GREMLIN Database
Q97XG0 - Sugar phosphate nucleotydyl transferase
UniProt: Q97XG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (314)
Sequences: 8919 (6092)
Seq/√Len: 343.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
298_I301_S3.6471.00
130_K160_D3.4331.00
314_L317_S3.1851.00
121_K125_S3.0291.00
299_E315_M3.0171.00
303_I309_I2.9251.00
300_Y316_D2.9171.00
143_N146_K2.8771.00
31_K39_E2.7551.00
130_K208_I2.6161.00
141_V159_S2.5641.00
94_K178_E2.5041.00
258_V275_K2.3551.00
282_G285_T2.3001.00
122_G205_N2.2981.00
179_K200_E2.2621.00
254_E272_K2.2031.00
3_A46_I2.1881.00
260_K277_I2.1861.00
123_S170_T2.1761.00
153_K157_K2.1521.00
271_G289_D2.1381.00
101_F171_D2.0901.00
21_G27_K2.0571.00
35_Q64_Y2.0181.00
141_V149_R2.0111.00
147_V206_Y1.9911.00
117_F127_L1.9851.00
3_A41_I1.9431.00
276_I279_S1.9411.00
303_I307_V1.9301.00
307_V323_S1.9301.00
100_K170_T1.9261.00
48_D76_T1.9201.00
143_N148_I1.9021.00
128_L206_Y1.8931.00
252_I269_Y1.8921.00
218_T239_E1.8851.00
295_G311_G1.8581.00
310_K327_K1.8411.00
135_N153_K1.8351.00
146_K203_E1.8181.00
277_I299_E1.7841.00
38_L49_I1.7681.00
269_Y286_S1.7581.00
306_N322_N1.7301.00
289_D310_K1.7221.00
261_N278_N1.7191.00
216_T225_A1.7071.00
117_F168_G1.6951.00
319_I323_S1.6891.00
115_R119_S1.6581.00
50_L78_V1.6411.00
175_E179_K1.6301.00
288_G310_K1.6291.00
272_K289_D1.6281.00
301_S314_L1.6101.00
308_R324_T1.6091.00
120_F207_E1.5991.00
237_K240_G1.5951.00
265_R283_P1.5771.00
58_P62_V1.5771.00
235_E239_E1.5651.00
41_I104_Y1.5641.00
84_R88_D1.5371.00
319_I325_V1.5261.00
151_V158_I1.5241.00
34_S65_Y1.5001.00
279_S282_G1.5001.00
146_K205_N1.4921.00
176_V200_E1.4911.00
176_V196_G1.4881.00
312_V327_K1.4871.00
305_D321_N1.4781.00
255_K272_K1.4741.00
117_F125_S1.4691.00
149_R156_E1.4661.00
35_Q39_E1.4551.00
260_K275_K1.4541.00
259_V262_S1.4521.00
100_K168_G1.4361.00
296_S312_V1.4251.00
286_S308_R1.4151.00
186_G189_E1.4021.00
313_S330_K1.3861.00
58_P79_Y1.3851.00
118_L168_G1.3771.00
124_A197_L1.3731.00
304_L321_N1.3701.00
304_L318_L1.3481.00
175_E200_E1.3441.00
220_K239_E1.3411.00
103_V169_F1.3201.00
33_I216_T1.3171.00
102_L168_G1.3171.00
250_R267_P1.3161.00
270_I274_T1.3151.00
88_D92_R1.3091.00
142_I161_L1.3031.00
123_S203_E1.3021.00
25_L64_Y1.2941.00
298_I303_I1.2911.00
53_L58_P1.2901.00
267_P284_F1.2861.00
297_E313_S1.2841.00
307_V319_I1.2691.00
248_D251_V1.2541.00
271_G274_T1.2521.00
88_D91_Y1.2511.00
281_I287_I1.2471.00
179_K196_G1.2441.00
253_L257_A1.2281.00
141_V151_V1.2171.00
48_D74_N1.2101.00
