GREMLIN Database
Q97XI1 - Protease, putative
UniProt: Q97XI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (320)
Sequences: 2185 (1358)
Seq/√Len: 75.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_V267_V4.1141.00
125_A145_V4.0311.00
111_I145_V3.9971.00
17_L64_I3.2461.00
103_F121_L3.0621.00
88_V110_L3.0401.00
243_Y251_F3.0261.00
68_Y95_L2.8971.00
242_Y297_M2.8001.00
238_E280_L2.7681.00
53_E57_S2.6701.00
92_V114_I2.6671.00
48_K51_Q2.6671.00
122_E146_N2.6061.00
28_G66_F2.5931.00
60_H101_D2.5391.00
30_F91_E2.4351.00
59_A66_F2.3741.00
56_I98_F2.3431.00
56_I100_V2.2141.00
268_K272_E2.2031.00
141_T172_R2.1931.00
13_L55_H2.1911.00
253_I267_V2.1511.00
320_G324_F2.1101.00
10_D55_H2.1071.00
162_K245_E2.0831.00
49_E94_K2.0601.00
17_L58_L2.0161.00
18_K58_L1.9971.00
10_D54_T1.9941.00
9_F12_S1.9141.00
177_L243_Y1.9121.00
14_L58_L1.9061.00
17_L62_Y1.8771.00
19_R264_L1.8641.00
137_V173_F1.8631.00
57_S61_S1.8481.00
325_F330_C1.8421.00
3_L271_A1.8251.00
244_E251_F1.8231.00
5_V253_I1.8151.00
76_L134_V1.8131.00
114_I123_V1.7981.00
236_R239_D1.7931.00
9_F45_P1.7491.00
241_K245_E1.7491.00
28_G52_F1.7401.00
141_T173_F1.7371.00
158_F246_I1.7211.00
29_S37_H1.7171.00
10_D14_L1.7021.00
137_V148_I1.6741.00
14_L54_T1.6591.00
16_G263_I1.6571.00
70_M92_V1.6551.00
138_E141_T1.6351.00
150_M161_L1.6331.00
68_Y100_V1.6291.00
320_G323_K1.6251.00
78_K200_T1.6121.00
277_G281_D1.6121.00
319_K324_F1.5810.99
96_V120_D1.5760.99
108_P139_E1.5620.99
131_I136_E1.5600.99
239_D293_K1.5350.99
70_M88_V1.5220.99
17_L59_A1.5000.99
237_P269_A1.4960.99
18_K62_Y1.4790.99
150_M175_I1.4790.99
325_F329_D1.4770.99
147_T174_E1.4740.99
58_L62_Y1.4710.99
94_K98_F1.4650.99
150_M177_L1.4400.99
111_I125_A1.4220.99
122_E174_E1.4150.99
237_P273_R1.4040.99
239_D297_M1.4010.99
168_S249_N1.3970.99
168_S175_I1.3950.99
53_E98_F1.3820.99
234_W292_T1.3820.99
137_V164_V1.3760.98
177_L296_Q1.3750.98
168_S171_N1.3730.98
217_L220_T1.3690.98
139_E143_L1.3660.98
95_L100_V1.3600.98
13_L59_A1.3480.98
73_N106_A1.3470.98
4_V250_R1.3460.98
88_V92_V1.3430.98
239_D242_Y1.3430.98
102_G124_S1.3320.98
125_A129_S1.3270.98
306_I309_S1.3110.98
236_R296_Q1.3060.98
301_P304_Y1.2910.98
89_M110_L1.2640.97
325_F328_N1.2640.97
141_T171_N1.2490.97
103_F114_I1.2420.97
123_V145_V1.2390.97
159_K162_K1.2310.97
319_K322_I1.2290.97
320_G325_F1.2210.97
282_L285_Y1.2190.97
105_V114_I1.2140.97
89_M113_L1.2130.97
272_E279_L1.2080.97
154_A164_V1.2070.97
321_W324_F1.2000.96
265_R286_P1.1990.96
105_V111_I1.1990.96
134_V163_E1.1920.96
12_S260_T1.1920.96
138_E142_N1.1900.96
