Q97XI1 - SULSO - GREMLIN Contacts

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Q97XI1 - Protease, putative

UniProt:	Q97XI1	Sequences: MKLVVATNFDDSLLEGLKRYPDVKYIFGSFKRTITGHGRAGFIVPHIKEEQFETHISLAHSYGIKFLYTMNTNTLLGKEYDTEFIGKVMKEVDKLVNFGVDGFIVALPFLIRLIRTEYPDLEVSASSFSRIRNVREVEEYTNLGVNTIIMHEDANRDFKLLKEVAALSRANRFEIELILNNSCLYGCPFRLTHDNISSVTSMVNGVNDVWFEYPVLLCATDVLNDPANLIRSRWIRPEDIKYYEEIGINRFKIAGRNKKTDWILRVVKAYAERKYEGDLLDLVSYPQGRAATKAVQMVNGPSSYFILTSVRIDNTKFPKGWIKFFFTNDCDTRSCKECKYCDIVAERVMTVNGEPFKSSEWSIRQPYPINIIPKFKERK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	379 (320)
Sequences:	2185 (1358)
Seq/√Len:	75.9

ECOLI - YEGQ YDCP
BACSU - YRRO
SULSO - Q97XI1 Q97WU8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_V	267_V	4.114	1.00
125_A	145_V	4.031	1.00
111_I	145_V	3.997	1.00
17_L	64_I	3.246	1.00
103_F	121_L	3.062	1.00
88_V	110_L	3.040	1.00
243_Y	251_F	3.026	1.00
68_Y	95_L	2.897	1.00
242_Y	297_M	2.800	1.00
238_E	280_L	2.768	1.00
53_E	57_S	2.670	1.00
92_V	114_I	2.667	1.00
48_K	51_Q	2.667	1.00
122_E	146_N	2.606	1.00
28_G	66_F	2.593	1.00
60_H	101_D	2.539	1.00
30_F	91_E	2.435	1.00
59_A	66_F	2.374	1.00
56_I	98_F	2.343	1.00
56_I	100_V	2.214	1.00
268_K	272_E	2.203	1.00
141_T	172_R	2.193	1.00
13_L	55_H	2.191	1.00
253_I	267_V	2.151	1.00
320_G	324_F	2.110	1.00
10_D	55_H	2.107	1.00
162_K	245_E	2.083	1.00
49_E	94_K	2.060	1.00
17_L	58_L	2.016	1.00
18_K	58_L	1.997	1.00
10_D	54_T	1.994	1.00
9_F	12_S	1.914	1.00
177_L	243_Y	1.912	1.00
14_L	58_L	1.906	1.00
17_L	62_Y	1.877	1.00
19_R	264_L	1.864	1.00
137_V	173_F	1.863	1.00
57_S	61_S	1.848	1.00
325_F	330_C	1.842	1.00
3_L	271_A	1.825	1.00
244_E	251_F	1.823	1.00
5_V	253_I	1.815	1.00
76_L	134_V	1.813	1.00
114_I	123_V	1.798	1.00
236_R	239_D	1.793	1.00
9_F	45_P	1.749	1.00
241_K	245_E	1.749	1.00
28_G	52_F	1.740	1.00
141_T	173_F	1.737	1.00
158_F	246_I	1.721	1.00
29_S	37_H	1.717	1.00
10_D	14_L	1.702	1.00
137_V	148_I	1.674	1.00
14_L	54_T	1.659	1.00
16_G	263_I	1.657	1.00
70_M	92_V	1.655	1.00
138_E	141_T	1.635	1.00
150_M	161_L	1.633	1.00
68_Y	100_V	1.629	1.00
320_G	323_K	1.625	1.00
78_K	200_T	1.612	1.00
277_G	281_D	1.612	1.00
319_K	324_F	1.581	0.99
96_V	120_D	1.576	0.99
108_P	139_E	1.562	0.99
131_I	136_E	1.560	0.99
239_D	293_K	1.535	0.99
70_M	88_V	1.522	0.99
17_L	59_A	1.500	0.99
237_P	269_A	1.496	0.99
18_K	62_Y	1.479	0.99
150_M	175_I	1.479	0.99
325_F	329_D	1.477	0.99
147_T	174_E	1.474	0.99
58_L	62_Y	1.471	0.99
94_K	98_F	1.465	0.99
