GREMLIN Database
Q97XG2 - Polysaccharide biosynthesis related protein
UniProt: Q97XG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 468 (429)
Sequences: 17636 (15181)
Seq/√Len: 733.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_K271_K4.2511.00
129_M132_E3.4861.00
41_A236_Q3.2401.00
196_F200_R3.2211.00
340_N343_P3.1621.00
311_L315_V3.1011.00
401_K405_L2.9691.00
293_I315_V2.8401.00
128_D262_F2.7951.00
342_R346_I2.7861.00
100_F103_Y2.7161.00
297_E301_I2.6181.00
340_N393_T2.6011.00
228_G231_Y2.5471.00
234_I309_E2.4881.00
402_E405_L2.4751.00
323_L380_T2.4111.00
351_N382_S2.3021.00
296_G311_L2.2961.00
66_I126_G2.2561.00
431_I434_V2.2471.00
358_T374_S2.2241.00
262_F266_L2.2101.00
219_D235_Y2.1961.00
223_T227_L2.1751.00
316_L369_M2.1711.00
207_L345_L2.1711.00
313_V368_I2.1161.00
347_L385_F2.0981.00
219_D359_S2.0921.00
337_F340_N2.0841.00
64_R68_Y2.0571.00
298_I301_I2.0471.00
296_G315_V2.0401.00
77_K81_G2.0191.00
227_L231_Y2.0161.00
33_S36_F1.9991.00
291_I295_I1.9801.00
156_N159_L1.9611.00
192_F196_F1.9351.00
295_I298_I1.9351.00
272_K276_L1.9211.00
9_K131_T1.9051.00
363_I371_G1.8851.00
416_E430_L1.8371.00
413_G417_A1.8261.00
370_G374_S1.8261.00
42_I224_A1.8161.00
285_T325_F1.8131.00
297_E311_L1.8131.00
312_E369_M1.8081.00
362_L374_S1.7991.00
65_E201_E1.7881.00
264_K337_F1.7821.00
316_L376_V1.7781.00
263_Y271_K1.7771.00
159_L163_I1.7341.00
131_T135_I1.7301.00
354_L381_I1.7071.00
227_L368_I1.7021.00
286_F410_P1.6931.00
316_L373_I1.6821.00
191_D194_F1.6651.00
128_D259_T1.6471.00
211_A349_I1.6371.00
289_V322_T1.6321.00
300_I310_G1.6291.00
361_L364_P1.6241.00
40_V44_Q1.6211.00
366_I373_I1.6201.00
222_T359_S1.6181.00
367_G370_G1.6151.00
290_I414_I1.6121.00
292_S318_L1.6061.00
222_T363_I1.5911.00
312_E315_V1.5901.00
313_V372_A1.5741.00
102_D106_L1.5611.00
323_L383_S1.5591.00
204_P345_L1.5531.00
274_S333_F1.5531.00
374_S378_V1.5251.00
316_L372_A1.5181.00
300_I314_F1.5161.00
219_D375_Q1.5151.00
384_L388_F1.5141.00
242_A317_L1.5131.00
297_E315_V1.5121.00
238_S310_G1.5011.00
309_E312_E1.4861.00
123_V127_M1.4761.00
362_L366_I1.4741.00
223_T371_G1.4701.00
144_R167_G1.4691.00
29_A237_F1.4671.00
68_Y339_R1.4541.00
346_I350_L1.4491.00
295_I299_I1.4441.00
320_S376_V1.4421.00
388_F392_R1.4301.00
263_Y273_M1.4301.00
222_T360_Y1.4241.00
357_L361_L1.4161.00
41_A233_G1.4131.00
150_I153_L1.4091.00
275_S279_I1.4071.00
361_L365_R1.4011.00
256_L277_S1.4001.00
428_I432_L1.3941.00
26_V30_K1.3801.00
103_Y106_L1.3781.00
61_I201_E1.3661.00
359_S363_I1.3651.00
282_S286_F1.3631.00
230_Y234_I1.3601.00
231_Y368_I1.3581.00
355_V359_S1.3561.00
34_P234_I1.3551.00
75_I78_E1.3551.00
78_E191_D1.3501.00
223_T232_L1.3501.00
129_M182_K1.3471.00
