GREMLIN Database
Q97XF9 - dTDP-4-dehydrorhamnose reductase (RfbD-2)
UniProt: Q97XF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (191)
Sequences: 33414 (21664)
Seq/√Len: 1567.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_I193_L2.8551.00
10_E13_K2.7531.00
138_G189_K2.5591.00
16_K20_Q2.5261.00
86_T128_I2.4561.00
127_A142_V2.3161.00
126_L199_Y2.2331.00
191_R197_D2.2201.00
84_I131_L2.1971.00
108_T167_K2.1951.00
110_L167_K2.1431.00
39_I128_I2.0711.00
188_S192_K2.0351.00
150_Y154_I2.0131.00
35_Y80_E1.9701.00
126_L130_E1.8831.00
75_A81_S1.8551.00
148_S151_E1.8541.00
58_P69_L1.8371.00
145_E191_R1.8181.00
54_E189_K1.7841.00
155_K158_E1.7661.00
22_V71_G1.7461.00
101_K105_E1.7251.00
155_K159_K1.7051.00
87_S185_L1.6751.00
23_K74_F1.6551.00
150_Y168_E1.6541.00
69_L73_I1.6191.00
138_G193_L1.6121.00
53_K56_N1.6121.00
190_A194_L1.6111.00
40_S44_V1.6061.00
115_Y146_R1.5731.00
143_A185_L1.5671.00
129_D133_D1.5361.00
20_Q23_K1.5031.00
38_H71_G1.4701.00
50_G53_K1.4381.00
15_Y70_L1.4371.00
29_G34_S1.4361.00
151_E154_I1.4221.00
110_L169_V1.4171.00
157_K163_P1.4161.00
23_K27_R1.4031.00
28_A32_V1.4021.00
73_I76_S1.3901.00
66_L70_L1.3691.00
117_S145_E1.3651.00
102_T107_K1.3601.00
146_R182_D1.3461.00
86_T124_L1.3371.00
39_I86_T1.3321.00
18_N67_S1.3241.00
29_G36_V1.3181.00
189_K193_L1.3061.00
154_I157_K1.3011.00
27_R30_R1.2941.00
25_I36_V1.2901.00
146_R184_S1.2901.00
76_S83_I1.2871.00
53_K186_D1.2811.00
19_S70_L1.2811.00
17_I21_A1.2631.00
121_A125_A1.2581.00
187_I191_R1.2571.00
12_D16_K1.2541.00
84_I128_I1.2381.00
147_I151_E1.2361.00
22_V38_H1.2331.00
38_H83_I1.2311.00
147_I202_D1.2291.00
45_F141_H1.2281.00
35_Y82_L1.2161.00
36_V75_A1.2131.00
38_H75_A1.2061.00
115_Y182_D1.2041.00
90_F120_S1.1961.00
95_F99_V1.1841.00
143_A187_I1.1841.00
52_Y56_N1.1801.00
122_R200_T1.1791.00
50_G56_N1.1781.00
108_T165_E1.1751.00
119_I124_L1.1491.00
187_I198_F1.1411.00
26_V75_A1.1361.00
26_V78_Y1.1301.00
46_D59_N1.1191.00
120_S200_T1.1121.00
15_Y19_S1.1091.00
55_D189_K1.0991.00
140_I189_K1.0971.00
27_R31_V1.0971.00
27_R78_Y1.0931.00
76_S81_S1.0771.00
115_Y148_S1.0701.00
142_V190_A1.0681.00
157_K164_G1.0621.00
22_V75_A1.0611.00
44_V58_P1.0581.00
15_Y67_S1.0551.00
130_E134_L1.0491.00
98_Y102_T1.0481.00
76_S139_I1.0461.00
8_E63_Y1.0301.00
26_V36_V1.0141.00
188_S191_R1.0131.00
66_L73_I1.0061.00
127_A190_A0.9981.00
85_R139_I0.9951.00
89_V124_L0.9931.00
28_A31_V0.9931.00
66_L77_S0.9791.00
131_L194_L0.9771.00
126_L200_T0.9771.00
20_Q24_H0.9701.00
82_L131_L0.9681.00
48_N52_Y0.9641.00
123_K144_G0.9631.00
147_I152_L0.9611.00
24_H28_A0.9561.00
83_I139_I0.9551.00
15_Y20_Q0.9451.00
40_S72_E0.9411.00
76_S79_D0.9411.00
155_K202_D0.9371.00
96_P152_L0.9341.00
30_R78_Y0.9301.00
113_K168_E0.9301.00
103_L157_K0.9291.00
100_Y156_I0.9231.00
54_E190_A0.9231.00
88_G116_Y0.9111.00
169_V174_S0.9111.00
120_S123_K0.9111.00
35_Y135_R0.9081.00
72_E85_R0.9051.00
51_N182_D0.9011.00
130_E194_L0.8931.00
98_Y101_K0.8901.00
71_G75_A0.8891.00
166_V169_V0.8881.00
151_E155_K0.8851.00
11_K66_L0.8841.00
94_G97_I0.8781.00
81_S137_T0.8751.00
70_L73_I0.8751.00
86_T89_V0.8721.00
47_G61_I0.8711.00