150_M	177_L	1.440	0.99
111_I	125_A	1.422	0.99
122_E	174_E	1.415	0.99
237_P	273_R	1.404	0.99
239_D	297_M	1.401	0.99
168_S	249_N	1.397	0.99
168_S	175_I	1.395	0.99
53_E	98_F	1.382	0.99
234_W	292_T	1.382	0.99
137_V	164_V	1.376	0.98
177_L	296_Q	1.375	0.98
168_S	171_N	1.373	0.98
217_L	220_T	1.369	0.98
139_E	143_L	1.366	0.98
95_L	100_V	1.360	0.98
13_L	59_A	1.348	0.98
73_N	106_A	1.347	0.98
4_V	250_R	1.346	0.98
88_V	92_V	1.343	0.98
239_D	242_Y	1.343	0.98
102_G	124_S	1.332	0.98
125_A	129_S	1.327	0.98
306_I	309_S	1.311	0.98
236_R	296_Q	1.306	0.98
301_P	304_Y	1.291	0.98
89_M	110_L	1.264	0.97
325_F	328_N	1.264	0.97
141_T	171_N	1.249	0.97
103_F	114_I	1.242	0.97
123_V	145_V	1.239	0.97
159_K	162_K	1.231	0.97
319_K	322_I	1.229	0.97
320_G	325_F	1.221	0.97
282_L	285_Y	1.219	0.97
105_V	114_I	1.214	0.97
89_M	113_L	1.213	0.97
272_E	279_L	1.208	0.97
154_A	164_V	1.207	0.97
321_W	324_F	1.200	0.96
265_R	286_P	1.199	0.96
105_V	111_I	1.199	0.96
134_V	163_E	1.192	0.96
12_S	260_T	1.192	0.96
138_E	142_N	1.190	0.96
53_E	94_K	1.187	0.96
32_R	87_K	1.181	0.96
112_R	116_T	1.180	0.96
163_E	170_A	1.176	0.96
326_F	329_D	1.175	0.96
208_D	213_Y	1.174	0.96
60_H	66_F	1.170	0.96
313_D	316_K	1.167	0.96
326_F	330_C	1.164	0.96
131_I	140_Y	1.162	0.96
215_V	228_N	1.160	0.96
36_G	87_K	1.155	0.96
55_H	66_F	1.150	0.95
31_K	51_Q	1.137	0.95
293_K	297_M	1.128	0.95
46_H	257_N	1.128	0.95
100_V	121_L	1.127	0.95
177_L	248_I	1.125	0.95
28_G	68_Y	1.119	0.95
113_L	117_E	1.118	0.95
59_A	64_I	1.106	0.94
141_T	170_A	1.105	0.94
189_F	228_N	1.101	0.94
75_L	160_L	1.100	0.94
44_V	257_N	1.073	0.93
235_I	280_L	1.073	0.93
55_H	59_A	1.071	0.93
322_I	325_F	1.071	0.93
90_K	93_D	1.070	0.93
135_R	138_E	1.068	0.93
196_I	206_V	1.067	0.93
311_R	315_T	1.064	0.93
40_A	202_M	1.064	0.93
129_S	140_Y	1.063	0.93
28_G	47_I	1.053	0.93
127_S	151_H	1.045	0.92
13_L	26_I	1.043	0.92
154_A	160_L	1.037	0.92
112_R	142_N	1.034	0.92
89_M	116_T	1.030	0.92
92_V	118_Y	1.013	0.91
312_I	316_K	1.010	0.91
320_G	326_F	1.010	0.91
162_K	169_R	1.009	0.91
323_K	326_F	1.000	0.91
41_G	202_M	0.994	0.90
191_L	197_S	0.989	0.90
309_S	312_I	0.987	0.90
115_R	142_N	0.986	0.90
177_L	246_I	0.986	0.90
25_Y	250_R	0.983	0.90
236_R	293_K	0.982	0.90
54_T	57_S	0.971	0.89
15_E	19_R	0.970	0.89
319_K	323_K	0.967	0.89
263_I	267_V	0.961	0.89
194_D	206_V	0.957	0.89
49_E	52_F	0.956	0.89
288_G	291_A	0.954	0.88
216_L	220_T	0.954	0.88
269_A	283_V	0.950	0.88
326_F	331_D	0.948	0.88
