GREMLIN Database
Q97XG8 - Multidrug-efflux transporter
UniProt: Q97XG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (226)
Sequences: 77514 (58259)
Seq/√Len: 3875.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_S210_A3.5731.00
95_F225_S2.6181.00
200_Y206_E2.6161.00
163_S176_F2.5931.00
129_L178_I2.4881.00
156_V183_G2.4221.00
243_T247_L2.4021.00
200_Y205_K2.3571.00
165_F243_T2.3441.00
115_P118_L2.2981.00
73_R76_F2.2171.00
158_S250_I2.1631.00
133_F182_L2.1581.00
99_Q229_T2.1461.00
146_L197_I2.1191.00
76_F206_E2.0921.00
155_F253_L2.0341.00
139_R143_K2.0181.00
153_G186_I1.9851.00
169_N172_G1.9591.00
171_I175_L1.9491.00
91_F221_G1.9231.00
98_S222_R1.8881.00
56_P60_K1.8711.00
145_N148_Y1.8681.00
75_Y78_K1.8341.00
162_L166_Y1.8331.00
160_S183_G1.7741.00
151_I253_L1.7641.00
200_Y204_S1.7301.00
38_L42_F1.7271.00
35_Y40_W1.7231.00
109_T119_I1.7221.00
240_V243_T1.6461.00
148_Y151_I1.6441.00
74_K206_E1.5981.00
158_S253_L1.5971.00
165_F246_S1.5831.00
126_N181_S1.5641.00
147_K151_I1.5521.00
140_Y144_L1.5361.00
107_Y112_L1.5201.00
240_V244_L1.5161.00
129_L133_F1.5111.00
114_I118_L1.4841.00
48_S52_L1.4561.00
64_R67_V1.4251.00
73_R77_I1.4191.00
83_L87_I1.4171.00
235_I239_E1.4131.00
162_L246_S1.4031.00
148_Y152_L1.3961.00
138_G142_I1.3951.00
133_F136_P1.3871.00
34_L37_Y1.3811.00
87_I217_A1.3781.00
151_I257_R1.3701.00
136_P139_R1.3661.00
246_S250_I1.3611.00
118_L121_Y1.3611.00
96_V249_G1.3391.00
141_M190_I1.3331.00
154_S252_G1.3271.00
135_E139_R1.3261.00
137_I186_I1.3241.00
52_L56_P1.3211.00
90_Q94_A1.3201.00
171_I174_T1.3141.00
160_S176_F1.3111.00
157_F249_G1.2941.00
81_K85_E1.2901.00
132_L135_E1.2821.00
71_V74_K1.2821.00
221_G225_S1.2741.00
109_T116_S1.2601.00
193_S197_I1.2551.00
247_L251_I1.2341.00
34_L38_L1.2331.00
158_S162_L1.2281.00
243_T246_S1.2271.00
152_L156_V1.2241.00
42_F45_L1.2191.00
196_Y211_M1.2191.00
170_I174_T1.2071.00
236_H240_V1.2021.00
130_S185_I1.1941.00
80_S84_M1.1841.00
73_R78_K1.1791.00
65_K68_N1.1711.00
118_L122_F1.1691.00
239_E243_T1.1551.00
45_L49_L1.1491.00
139_R142_I1.1491.00
154_S253_L1.1451.00
60_K64_R1.1431.00
172_G175_L1.1301.00
179_F183_G1.1221.00
160_S180_I1.1191.00
155_F159_M1.1151.00
72_N75_Y1.1101.00
49_L53_I1.1091.00
121_Y125_L1.1021.00
163_S166_Y1.0951.00
62_D65_K1.0901.00
244_L248_I1.0891.00
46_L50_G1.0891.00
145_N149_M1.0851.00
57_I60_K1.0791.00
58_V62_D1.0731.00
151_I155_F1.0731.00
114_I122_F1.0711.00
71_V75_Y1.0701.00
172_G176_F1.0661.00
144_L148_Y1.0661.00
