Q97XG8 - SULSO - GREMLIN Contacts

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Q97XG8 - Multidrug-efflux transporter

UniProt:	Q97XG8	Sequences: MSSPSVKDLLLSFSRFRAGINLGWVIGPIIGGLLYYYLGWNFILLLGSLGNLISIPIVYKLDNRKSVNNVVNRKYFIKPSKYLMEIILVQFIFAFVASQILFGFTVYSTNILKIPSLLIGYFISLNSLLSALFQEPIGRYMIKLNLKYMYILGSFVFSMSYLSIFYLGNIIGLTLFIIFISLGEIILNPIILSISYIVSYKYHSKEIGMAMGFTRMAEGLGRAFSTSVTAYLFSIHDYEVSFTLLSLIGIIGLIVNRVVYTSLEN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	265 (226)
Sequences:	77514 (58259)
Seq/√Len:	3875.3

ECOLI - KGTP NEPI LACY SHIA UHPC NANT PROP YDJE MDFA XYLE YAAU MDTG YDFJ AMPG DGOT YDHP MDTM NUPG YDJK GLPT ARAE MDTL GALP ENTS YJJL XAPB UIDB EXUT YJIJ YEBQ YJHB YDIM NARK ARAJ YHJE SETB YGCS SETC HSRA MDTH YEAN YAJR BCR SOTB TSGA CYNX EMRD YDHC SETA GARP YICJ YDEE YBJJ NARU RHMT YHHS UHPT YHJX YNFM FSR YQCE GUDP HCAT YGAY MELB YIHN YIHO YEGT YAGG YDIN MHPT FUCP YIHP YFCJ LPLT YCAD MDTD EMRY EMRB
BACSU - YWOD MMR NAIP YYBO PBUE YFHI YJBB YBCL YDDS YYAJ CSBC ARAE YHJO GLPT YFMI YWTG YNCC EXUT YUXJ YVMA YFKL YFIG TCRB YWBF YYCB YKUC YTBD YTTB BBEX IOLT YFIS YOAB YCNB YBFB YFKF GUDP YXLH NASA NARK YDEG YQGE YFMO YUBD YVKA IOLF YWFA CSBX YCEJ YQJV YNAJ YFNC YITG YVQJ YXAM YDGK YXIO YJMB YWOG GUTA GLCP BMR1 YCXA YYBF YHCA LMRB BMR2 YDER YUSP BMR3 YFIU
HALSA - Q9HSE5 Q9HMR5 Q9HMQ8 Q9HSK3 Q9HSM8 Q9HPD6 O54630 Q9HRX5 Q9HS33 Q9HN67
SULSO - Q97XG8 Q97VQ5 Q97WS7 Q97U98 Q97VT2 Q97UY7 Q97U80 Q97VV2 Q97U43 Q97Y11 Q97UR4 Q7LX65 Q97WR1 Q97YL8 Q97XW7 Q97VU3 Q97X63 Q97U99 Q97Z36 Q980K3 Q97WT1 Q97X92 Q97U76 Q97VB7 Q97YY8 Q7LX71 Q97U71 Q97VB9 Q97ZC9 Q97Y43 Q97UD8 Q97Z07 Q97V89 Q97YG2 Q97X47 Q97UK1 Q97YH0 Q97YI4 Q97UJ4 Q97X02 Q97WR9 Q97VD1 Q97U91 Q97VC8 Q97Z05 Q97Y15 Q97WP8 Q97WJ7 Q97UY6 Q97YW8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_S	210_A	3.573	1.00
95_F	225_S	2.618	1.00
200_Y	206_E	2.616	1.00
163_S	176_F	2.593	1.00
129_L	178_I	2.488	1.00
156_V	183_G	2.422	1.00
243_T	247_L	2.402	1.00
200_Y	205_K	2.357	1.00
165_F	243_T	2.344	1.00
115_P	118_L	2.298	1.00
73_R	76_F	2.217	1.00
158_S	250_I	2.163	1.00
133_F	182_L	2.158	1.00
99_Q	229_T	2.146	1.00
146_L	197_I	2.119	1.00
76_F	206_E	2.092	1.00
155_F	253_L	2.034	1.00
139_R	143_K	2.018	1.00
153_G	186_I	1.985	1.00
169_N	172_G	1.959	1.00
171_I	175_L	1.949	1.00
91_F	221_G	1.923	1.00
98_S	222_R	1.888	1.00
56_P	60_K	1.871	1.00
145_N	148_Y	1.868	1.00
75_Y	78_K	1.834	1.00
162_L	166_Y	1.833	1.00
160_S	183_G	1.774	1.00
151_I	253_L	1.764	1.00
200_Y	204_S	1.730	1.00
38_L	42_F	1.727	1.00