104_I	251_F	0.947	0.88
93_D	117_E	0.946	0.88
154_A	161_L	0.944	0.88
321_W	326_F	0.943	0.88
93_D	118_Y	0.941	0.88
321_W	325_F	0.939	0.88
182_S	234_W	0.934	0.87
311_R	314_N	0.928	0.87
3_L	266_V	0.924	0.87
96_V	121_L	0.923	0.87
114_I	118_Y	0.920	0.87
50_E	53_E	0.917	0.86
91_E	95_L	0.902	0.86
2_K	25_Y	0.901	0.85
311_R	317_F	0.900	0.85
53_E	97_N	0.898	0.85
238_E	293_K	0.895	0.85
131_I	137_V	0.890	0.85
324_F	328_N	0.888	0.85
116_T	142_N	0.886	0.85
107_L	181_N	0.886	0.85
275_Y	278_D	0.882	0.84
273_R	279_L	0.875	0.84
125_A	131_I	0.874	0.84
105_V	123_V	0.874	0.84
85_I	113_L	0.872	0.84
92_V	110_L	0.864	0.83
11_D	260_T	0.864	0.83
280_L	284_S	0.864	0.83
236_R	297_M	0.863	0.83
56_I	66_F	0.862	0.83
89_M	93_D	0.860	0.83
269_A	279_L	0.857	0.82
31_K	48_K	0.856	0.82
102_G	239_D	0.855	0.82
125_A	140_Y	0.851	0.82
13_L	47_I	0.848	0.82
243_Y	246_I	0.845	0.82
340_Y	343_I	0.845	0.82
231_R	305_F	0.843	0.81
93_D	97_N	0.841	0.81
189_F	193_H	0.840	0.81
115_R	123_V	0.837	0.81
37_H	40_A	0.835	0.81
56_I	60_H	0.833	0.81
37_H	72_T	0.832	0.81
197_S	200_T	0.831	0.81
336_K	340_Y	0.831	0.81
327_T	330_C	0.831	0.81
146_N	174_E	0.830	0.80
130_R	151_H	0.829	0.80
312_I	315_T	0.829	0.80
175_I	248_I	0.824	0.80
241_K	244_E	0.824	0.80
104_I	149_I	0.821	0.80
311_R	316_K	0.820	0.80
137_V	175_I	0.815	0.79
222_V	225_D	0.813	0.79
95_L	98_F	0.809	0.79
251_F	283_V	0.808	0.79
130_R	186_G	0.808	0.79
108_P	140_Y	0.800	0.78
319_K	325_F	0.800	0.78
312_I	317_F	0.799	0.78
324_F	331_D	0.799	0.78
214_P	218_C	0.799	0.78
300_G	304_Y	0.798	0.78
41_G	198_S	0.795	0.77
85_I	134_V	0.795	0.77
235_I	238_E	0.794	0.77
4_V	25_Y	0.793	0.77
319_K	326_F	0.792	0.77
150_M	164_V	0.789	0.77
207_N	231_R	0.788	0.77
246_I	251_F	0.780	0.76
131_I	145_V	0.780	0.76
111_I	123_V	0.780	0.76
74_T	88_V	0.778	0.76
38_G	72_T	0.778	0.76
92_V	113_L	0.776	0.76
89_M	117_E	0.775	0.76
268_K	282_L	0.774	0.76
309_S	314_N	0.773	0.75
56_I	94_K	0.772	0.75
41_G	257_N	0.771	0.75
266_V	283_V	0.769	0.75
67_L	102_G	0.768	0.75
30_F	70_M	0.766	0.75
295_V	304_Y	0.763	0.75
179_L	251_F	0.760	0.74
105_V	110_L	0.759	0.74
86_G	89_M	0.759	0.74
115_R	146_N	0.757	0.74
248_I	251_F	0.757	0.74
324_F	333_R	0.757	0.74
15_E	260_T	0.752	0.73
240_I	244_E	0.752	0.73
324_F	330_C	0.750	0.73
215_V	229_L	0.750	0.73
141_T	146_N	0.748	0.73
150_M	249_N	0.748	0.73
214_P	217_L	0.745	0.73
323_K	333_R	0.726	0.71
179_L	253_I	0.724	0.71
307_L	312_I	0.722	0.70
137_V	141_T	0.722	0.70
10_D	58_L	0.721	0.70
