GREMLIN Database
Q97XG1 - dTDP-Glucose 4,6-dehydratase (RfbB-3)
UniProt: Q97XG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (284)
Sequences: 59659 (42156)
Seq/√Len: 2501.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_G27_V3.4081.00
240_I278_K2.8451.00
17_E208_R2.8441.00
209_I226_I2.8181.00
58_H103_K2.7401.00
271_K274_V2.6001.00
88_T92_L2.5771.00
276_P279_E2.4871.00
66_I214_M2.4311.00
28_V50_A2.3821.00
243_E278_K2.3681.00
82_R85_D2.3051.00
107_K155_K2.2731.00
111_I210_I2.2551.00
222_E269_K2.2341.00
17_E21_R2.2071.00
3_I15_V2.1481.00
68_V214_M2.1321.00
4_I69_N2.1181.00
69_N110_H2.1151.00
17_E211_Y2.0491.00
26_I46_E2.0121.00
235_L239_K2.0091.00
21_R215_E1.9911.00
26_I64_S1.9871.00
208_R212_D1.9611.00
145_V156_A1.9411.00
244_I282_R1.9331.00
2_I64_S1.9051.00
24_K46_E1.8811.00
161_P210_I1.8681.00
240_I243_E1.8581.00
165_Y280_G1.8531.00
55_E99_E1.8251.00
270_L274_V1.8171.00
26_I48_I1.7921.00
233_S236_D1.7911.00
204_E283_K1.7851.00
53_R88_T1.7761.00
159_V213_I1.7481.00
123_D126_S1.6961.00
14_F207_V1.6901.00
14_F68_V1.6881.00
58_H100_A1.6881.00
95_V99_E1.6711.00
17_E20_K1.6391.00
31_L47_F1.6361.00
95_V144_F1.6361.00
180_I184_L1.6341.00
282_R286_E1.6091.00
102_R152_Y1.5801.00
202_Y283_K1.5681.00
92_L95_V1.5621.00
14_F70_F1.5531.00
236_D239_K1.5451.00
211_Y215_E1.5321.00
187_H252_K1.5141.00
117_Y225_N1.5141.00
21_R211_Y1.5131.00
10_I164_N1.5051.00
240_I244_I1.5041.00
55_E96_N1.5001.00
15_V27_V1.4931.00
67_V101_A1.4821.00
36_R39_N1.4771.00
275_T283_K1.4771.00
69_N94_V1.4771.00
87_V140_S1.4691.00
112_S116_V1.4681.00
139_A143_L1.4611.00
84_Q88_T1.4561.00
94_V141_A1.4321.00
212_D216_R1.4171.00
23_I215_E1.4091.00
107_K157_I1.4021.00
90_N137_S1.4011.00
97_L108_Y1.3981.00
58_H104_Y1.3911.00
17_E207_V1.3831.00
70_F111_I1.3801.00
68_V210_I1.3761.00
35_G39_N1.3741.00
52_V93_G1.3701.00
161_P206_T1.3611.00
128_L139_A1.3581.00
279_E283_K1.3541.00
235_L253_F1.3401.00
134_Y138_K1.3341.00
202_Y280_G1.3311.00
181_R186_M1.3311.00
159_V210_I1.3291.00
7_A29_D1.3191.00
16_R168_R1.3151.00
98_L148_Y1.3101.00
143_L146_K1.3051.00
279_E282_R1.2921.00
99_E102_R1.2891.00
203_V207_V1.2881.00
111_I161_P1.2861.00
6_G15_V1.2681.00
59_D62_K1.2661.00
110_H145_V1.2661.00
61_V67_V1.2571.00
55_E58_H1.2561.00
101_A108_Y1.2511.00
199_D229_G1.2501.00
110_H141_A1.2301.00
197_E231_R1.2201.00
18_V211_Y1.2061.00
62_K104_Y1.1961.00
160_R223_V1.1941.00
189_P252_K1.1891.00
201_I206_T1.1821.00
146_K158_I1.1741.00
16_R20_K1.1671.00
101_A106_F1.1631.00
149_V156_A1.1591.00
58_H62_K1.1461.00
146_K223_V1.1461.00
275_T279_E1.1431.00
124_E269_K1.1381.00
19_N45_H1.1351.00
99_E103_K1.1321.00
17_E204_E1.1231.00
52_V71_A1.1191.00
136_A140_S1.1161.00
187_H250_K1.1051.00
61_V64_S1.1031.00
242_G248_E1.1011.00
162_S266_M1.0971.00
27_V45_H1.0971.00
195_R235_L1.0961.00
13_A204_E1.0851.00
98_L108_Y1.0711.00
232_Y277_L1.0701.00
57_I100_A1.0661.00
160_R225_N1.0651.00
202_Y275_T1.0621.00
239_K242_G1.0571.00
70_F210_I1.0541.00
109_V159_V1.0531.00
9_F166_G1.0481.00
110_H158_I1.0471.00