84_M88_L1.0651.00
31_G35_Y1.0561.00
144_L149_M1.0551.00
103_G230_A1.0501.00
75_Y79_P1.0491.00
65_K70_V1.0431.00
175_L179_F1.0381.00
244_L247_L1.0371.00
132_L136_P1.0371.00
62_D66_S1.0251.00
94_A218_E1.0191.00
50_G53_I1.0191.00
195_S214_T1.0171.00
78_K84_M1.0171.00
154_S187_L1.0041.00
32_G35_Y1.0021.00
63_N66_S1.0021.00
136_P140_Y0.9961.00
106_V110_N0.9861.00
45_L48_S0.9831.00
82_Y85_E0.9751.00
42_F46_L0.9711.00
204_S207_I0.9681.00
254_I258_V0.9671.00
158_S249_G0.9611.00
236_H239_E0.9601.00
72_N77_I0.9541.00
159_M163_S0.9541.00
128_L132_L0.9521.00
161_Y165_F0.9511.00
230_A234_S0.9501.00
208_G212_G0.9491.00
74_K77_I0.9411.00
76_F79_P0.9371.00
47_G51_N0.9321.00
55_I59_Y0.9281.00
231_Y235_I0.9271.00
66_S69_N0.9241.00
152_L155_F0.9231.00
92_I252_G0.9191.00
156_V160_S0.9141.00
38_L41_N0.9141.00
158_S246_S0.9121.00
108_S114_I0.9071.00
160_S179_F0.9051.00
74_K209_M0.8961.00
153_G187_L0.8901.00
155_F158_S0.8881.00
196_Y207_I0.8841.00
90_Q214_T0.8811.00
81_K84_M0.8791.00
175_L178_I0.8731.00
107_Y111_I0.8691.00
178_I181_S0.8691.00
43_I47_G0.8681.00
231_Y234_S0.8581.00
241_S244_L0.8561.00
181_S185_I0.8511.00
253_L257_R0.8491.00
150_Y191_I0.8461.00
57_I61_L0.8391.00
79_P82_Y0.8361.00
49_L52_L0.8351.00
133_F185_I0.8311.00
189_P193_S0.8261.00
223_A227_S0.8201.00
151_I154_S0.8181.00
160_S163_S0.8171.00
168_G172_G0.8171.00
93_F187_L0.8071.00
65_K69_N0.8071.00
192_L214_T0.8041.00
108_S112_L0.8041.00
174_T177_I0.8031.00
206_E209_M0.7991.00
192_L196_Y0.7991.00
106_V109_T0.7991.00
64_R68_N0.7991.00
51_N55_I0.7971.00
157_F183_G0.7961.00
251_I255_V0.7911.00
250_I254_I0.7911.00
219_G222_R0.7791.00
129_L132_L0.7731.00
122_F170_I0.7711.00
72_N76_F0.7661.00
39_G42_F0.7591.00
63_N67_V0.7581.00
140_Y149_M0.7561.00
38_L45_L0.7521.00
255_V259_V0.7491.00
41_N44_L0.7451.00
56_P59_Y0.7431.00
180_I184_E0.7431.00
153_G183_G0.7381.00
61_L64_R0.7381.00
227_S231_Y0.7331.00
90_Q218_E0.7321.00
228_V245_L0.7311.00
94_A98_S0.7291.00
174_T178_I0.7291.00
41_N45_L0.7291.00
97_A188_N0.7281.00
53_I57_I0.7251.00
159_M162_L0.7241.00
71_V76_F0.7211.00
215_R218_E0.7171.00
125_L129_L0.7121.00
86_I195_S0.7121.00
152_L186_I0.7101.00
82_Y198_V0.7101.00
176_F179_F0.7071.00
149_M152_L0.7031.00
232_L236_H0.7011.00
124_S127_S0.6971.00
217_A221_G0.6941.00
216_M219_G0.6931.00
151_I158_S0.6931.00
99_Q245_L0.6891.00
58_V61_L0.6881.00
245_L252_G0.6871.00
87_I213_F0.6861.00
151_I256_N0.6851.00
207_I211_M0.6831.00
162_L165_F0.6821.00