42_D87_S0.8711.00
13_K17_I0.8571.00
42_D185_L0.8531.00
126_L129_D0.8501.00
83_I137_T0.8481.00
99_V153_A0.8461.00
47_G181_Y0.8411.00
12_D23_K0.8341.00
189_K192_K0.8281.00
70_L74_F0.8211.00
49_K56_N0.8191.00
131_L190_A0.8181.00
22_V26_V0.8111.00
114_G149_R0.8111.00
82_L140_I0.8061.00
145_E187_I0.8051.00
103_L156_I0.7981.00
130_E133_D0.7921.00
44_V72_E0.7881.00
84_I127_A0.7831.00
63_Y66_L0.7751.00
85_R141_H0.7741.00
157_K162_L0.7671.00
19_S67_S0.7651.00
154_I158_E0.7651.00
157_K166_V0.7641.00
24_H27_R0.7631.00
60_P69_L0.7621.00
37_I128_I0.7611.00
180_P183_S0.7601.00
100_Y104_K0.7591.00
106_G162_L0.7541.00
191_R198_F0.7511.00
58_P139_I0.7461.00
136_K193_L0.7421.00
14_A67_S0.7391.00
9_I176_I0.7371.00
100_Y160_F0.7361.00
129_D132_L0.7331.00
92_N95_F0.7291.00
102_T110_L0.7281.00
73_I77_S0.7151.00
13_K16_K0.7131.00
80_E136_K0.7101.00
21_A24_H0.7061.00
99_V109_V0.7041.00
102_T106_G0.7031.00
91_R121_A0.7001.00
37_I84_I0.6931.00
26_V74_F0.6901.00
53_K188_S0.6881.00
16_K24_H0.6861.00
37_I132_L0.6811.00
74_F77_S0.6771.00
43_Y65_G0.6741.00
48_N51_N0.6701.00
130_E195_T0.6621.00
127_A196_I0.6611.00
157_K160_F0.6601.00
19_S74_F0.6561.00
111_A153_A0.6521.00
89_V119_I0.6521.00
162_L165_E0.6471.00
39_I84_I0.6391.00
125_A129_D0.6371.00
37_I82_L0.6341.00
109_V112_F0.6321.00
147_I155_K0.6311.00
117_S144_G0.6281.00
15_Y66_L0.6271.00
123_K126_L0.6271.00
23_K78_Y0.6261.00
153_A157_K0.6261.00
29_G32_V0.6251.00
102_T105_E0.6241.00
11_K63_Y0.6101.00
126_L196_I0.6081.00
82_L137_T0.6031.00
16_K27_R0.6001.00
115_Y184_S0.5991.00
42_D183_S0.5981.00
109_V113_K0.5921.00
187_I190_A0.5891.00
144_G198_F0.5841.00
176_I179_R0.5841.00
140_I190_A0.5821.00
75_A83_I0.5821.00
113_K181_Y0.5811.00
15_Y23_K0.5801.00
87_S143_A0.5801.00
22_V25_I0.5801.00
93_K97_I0.5651.00
122_R126_L0.5631.00
118_P149_R0.5631.00
84_I142_V0.5621.00
94_G98_Y0.5621.00
44_V85_R0.5571.00
103_L109_V0.5571.00
58_P73_I0.5561.00
158_E164_G0.5561.00
93_K98_Y0.5541.00
80_E137_T0.5531.00
15_Y74_F0.5511.00
150_Y166_V0.5491.00
187_I196_I0.5471.00
19_S23_K0.5471.00
26_V29_G0.5441.00
101_K107_K0.5441.00
152_L202_D0.5431.00
95_F149_R0.5431.00
25_I29_G0.5421.00
48_N56_N0.5411.00
116_Y149_R0.5391.00
82_L138_G0.5391.00
51_N56_N0.5371.00
54_E141_H0.5311.00
99_V103_L0.5311.00
154_I166_V0.5291.00
84_I124_L0.5281.00
60_P66_L0.5281.00
153_A166_V0.5241.00
190_A193_L0.5241.00
101_K104_K0.5221.00
12_D20_Q0.5191.00
36_V81_S0.5171.00
62_N65_G0.5161.00
92_N97_I0.5151.00
74_F78_Y0.5141.00
76_S138_G0.5121.00
104_K160_F0.5111.00
144_G187_I0.5091.00
118_P152_L0.5061.00
145_E197_D0.5031.00
82_L134_L0.5001.00
103_L160_F0.5001.00
97_I101_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ggsA 1 0.9952 100 0.324 Contact Map
1rkxA 3 0.9614 100 0.35 Contact Map
1i24A 4 0.9855 100 0.351 Contact Map
1n7hA 4 1 100 0.358 Contact Map
3sxpA 3 0.9662 100 0.359 Contact Map
2b69A 2 0.9807 100 0.36 Contact Map
1vl0A 3 0.9952 100 0.36 Contact Map
1sb8A 2 1 100 0.36 Contact Map
1oc2A 2 0.9807 100 0.363 Contact Map
4wkgA 5 1 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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