GREMLIN Database
Q97XI3 - Potassium channel protein, putative
UniProt: Q97XI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (296)
Sequences: 3104 (2459)
Seq/√Len: 142.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_A210_L5.1711.00
299_R317_E4.3021.00
193_A217_L3.9661.00
132_L143_V3.7251.00
127_K189_E3.7011.00
186_G189_E3.5521.00
211_Q219_V3.3811.00
183_L188_K3.2391.00
297_I311_T3.1911.00
67_T71_Y2.9541.00
279_V313_L2.8291.00
207_T237_A2.7751.00
284_R287_D2.7241.00
128_G191_K2.7101.00
56_S83_K2.5791.00
268_R272_M2.4211.00
211_Q238_D2.3751.00
174_G181_T2.2491.00
267_E272_M2.1881.00
313_L319_L2.1111.00
71_Y74_N2.0921.00
172_I185_A2.0831.00
299_R311_T2.0771.00
285_I289_P2.0701.00
203_A221_V2.0391.00
195_V203_A2.0361.00
299_R314_N2.0331.00
64_V70_L1.9471.00
47_I54_W1.9431.00
70_L74_N1.9421.00
79_P82_E1.9341.00
156_L181_T1.9101.00
130_T192_N1.8781.00
286_K310_E1.8561.00
197_L206_V1.8491.00
156_L185_A1.8021.00
35_L39_V1.7721.00
39_V46_F1.7511.00
64_V68_V1.7471.00
74_N77_Q1.7201.00
267_E271_D1.6851.00
214_N217_L1.6841.00
285_I288_L1.6551.00
46_F86_L1.6211.00
81_N84_I1.6101.00
187_V210_L1.5851.00
68_V71_Y1.5761.00
111_R114_W1.5241.00
60_A74_N1.5221.00
45_V49_Y1.5151.00
87_T91_I1.5031.00
324_N327_T1.5011.00
130_T146_L1.4961.00
218_Q238_D1.4961.00
39_V43_A1.4951.00
64_V67_T1.4911.00
160_K173_L1.4781.00
136_G139_L1.4721.00
131_I187_V1.4711.00
187_V214_N1.4681.00
296_A320_V1.4341.00
156_L172_I1.4301.00
74_N79_P1.4271.00
67_T70_L1.4071.00
44_V48_T1.3921.00
129_H190_A1.3781.00
74_N82_E1.3771.00
43_A47_I1.3711.00
86_L91_I1.3691.00
63_N90_I1.3621.00
160_K164_D1.3581.00
279_V283_R1.3571.00
269_S272_M1.3531.00
53_D56_S1.3531.00
57_A61_G1.3171.00
42_N45_V1.3081.00
210_L217_L1.2911.00
199_D202_E1.2871.00
59_Y62_V1.2731.00
290_D327_T1.2711.00
68_V74_N1.2641.00
299_R304_D1.2641.00
59_Y63_N1.2621.00
35_L46_F1.2621.00
276_I318_Q1.2501.00
168_G171_V1.2481.00
291_G327_T1.2361.00
163_A171_V1.2331.00
260_I263_L1.2171.00
200_D228_L1.2111.00
89_T94_V1.2101.00
71_Y77_Q1.2091.00
157_T162_I1.2081.00
183_L213_L1.2071.00
58_I87_T1.2051.00
288_L313_L1.1941.00
208_L235_A1.1931.00
257_S261_A1.1931.00
66_T90_I1.1801.00
314_N317_E1.1801.00
267_E273_I1.1761.00
281_K315_I1.1681.00
41_I44_V1.1581.00
86_L90_I1.1500.99
34_L41_I1.1490.99
54_W58_I1.1480.99
60_A63_N1.1470.99
56_S59_Y1.1370.99