166_Y243_T0.6811.00
80_S206_E0.6801.00
224_F228_V0.6771.00
130_S184_E0.6771.00
167_L176_F0.6761.00
61_L65_K0.6741.00
63_N68_N0.6741.00
38_L44_L0.6731.00
126_N177_I0.6711.00
117_L121_Y0.6671.00
186_I190_I0.6651.00
237_D240_V0.6631.00
161_Y180_I0.6621.00
88_L92_I0.6601.00
108_S122_F0.6591.00
127_S131_A0.6561.00
126_N180_I0.6531.00
108_S173_L0.6471.00
189_P192_L0.6471.00
249_G253_L0.6471.00
169_N174_T0.6451.00
44_L48_S0.6421.00
121_Y124_S0.6391.00
98_S218_E0.6381.00
80_S198_V0.6381.00
232_L244_L0.6361.00
98_S101_L0.6351.00
52_L59_Y0.6341.00
89_V256_N0.6321.00
54_S58_V0.6311.00
124_S128_L0.6281.00
252_G256_N0.6241.00
103_G106_V0.6181.00
71_V78_K0.6161.00
178_I182_L0.6131.00
102_F105_T0.6131.00
157_F160_S0.6101.00
187_L191_I0.6091.00
59_Y63_N0.6081.00
55_I58_V0.6071.00
248_I252_G0.6061.00
236_H241_S0.6031.00
31_G34_L0.6021.00
80_S83_L0.6021.00
194_I198_V0.6011.00
83_L199_S0.5981.00
242_F246_S0.5921.00
84_M87_I0.5901.00
31_G49_L0.5901.00
116_S120_G0.5881.00
87_I91_F0.5841.00
103_G229_T0.5841.00
192_L215_R0.5831.00
254_I257_R0.5821.00
228_V231_Y0.5801.00
128_L131_A0.5731.00
115_P119_I0.5731.00
64_R76_F0.5681.00
66_S70_V0.5671.00
43_I46_L0.5661.00
162_L243_T0.5641.00
51_N58_V0.5631.00
85_E89_V0.5621.00
179_F186_I0.5611.00
44_L47_G0.5601.00
176_F180_I0.5541.00
227_S230_A0.5531.00
164_I177_I0.5521.00
100_I104_F0.5511.00
226_T230_A0.5511.00
192_L211_M0.5471.00
133_F137_I0.5451.00
222_R225_S0.5431.00
108_S119_I0.5421.00
33_L37_Y0.5411.00
221_G224_F0.5411.00
74_K78_K0.5401.00
89_V191_I0.5401.00
235_I238_Y0.5361.00
122_F125_L0.5351.00
233_F241_S0.5331.00
137_I140_Y0.5331.00
101_L130_S0.5301.00
170_I175_L0.5281.00
32_G36_Y0.5261.00
193_S196_Y0.5261.00
71_V77_I0.5251.00
80_S200_Y0.5221.00
251_I254_I0.5221.00
67_V70_V0.5211.00
73_R213_F0.5211.00
87_I214_T0.5181.00
53_I56_P0.5141.00
142_I146_L0.5081.00
137_I141_M0.5081.00
199_S206_E0.5081.00
156_V182_L0.5051.00
140_Y143_K0.5051.00
97_A184_E0.5001.00
135_E138_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9849 100 0.308 Contact Map
1pw4A 1 0.9736 99.9 0.344 Contact Map
3wdoA 1 0.9736 99.9 0.363 Contact Map
4j05A 3 0.9283 99.9 0.366 Contact Map
4pypA 1 0.966 99.9 0.383 Contact Map
3o7qA 1 0.966 99.9 0.385 Contact Map
4w6vA 1 0.9547 99.9 0.393 Contact Map
2gfpA 2 0.9585 99.9 0.395 Contact Map
4xnjA 1 0.966 99.9 0.399 Contact Map
4m64A 1 0.9962 99.9 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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