28_V60_I1.0471.00
12_S168_R1.0321.00
28_V57_I1.0281.00
102_R154_I1.0281.00
89_T93_G1.0251.00
144_F147_A1.0241.00
244_I285_V1.0231.00
120_E126_S1.0201.00
56_E59_D1.0191.00
78_R82_R1.0151.00
164_N206_T1.0101.00
26_I63_N1.0091.00
73_E89_T1.0071.00
142_D160_R1.0021.00
66_I107_K1.0021.00
19_N44_E1.0011.00
155_K220_R1.0011.00
100_A104_Y0.9951.00
61_V100_A0.9891.00
108_Y145_V0.9871.00
146_K156_A0.9821.00
48_I60_I0.9781.00
278_K282_R0.9781.00
174_L178_V0.9761.00
231_R263_R0.9731.00
165_Y202_Y0.9701.00
202_Y205_D0.9671.00
96_N99_E0.9661.00
195_R233_S0.9651.00
4_I71_A0.9641.00
147_A151_T0.9621.00
98_L144_F0.9621.00
9_F203_V0.9601.00
92_L96_N0.9591.00
245_M285_V0.9561.00
19_N25_P0.9541.00
242_G249_V0.9431.00
2_I28_V0.9411.00
205_D228_G0.9381.00
23_I65_D0.9371.00
212_D215_E0.9351.00
224_Y273_E0.9301.00
14_F18_V0.9231.00
61_V104_Y0.9211.00
283_K286_E0.9201.00
98_L145_V0.9151.00
164_N201_I0.9131.00
30_L51_D0.9111.00
55_E103_K0.9091.00
122_A126_S0.9081.00
32_T49_R0.9021.00
244_I281_L0.8931.00
112_S142_D0.8931.00
54_S57_I0.8901.00
242_G247_K0.8891.00
87_V91_V0.8861.00
91_V140_S0.8841.00
4_I97_L0.8791.00
13_A17_E0.8771.00
123_D267_T0.8761.00
15_V25_P0.8751.00
227_P266_M0.8731.00
180_I183_F0.8721.00
232_Y236_D0.8671.00
268_T272_Y0.8651.00
197_E233_S0.8611.00
158_I223_V0.8551.00
159_V226_I0.8531.00
13_A203_V0.8511.00
96_N100_A0.8481.00
120_E123_D0.8441.00
57_I96_N0.8431.00
146_K150_R0.8421.00
208_R275_T0.8401.00
100_A103_K0.8401.00
261_D264_Y0.8351.00
194_G235_L0.8301.00
157_I213_I0.8301.00
35_G38_E0.8281.00
38_E41_I0.8261.00
1_M23_I0.8261.00
29_D47_F0.8241.00
244_I278_K0.8241.00
204_E275_T0.8211.00
87_V92_L0.8191.00
255_D258_P0.8191.00
93_G96_N0.8161.00
31_L49_R0.8151.00
13_A16_R0.8141.00
130_P135_S0.8141.00
24_K44_E0.8141.00
53_R89_T0.8101.00
114_D162_S0.8091.00
232_Y237_V0.8061.00
125_D269_K0.8061.00
177_K181_R0.7961.00
61_V101_A0.7941.00
140_S143_L0.7921.00
168_R171_P0.7881.00
94_V145_V0.7851.00
37_K49_R0.7841.00
141_A145_V0.7831.00
239_K243_E0.7831.00
208_R211_Y0.7781.00
87_V137_S0.7741.00
86_F137_S0.7731.00
252_K255_D0.7691.00
99_E148_Y0.7641.00
162_S227_P0.7591.00
167_P283_K0.7521.00
67_V97_L0.7471.00
102_R153_G0.7461.00
224_Y269_K0.7431.00
73_E85_D0.7431.00
148_Y152_Y0.7431.00
2_I50_A0.7421.00
177_K180_I0.7341.00
69_N97_L0.7331.00
205_D208_R0.7271.00
107_K217_S0.7251.00
143_L147_A0.7231.00
80_I133_P0.7231.00
94_V98_L0.7221.00
14_F210_I0.7221.00
275_T280_G0.7201.00
67_V108_Y0.7191.00
236_D240_I0.7171.00
116_V142_D0.7151.00
83_P136_A0.7141.00
85_D88_T0.7131.00
237_V277_L0.7091.00
254_V257_R0.7081.00
26_I60_I0.7051.00
173_K176_P0.7001.00
79_S86_F0.7001.00
182_T242_G0.7001.00
240_I277_L0.6991.00
18_V214_M0.6961.00
13_A207_V0.6961.00
179_I183_F0.6951.00
51_D54_S0.6941.00
231_R265_C0.6861.00
115_E135_S0.6861.00
124_E225_N0.6851.00
263_R267_T0.6841.00
270_L273_E0.6821.00
140_S144_F0.6821.00
230_Q276_P0.6801.00
197_E263_R0.6771.00
73_E90_N0.6761.00
73_E86_F0.6761.00
23_I66_I0.6731.00
132_S135_S0.6691.00
116_V128_L0.6671.00
2_I67_V0.6651.00
