GREMLIN Database
Q97XG4 - Uncharacterized protein
UniProt: Q97XG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (204)
Sequences: 800 (758)
Seq/√Len: 53.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_I199_V5.0211.00
115_Y134_L4.2661.00
141_E198_R4.1911.00
138_A170_S3.5891.00
140_G170_S3.4421.00
108_F176_V3.3601.00
144_E167_R3.3041.00
174_S202_D3.1631.00
89_A118_A3.1471.00
112_L166_I3.0931.00
209_S239_F3.0381.00
174_S203_K2.9761.00
172_S175_T2.9521.00
141_E201_N2.9511.00
142_D175_T2.9331.00
89_A107_A2.8381.00
140_G195_G2.7151.00
86_Q189_D2.6461.00
115_Y119_L2.5081.00
94_T98_Y2.4901.00
87_A139_I2.3791.00
115_Y136_N2.1181.00
115_Y118_A2.0281.00
135_R176_V1.9871.00
104_Y133_V1.9080.99
190_L199_V1.8890.99
146_E167_R1.8330.99
138_A168_V1.8240.99
106_Y135_R1.7970.99
142_D171_V1.7500.99
111_Q114_C1.7430.99
108_F139_I1.7260.99
99_A131_R1.7110.99
139_I199_V1.6920.99
82_K186_D1.6310.98
187_I212_R1.6180.98
171_V175_T1.6130.98
146_E165_R1.5980.98
120_T123_K1.5960.98
144_E169_R1.5900.98
95_A132_V1.5380.98
90_Y93_E1.5300.97
145_I170_S1.5140.97
122_L132_V1.4970.97
84_I98_Y1.4920.97
147_F156_T1.4920.97
69_L73_H1.4370.96
208_F239_F1.4260.96
99_A105_V1.4010.96
119_L134_L1.3640.95
137_W171_V1.3350.94
196_E213_I1.3270.94
39_F42_K1.3270.94
87_A190_L1.3220.94
188_L209_S1.3190.94
99_A128_L1.3000.94
192_I195_G1.2930.93
205_I208_F1.2800.93
121_N124_L1.2610.93
142_D172_S1.2500.92
96_L121_N1.2440.92
112_L136_N1.2350.92
81_N102_G1.2200.91
197_F202_D1.2100.91
211_V234_L1.1990.90
192_I215_Y1.1980.90
110_P136_N1.1890.90
66_E73_H1.1870.90
87_A199_V1.1800.90
202_D209_S1.1790.90
137_W169_R1.1790.90
232_E236_S1.1660.89
85_I108_F1.1650.89
108_F135_R1.1650.89
186_D209_S1.1250.87
110_P138_A1.1170.87
197_F201_N1.1100.87
107_A118_A1.0980.86
140_G143_G1.0840.85
67_T73_H1.0790.85
205_I209_S1.0770.85
188_L211_V1.0710.85
122_L134_L1.0600.84
90_Y214_E1.0520.84
197_F233_K1.0480.83
94_T216_N1.0460.83
192_I202_D1.0450.83
87_A192_I1.0430.83
198_R201_N1.0340.83
64_F68_F1.0320.82
81_N103_A1.0210.82
79_L84_I1.0200.82
193_K196_E1.0050.81
139_I172_S1.0030.81
191_D214_E0.9950.80
174_S205_I0.9900.80
84_I95_A0.9820.79
66_E69_L0.9780.79
188_L203_K0.9720.78
118_A122_L0.9690.78
215_Y230_L0.9630.78
192_I216_N0.9600.78
192_I214_E0.9570.77
177_L239_F0.9500.77
201_N229_Y0.9440.76
145_I158_Y0.9370.76
153_N158_Y0.9350.76
45_I48_T0.9350.76
106_Y176_V0.9180.74
214_E217_T0.9030.73
91_V214_E0.8990.73
37_W42_K0.8970.73
66_E70_Y0.8940.72
211_V239_F0.8840.72
183_S207_K0.8780.71
226_D229_Y0.8590.69
199_V202_D0.8570.69
149_N156_T0.8520.69
140_G198_R0.8430.68
108_F172_S0.8430.68
135_R139_I0.8370.67
215_Y244_I0.8360.67
173_I203_K0.8350.67
214_E228_T0.8320.67
111_Q156_T0.8290.67
118_A134_L0.8220.66
95_A105_V0.8100.65
139_I171_V0.8080.65
216_N219_I0.8030.64
84_I105_V0.7960.63
96_L125_N0.7910.63
213_I230_L0.7900.63
108_F173_I0.7840.62
181_N244_I0.7830.62
172_S202_D0.7770.62
140_G145_I0.7750.61
111_Q213_I0.7730.61
167_R239_F0.7680.61
85_I173_I0.7640.60
217_T226_D0.7640.60
112_L193_K0.7600.60
106_Y133_V0.7540.59
83_K106_Y0.7490.59
57_K60_D0.7430.58
89_A109_E0.7400.58
85_I137_W0.7350.57
87_A177_L0.7330.57
138_A158_Y0.7310.57
85_I106_Y0.7260.56
119_L123_K0.7250.56
82_K210_I0.7210.56
82_K193_K0.7140.55
66_E72_I0.7130.55
185_P207_K0.7130.55
190_L214_E0.7120.55
48_T52_I0.7110.55
99_A125_N0.7080.54
90_Y114_C0.7060.54
81_N101_R0.6980.53
190_L196_E0.6960.53