142_I206_Y1.2001.00
105_L108_N1.1921.00
236_R240_G1.1911.00
116_K119_S1.1881.00
254_E271_G1.1871.00
195_Q199_N1.1831.00
22_P60_R1.1711.00
264_I268_A1.1681.00
60_R63_D1.1661.00
257_A274_T1.1661.00
136_R153_K1.1641.00
50_L96_L1.1591.00
36_W229_L1.1521.00
312_V329_T1.1521.00
214_K228_F1.1521.00
133_N136_R1.1431.00
254_E257_A1.1421.00
104_Y114_L1.1391.00
128_L140_A1.1391.00
112_Y212_W1.1381.00
196_G200_E1.1381.00
284_F306_N1.1261.00
73_V76_T1.1241.00
66_G77_Y1.1241.00
73_V77_Y1.1241.00
99_E171_D1.1021.00
120_F205_N1.1011.00
90_V103_V1.1001.00
212_W228_F1.0971.00
29_A229_L1.0961.00
278_N300_Y1.0951.00
289_D305_D1.0901.00
54_G83_A1.0901.00
261_N279_S1.0871.00
91_Y94_K1.0801.00
307_V320_G1.0771.00
311_G328_G1.0741.00
59_T63_D1.0711.00
220_K224_E1.0671.00
275_K297_E1.0671.00
274_T289_D1.0641.00
281_I285_T1.0631.00
302_V318_L1.0611.00
21_G60_R1.0581.00
282_G287_I1.0501.00
27_K32_P1.0481.00
32_P35_Q1.0481.00
233_Y237_K1.0421.00
43_D113_D1.0411.00
154_P184_W1.0401.00
24_Q106_G1.0361.00
139_V162_A1.0301.00
28_V226_N1.0281.00
83_A88_D1.0261.00
133_N153_K1.0211.00
128_L161_L1.0171.00
218_T221_D1.0131.00
184_W189_E1.0111.00
62_V79_Y1.0081.00
121_K170_T1.0021.00
262_S279_S0.9971.00
32_P64_Y0.9921.00
35_Q68_G0.9851.00
163_L167_Y0.9811.00
132_D160_D0.9801.00
75_I78_V0.9771.00
34_S61_V0.9771.00
314_L319_I0.9751.00
124_A169_F0.9731.00
214_K224_E0.9711.00
172_E175_E0.9701.00
262_S276_I0.9701.00
87_A180_L0.9671.00
42_R74_N0.9601.00
131_V162_A0.9581.00
116_K120_F0.9541.00
176_V197_L0.9531.00
268_A281_I0.9461.00
145_N208_I0.9461.00
74_N77_Y0.9311.00
181_K188_L0.9291.00
91_Y178_E0.9221.00
268_A285_T0.9191.00
242_V245_S0.9151.00
265_R268_A0.9121.00
138_G152_E0.9091.00
4_V101_F0.9081.00
234_A238_I0.9041.00
40_Q113_D0.8991.00
100_K121_K0.8981.00
53_L62_V0.8971.00
220_K235_E0.8951.00
99_E170_T0.8911.00
266_G283_P0.8901.00
151_V156_E0.8861.00
59_T62_V0.8741.00
285_T298_I0.8731.00
263_V280_Y0.8711.00
175_E178_E0.8651.00
11_G23_K0.8651.00
121_K168_G0.8611.00
126_I147_V0.8601.00
34_S51_L0.8581.00
253_L259_V0.8581.00
283_P305_D0.8561.00
54_G88_D0.8551.00
147_V204_V0.8481.00
169_F193_A0.8481.00
309_I315_M0.8471.00
313_S328_G0.8441.00
53_L77_Y0.8441.00
264_I270_I0.8411.00
38_L75_I0.8391.00
243_E248_D0.8391.00
170_T173_I0.8311.00
173_I197_L0.8281.00
228_F231_D0.8271.00
243_E247_I0.8221.00
102_L118_L0.8211.00
198_I204_V0.8201.00
307_V321_N0.8201.00
297_E311_G0.8181.00
279_S283_P0.8171.00
129_A162_A0.8161.00
123_S173_I0.8141.00
280_Y283_P0.8131.00
122_G203_E0.8111.00
