GREMLIN Database
Q97XG9 - First ORF in transposon ISC1491
UniProt: Q97XG9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (219)
Sequences: 2856 (2249)
Seq/√Len: 151.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_I114_F5.4771.00
22_A107_A3.9011.00
176_E216_K3.1021.00
63_G84_Y2.8811.00
21_V53_L2.7931.00
145_K152_E2.7571.00
145_K148_Q2.7521.00
146_I219_E2.6531.00
139_R143_M2.5241.00
228_M231_S2.5211.00
94_L110_L2.5001.00
64_I110_L2.4441.00
217_S221_M2.2271.00
18_K42_E2.2151.00
10_F23_K2.1961.00
213_D220_A2.1621.00
212_V216_K2.1511.00
15_S20_T2.1171.00
12_I75_L2.0281.00
213_D221_M1.9831.00
24_A111_A1.9331.00
189_R193_K1.9321.00
210_Q221_M1.9011.00
10_F57_L1.8721.00
12_I19_L1.8511.00
32_K36_E1.8501.00
136_T229_I1.8371.00
150_K167_F1.8221.00
138_Y142_L1.8091.00
65_M86_V1.8091.00
16_R158_E1.8041.00
147_T151_N1.7971.00
143_M146_I1.7361.00
153_I208_L1.7301.00
95_K98_F1.6991.00
78_E82_K1.6941.00
15_S18_K1.6751.00
46_D49_G1.6591.00
20_T42_E1.6261.00
41_R56_F1.6191.00
206_L228_M1.5861.00
214_L217_S1.5841.00
213_D217_S1.5381.00
92_L96_E1.5151.00
164_I171_G1.5111.00
44_K49_G1.5101.00
226_E229_I1.5091.00
11_A111_A1.5091.00
188_E191_E1.4981.00
132_L229_I1.4881.00
22_A108_Q1.4861.00
57_L63_G1.4551.00
20_T40_V1.4471.00
77_E130_R1.4361.00
153_I215_L1.4321.00
139_R226_E1.4141.00
223_K226_E1.3991.00
145_K149_V1.3951.00
144_R148_Q1.3911.00
98_F109_R1.3481.00
108_Q112_K1.3401.00
146_I215_L1.3251.00
112_K116_L1.3231.00
178_L181_G1.3191.00
218_L222_V1.3061.00
24_A115_I1.3041.00
58_G61_K1.2781.00
143_M222_V1.2711.00
214_L221_M1.2651.00
209_K224_E1.2641.00
62_E87_T1.2551.00
194_E198_R1.2471.00
146_I222_V1.2441.00
12_I21_V1.2381.00
40_V108_Q1.2251.00
146_I150_K1.2101.00
68_T71_Y1.1621.00
148_Q151_N1.1561.00
214_L218_L1.1551.00
63_G79_L1.1471.00
142_L222_V1.1351.00
222_V226_E1.1190.99
181_G184_L1.1050.99
219_E223_K1.0890.99
41_R52_E1.0810.99
97_V113_A1.0790.99
188_E193_K1.0770.99
8_R23_K1.0730.99
9_G114_F1.0700.99
48_E52_E1.0670.99
43_F56_F1.0630.99
168_D171_G1.0610.99
43_F49_G1.0610.99
40_V104_K1.0570.99
65_M76_H1.0530.99
19_L45_Y1.0480.99
128_E235_Q1.0470.99
224_E228_M1.0440.99
101_K106_D1.0430.99
143_M147_T1.0430.99
193_K197_G1.0420.99
15_S19_L1.0370.99
54_I84_Y1.0370.99
23_K39_E1.0300.99
72_F88_L1.0260.99
193_K196_L1.0220.99
215_L219_E1.0200.99
188_E196_L1.0180.99
230_I234_P1.0150.99
228_M232_K1.0110.99
218_L221_M1.0030.99