67_T74_N1.1340.99
285_I294_P1.1280.99
286_K309_K1.1260.99
60_A86_L1.1220.99
38_A42_N1.1200.99
91_I95_G1.1200.99
90_I94_V1.1060.99
31_Q42_N1.1060.99
59_Y64_V1.1020.99
257_S260_I1.1010.99
71_Y76_Y1.0910.99
90_I95_G1.0900.99
187_V193_A1.0850.99
74_N83_K1.0850.99
39_V47_I1.0820.99
162_I165_K1.0720.99
55_I87_T1.0680.99
126_M170_N1.0630.99
142_A194_I1.0630.99
295_L322_L1.0610.99
158_T175_D1.0590.99
130_T191_K1.0510.99
115_N118_K1.0470.99
35_L47_I1.0430.99
69_G74_N1.0430.99
180_N183_L1.0430.99
76_Y81_N1.0420.99
297_I317_E1.0410.99
157_T171_V1.0410.99
166_I171_V1.0400.99
51_H54_W1.0380.99
200_D208_L1.0380.99
176_P206_V1.0380.99
157_T163_A1.0380.99
30_V38_A1.0360.99
284_R312_E1.0350.99
42_N89_T1.0330.99
63_N74_N1.0320.99
64_V71_Y1.0310.99
59_Y83_K1.0240.99
64_V69_G1.0240.99
133_I193_A1.0230.99
270_G273_I1.0180.99
43_A46_F1.0120.99
237_A240_V1.0090.99
162_I166_I1.0060.99
59_Y86_L0.9980.99
76_Y82_E0.9930.98
59_Y67_T0.9900.98
42_N46_F0.9900.98
70_L75_I0.9830.98
219_V238_D0.9800.98
154_I172_I0.9800.98
163_A166_I0.9780.98
67_T79_P0.9760.98
223_I232_F0.9730.98
98_T102_Q0.9730.98
138_E222_A0.9680.98
42_N48_T0.9670.98
195_V207_T0.9630.98
261_A266_P0.9580.98
31_Q43_A0.9570.98
43_A48_T0.9570.98
94_V98_T0.9570.98
132_L155_V0.9560.98
42_N47_I0.9540.98
81_N85_I0.9540.98
284_R289_P0.9530.98
36_G48_T0.9510.98
28_I31_Q0.9500.98
151_I191_K0.9490.98
58_I61_G0.9490.98
142_A248_G0.9490.98
131_I217_L0.9490.98
57_A60_A0.9460.98
29_Y32_I0.9380.98
70_L77_Q0.9340.98
204_L208_L0.9330.98
71_Y75_I0.9290.98
117_V120_R0.9280.98
38_A43_A0.9200.97
142_A146_L0.9180.97
68_V90_I0.9130.97
59_Y74_N0.9120.97
35_L49_Y0.9110.97
197_L202_E0.9100.97
91_I94_V0.9060.97
142_A147_N0.9020.97
29_Y33_I0.9000.97
34_L37_V0.8990.97
114_W118_K0.8960.97
45_V85_I0.8910.97
194_I255_A0.8900.97
153_Y169_D0.8890.97
77_Q82_E0.8880.97
195_V221_V0.8860.97
280_T283_R0.8850.97
58_I62_V0.8820.97
31_Q45_V0.8800.97
136_G222_A0.8780.97
279_V282_K0.8760.97
276_I280_T0.8750.97
31_Q46_F0.8730.97
31_Q38_A0.8680.96
263_L266_P0.8650.96
102_Q106_A0.8610.96
269_S273_I0.8490.96
46_F49_Y0.8400.96
135_N140_L0.8370.96
133_I217_L0.8330.95
226_D245_D0.8310.95
300_G314_N0.8200.95
268_R273_I0.8200.95
277_F283_R0.8170.95
143_V153_Y0.8140.95
131_I193_A0.8070.95
104_I285_I0.8020.94
106_A109_I0.8010.94
278_H318_Q0.8010.94
67_T83_K0.7980.94
142_A196_M0.7960.94