35_Y	40_W	1.723	1.00
109_T	119_I	1.722	1.00
240_V	243_T	1.646	1.00
148_Y	151_I	1.644	1.00
74_K	206_E	1.598	1.00
158_S	253_L	1.597	1.00
165_F	246_S	1.583	1.00
126_N	181_S	1.564	1.00
147_K	151_I	1.552	1.00
140_Y	144_L	1.536	1.00
107_Y	112_L	1.520	1.00
240_V	244_L	1.516	1.00
129_L	133_F	1.511	1.00
114_I	118_L	1.484	1.00
48_S	52_L	1.456	1.00
64_R	67_V	1.425	1.00
73_R	77_I	1.419	1.00
83_L	87_I	1.417	1.00
235_I	239_E	1.413	1.00
162_L	246_S	1.403	1.00
148_Y	152_L	1.396	1.00
138_G	142_I	1.395	1.00
133_F	136_P	1.387	1.00
34_L	37_Y	1.381	1.00
87_I	217_A	1.378	1.00
151_I	257_R	1.370	1.00
136_P	139_R	1.366	1.00
246_S	250_I	1.361	1.00
118_L	121_Y	1.361	1.00
96_V	249_G	1.339	1.00
141_M	190_I	1.333	1.00
154_S	252_G	1.327	1.00
135_E	139_R	1.326	1.00
137_I	186_I	1.324	1.00
52_L	56_P	1.321	1.00
90_Q	94_A	1.320	1.00
171_I	174_T	1.314	1.00
160_S	176_F	1.311	1.00
157_F	249_G	1.294	1.00
81_K	85_E	1.290	1.00
132_L	135_E	1.282	1.00
71_V	74_K	1.282	1.00
221_G	225_S	1.274	1.00
109_T	116_S	1.260	1.00
193_S	197_I	1.255	1.00
247_L	251_I	1.234	1.00
34_L	38_L	1.233	1.00
158_S	162_L	1.228	1.00
243_T	246_S	1.227	1.00
152_L	156_V	1.224	1.00
42_F	45_L	1.219	1.00
196_Y	211_M	1.219	1.00
170_I	174_T	1.207	1.00
236_H	240_V	1.202	1.00
130_S	185_I	1.194	1.00
80_S	84_M	1.184	1.00
73_R	78_K	1.179	1.00
65_K	68_N	1.171	1.00
118_L	122_F	1.169	1.00
239_E	243_T	1.155	1.00
45_L	49_L	1.149	1.00
139_R	142_I	1.149	1.00
154_S	253_L	1.145	1.00
60_K	64_R	1.143	1.00
172_G	175_L	1.130	1.00
179_F	183_G	1.122	1.00
160_S	180_I	1.119	1.00
155_F	159_M	1.115	1.00
72_N	75_Y	1.110	1.00
49_L	53_I	1.109	1.00
121_Y	125_L	1.102	1.00
163_S	166_Y	1.095	1.00
62_D	65_K	1.090	1.00
244_L	248_I	1.089	1.00
46_L	50_G	1.089	1.00
145_N	149_M	1.085	1.00
57_I	60_K	1.079	1.00
58_V	62_D	1.073	1.00
151_I	155_F	1.073	1.00
114_I	122_F	1.071	1.00
71_V	75_Y	1.070	1.00
172_G	176_F	1.066	1.00
144_L	148_Y	1.066	1.00
84_M	88_L	1.065	1.00
31_G	35_Y	1.056	1.00
144_L	149_M	1.055	1.00
103_G	230_A	1.050	1.00
75_Y	79_P	1.049	1.00
65_K	70_V	1.043	1.00
175_L	179_F	1.038	1.00
244_L	247_L	1.037	1.00
132_L	136_P	1.037	1.00
62_D	66_S	1.025	1.00
94_A	218_E	1.019	1.00
50_G	53_I	1.019	1.00
195_S	214_T	1.017	1.00
78_K	84_M	1.017	1.00
154_S	187_L	1.004	1.00
32_G	35_Y	1.002	1.00
63_N	66_S	1.002	1.00
136_P	140_Y	0.996	1.00
106_V	110_N	0.986	1.00
45_L	48_S	0.983	1.00
82_Y	85_E	0.975	1.00
42_F	46_L	0.971	1.00
204_S	207_I	0.968	1.00
254_I	258_V	0.967	1.00
158_S	249_G	0.961	1.00
236_H	239_E	0.960	1.00
72_N	77_I	0.954	1.00