225_V229_I1.0010.99
21_V43_F0.9970.99
67_S88_L0.9920.99
187_E192_L0.9880.99
141_S152_E0.9750.99
165_E171_G0.9710.99
231_S235_Q0.9640.98
52_E55_K0.9630.98
32_K35_V0.9610.98
54_I82_K0.9540.98
11_A79_L0.9540.98
211_L214_L0.9540.98
12_I53_L0.9520.98
153_I167_F0.9510.98
145_K214_L0.9500.98
62_E85_K0.9490.98
50_I75_L0.9430.98
186_K189_R0.9400.98
200_L204_E0.9380.98
190_D194_E0.9330.98
47_N51_E0.9140.98
182_E186_K0.9110.98
64_I89_I0.9100.98
70_P158_E0.9100.98
181_G185_S0.9070.98
210_Q224_E0.9020.98
190_D193_K0.8830.97
9_G115_I0.8750.97
192_L196_L0.8720.97
62_E114_F0.8670.97
10_F63_G0.8630.97
231_S234_P0.8590.97
76_H88_L0.8540.97
76_H86_V0.8540.97
170_R173_A0.8510.97
21_V41_R0.8510.97
50_I78_E0.8500.97
43_F50_I0.8480.97
189_R196_L0.8480.97
149_V152_E0.8460.97
226_E230_I0.8430.96
174_L178_L0.8400.96
140_E144_R0.8380.96
110_L115_I0.8340.96
215_L218_L0.8310.96
89_I94_L0.8280.96
219_E222_V0.8230.96
191_E194_E0.8180.96
227_D235_Q0.8090.96
93_H96_E0.8070.95
19_L43_F0.8050.95
75_L79_L0.8050.95
187_E193_K0.8010.95
152_E155_K0.7930.95
71_Y90_N0.7920.95
15_S72_F0.7900.95
141_S144_R0.7870.95
195_K198_R0.7870.95
22_A40_V0.7860.95
206_L210_Q0.7860.95
188_E192_L0.7860.95
14_V65_M0.7850.95
78_E81_E0.7840.95
43_F53_L0.7830.95
67_S91_P0.7820.95
11_A107_A0.7800.95
14_V71_Y0.7800.95
232_K235_Q0.7800.95
222_V229_I0.7800.95
221_M224_E0.7770.94
151_N155_K0.7740.94
212_V215_L0.7730.94
216_K220_A0.7700.94
208_L212_V0.7690.94
49_G52_E0.7650.94
216_K223_K0.7640.94
32_K38_N0.7600.94
48_E194_E0.7550.94
67_S102_T0.7540.94
110_L113_A0.7540.94
15_S89_I0.7470.93
149_V153_I0.7470.93
89_I119_V0.7460.93
149_V211_L0.7370.93
130_R134_E0.7350.93
65_M88_L0.7320.92
167_F171_G0.7320.92
20_T104_K0.7280.92
187_E191_E0.7280.92
210_Q213_D0.7280.92
208_L215_L0.7270.92
10_F79_L0.7260.92
55_K82_K0.7250.92
206_L209_K0.7220.92
211_L215_L0.7170.92
139_R222_V0.7120.91
210_Q225_V0.7090.91
15_S67_S0.7080.91
17_D158_E0.7070.91
64_I94_L0.7070.91
14_V70_P0.7040.91
67_S94_L0.6970.91
35_V38_N0.6950.90
178_L184_L0.6940.90
204_E211_L0.6920.90
33_R36_E0.6920.90
91_P96_E0.6820.90
217_S220_A0.6790.89
10_F21_V0.6770.89
170_R174_L0.6740.89
191_E196_L0.6720.89
179_S183_G0.6660.88
173_A177_K0.6640.88
64_I119_V0.6610.88
142_L218_L0.6610.88
162_Y178_L0.6600.88
177_K195_K0.6570.88
22_A111_A0.6540.88
22_A37_V0.6530.87
220_A224_E0.6520.87
94_L98_F0.6510.87
67_S137_R0.6510.87