95_L	103_F	0.718	0.70
132_R	151_H	0.715	0.70
195_N	208_D	0.714	0.70
181_N	207_N	0.713	0.69
299_N	303_S	0.713	0.69
37_H	69_T	0.708	0.69
70_M	91_E	0.707	0.69
182_S	292_T	0.703	0.68
313_D	317_F	0.702	0.68
136_E	140_Y	0.701	0.68
52_F	98_F	0.701	0.68
177_L	251_F	0.697	0.68
281_D	285_Y	0.697	0.68
307_L	310_V	0.696	0.68
192_T	197_S	0.695	0.68
106_A	249_N	0.694	0.67
161_L	177_L	0.692	0.67
161_L	246_I	0.678	0.66
148_I	251_F	0.677	0.65
323_K	328_N	0.674	0.65
170_A	173_F	0.673	0.65
14_L	18_K	0.673	0.65
12_S	259_K	0.671	0.65
49_E	53_E	0.670	0.65
104_I	179_L	0.670	0.65
134_V	170_A	0.669	0.65
67_L	106_A	0.667	0.64
38_G	211_F	0.666	0.64
161_L	164_V	0.664	0.64
275_Y	279_L	0.660	0.64
24_K	64_I	0.660	0.64
85_I	88_V	0.658	0.63
158_F	296_Q	0.655	0.63
19_R	267_V	0.655	0.63
164_V	169_R	0.654	0.63
323_K	335_C	0.651	0.62
2_K	250_R	0.650	0.62
310_V	314_N	0.648	0.62
13_L	58_L	0.648	0.62
38_G	106_A	0.646	0.62
138_E	170_A	0.646	0.62
241_K	293_K	0.643	0.62
231_R	288_G	0.642	0.61
56_I	64_I	0.638	0.61
235_I	291_A	0.637	0.61
281_D	327_T	0.637	0.61
13_L	17_L	0.637	0.61
48_K	54_T	0.635	0.61
37_H	41_G	0.635	0.61
286_P	291_A	0.634	0.60
44_V	127_S	0.630	0.60
52_F	68_Y	0.629	0.60
171_N	175_I	0.629	0.60
239_D	296_Q	0.628	0.60
134_V	138_E	0.620	0.59
137_V	150_M	0.619	0.59
269_A	282_L	0.619	0.59
330_C	341_C	0.618	0.58
89_M	118_Y	0.616	0.58
118_Y	121_L	0.616	0.58
9_F	46_H	0.614	0.58
158_F	236_R	0.614	0.58
196_I	202_M	0.614	0.58
338_C	343_I	0.614	0.58
336_K	339_K	0.613	0.58
75_L	191_L	0.613	0.58
306_I	310_V	0.613	0.58
28_G	64_I	0.612	0.58
115_R	120_D	0.611	0.58
245_E	274_K	0.610	0.57
108_P	125_A	0.609	0.57
215_V	218_C	0.604	0.57
212_E	218_C	0.603	0.57
325_F	331_D	0.602	0.56
162_K	242_Y	0.602	0.56
89_M	114_I	0.600	0.56
157_D	160_L	0.600	0.56
96_V	118_Y	0.598	0.56
186_G	211_F	0.597	0.56
238_E	277_G	0.597	0.56
301_P	305_F	0.597	0.56
154_A	157_D	0.596	0.56
148_I	175_I	0.584	0.54
328_N	331_D	0.583	0.54
205_G	209_V	0.583	0.54
105_V	109_F	0.583	0.54
159_K	242_Y	0.582	0.54
297_M	300_G	0.582	0.54
202_M	229_L	0.580	0.54
181_N	189_F	0.579	0.54
72_T	267_V	0.578	0.53
272_E	276_E	0.577	0.53
179_L	243_Y	0.577	0.53
12_S	16_G	0.577	0.53
314_N	322_I	0.575	0.53
216_L	219_A	0.575	0.53
236_R	295_V	0.573	0.53
151_H	234_W	0.571	0.53
70_M	114_I	0.569	0.52
127_S	206_V	0.567	0.52
158_F	239_D	0.566	0.52
76_L	163_E	0.565	0.52
96_V	119_P	0.565	0.52
179_L	291_A	0.563	0.52
261_D	265_R	0.563	0.52
334_S	337_E	0.562	0.51
324_F	329_D	0.562	0.51
