	0.74
172_I	181_T	0.546	0.74
88_L	91_I	0.544	0.74
139_L	155_V	0.541	0.74
179_D	209_K	0.541	0.74
30_V	42_N	0.541	0.74
170_N	181_T	0.540	0.73
63_N	70_L	0.538	0.73
30_V	33_I	0.535	0.73
245_D	249_R	0.533	0.72
223_I	242_S	0.533	0.72
285_I	309_K	0.529	0.72
33_I	48_T	0.528	0.72
32_I	43_A	0.527	0.72
307_F	310_E	0.527	0.72
269_S	274_I	0.526	0.71
253_S	320_V	0.524	0.71
95_G	105_I	0.523	0.71
277_F	290_D	0.522	0.71
187_V	213_L	0.521	0.71
146_L	153_Y	0.518	0.70
131_I	156_L	0.517	0.70
56_S	62_V	0.517	0.70
259_N	266_P	0.515	0.70
98_T	109_I	0.512	0.69
33_I	39_V	0.512	0.69
96_L	242_S	0.512	0.69
39_V	176_P	0.512	0.69
221_V	232_F	0.511	0.69
64_V	82_E	0.510	0.69
161_D	165_K	0.509	0.69
286_K	289_P	0.509	0.69
90_I	98_T	0.508	0.69
292_V	323_G	0.508	0.69
58_I	88_L	0.507	0.69
277_F	321_V	0.505	0.68
68_V	76_Y	0.505	0.68
63_N	67_T	0.505	0.68
42_N	49_Y	0.505	0.68
296_A	305_P	0.504	0.68
175_D	235_A	0.502	0.68
35_L	44_V	0.502	0.68
136_G	176_P	0.501	0.68
133_I	182_L	0.501	0.68
174_G	185_A	0.500	0.68

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1lnqA	6	0.8512	100	0.329	Contact Map
4gx0A	3	0.9107	100	0.382	Contact Map
3nafA	3	0.6518	100	0.473	Contact Map
3mt5A	5	0.6131	100	0.549	Contact Map
2aefA	2	0.6131	100	0.554	Contact Map
4hpfA	3	0.5923	100	0.56	Contact Map
4g65A	2	0.622	100	0.624	Contact Map
3l4bC	2	0.6131	99.9	0.646	Contact Map
4j91A	3	0.6101	99.9	0.67	Contact Map
2r9rB	3	0.3393	99.8	0.711	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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