192_I196_E0.6950.53
42_K50_S0.6890.52
48_T54_F0.6890.52
39_F50_S0.6860.52
143_G170_S0.6840.52
138_A145_I0.6840.52
51_G56_I0.6840.52
87_A172_S0.6830.52
190_L217_T0.6820.52
170_S195_G0.6810.52
202_D216_N0.6810.52
38_K45_I0.6800.52
111_Q147_F0.6780.51
147_F166_I0.6770.51
42_K178_E0.6760.51
94_T205_I0.6760.51
217_T230_L0.6760.51
229_Y232_E0.6760.51
231_I235_R0.6750.51
143_G147_F0.6750.51
45_I55_S0.6730.51
93_E97_Y0.6710.51
188_L208_F0.6640.50
187_I210_I0.6630.50
216_N226_D0.6610.50
138_A143_G0.6570.49
245_Y248_N0.6550.49
114_C118_A0.6510.48
73_H189_D0.6500.48
63_I72_I0.6450.48
54_F96_L0.6450.48
91_V153_N0.6440.48
88_G194_G0.6440.48
136_N169_R0.6410.47
232_E235_R0.6380.47
201_N236_S0.6380.47
38_K51_G0.6320.46
133_V244_I0.6230.46
209_S242_I0.6160.45
173_I188_L0.6140.45
174_S204_S0.6130.44
39_F43_Y0.6120.44
197_F229_Y0.6120.44
200_I231_I0.6100.44
174_S209_S0.6100.44
242_I247_H0.6100.44
135_R177_L0.6100.44
100_K197_F0.6070.44
138_A193_K0.6040.44
94_T97_Y0.6030.43
188_L216_N0.6010.43
116_N119_L0.6010.43
231_I239_F0.6000.43
216_N231_I0.6000.43
105_V132_V0.5990.43
63_I198_R0.5990.43
195_G198_R0.5980.43
128_L132_V0.5950.43
200_I239_F0.5930.42
157_S187_I0.5920.42
110_P189_D0.5900.42
84_I180_F0.5900.42
125_N148_P0.5890.42
173_I201_N0.5880.42
85_I188_L0.5870.42
42_K45_I0.5870.42
193_K216_N0.5870.42
106_Y161_S0.5850.42
39_F48_T0.5840.41
98_Y189_D0.5830.41
38_K144_E0.5830.41
200_I230_L0.5820.41
37_W96_L0.5810.41
95_A125_N0.5800.41
135_R169_R0.5790.41
87_A214_E0.5790.41
198_R239_F0.5780.41
98_Y185_P0.5770.41
192_I219_I0.5750.41
97_Y239_F0.5750.41
106_Y190_L0.5710.40
40_D43_Y0.5700.40
95_A107_A0.5660.40
137_W199_V0.5660.40
80_E131_R0.5650.40
60_D63_I0.5650.40
217_T231_I0.5620.39
201_N233_K0.5600.39
85_I185_P0.5600.39
142_D176_V0.5600.39
68_F73_H0.5580.39
121_N125_N0.5570.39
174_S208_F0.5550.39
100_K119_L0.5550.39
214_E231_I0.5540.38
172_S203_K0.5510.38
65_S69_L0.5510.38
95_A101_R0.5500.38
161_S184_Q0.5490.38
119_L136_N0.5480.38
116_N123_K0.5460.38
176_V185_P0.5450.38
80_E164_D0.5430.37
104_Y206_Q0.5400.37
209_S217_T0.5370.37
217_T239_F0.5360.37
142_D169_R0.5360.37
100_K204_S0.5350.37
79_L98_Y0.5320.36
84_I102_G0.5310.36
171_V176_V0.5310.36
179_E236_S0.5310.36
87_A202_D0.5280.36
96_L118_A0.5250.36
94_T212_R0.5240.35
215_Y219_I0.5220.35
42_K46_L0.5210.35
197_F204_S0.5210.35
88_G92_G0.5210.35
167_R187_I0.5200.35
41_E132_V0.5200.35
107_A134_L0.5200.35
71_D229_Y0.5170.35
216_N242_I0.5170.35
135_R179_E0.5170.35
94_T214_E0.5160.35
61_P73_H0.5140.35
168_V177_L0.5140.35
186_D192_I0.5130.34
133_V243_R0.5100.34
84_I186_D0.5100.34
176_V184_Q0.5100.34
89_A121_N0.5090.34
84_I208_F0.5080.34
211_V228_T0.5060.34
84_I196_E0.5050.34
158_Y168_V0.5050.34
128_L190_L0.5040.34
62_V128_L0.5030.33
45_I53_K0.5030.33
73_H94_T0.5020.33
227_V231_I0.5020.33
127_E184_Q0.5010.33
90_Y205_I0.5010.33
107_A238_G0.5010.33
139_I168_V0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.8674 100 0.49 Contact Map
3k6rA 1 0.8106 98 0.848 Contact Map
3a27A 1 0.7652 98 0.848 Contact Map
3opnA 1 0.678 97.6 0.861 Contact Map
3sm3A 2 0.697 97.5 0.861 Contact Map
2jjqA 1 0.8068 97.4 0.865 Contact Map
4ikpA 3 0.7879 97.4 0.865 Contact Map
2yxdA 4 0.6591 97.4 0.866 Contact Map
3lpmA 2 0.6856 97.3 0.867 Contact Map
3lccA 1 0.7841 97.3 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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