205_L228_L0.7950.94
146_L149_L0.7900.94
183_L186_G0.7830.94
115_N119_A0.7820.94
197_L222_A0.7800.94
52_L57_A0.7770.93
31_Q35_L0.7770.93
67_T82_E0.7720.93
176_P182_L0.7710.93
293_V296_A0.7670.93
298_I318_Q0.7670.93
32_I40_L0.7650.93
78_M82_E0.7640.93
207_T219_V0.7630.93
196_M222_A0.7600.93
232_F236_G0.7590.93
71_Y79_P0.7590.93
40_L44_V0.7550.92
32_I35_L0.7530.92
157_T176_P0.7520.92
278_H281_K0.7480.92
80_S85_I0.7470.92
276_I279_V0.7470.92
62_V87_T0.7470.92
207_T221_V0.7460.92
32_I36_G0.7460.92
197_L207_T0.7440.92
44_V47_I0.7440.92
268_R271_D0.7430.92
28_I36_G0.7400.92
143_V155_V0.7390.92
76_Y79_P0.7390.92
229_R233_N0.7380.92
200_D223_I0.7370.92
58_I64_V0.7360.91
166_I169_D0.7350.91
49_Y85_I0.7340.91
138_E196_M0.7330.91
44_V49_Y0.7330.91
304_D311_T0.7270.91
64_V74_N0.7200.91
257_S263_L0.7180.90
231_L234_T0.7150.90
70_L82_E0.7150.90
139_L222_A0.7130.90
133_I176_P0.7060.90
78_M81_N0.7060.90
152_D187_V0.7050.90
254_A261_A0.7050.90
297_I304_D0.7040.90
38_A46_F0.7010.89
39_V49_Y0.6980.89
294_P319_L0.6970.89
299_R302_R0.6930.89
94_V104_I0.6930.89
129_H154_I0.6930.89
69_G77_Q0.6910.89
94_V97_Y0.6890.89
66_T70_L0.6870.88
40_L281_K0.6870.88
67_T76_Y0.6840.88
57_A63_N0.6810.88
52_L60_A0.6810.88
63_N71_Y0.6800.88
112_S118_K0.6790.88
296_A303_I0.6780.88
111_R117_V0.6780.88
75_I83_K0.6770.88
153_Y161_D0.6750.88
223_I240_V0.6750.88
100_I277_F0.6750.88
74_N81_N0.6740.87
221_V237_A0.6730.87
157_T166_I0.6690.87
95_G98_T0.6690.87
103_S106_A0.6660.87
193_A288_L0.6650.87
136_G142_A0.6640.87
60_A76_Y0.6590.86
111_R115_N0.6570.86
36_G43_A0.6550.86
116_D120_R0.6520.86
101_V105_I0.6510.86
220_I251_A0.6490.85
259_N264_I0.6490.85
275_G279_V0.6470.85
262_G266_P0.6450.85
36_G42_N0.6440.85
34_L42_N0.6390.85
49_Y81_N0.6380.84
129_H185_A0.6370.84
118_K122_R0.6320.84
103_S107_T0.6280.84
204_L232_F0.6280.84
55_I80_S0.6270.83
112_S119_A0.6270.83
39_V44_V0.6260.83
83_K200_D0.6240.83
51_H60_A0.6230.83
94_V101_V0.6230.83
55_I59_Y0.6220.83
302_R305_P0.6210.83
46_F87_T0.6210.83
59_Y70_L0.6210.83
131_I190_A0.6190.83
162_I294_P0.6180.83
30_V34_L0.6180.83
282_K315_I0.6150.82
241_I316_G0.6150.82
140_L144_R0.6140.82
87_T90_I0.6140.82
34_L38_A0.6130.82
65_V205_L0.6130.82
136_G157_T0.6110.82
135_N139_L0.6100.82
28_I32_I0.6100.82
267_E278_H0.6090.82
100_I104_I0.6090.82
276_I320_V0.6080.82
32_I42_N0.6060.81
312_E316_G0.6060.81
