GREMLIN Database
Q97XI0 - Orf in partial transposon ISC1904
UniProt: Q97XI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (185)
Sequences: 476 (334)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.3151.00
60_A78_L4.1401.00
82_V119_V3.6211.00
117_R144_E3.6001.00
103_F126_L2.6880.99
58_L148_I2.6610.99
7_A11_L2.6350.99
110_I138_C2.6140.99
13_I21_Y2.4550.98
91_D102_G2.4510.98
17_T21_Y2.4170.98
85_Y146_V2.3670.98
5_K9_Q2.3290.98
106_L115_V2.2800.98
135_E139_K2.2640.97
111_L141_H2.2030.97
16_A19_R2.1400.96
18_L39_F1.9870.94
58_L78_L1.9300.94
22_V37_W1.9040.93
98_M132_E1.8850.93
2_L7_A1.8530.92
3_R34_S1.8510.92
96_L129_F1.8310.92
75_V90_T1.7800.90
58_L88_V1.7780.90
119_V132_E1.7570.90
55_K109_M1.7410.89
77_Y121_A1.7160.89
110_I118_V1.7100.88
22_V29_P1.6730.87
75_V88_V1.6680.87
131_F145_I1.6470.86
87_Q109_M1.6150.85
127_V131_F1.6120.85
110_I115_V1.5370.82
168_V179_S1.5320.82
12_G142_N1.5190.82
27_I30_V1.5110.81
89_I102_G1.4990.81
40_R43_D1.4820.80
98_M169_L1.4680.79
131_F147_V1.4640.79
138_C143_C1.4550.79
119_V146_V1.4490.78
16_A24_K1.4380.78
4_P19_R1.4360.78
169_L172_G1.4120.76
109_M114_E1.3980.76
26_Y33_Q1.3710.74
17_T20_E1.3600.74
31_I37_W1.3570.74
7_A27_I1.3490.73
168_V172_G1.3410.73
96_L130_G1.3370.72
157_E161_E1.3210.71
57_V75_V1.2880.69
91_D169_L1.2860.69
110_I120_I1.2780.69
14_S20_E1.2410.67
7_A44_V1.2290.66
72_V76_K1.2230.65
56_V144_E1.2030.64
107_L111_L1.2010.64
8_C13_I1.1990.64
70_D73_N1.1890.63
64_S67_Q1.1870.63
4_P18_L1.1800.63
76_K79_E1.1610.61
122_Y161_E1.1570.61
22_V39_F1.1450.60
172_G177_M1.1440.60
138_C174_L1.1400.60
62_V67_Q1.1360.60
78_L148_I1.1330.59
15_Y19_R1.1290.59
81_Q85_Y1.1230.59
121_A180_H1.1160.58
95_G126_L1.1120.58
20_E23_K1.0990.57
8_C15_Y1.0930.57
14_S174_L1.0880.56
161_E172_G1.0860.56
67_Q70_D1.0830.56
56_V119_V1.0830.56
22_V27_I1.0520.54
175_Y178_R1.0480.53
58_L82_V1.0410.53
122_Y153_K1.0410.53
54_R142_N1.0230.52
75_V107_L1.0140.51
28_K43_D1.0130.51
62_V71_L1.0110.51
8_C18_L0.9960.50
82_V85_Y0.9900.49
2_L38_R0.9890.49
13_I20_E0.9870.49
89_I106_L0.9830.49
166_I176_G0.9820.49
3_R38_R0.9770.48
8_C173_K0.9640.47
127_V134_L0.9630.47
91_D121_A0.9580.47
39_F43_D0.9570.47
117_R146_V0.9540.47
57_V89_I0.9500.46
172_G179_S0.9490.46
56_V93_G0.9420.46
131_F134_L0.9370.45
89_I118_V0.9350.45
168_V180_H0.9240.44
51_V147_V0.9150.44
43_D46_K0.9100.43
27_I134_L0.9080.43
4_P29_P0.8920.42
68_K181_E0.8880.42
153_K161_E0.8770.41
157_E160_V0.8760.41
4_P15_Y0.8720.41
158_E170_F0.8620.40
110_I143_C0.8610.40
19_R39_F0.8590.40
81_Q146_V0.8570.40
129_F162_D0.8570.40
67_Q73_N0.8560.40
11_L18_L0.8490.39
7_A18_L0.8440.39
26_Y34_S0.8440.39
2_L11_L0.8380.38
138_C171_S0.8310.38
19_R22_V0.8190.37
77_Y149_N0.8190.37
98_M127_V0.8190.37
173_K177_M0.8180.37
42_E73_N0.8130.37
5_K34_S0.8120.37
159_L168_V0.8040.36
179_S185_V0.8020.36
6_E146_V0.7970.36
85_Y148_I0.7960.36
108_R140_S0.7950.36
18_L22_V0.7890.35
7_A38_R0.7890.35
72_V75_V0.7780.34
163_L167_L0.7780.34
22_V31_I0.7760.34
95_G103_F0.7690.34
78_L151_E0.7670.34