159_M	163_S	0.954	1.00
128_L	132_L	0.952	1.00
161_Y	165_F	0.951	1.00
230_A	234_S	0.950	1.00
208_G	212_G	0.949	1.00
74_K	77_I	0.941	1.00
76_F	79_P	0.937	1.00
47_G	51_N	0.932	1.00
55_I	59_Y	0.928	1.00
231_Y	235_I	0.927	1.00
66_S	69_N	0.924	1.00
152_L	155_F	0.923	1.00
92_I	252_G	0.919	1.00
156_V	160_S	0.914	1.00
38_L	41_N	0.914	1.00
158_S	246_S	0.912	1.00
108_S	114_I	0.907	1.00
160_S	179_F	0.905	1.00
74_K	209_M	0.896	1.00
153_G	187_L	0.890	1.00
155_F	158_S	0.888	1.00
196_Y	207_I	0.884	1.00
90_Q	214_T	0.881	1.00
81_K	84_M	0.879	1.00
175_L	178_I	0.873	1.00
107_Y	111_I	0.869	1.00
178_I	181_S	0.869	1.00
43_I	47_G	0.868	1.00
231_Y	234_S	0.858	1.00
241_S	244_L	0.856	1.00
181_S	185_I	0.851	1.00
253_L	257_R	0.849	1.00
150_Y	191_I	0.846	1.00
57_I	61_L	0.839	1.00
79_P	82_Y	0.836	1.00
49_L	52_L	0.835	1.00
133_F	185_I	0.831	1.00
189_P	193_S	0.826	1.00
223_A	227_S	0.820	1.00
151_I	154_S	0.818	1.00
160_S	163_S	0.817	1.00
168_G	172_G	0.817	1.00
93_F	187_L	0.807	1.00
65_K	69_N	0.807	1.00
192_L	214_T	0.804	1.00
108_S	112_L	0.804	1.00
174_T	177_I	0.803	1.00
206_E	209_M	0.799	1.00
192_L	196_Y	0.799	1.00
106_V	109_T	0.799	1.00
64_R	68_N	0.799	1.00
51_N	55_I	0.797	1.00
157_F	183_G	0.796	1.00
251_I	255_V	0.791	1.00
250_I	254_I	0.791	1.00
219_G	222_R	0.779	1.00
129_L	132_L	0.773	1.00
122_F	170_I	0.771	1.00
72_N	76_F	0.766	1.00
39_G	42_F	0.759	1.00
63_N	67_V	0.758	1.00
140_Y	149_M	0.756	1.00
38_L	45_L	0.752	1.00
255_V	259_V	0.749	1.00
41_N	44_L	0.745	1.00
56_P	59_Y	0.743	1.00
180_I	184_E	0.743	1.00
153_G	183_G	0.738	1.00
61_L	64_R	0.738	1.00
227_S	231_Y	0.733	1.00
90_Q	218_E	0.732	1.00
228_V	245_L	0.731	1.00
94_A	98_S	0.729	1.00
174_T	178_I	0.729	1.00
41_N	45_L	0.729	1.00
97_A	188_N	0.728	1.00
53_I	57_I	0.725	1.00
159_M	162_L	0.724	1.00
71_V	76_F	0.721	1.00
215_R	218_E	0.717	1.00
125_L	129_L	0.712	1.00
86_I	195_S	0.712	1.00
152_L	186_I	0.710	1.00
82_Y	198_V	0.710	1.00
176_F	179_F	0.707	1.00
149_M	152_L	0.703	1.00
232_L	236_H	0.701	1.00
124_S	127_S	0.697	1.00
217_A	221_G	0.694	1.00
216_M	219_G	0.693	1.00
151_I	158_S	0.693	1.00
99_Q	245_L	0.689	1.00
58_V	61_L	0.688	1.00
245_L	252_G	0.687	1.00
87_I	213_F	0.686	1.00
151_I	256_N	0.685	1.00
207_I	211_M	0.683	1.00
162_L	165_F	0.682	1.00
166_Y	243_T	0.681	1.00
80_S	206_E	0.680	1.00
224_F	228_V	0.677	1.00
130_S	184_E	0.677	1.00
167_L	176_F	0.676	1.00
61_L	65_K	0.674	1.00
63_N	68_N	0.674	1.00
38_L	44_L	0.673	1.00
126_N	177_I	0.671	1.00
117_L	121_Y	0.667	1.00
186_I	190_I	0.665	1.00
237_D	240_V	0.663	1.00