112_F115_L1.3361.00
25_F240_L1.3281.00
24_F145_W1.3161.00
291_I413_G1.3151.00
218_G356_L1.3111.00
109_P112_F1.2951.00
16_T138_N1.2931.00
347_L389_Y1.2901.00
410_P414_I1.2861.00
15_T19_I1.2831.00
369_M372_A1.2831.00
222_T226_L1.2801.00
228_G232_L1.2791.00
203_L207_L1.2791.00
217_Q220_R1.2741.00
30_K305_P1.2731.00
36_F39_K1.2701.00
84_L87_P1.2681.00
238_S313_V1.2651.00
78_E82_K1.2631.00
330_L387_I1.2551.00
17_N141_L1.2541.00
308_K312_E1.2451.00
136_T175_N1.2431.00
274_S330_L1.2371.00
234_I310_G1.2311.00
22_L26_V1.2291.00
81_G85_S1.2231.00
158_Y161_V1.2101.00
146_G150_I1.2031.00
55_Y59_G1.1981.00
263_Y268_K1.1961.00
362_L365_R1.1931.00
320_S372_A1.1911.00
65_E197_R1.1901.00
65_E68_Y1.1901.00
413_G427_L1.1851.00
204_P342_R1.1841.00
151_A154_Y1.1801.00
313_V369_M1.1771.00
333_F390_S1.1751.00
409_I434_V1.1691.00
260_A336_A1.1621.00
292_S314_F1.1511.00
19_I23_I1.1471.00
98_L102_D1.1461.00
164_W168_G1.1461.00
300_I311_L1.1431.00
347_L386_I1.1371.00
397_S400_R1.1351.00
354_L358_T1.1351.00
31_I152_V1.1341.00
353_S357_L1.1341.00
237_F304_F1.1281.00
176_Y180_S1.1241.00
147_I163_I1.1241.00
37_F41_A1.1231.00
155_H159_L1.1231.00
421_P425_F1.1161.00
39_K229_S1.1161.00
29_A304_F1.1161.00
208_S344_F1.1151.00
319_I376_V1.1141.00
211_A345_L1.1121.00
67_S126_G1.1091.00
355_V378_V1.1081.00
358_T362_L1.1071.00
201_E341_L1.1041.00
360_Y364_P1.1031.00
7_A255_V1.1011.00
257_L261_S1.0991.00
259_T262_F1.0991.00
64_R339_R1.0981.00
79_V83_F1.0901.00
85_S89_L1.0901.00
211_A352_G1.0891.00
346_I349_I1.0871.00
223_T235_Y1.0861.00
238_S317_L1.0851.00
79_V82_K1.0791.00
326_P383_S1.0761.00
366_I370_G1.0761.00
78_E81_G1.0721.00
177_A181_K1.0651.00
42_I232_L1.0591.00
173_S177_A1.0541.00
214_L352_G1.0521.00
215_S355_V1.0521.00
194_F197_R1.0471.00
62_I83_F1.0441.00
431_I435_F1.0411.00
10_N255_V1.0361.00
96_I100_F1.0351.00
69_L72_K1.0331.00
417_A427_L1.0321.00
355_V375_Q1.0321.00
343_P389_Y1.0301.00
99_I103_Y1.0291.00
349_I353_S1.0281.00
120_M176_Y1.0261.00
308_K311_L1.0231.00
14_T18_V1.0231.00
136_T174_M1.0171.00
365_R369_M1.0161.00
163_I167_G1.0131.00
283_L435_F1.0111.00
61_I198_H1.0101.00
359_S375_Q1.0081.00
409_I413_G1.0071.00
199_F202_G1.0071.00
330_L386_I1.0071.00
320_S323_L1.0051.00
242_A321_A1.0051.00
289_V293_I1.0041.00
100_F104_V1.0021.00
296_G314_F1.0021.00
174_M178_F0.9971.00
315_V319_I0.9961.00
317_L372_A0.9961.00
13_V134_A0.9941.00
412_V434_V0.9931.00
430_L434_V0.9931.00
11_L251_A0.9921.00
300_I304_F0.9911.00
101_P105_K0.9911.00
130_F255_V0.9861.00
143_I170_L0.9831.00
20_I145_W0.9821.00
293_I296_G0.9801.00
343_P346_I0.9801.00
432_L436_K0.9771.00
27_I31_I0.9731.00
61_I65_E0.9661.00
293_I319_I0.9641.00
162_K166_L0.9561.00
69_L75_I0.9541.00