85_D89_T0.6651.00
37_K40_L0.6631.00
263_R266_M0.6591.00
72_A90_N0.6571.00
102_R148_Y0.6531.00
12_S16_R0.6531.00
179_I241_I0.6421.00
42_G45_H0.6411.00
167_P202_Y0.6381.00
136_A143_L0.6361.00
60_I64_S0.6351.00
87_V136_A0.6351.00
207_V211_Y0.6331.00
10_I206_T0.6331.00
189_P254_V0.6291.00
21_R208_R0.6281.00
242_G245_M0.6281.00
199_D228_G0.6231.00
179_I285_V0.6191.00
159_V209_I0.6161.00
156_A221_G0.6131.00
144_F148_Y0.6131.00
66_I109_V0.6121.00
244_I286_E0.6121.00
137_S141_A0.6091.00
83_P133_P0.6091.00
69_N108_Y0.6081.00
109_V214_M0.6071.00
3_I18_V0.6071.00
178_V181_R0.6071.00
21_R212_D0.6051.00
130_P139_A0.6041.00
196_A234_V0.6021.00
163_N198_R0.6011.00
133_P136_A0.5991.00
109_V213_I0.5971.00
63_N104_Y0.5961.00
7_A31_L0.5961.00
185_N247_K0.5951.00
251_V254_V0.5941.00
57_I61_V0.5931.00
181_R189_P0.5911.00
101_A104_Y0.5891.00
199_D231_R0.5891.00
211_Y214_M0.5871.00
90_N134_Y0.5861.00
128_L143_L0.5851.00
161_P164_N0.5811.00
147_A150_R0.5801.00
31_L36_R0.5791.00
55_E100_A0.5771.00
36_R40_L0.5771.00
136_A147_A0.5771.00
50_A60_I0.5721.00
167_P204_E0.5701.00
157_I224_Y0.5681.00
264_Y267_T0.5671.00
205_D275_T0.5631.00
216_R224_Y0.5631.00
238_I242_G0.5611.00
173_K177_K0.5601.00
208_R272_Y0.5591.00
109_V210_I0.5581.00
217_S220_R0.5531.00
178_V182_T0.5531.00
15_V19_N0.5531.00
145_V158_I0.5521.00
98_L102_R0.5501.00
111_I159_V0.5501.00
148_Y154_I0.5491.00
240_I281_L0.5481.00
94_V110_H0.5471.00
68_V211_Y0.5471.00
133_P137_S0.5441.00
118_G129_Q0.5421.00
212_D274_V0.5421.00
18_V68_V0.5411.00
2_I60_I0.5391.00
230_Q278_K0.5391.00
142_D158_I0.5371.00
134_Y137_S0.5361.00
190_I253_F0.5361.00
175_I237_V0.5351.00
3_I6_G0.5331.00
155_K218_E0.5331.00
95_V147_A0.5321.00
229_G271_K0.5321.00
165_Y228_G0.5311.00
206_T226_I0.5311.00
178_V188_V0.5301.00
23_I211_Y0.5301.00
157_I222_E0.5281.00
232_Y240_I0.5281.00
61_V106_F0.5281.00
16_R204_E0.5261.00
3_I27_V0.5251.00
9_F13_A0.5251.00
162_S199_D0.5231.00
70_F161_P0.5221.00
128_L223_V0.5211.00
149_V221_G0.5191.00
220_R224_Y0.5191.00
169_Q173_K0.5191.00
253_F256_D0.5181.00
213_I274_V0.5181.00
13_A168_R0.5171.00
67_V106_F0.5171.00
76_V79_S0.5161.00
61_V97_L0.5141.00
209_I212_D0.5131.00
101_A154_I0.5121.00
27_V47_F0.5121.00
212_D271_K0.5121.00
146_K149_V0.5091.00
52_V57_I0.5091.00
35_G40_L0.5091.00
50_A57_I0.5081.00
79_S133_P0.5061.00
182_T241_I0.5061.00
241_I281_L0.5051.00
75_H78_R0.5041.00
157_I216_R0.5041.00
23_I214_M0.5031.00
101_A105_D0.5031.00
113_T116_V0.5031.00
181_R185_N0.5021.00
112_S160_R0.5011.00
113_T138_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oc2A 2 0.9936 100 0.243 Contact Map
1sb8A 2 0.9391 100 0.246 Contact Map
2q1sA 2 0.9615 100 0.249 Contact Map
3rufA 2 0.9391 100 0.252 Contact Map
2hunA 2 0.984 100 0.255 Contact Map
4wkgA 5 0.9423 100 0.26 Contact Map
1orrA 3 0.9327 100 0.26 Contact Map
2bllA 2 0.9455 100 0.262 Contact Map
2c20A 2 0.9455 100 0.263 Contact Map
3m2pA 2 0.9103 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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