155_V169_D0.6060.81
146_L192_N0.6050.81
34_L46_F0.6000.81
139_L143_V0.5940.80
66_T71_Y0.5930.80
66_T69_G0.5930.80
155_V192_N0.5910.80
33_I310_E0.5900.80
87_T95_G0.5890.79
311_T314_N0.5870.79
45_V48_T0.5870.79
77_Q83_K0.5860.79
32_I48_T0.5840.79
36_G40_L0.5840.79
260_I268_R0.5830.79
228_L231_L0.5820.79
77_Q90_I0.5820.79
57_A64_V0.5810.79
183_L217_L0.5810.79
259_N265_F0.5790.78
218_Q239_L0.5780.78
37_V48_T0.5780.78
207_T232_F0.5770.78
36_G41_I0.5770.78
95_G99_S0.5770.78
80_S83_K0.5760.78
62_V67_T0.5740.78
66_T91_I0.5740.78
133_I206_V0.5730.78
37_V47_I0.5720.78
187_V217_L0.5690.77
76_Y80_S0.5690.77
195_V210_L0.5680.77
130_T239_L0.5670.77
43_A58_I0.5670.77
290_D293_V0.5640.77
101_V109_I0.5610.76
60_A68_V0.5610.76
59_Y66_T0.5600.76
35_L40_L0.5590.76
35_L54_W0.5580.76
139_L176_P0.5570.76
209_K231_L0.5570.76
176_P198_E0.5560.76
205_L231_L0.5490.75
82_E85_I0.5480.74
82_E90_I0.5480.74
259_N262_G0.5470.74
132_L232_F0.5460.74
52_L76_Y0.5460.74
172_I181_T0.5460.74
88_L91_I0.5440.74
139_L155_V0.5410.74
179_D209_K0.5410.74
30_V42_N0.5410.74
170_N181_T0.5400.73
63_N70_L0.5380.73
30_V33_I0.5350.73
245_D249_R0.5330.72
223_I242_S0.5330.72
285_I309_K0.5290.72
33_I48_T0.5280.72
32_I43_A0.5270.72
307_F310_E0.5270.72
269_S274_I0.5260.71
253_S320_V0.5240.71
95_G105_I0.5230.71
277_F290_D0.5220.71
187_V213_L0.5210.71
146_L153_Y0.5180.70
131_I156_L0.5170.70
56_S62_V0.5170.70
259_N266_P0.5150.70
98_T109_I0.5120.69
33_I39_V0.5120.69
96_L242_S0.5120.69
39_V176_P0.5120.69
221_V232_F0.5110.69
64_V82_E0.5100.69
161_D165_K0.5090.69
286_K289_P0.5090.69
90_I98_T0.5080.69
292_V323_G0.5080.69
58_I88_L0.5070.69
277_F321_V0.5050.68
68_V76_Y0.5050.68
63_N67_T0.5050.68
42_N49_Y0.5050.68
296_A305_P0.5040.68
175_D235_A0.5020.68
35_L44_V0.5020.68
136_G176_P0.5010.68
133_I182_L0.5010.68
174_G185_A0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lnqA 6 0.8512 100 0.329 Contact Map
4gx0A 3 0.9107 100 0.382 Contact Map
3nafA 3 0.6518 100 0.473 Contact Map
3mt5A 5 0.6131 100 0.549 Contact Map
2aefA 2 0.6131 100 0.554 Contact Map
4hpfA 3 0.5923 100 0.56 Contact Map
4g65A 2 0.622 100 0.624 Contact Map
3l4bC 2 0.6131 99.9 0.646 Contact Map
4j91A 3 0.6101 99.9 0.67 Contact Map
2r9rB 3 0.3393 99.8 0.711 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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