53_E94_K1.1870.96
32_R87_K1.1810.96
112_R116_T1.1800.96
163_E170_A1.1760.96
326_F329_D1.1750.96
208_D213_Y1.1740.96
60_H66_F1.1700.96
313_D316_K1.1670.96
326_F330_C1.1640.96
131_I140_Y1.1620.96
215_V228_N1.1600.96
36_G87_K1.1550.96
55_H66_F1.1500.95
31_K51_Q1.1370.95
293_K297_M1.1280.95
46_H257_N1.1280.95
100_V121_L1.1270.95
177_L248_I1.1250.95
28_G68_Y1.1190.95
113_L117_E1.1180.95
59_A64_I1.1060.94
141_T170_A1.1050.94
189_F228_N1.1010.94
75_L160_L1.1000.94
44_V257_N1.0730.93
235_I280_L1.0730.93
55_H59_A1.0710.93
322_I325_F1.0710.93
90_K93_D1.0700.93
135_R138_E1.0680.93
196_I206_V1.0670.93
311_R315_T1.0640.93
40_A202_M1.0640.93
129_S140_Y1.0630.93
28_G47_I1.0530.93
127_S151_H1.0450.92
13_L26_I1.0430.92
154_A160_L1.0370.92
112_R142_N1.0340.92
89_M116_T1.0300.92
92_V118_Y1.0130.91
312_I316_K1.0100.91
320_G326_F1.0100.91
162_K169_R1.0090.91
323_K326_F1.0000.91
41_G202_M0.9940.90
191_L197_S0.9890.90
309_S312_I0.9870.90
115_R142_N0.9860.90
177_L246_I0.9860.90
25_Y250_R0.9830.90
236_R293_K0.9820.90
54_T57_S0.9710.89
15_E19_R0.9700.89
319_K323_K0.9670.89
263_I267_V0.9610.89
194_D206_V0.9570.89
49_E52_F0.9560.89
288_G291_A0.9540.88
216_L220_T0.9540.88
269_A283_V0.9500.88
326_F331_D0.9480.88
104_I251_F0.9470.88
93_D117_E0.9460.88
154_A161_L0.9440.88
321_W326_F0.9430.88
93_D118_Y0.9410.88
321_W325_F0.9390.88
182_S234_W0.9340.87
311_R314_N0.9280.87
3_L266_V0.9240.87
96_V121_L0.9230.87
114_I118_Y0.9200.87
50_E53_E0.9170.86
91_E95_L0.9020.86
2_K25_Y0.9010.85
311_R317_F0.9000.85
53_E97_N0.8980.85
238_E293_K0.8950.85
131_I137_V0.8900.85
324_F328_N0.8880.85
116_T142_N0.8860.85
107_L181_N0.8860.85
275_Y278_D0.8820.84
273_R279_L0.8750.84
125_A131_I0.8740.84
105_V123_V0.8740.84
85_I113_L0.8720.84
92_V110_L0.8640.83
11_D260_T0.8640.83
280_L284_S0.8640.83
236_R297_M0.8630.83
56_I66_F0.8620.83
89_M93_D0.8600.83
269_A279_L0.8570.82
31_K48_K0.8560.82
102_G239_D0.8550.82
125_A140_Y0.8510.82
13_L47_I0.8480.82
243_Y246_I0.8450.82
340_Y343_I0.8450.82
231_R305_F0.8430.81
93_D97_N0.8410.81
189_F193_H0.8400.81
115_R123_V0.8370.81
37_H40_A0.8350.81
56_I60_H0.8330.81
37_H72_T0.8320.81
197_S200_T0.8310.81
336_K340_Y0.8310.81
327_T330_C0.8310.81
146_N174_E0.8300.80
130_R151_H0.8290.80
312_I315_T0.8290.80
175_I248_I0.8240.80
241_K244_E0.8240.80
104_I149_I0.8210.80
311_R316_K0.8200.80
137_V175_I0.8150.79
222_V225_D0.8130.79
95_L98_F0.8090.79
251_F283_V0.8080.79
130_R186_G0.8080.79
108_P140_Y0.8000.78
319_K325_F0.8000.78
312_I317_F0.7990.78
324_F331_D0.7990.78
214_P218_C0.7990.78
300_G304_Y0.7980.78