139_K173_K0.7650.34
84_E119_V0.7640.34
3_R33_Q0.7600.33
63_S67_Q0.7570.33
73_N164_V0.7520.33
57_V106_L0.7510.33
118_V145_I0.7510.33
44_V118_V0.7470.32
163_L176_G0.7440.32
19_R36_K0.7400.32
70_D121_A0.7400.32
148_I156_E0.7350.32
155_P177_M0.7310.31
93_G165_S0.7300.31
153_K173_K0.7270.31
160_V163_L0.7270.31
64_S73_N0.7240.31
55_K87_Q0.7210.31
107_L146_V0.7190.31
78_L143_C0.7180.31
27_I43_D0.7130.30
121_A168_V0.7080.30
4_P7_A0.7070.30
79_E88_V0.7040.30
97_N141_H0.7010.30
92_I145_I0.6960.29
152_D167_L0.6910.29
100_R127_V0.6890.29
76_K80_E0.6870.29
19_R31_I0.6830.29
34_S113_N0.6680.28
93_G154_T0.6640.28
54_R143_C0.6630.27
81_Q149_N0.6620.27
63_S128_R0.6530.27
9_Q68_K0.6530.27
163_L166_I0.6520.27
8_C103_F0.6510.27
56_V87_Q0.6470.27
13_I16_A0.6470.27
73_N76_K0.6410.26
30_V38_R0.6400.26
162_D176_G0.6360.26
85_Y121_A0.6330.26
118_V147_V0.6290.26
55_K116_S0.6270.25
123_P167_L0.6250.25
96_L133_I0.6250.25
57_V115_V0.6240.25
120_I145_I0.6240.25
111_L137_V0.6230.25
145_I148_I0.6120.25
6_E159_L0.6110.25
64_S176_G0.6060.24
14_S22_V0.6050.24
44_V48_M0.6030.24
50_I76_K0.6020.24
19_R37_W0.6020.24
103_F127_V0.6000.24
33_Q113_N0.5990.24
159_L162_D0.5970.24
77_Y165_S0.5970.24
120_I162_D0.5960.24
118_V185_V0.5960.24
103_F116_S0.5950.24
134_L138_C0.5940.24
147_V167_L0.5930.24
149_N152_D0.5920.24
6_E43_D0.5910.24
3_R36_K0.5910.24
23_K31_I0.5900.23
28_K47_L0.5890.23
129_F176_G0.5880.23
39_F44_V0.5790.23
77_Y180_H0.5760.23
15_Y37_W0.5760.23
134_L159_L0.5700.22
103_F169_L0.5690.22
130_G171_S0.5660.22
129_F166_I0.5620.22
6_E32_L0.5600.22
29_P43_D0.5570.22
16_A20_E0.5560.22
89_I104_L0.5550.22
80_E105_K0.5520.22
134_L155_P0.5490.21
48_M51_V0.5470.21
162_D166_I0.5470.21
171_S177_M0.5470.21
50_I116_S0.5470.21
6_E57_V0.5460.21
54_R112_N0.5430.21
110_I145_I0.5410.21
16_A36_K0.5400.21
30_V43_D0.5400.21
12_G129_F0.5370.21
104_L136_E0.5360.21
119_V134_L0.5350.21
31_I36_K0.5310.21
126_L133_I0.5290.20
13_I18_L0.5290.20
100_R155_P0.5280.20
118_V126_L0.5280.20
101_K156_E0.5270.20
137_V140_S0.5270.20
29_P39_F0.5270.20
4_P8_C0.5260.20
93_G144_E0.5240.20
146_V152_D0.5220.20
22_V32_L0.5220.20
120_I143_C0.5220.20
99_K173_K0.5160.20
183_E187_K0.5120.20
119_V136_E0.5120.20
97_N106_L0.5080.20
154_T180_H0.5080.20
8_C12_G0.5070.19
98_M103_F0.5070.19
99_K141_H0.5070.19
99_K164_V0.5060.19
153_K158_E0.5050.19
101_K116_S0.5040.19
172_G180_H0.5020.19
13_I38_R0.5020.19
23_K101_K0.5020.19
32_L36_K0.5020.19
66_T122_Y0.5010.19
2_L22_V0.5010.19
91_D145_I0.5010.19
179_S182_Y0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7216 100 0.641 Contact Map
3lhkA 2 0.732 100 0.646 Contact Map
3g13A 2 0.7165 99.8 0.733 Contact Map
3bvpA 4 0.6289 99.8 0.74 Contact Map
3guvA 2 0.6907 99.8 0.747 Contact Map
2mhcA 1 0.5567 99.8 0.75 Contact Map
4bqqA 2 0.6804 99.8 0.751 Contact Map
2gm5A 4 0.6186 99.8 0.753 Contact Map
1gdtA 2 0.6856 99.8 0.757 Contact Map
3pkzA 4 0.5722 99.7 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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