335_V344_F0.9531.00
219_D355_V0.9501.00
63_T122_A0.9501.00
6_N128_D0.9481.00
239_A243_G0.9471.00
381_I385_F0.9471.00
83_F198_H0.9471.00
48_I52_T0.9441.00
132_E178_F0.9411.00
276_L279_I0.9391.00
263_Y266_L0.9391.00
45_L220_R0.9381.00
68_Y72_K0.9371.00
80_V123_V0.9361.00
410_P413_G0.9351.00
301_I308_K0.9311.00
388_F391_I0.9231.00
334_I389_Y0.9221.00
34_P233_G0.9221.00
40_V160_F0.9211.00
165_T168_G0.9201.00
287_L290_I0.9181.00
376_V379_A0.9171.00
197_R339_R0.9171.00
61_I202_G0.9171.00
200_R203_L0.9161.00
34_P307_Y0.9111.00
87_P91_L0.9091.00
236_Q240_L0.9061.00
140_F144_R0.9051.00
279_I283_L0.9041.00
193_A196_F0.9031.00
373_I376_V0.9031.00
385_F388_F0.8991.00
369_M373_I0.8971.00
8_L12_S0.8971.00
44_Q48_I0.8941.00
25_F304_F0.8931.00
299_I303_F0.8921.00
82_K195_L0.8911.00
142_V146_G0.8891.00
7_A252_L0.8881.00
167_G171_S0.8881.00
238_S314_F0.8871.00
81_G84_L0.8861.00
66_I127_M0.8861.00
259_T263_Y0.8811.00
26_V304_F0.8811.00
373_I377_I0.8771.00
226_L363_I0.8761.00
293_I297_E0.8731.00
165_T169_I0.8721.00
199_F203_L0.8721.00
162_K165_T0.8701.00
10_N134_A0.8681.00
359_S362_L0.8641.00
7_A11_L0.8531.00
310_G313_V0.8471.00
293_I318_L0.8411.00
168_G172_V0.8411.00
88_F92_P0.8391.00
28_T160_F0.8391.00
171_S175_N0.8381.00
175_N179_I0.8371.00
358_T361_L0.8361.00
148_A163_I0.8341.00
26_V29_A0.8341.00
273_M276_L0.8311.00
144_R148_A0.8281.00
9_K13_V0.8281.00
20_I24_F0.8261.00
83_F87_P0.8251.00
25_F29_A0.8251.00
94_F98_L0.8241.00
82_K86_F0.8241.00
223_T368_I0.8231.00
320_S375_Q0.8191.00
6_N255_V0.8191.00
99_I102_D0.8181.00
220_R232_L0.8171.00
40_V157_I0.8171.00
237_F307_Y0.8161.00
5_K131_T0.8121.00
70_Y76_T0.8121.00
290_I410_P0.8111.00
109_P165_T0.8111.00
64_R341_L0.8101.00
213_F217_Q0.8101.00
281_L325_F0.8061.00
237_F240_L0.8031.00
356_L360_Y0.8031.00
345_L349_I0.8021.00
255_V258_P0.8021.00
344_F348_S0.8011.00
233_G237_F0.8001.00
332_N335_V0.7961.00
70_Y127_M0.7901.00
288_T291_I0.7871.00
76_T79_V0.7871.00
358_T377_I0.7861.00
294_P414_I0.7821.00
319_I323_L0.7811.00
221_V225_Y0.7811.00
220_R236_Q0.7781.00
334_I344_F0.7761.00
82_K85_S0.7751.00
48_I51_S0.7721.00
364_P371_G0.7721.00
111_L115_L0.7711.00
175_N178_F0.7691.00
217_Q221_V0.7691.00
4_I8_L0.7671.00
240_L244_V0.7671.00
235_Y317_L0.7671.00
226_L360_Y0.7631.00
80_V83_F0.7631.00
28_T148_A0.7621.00
71_A266_L0.7611.00
385_F389_Y0.7611.00
125_I133_S0.7611.00
66_I76_T0.7601.00
32_S36_F0.7591.00
97_L105_K0.7581.00
68_Y265_A0.7571.00
35_A229_S0.7561.00
75_I194_F0.7531.00
389_Y393_T0.7521.00
200_R204_P0.7511.00
187_L190_P0.7461.00
27_I149_I0.7451.00
145_W149_I0.7451.00
87_P90_V0.7431.00
140_F171_S0.7431.00
350_L385_F0.7411.00
296_G318_L0.7411.00
250_G254_G0.7391.00
132_E135_I0.7381.00
62_I66_I0.7381.00