21_V57_L0.6490.87
65_M110_L0.6420.87
83_G231_S0.6420.87
209_K213_D0.6380.86
188_E195_K0.6350.86
138_Y141_S0.6340.86
174_L181_G0.6340.86
203_A206_L0.6320.86
65_M72_F0.6270.85
210_Q228_M0.6240.85
67_S72_F0.6240.85
224_E232_K0.6230.85
178_L187_E0.6220.85
202_D228_M0.6220.85
52_E56_F0.6210.85
12_I18_K0.6200.85
72_F76_H0.6190.85
165_E170_R0.6180.84
206_L218_L0.6160.84
189_R197_G0.6150.84
154_R166_P0.6140.84
175_L181_G0.6090.84
227_D231_S0.6060.83
97_V102_T0.6050.83
41_R49_G0.6040.83
126_T130_R0.6000.83
227_D230_I0.5990.83
223_K227_D0.5990.83
204_E207_A0.5980.83
34_E39_E0.5940.82
99_G121_G0.5930.82
12_I84_Y0.5920.82
203_A207_A0.5910.82
54_I78_E0.5910.82
151_N154_R0.5900.82
227_D234_P0.5890.82
172_M179_S0.5860.81
89_I110_L0.5820.81
49_G56_F0.5820.81
201_N205_K0.5820.81
213_D224_E0.5800.81
185_S188_E0.5780.80
135_L139_R0.5740.80
205_K209_K0.5710.80
88_L93_H0.5700.79
14_V79_L0.5690.79
39_E53_L0.5690.79
76_H124_I0.5670.79
8_R57_L0.5670.79
215_L225_V0.5670.79
230_I233_I0.5670.79
15_S75_L0.5660.79
216_K219_E0.5650.79
62_E120_K0.5640.79
179_S182_E0.5640.79
224_E227_D0.5620.78
142_L221_M0.5570.78
37_V40_V0.5550.78
97_V109_R0.5550.78
87_T121_G0.5540.78
229_I233_I0.5510.77
200_L205_K0.5460.76
139_R146_I0.5450.76
48_E51_E0.5450.76
174_L177_K0.5440.76
66_E71_Y0.5410.76
94_L105_L0.5370.75
205_K212_V0.5370.75
177_K181_G0.5360.75
72_F122_S0.5360.75
34_E37_V0.5350.75
144_R194_E0.5310.75
173_A176_E0.5300.74
220_A225_V0.5270.74
194_E197_G0.5270.74
58_G83_G0.5270.74
126_T129_I0.5250.74
176_E213_D0.5250.74
209_K225_V0.5250.74
169_K173_A0.5250.74
66_E91_P0.5240.74
53_L56_F0.5220.73
67_S122_S0.5200.73
127_G131_E0.5190.73
81_E194_E0.5180.73
204_E215_L0.5140.72
76_H160_A0.5110.72
200_L203_A0.5090.71
45_Y162_Y0.5060.71
105_L108_Q0.5030.71
83_G220_A0.5030.71
154_R158_E0.5020.70
219_E224_E0.5010.70
134_E159_M0.5000.70
174_L179_S0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.4408 96.4 0.875 Contact Map
4ep4A 2 0.5469 95.8 0.882 Contact Map
1nu0A 1 0.4204 93.2 0.896 Contact Map
1vhxA 2 0.4327 90.2 0.904 Contact Map
1iv0A 1 0.3306 73.4 0.922 Contact Map
3ifrA 2 0.7429 60.7 0.928 Contact Map
3cpeA 1 0.6735 56.9 0.93 Contact Map
3id6A 2 0.8408 53.7 0.931 Contact Map
3c6aA 1 0.649 48.9 0.933 Contact Map
3hz6A 1 0.751 48.1 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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