126_I140_A0.8041.00
124_A204_V0.8021.00
41_I46_I0.8011.00
161_L208_I0.7971.00
271_G288_G0.7931.00
227_S230_L0.7921.00
251_V264_I0.7911.00
25_L60_R0.7901.00
49_I73_V0.7881.00
248_D265_R0.7881.00
180_L193_A0.7871.00
311_G327_K0.7861.00
251_V268_A0.7841.00
296_S327_K0.7771.00
129_A213_W0.7761.00
288_G295_G0.7731.00
296_S310_K0.7701.00
251_V265_R0.7691.00
56_N60_R0.7691.00
44_S114_L0.7671.00
32_P36_W0.7651.00
37_V104_Y0.7621.00
231_D235_E0.7621.00
4_V50_L0.7621.00
124_A194_I0.7601.00
245_S251_V0.7591.00
51_L65_Y0.7561.00
5_I41_I0.7561.00
267_P272_K0.7501.00
196_G199_N0.7481.00
149_R195_Q0.7471.00
35_Q65_Y0.7421.00
42_R49_I0.7411.00
296_S309_I0.7380.99
23_K107_D0.7360.99
76_T96_L0.7330.99
74_N78_V0.7320.99
233_Y236_R0.7300.99
13_R23_K0.7300.99
242_V246_T0.7290.99
250_R253_L0.7290.99
22_P56_N0.7280.99
244_N261_N0.7280.99
113_D116_K0.7280.99
248_D266_G0.7270.99
105_L165_G0.7220.99
270_I276_I0.7200.99
309_I312_V0.7190.99
131_V160_D0.7180.99
251_V254_E0.7180.99
254_E269_Y0.7160.99
180_L191_T0.7130.99
6_L105_L0.7050.99
312_V325_V0.7040.99
5_I38_L0.7020.99
29_A36_W0.7010.99
271_G286_S0.7000.99
254_E289_D0.6960.99
38_L65_Y0.6920.99
116_K210_Q0.6900.99
164_V213_W0.6900.99
102_L114_L0.6890.99
214_K225_A0.6890.99
309_I314_L0.6850.99
326_E329_T0.6820.99
252_I255_K0.6800.99
176_V193_A0.6760.99
50_L97_V0.6750.99
39_E43_D0.6710.99
288_G305_D0.6700.99
304_L320_G0.6690.99
128_L147_V0.6690.99
4_V90_V0.6680.99
62_V77_Y0.6660.99
279_S298_I0.6620.99
84_R188_L0.6610.99
254_E274_T0.6570.99
310_K313_S0.6570.99
140_A147_V0.6550.99
148_I198_I0.6550.99
312_V328_G0.6540.99
40_Q44_S0.6540.99
29_A226_N0.6490.99
297_E310_K0.6460.99
237_K253_L0.6450.99
274_T277_I0.6430.99
247_I251_V0.6430.99
184_W187_E0.6430.99
50_L93_V0.6430.99
267_P283_P0.6420.99
256_G272_K0.6420.99
228_F232_R0.6420.99
116_K207_E0.6380.99
28_V33_I0.6370.99
244_N247_I0.6340.98
9_G23_K0.6300.98
300_Y315_M0.6290.98
209_I213_W0.6280.98
246_T263_V0.6280.98
283_P287_I0.6280.98
52_I89_A0.6270.98
33_I37_V0.6270.98
298_I309_I0.6270.98
324_T327_K0.6250.98
126_I204_V0.6240.98
141_V148_I0.6220.98
286_S302_V0.6190.98
243_E250_R0.6150.98
100_K118_L0.6130.98
31_K36_W0.6130.98
306_N321_N0.6100.98
297_E300_Y0.6100.98
180_L196_G0.6050.98
260_K265_R0.6050.98
93_V97_V0.6040.98
226_N230_L0.6020.98
276_I281_I0.6010.98
296_S311_G0.6000.98
107_D215_D0.6000.98
301_S317_S0.5990.98
248_D252_I0.5980.98
6_L52_I0.5980.98
224_E227_S0.5980.98
246_T249_G0.5970.98
46_I118_L0.5960.98
82_K88_D0.5950.98
147_V150_L0.5950.98
141_V158_I0.5910.98