121_T125_I0.7381.00
389_Y392_R0.7371.00
391_I394_S0.7351.00
211_A348_S0.7331.00
257_L332_N0.7331.00
160_F164_W0.7331.00
210_F214_L0.7321.00
37_F233_G0.7321.00
320_S379_A0.7311.00
178_F182_K0.7301.00
208_S348_S0.7291.00
37_F237_F0.7251.00
387_I391_I0.7241.00
249_L253_G0.7221.00
233_G236_Q0.7201.00
332_N336_A0.7181.00
190_P195_L0.7161.00
241_V304_F0.7161.00
319_I322_T0.7151.00
51_S55_Y0.7151.00
42_I45_L0.7141.00
287_L410_P0.7101.00
290_I294_P0.7071.00
11_L15_T0.7051.00
94_F97_L0.7041.00
215_S352_G0.7031.00
16_T142_V0.7031.00
98_L103_Y0.7021.00
289_V318_L0.7001.00
269_D337_F0.7001.00
68_Y197_R0.7001.00
307_Y310_G0.6981.00
69_L74_E0.6981.00
354_L357_L0.6981.00
359_S371_G0.6941.00
402_E406_L0.6931.00
147_I150_I0.6921.00
283_L287_L0.6911.00
219_D239_A0.6901.00
205_V341_L0.6901.00
336_A339_R0.6881.00
327_I383_S0.6861.00
347_L351_N0.6861.00
427_L431_I0.6851.00
217_Q243_G0.6851.00
116_L120_M0.6851.00
412_V415_Y0.6841.00
227_L363_I0.6841.00
414_I417_A0.6841.00
158_Y162_K0.6841.00
86_F195_L0.6821.00
380_T384_L0.6791.00
63_T126_G0.6791.00
287_L413_G0.6781.00
63_T67_S0.6781.00
411_V415_Y0.6771.00
33_S307_Y0.6751.00
284_L288_T0.6751.00
430_L433_L0.6741.00
404_I408_L0.6731.00
159_L162_K0.6731.00
35_A39_K0.6731.00
204_P341_L0.6721.00
4_I7_A0.6671.00
98_L104_V0.6651.00
144_R163_I0.6651.00
47_E51_S0.6641.00
16_T20_I0.6581.00
431_I436_K0.6581.00
36_F157_I0.6581.00
12_S16_T0.6581.00
330_L390_S0.6571.00
136_T171_S0.6561.00
376_V380_T0.6561.00
403_I406_L0.6551.00
345_L348_S0.6501.00
301_I311_L0.6481.00
240_L243_G0.6481.00
125_I130_F0.6471.00
224_A232_L0.6441.00
281_L329_S0.6431.00
218_G222_T0.6411.00
141_L144_R0.6411.00
97_L104_V0.6401.00
110_Y114_Y0.6381.00
28_T37_F0.6331.00
116_L172_V0.6331.00
78_E194_F0.6321.00
57_I202_G0.6321.00
350_L353_S0.6301.00
3_P7_A0.6301.00
21_A25_F0.6281.00
195_L199_F0.6281.00
17_N21_A0.6281.00
362_L370_G0.6271.00
198_H202_G0.6271.00
227_L367_G0.6271.00
205_V335_V0.6261.00
242_A245_P0.6241.00
375_Q379_A0.6241.00
324_P379_A0.6241.00
201_E205_V0.6231.00
100_F105_K0.6231.00
314_F318_L0.6221.00
209_S213_F0.6211.00
287_L431_I0.6211.00
124_M179_I0.6171.00
88_F91_L0.6171.00
334_I390_S0.6141.00
279_I402_E0.6131.00
8_L15_T0.6121.00
211_A215_S0.6111.00
117_N172_V0.6101.00
89_L92_P0.6091.00
119_V122_A0.6081.00
113_L169_I0.6071.00
341_L344_F0.6031.00
399_G402_E0.5991.00
177_A180_S0.5981.00
330_L383_S0.5981.00
248_I251_A0.5971.00
259_T273_M0.5971.00
273_M277_S0.5961.00
28_T32_S0.5951.00
240_L304_F0.5951.00
277_S329_S0.5941.00
81_G188_P0.5931.00
208_S212_G0.5921.00
38_G233_G0.5911.00
34_P230_Y0.5901.00
257_L336_A0.5891.00
147_I166_L0.5881.00
343_P347_L0.5871.00
80_V84_L0.5871.00
172_V176_Y0.5861.00
333_F337_F0.5851.00