41_G198_S0.7950.77
85_I134_V0.7950.77
235_I238_E0.7940.77
4_V25_Y0.7930.77
319_K326_F0.7920.77
150_M164_V0.7890.77
207_N231_R0.7880.77
246_I251_F0.7800.76
131_I145_V0.7800.76
111_I123_V0.7800.76
74_T88_V0.7780.76
38_G72_T0.7780.76
92_V113_L0.7760.76
89_M117_E0.7750.76
268_K282_L0.7740.76
309_S314_N0.7730.75
56_I94_K0.7720.75
41_G257_N0.7710.75
266_V283_V0.7690.75
67_L102_G0.7680.75
30_F70_M0.7660.75
295_V304_Y0.7630.75
179_L251_F0.7600.74
105_V110_L0.7590.74
86_G89_M0.7590.74
115_R146_N0.7570.74
248_I251_F0.7570.74
324_F333_R0.7570.74
15_E260_T0.7520.73
240_I244_E0.7520.73
324_F330_C0.7500.73
215_V229_L0.7500.73
141_T146_N0.7480.73
150_M249_N0.7480.73
214_P217_L0.7450.73
323_K333_R0.7260.71
179_L253_I0.7240.71
307_L312_I0.7220.70
137_V141_T0.7220.70
10_D58_L0.7210.70
95_L103_F0.7180.70
132_R151_H0.7150.70
195_N208_D0.7140.70
181_N207_N0.7130.69
299_N303_S0.7130.69
37_H69_T0.7080.69
70_M91_E0.7070.69
182_S292_T0.7030.68
313_D317_F0.7020.68
136_E140_Y0.7010.68
52_F98_F0.7010.68
177_L251_F0.6970.68
281_D285_Y0.6970.68
307_L310_V0.6960.68
192_T197_S0.6950.68
106_A249_N0.6940.67
161_L177_L0.6920.67
161_L246_I0.6780.66
148_I251_F0.6770.65
323_K328_N0.6740.65
170_A173_F0.6730.65
14_L18_K0.6730.65
12_S259_K0.6710.65
49_E53_E0.6700.65
104_I179_L0.6700.65
134_V170_A0.6690.65
67_L106_A0.6670.64
38_G211_F0.6660.64
161_L164_V0.6640.64
275_Y279_L0.6600.64
24_K64_I0.6600.64
85_I88_V0.6580.63
158_F296_Q0.6550.63
19_R267_V0.6550.63
164_V169_R0.6540.63
323_K335_C0.6510.62
2_K250_R0.6500.62
310_V314_N0.6480.62
13_L58_L0.6480.62
38_G106_A0.6460.62
138_E170_A0.6460.62
241_K293_K0.6430.62
231_R288_G0.6420.61
56_I64_I0.6380.61
235_I291_A0.6370.61
281_D327_T0.6370.61
13_L17_L0.6370.61
48_K54_T0.6350.61
37_H41_G0.6350.61
286_P291_A0.6340.60
44_V127_S0.6300.60
52_F68_Y0.6290.60
171_N175_I0.6290.60
239_D296_Q0.6280.60
134_V138_E0.6200.59
137_V150_M0.6190.59
269_A282_L0.6190.59
330_C341_C0.6180.58
89_M118_Y0.6160.58
118_Y121_L0.6160.58
9_F46_H0.6140.58
158_F236_R0.6140.58
196_I202_M0.6140.58
338_C343_I0.6140.58
336_K339_K0.6130.58
75_L191_L0.6130.58
306_I310_V0.6130.58
28_G64_I0.6120.58
115_R120_D0.6110.58
245_E274_K0.6100.57
108_P125_A0.6090.57
215_V218_C0.6040.57
212_E218_C0.6030.57
325_F331_D0.6020.56
162_K242_Y0.6020.56
89_M114_I0.6000.56
157_D160_L0.6000.56
96_V118_Y0.5980.56
186_G211_F0.5970.56
238_E277_G0.5970.56
301_P305_F0.5970.56
154_A157_D0.5960.56
148_I175_I0.5840.54
328_N331_D0.5830.54
205_G209_V0.5830.54
105_V109_F0.5830.54
159_K242_Y0.5820.54
297_M300_G0.5820.54