9_G13_R0.5890.98
288_G296_S0.5890.98
311_G314_L0.5870.97
15_R19_H0.5860.97
42_R68_G0.5850.97
246_T261_N0.5840.97
184_W188_L0.5820.97
75_I80_Q0.5820.97
125_S207_E0.5820.97
242_V260_K0.5810.97
111_F166_V0.5790.97
3_A44_S0.5780.97
8_G52_I0.5780.97
176_V179_K0.5770.97
50_L76_T0.5760.97
47_K74_N0.5760.97
24_Q61_V0.5750.97
257_A270_I0.5740.97
257_A276_I0.5740.97
288_G308_R0.5740.97
249_G266_G0.5730.97
250_R254_E0.5710.97
75_I79_Y0.5700.97
224_E228_F0.5700.97
187_E192_D0.5690.97
221_D224_E0.5690.97
93_V96_L0.5680.97
310_K315_M0.5660.97
241_E244_N0.5650.97
51_L75_I0.5650.97
243_E252_I0.5650.97
251_V266_G0.5650.97
36_W39_E0.5650.97
298_I314_L0.5640.97
67_D77_Y0.5630.97
257_A289_D0.5610.97
40_Q43_D0.5610.97
125_S168_G0.5600.97
299_E313_S0.5600.97
91_Y177_I0.5590.97
268_A278_N0.5590.97
257_A272_K0.5580.97
76_T79_Y0.5580.97
242_V250_R0.5580.97
285_T307_V0.5570.97
252_I267_P0.5550.96
243_E246_T0.5520.96
161_L206_Y0.5520.96
295_G310_K0.5510.96
282_G305_D0.5500.96
315_M330_K0.5500.96
185_R189_E0.5500.96
146_K198_I0.5480.96
247_I266_G0.5470.96
187_E191_T0.5470.96
122_G125_S0.5460.96
127_L166_V0.5450.96
261_N266_G0.5420.96
40_Q114_L0.5420.96
136_R221_D0.5400.96
7_H51_L0.5400.96
259_V264_I0.5390.96
320_G323_S0.5370.96
311_G324_T0.5370.96
62_V66_G0.5360.96
99_E172_E0.5360.96
94_K97_V0.5360.96
229_L233_Y0.5310.95
88_D188_L0.5300.95
39_E42_R0.5290.95
274_T288_G0.5290.95
307_V325_V0.5290.95
44_S115_R0.5280.95
279_S285_T0.5280.95
105_L167_Y0.5270.95
268_A282_G0.5270.95
104_Y166_V0.5270.95
42_R73_V0.5270.95
244_N248_D0.5250.95
73_V78_V0.5250.95
29_A233_Y0.5220.95
10_Q83_A0.5220.95
128_L208_I0.5210.95
42_R72_G0.5180.95
130_K161_L0.5170.95
63_D66_G0.5170.95
303_I319_I0.5120.95
214_K221_D0.5100.94
263_V266_G0.5080.94
304_L323_S0.5080.94
265_R282_G0.5070.94
279_S295_G0.5060.94
86_L107_D0.5060.94
131_V134_P0.5050.94
183_S189_E0.5050.94
242_V247_I0.5030.94
245_S248_D0.5030.94
183_S186_G0.5020.94
193_A196_G0.5020.94
26_I219_P0.5010.94
301_S315_M0.5010.94
68_G72_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggoA 3 0.9535 100 0.382 Contact Map
3brkX 2 0.9419 100 0.385 Contact Map
1yp2A 4 0.9593 100 0.4 Contact Map
4g3qA 3 0.9709 100 0.435 Contact Map
2v0hA 3 0.9593 100 0.442 Contact Map
1hm9A 3 0.9535 100 0.442 Contact Map
4fceA 3 0.9448 100 0.453 Contact Map
2icyA 1 0.9012 100 0.511 Contact Map
2i5kA 5 0.9012 100 0.534 Contact Map
3jukA 3 0.6715 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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