38_G	257_N	0.561	0.51
238_E	241_K	0.561	0.51
28_G	59_A	0.561	0.51
158_F	243_Y	0.560	0.51
38_G	207_N	0.560	0.51
94_K	97_N	0.558	0.51
29_S	67_L	0.558	0.51
316_K	319_K	0.556	0.51
128_F	196_I	0.553	0.50
177_L	236_R	0.553	0.50
178_I	254_A	0.551	0.50
17_L	26_I	0.549	0.50
334_S	340_Y	0.548	0.50
8_N	213_Y	0.548	0.50
137_V	170_A	0.547	0.50
106_A	197_S	0.547	0.50
182_S	231_R	0.546	0.49
109_F	119_P	0.545	0.49
99_G	121_L	0.544	0.49
159_K	224_N	0.543	0.49
224_N	227_A	0.543	0.49
77_G	90_K	0.542	0.49
9_F	290_A	0.540	0.49
170_A	175_I	0.538	0.48
303_S	307_L	0.537	0.48
52_F	149_I	0.537	0.48
16_G	287_Q	0.536	0.48
138_E	172_R	0.536	0.48
281_D	284_S	0.535	0.48
287_Q	311_R	0.534	0.48
10_D	59_A	0.532	0.48
12_S	263_I	0.532	0.48
56_I	213_Y	0.531	0.48
69_T	266_V	0.530	0.47
128_F	262_W	0.528	0.47
5_V	263_I	0.528	0.47
331_D	340_Y	0.526	0.47
317_F	321_W	0.526	0.47
26_I	55_H	0.525	0.47
205_G	210_W	0.524	0.47
293_K	300_G	0.524	0.47
306_I	317_F	0.523	0.47
118_Y	151_H	0.523	0.47
146_N	173_F	0.522	0.46
53_E	162_K	0.522	0.46
266_V	270_Y	0.521	0.46
96_V	115_R	0.521	0.46
100_V	229_L	0.521	0.46
19_R	268_K	0.521	0.46
140_Y	145_V	0.517	0.46
290_A	313_D	0.517	0.46
321_W	328_N	0.516	0.46
12_S	261_D	0.516	0.46
132_R	186_G	0.515	0.46
31_K	291_A	0.514	0.45
210_W	254_A	0.514	0.45
51_Q	54_T	0.513	0.45
330_C	333_R	0.512	0.45
169_R	173_F	0.512	0.45
334_S	341_C	0.512	0.45
72_T	75_L	0.510	0.45
188_P	191_L	0.509	0.45
323_K	330_C	0.508	0.45
191_L	198_S	0.507	0.45
122_E	149_I	0.507	0.45
182_S	186_G	0.506	0.44
85_I	89_M	0.506	0.44
17_L	66_F	0.505	0.44
168_S	172_R	0.505	0.44
104_I	139_E	0.505	0.44
159_K	297_M	0.505	0.44
184_L	189_F	0.505	0.44
152_E	210_W	0.503	0.44
172_R	175_I	0.503	0.44
306_I	312_I	0.503	0.44
109_F	258_K	0.503	0.44
30_F	52_F	0.503	0.44
19_R	37_H	0.502	0.44
12_S	236_R	0.501	0.44
246_I	249_N	0.501	0.44
320_G	328_N	0.501	0.44
54_T	58_L	0.501	0.44
102_G	182_S	0.500	0.44
190_R	210_W	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bdqA	2	0.4934	97.6	0.935	Contact Map
3f4wA	2	0.3694	97.2	0.94	Contact Map
3iixA	1	0.4591	96.9	0.942	Contact Map
2ftpA	3	0.5198	96.7	0.944	Contact Map
3bleA	2	0.5567	96.7	0.944	Contact Map
3t7vA	1	0.4433	96.6	0.945	Contact Map
1y0eA	2	0.3588	96.5	0.946	Contact Map
1mzhA	2	0.4011	96.4	0.946	Contact Map
3q58A	2	0.3615	96.3	0.947	Contact Map
4ml9A	2	0.3879	96.3	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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