202_M229_L0.5800.54
181_N189_F0.5790.54
72_T267_V0.5780.53
272_E276_E0.5770.53
179_L243_Y0.5770.53
12_S16_G0.5770.53
314_N322_I0.5750.53
216_L219_A0.5750.53
236_R295_V0.5730.53
151_H234_W0.5710.53
70_M114_I0.5690.52
127_S206_V0.5670.52
158_F239_D0.5660.52
76_L163_E0.5650.52
96_V119_P0.5650.52
179_L291_A0.5630.52
261_D265_R0.5630.52
334_S337_E0.5620.51
324_F329_D0.5620.51
38_G257_N0.5610.51
238_E241_K0.5610.51
28_G59_A0.5610.51
158_F243_Y0.5600.51
38_G207_N0.5600.51
94_K97_N0.5580.51
29_S67_L0.5580.51
316_K319_K0.5560.51
128_F196_I0.5530.50
177_L236_R0.5530.50
178_I254_A0.5510.50
17_L26_I0.5490.50
334_S340_Y0.5480.50
8_N213_Y0.5480.50
137_V170_A0.5470.50
106_A197_S0.5470.50
182_S231_R0.5460.49
109_F119_P0.5450.49
99_G121_L0.5440.49
159_K224_N0.5430.49
224_N227_A0.5430.49
77_G90_K0.5420.49
9_F290_A0.5400.49
170_A175_I0.5380.48
303_S307_L0.5370.48
52_F149_I0.5370.48
16_G287_Q0.5360.48
138_E172_R0.5360.48
281_D284_S0.5350.48
287_Q311_R0.5340.48
10_D59_A0.5320.48
12_S263_I0.5320.48
56_I213_Y0.5310.48
69_T266_V0.5300.47
128_F262_W0.5280.47
5_V263_I0.5280.47
331_D340_Y0.5260.47
317_F321_W0.5260.47
26_I55_H0.5250.47
205_G210_W0.5240.47
293_K300_G0.5240.47
306_I317_F0.5230.47
118_Y151_H0.5230.47
146_N173_F0.5220.46
53_E162_K0.5220.46
266_V270_Y0.5210.46
96_V115_R0.5210.46
100_V229_L0.5210.46
19_R268_K0.5210.46
140_Y145_V0.5170.46
290_A313_D0.5170.46
321_W328_N0.5160.46
12_S261_D0.5160.46
132_R186_G0.5150.46
31_K291_A0.5140.45
210_W254_A0.5140.45
51_Q54_T0.5130.45
330_C333_R0.5120.45
169_R173_F0.5120.45
334_S341_C0.5120.45
72_T75_L0.5100.45
188_P191_L0.5090.45
323_K330_C0.5080.45
191_L198_S0.5070.45
122_E149_I0.5070.45
182_S186_G0.5060.44
85_I89_M0.5060.44
17_L66_F0.5050.44
168_S172_R0.5050.44
104_I139_E0.5050.44
159_K297_M0.5050.44
184_L189_F0.5050.44
152_E210_W0.5030.44
172_R175_I0.5030.44
306_I312_I0.5030.44
109_F258_K0.5030.44
30_F52_F0.5030.44
19_R37_H0.5020.44
12_S236_R0.5010.44
246_I249_N0.5010.44
320_G328_N0.5010.44
54_T58_L0.5010.44
102_G182_S0.5000.44
190_R210_W0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bdqA 2 0.4934 97.6 0.935 Contact Map
3f4wA 2 0.3694 97.2 0.94 Contact Map
3iixA 1 0.4591 96.9 0.942 Contact Map
2ftpA 3 0.5198 96.7 0.944 Contact Map
3bleA 2 0.5567 96.7 0.944 Contact Map
3t7vA 1 0.4433 96.6 0.945 Contact Map
1y0eA 2 0.3588 96.5 0.946 Contact Map
1mzhA 2 0.4011 96.4 0.946 Contact Map
3q58A 2 0.3615 96.3 0.947 Contact Map
4ml9A 2 0.3879 96.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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