164_W167_G0.5831.00
316_L319_I0.5821.00
98_L101_P0.5821.00
331_T344_F0.5821.00
324_P328_G0.5811.00
55_Y87_P0.5801.00
26_V303_F0.5801.00
290_I293_I0.5771.00
297_E308_K0.5771.00
354_L378_V0.5751.00
101_P104_V0.5711.00
32_S157_I0.5701.00
76_T80_V0.5701.00
258_P262_F0.5691.00
220_R239_A0.5691.00
408_L412_V0.5691.00
252_L256_L0.5681.00
408_L411_V0.5681.00
115_L119_V0.5671.00
286_F322_T0.5661.00
182_K185_L0.5651.00
331_T335_V0.5631.00
197_R201_E0.5631.00
276_L280_F0.5591.00
18_V21_A0.5581.00
172_V175_N0.5571.00
212_G216_S0.5571.00
96_I99_I0.5561.00
119_V123_V0.5561.00
38_G230_Y0.5561.00
82_K87_P0.5541.00
97_L100_F0.5531.00
135_I139_F0.5531.00
13_V138_N0.5531.00
76_T127_M0.5521.00
130_F133_S0.5501.00
413_G416_E0.5501.00
355_V358_T0.5481.00
214_L218_G0.5471.00
113_L172_V0.5471.00
429_L433_L0.5451.00
298_I302_H0.5451.00
200_R342_R0.5451.00
260_A333_F0.5441.00
375_Q378_V0.5441.00
42_I220_R0.5431.00
349_I352_G0.5421.00
400_R404_I0.5411.00
85_S88_F0.5401.00
272_K275_S0.5401.00
136_T178_F0.5391.00
235_Y239_A0.5381.00
322_T325_F0.5371.00
406_L410_P0.5361.00
301_I304_F0.5361.00
42_I225_Y0.5351.00
42_I221_V0.5351.00
97_L101_P0.5351.00
139_F174_M0.5321.00
294_P297_E0.5321.00
282_S322_T0.5311.00
117_N121_T0.5301.00
226_L364_P0.5281.00
67_S261_S0.5271.00
157_I161_V0.5261.00
137_G141_L0.5261.00
251_A254_G0.5251.00
233_G307_Y0.5231.00
65_E198_H0.5201.00
46_L50_T0.5201.00
109_P114_Y0.5191.00
237_F310_G0.5191.00
318_L321_A0.5181.00
120_M124_M0.5181.00
149_I152_V0.5181.00
29_A307_Y0.5171.00
403_I407_F0.5161.00
344_F386_I0.5151.00
40_V161_V0.5151.00
18_V247_M0.5141.00
168_G171_S0.5141.00
10_N14_T0.5131.00
287_L291_I0.5131.00
379_A383_S0.5131.00
267_G270_E0.5131.00
149_I153_L0.5131.00
38_G228_G0.5121.00
340_N344_F0.5121.00
231_Y234_I0.5121.00
208_S345_L0.5111.00
260_A274_S0.5111.00
231_Y309_E0.5111.00
45_L49_V0.5111.00
144_R147_I0.5111.00
416_E426_L0.5081.00
141_L145_W0.5071.00
372_A376_V0.5071.00
379_A382_S0.5061.00
166_L170_L0.5051.00
282_S326_P0.5051.00
351_N378_V0.5041.00
44_Q164_W0.5041.00
327_I386_I0.5041.00
266_L269_D0.5031.00
49_V213_F0.5031.00
267_G271_K0.5031.00
91_L94_F0.5020.99
208_S211_A0.5010.99
46_L221_V0.5010.99
143_I147_I0.5010.99
382_S386_I0.5010.99
391_I395_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8504 100 0.433 Contact Map
4humA 1 0.8632 100 0.437 Contact Map
3w4tA 1 0.8419 100 0.437 Contact Map
3mktA 1 0.8568 100 0.442 Contact Map
1pw4A 1 0.7714 22.3 0.952 Contact Map
2cfqA 1 0.7842 20.9 0.952 Contact Map
4n7wA 2 0.3996 16 0.955 Contact Map
3zuxA 1 0.3846 14.4 0.956 Contact Map
2ketA 1 0.0385 8.8 0.96 Contact Map
1lypA 1 0.0598 7.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0117 seconds.