161_Y	180_I	0.662	1.00
88_L	92_I	0.660	1.00
108_S	122_F	0.659	1.00
127_S	131_A	0.656	1.00
126_N	180_I	0.653	1.00
108_S	173_L	0.647	1.00
189_P	192_L	0.647	1.00
249_G	253_L	0.647	1.00
169_N	174_T	0.645	1.00
44_L	48_S	0.642	1.00
121_Y	124_S	0.639	1.00
98_S	218_E	0.638	1.00
80_S	198_V	0.638	1.00
232_L	244_L	0.636	1.00
98_S	101_L	0.635	1.00
52_L	59_Y	0.634	1.00
89_V	256_N	0.632	1.00
54_S	58_V	0.631	1.00
124_S	128_L	0.628	1.00
252_G	256_N	0.624	1.00
103_G	106_V	0.618	1.00
71_V	78_K	0.616	1.00
178_I	182_L	0.613	1.00
102_F	105_T	0.613	1.00
157_F	160_S	0.610	1.00
187_L	191_I	0.609	1.00
59_Y	63_N	0.608	1.00
55_I	58_V	0.607	1.00
248_I	252_G	0.606	1.00
236_H	241_S	0.603	1.00
31_G	34_L	0.602	1.00
80_S	83_L	0.602	1.00
194_I	198_V	0.601	1.00
83_L	199_S	0.598	1.00
242_F	246_S	0.592	1.00
84_M	87_I	0.590	1.00
31_G	49_L	0.590	1.00
116_S	120_G	0.588	1.00
87_I	91_F	0.584	1.00
103_G	229_T	0.584	1.00
192_L	215_R	0.583	1.00
254_I	257_R	0.582	1.00
228_V	231_Y	0.580	1.00
128_L	131_A	0.573	1.00
115_P	119_I	0.573	1.00
64_R	76_F	0.568	1.00
66_S	70_V	0.567	1.00
43_I	46_L	0.566	1.00
162_L	243_T	0.564	1.00
51_N	58_V	0.563	1.00
85_E	89_V	0.562	1.00
179_F	186_I	0.561	1.00
44_L	47_G	0.560	1.00
176_F	180_I	0.554	1.00
227_S	230_A	0.553	1.00
164_I	177_I	0.552	1.00
100_I	104_F	0.551	1.00
226_T	230_A	0.551	1.00
192_L	211_M	0.547	1.00
133_F	137_I	0.545	1.00
222_R	225_S	0.543	1.00
108_S	119_I	0.542	1.00
33_L	37_Y	0.541	1.00
221_G	224_F	0.541	1.00
74_K	78_K	0.540	1.00
89_V	191_I	0.540	1.00
235_I	238_Y	0.536	1.00
122_F	125_L	0.535	1.00
233_F	241_S	0.533	1.00
137_I	140_Y	0.533	1.00
101_L	130_S	0.530	1.00
170_I	175_L	0.528	1.00
32_G	36_Y	0.526	1.00
193_S	196_Y	0.526	1.00
71_V	77_I	0.525	1.00
80_S	200_Y	0.522	1.00
251_I	254_I	0.522	1.00
67_V	70_V	0.521	1.00
73_R	213_F	0.521	1.00
87_I	214_T	0.518	1.00
53_I	56_P	0.514	1.00
142_I	146_L	0.508	1.00
137_I	141_M	0.508	1.00
199_S	206_E	0.508	1.00
156_V	182_L	0.505	1.00
140_Y	143_K	0.505	1.00
97_A	184_E	0.500	1.00
135_E	138_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.9849	100	0.308	Contact Map
1pw4A	1	0.9736	99.9	0.344	Contact Map
3wdoA	1	0.9736	99.9	0.363	Contact Map
4j05A	3	0.9283	99.9	0.366	Contact Map
4pypA	1	0.966	99.9	0.383	Contact Map
3o7qA	1	0.966	99.9	0.385	Contact Map
4w6vA	1	0.9547	99.9	0.393	Contact Map
2gfpA	2	0.9585	99.9	0.395	Contact Map
4xnjA	1	0.966	99.9	0.399	Contact Map
4m64A	1	0.9962	99.9	0.411	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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