GREMLIN Database
Q97XF4 - Uncharacterized protein
UniProt: Q97XF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (123)
Sequences: 550 (496)
Seq/√Len: 44.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_A106_Y3.8701.00
43_A47_L3.8501.00
89_E111_K3.6771.00
48_P80_L3.3391.00
15_I54_G2.8041.00
14_V47_L2.6631.00
16_K21_E2.6561.00
42_L113_L2.5991.00
99_I104_A2.4261.00
90_M105_A2.3101.00
108_A112_V2.2651.00
13_V27_A2.1821.00
49_F105_A2.0580.99
21_E60_S2.0270.99
52_L101_I1.9480.99
51_V73_L1.9260.99
17_W27_A1.9190.99
17_W31_K1.8420.99
47_L78_I1.8100.99
14_V17_W1.7720.98
71_K88_D1.7140.98
119_T125_I1.7060.98
45_C82_G1.6230.97
43_A78_I1.6170.97
21_E24_S1.5940.97
122_E126_R1.5880.97
43_A80_L1.4420.94
66_L91_V1.4260.94
86_I90_M1.4140.93
42_L81_Y1.4040.93
16_K120_A1.3760.93
47_L106_Y1.3160.91
89_E92_S1.3120.91
100_T104_A1.3110.91
11_A15_I1.2990.90
81_Y108_A1.2930.90
44_P106_Y1.2870.90
43_A106_Y1.2680.89
107_I124_L1.2590.89
53_N102_Y1.2150.87
97_Y100_T1.2000.86
15_I19_V1.1750.85
106_Y109_L1.1750.85
81_Y109_L1.1680.85
51_V54_G1.1640.84
9_V41_L1.1390.83
11_A51_V1.1370.83
89_E108_A1.1320.83
18_F69_V1.1210.82
19_V61_L1.1090.81
99_I107_I1.0690.79
46_I101_I1.0650.79
57_Y60_S1.0490.78
41_L118_Y1.0300.76
18_F28_L1.0000.74
56_K91_V0.9950.74
93_L99_I0.9900.73
99_I127_K0.9830.73
37_G47_L0.9790.73
62_G65_E0.9790.73
66_L110_G0.9570.71
26_E29_I0.9330.69
9_V14_V0.9330.69
108_A111_K0.9290.69
7_A115_E0.9270.68
76_F104_A0.9230.68
63_E67_E0.9140.67
7_A116_K0.9060.67
123_R126_R0.8940.66
100_T123_R0.8870.65
13_V16_K0.8810.64
65_E72_I0.8800.64
9_V13_V0.8720.64
47_L80_L0.8710.64
100_T107_I0.8690.63
13_V26_E0.8570.62
44_P77_Q0.8500.62
11_A54_G0.8450.61
7_A17_W0.8380.60
29_I63_E0.8350.60
56_K100_T0.8280.60
49_F54_G0.8230.59
46_I105_A0.8220.59
27_A120_A0.8070.58
106_Y123_R0.8010.57
97_Y104_A0.7990.57
13_V17_W0.7870.56
14_V43_A0.7850.55
67_E114_N0.7820.55
97_Y107_I0.7780.55
17_W118_Y0.7770.55
121_D124_L0.7710.54
61_L66_L0.7640.53
15_I55_L0.7590.53
59_Y71_K0.7560.53
21_E58_T0.7530.52
85_N134_V0.7500.52
94_S123_R0.7460.52
101_I107_I0.7390.51
81_Y112_V0.7370.51
102_Y124_L0.7370.51
11_A14_V0.7250.50
78_I104_A0.7210.49
46_I59_Y0.7200.49
74_S122_E0.7110.48
7_A67_E0.7070.48
98_G122_E0.7050.48
53_N100_T0.7020.47
40_D79_T0.6990.47
37_G126_R0.6800.45
72_I80_L0.6800.45
128_V131_L0.6760.45
9_V20_N0.6710.44
19_V55_L0.6710.44
51_V93_L0.6690.44
91_V98_G0.6690.44
100_T105_A0.6690.44
45_C84_E0.6680.44
99_I129_K0.6670.44
20_N24_S0.6650.44
22_N60_S0.6620.44
93_L104_A0.6580.43
54_G59_Y0.6550.43
23_Y120_A0.6550.43
45_C49_F0.6530.43
53_N56_K0.6500.42
53_N57_Y0.6500.42
38_L41_L0.6460.42
16_K24_S0.6460.42
56_K94_S0.6440.42
45_C83_F0.6380.41
53_N101_I0.6350.41
22_N58_T0.6350.41
19_V54_G0.6310.41
71_K114_N0.6290.40
126_R129_K0.6270.40
71_K122_E0.6240.40
89_E129_K0.6230.40
71_K79_T0.6210.40
19_V127_K0.6120.39
88_D114_N0.6080.39
116_K133_F0.6080.39
46_I49_F0.5930.37
41_L78_I0.5900.37
78_I127_K0.5880.37
46_I77_Q0.5820.36
55_L69_V0.5770.36
93_L108_A0.5740.35
49_F53_N0.5740.35
69_V123_R0.5700.35
28_L37_G0.5640.35
21_E41_L0.5630.35
61_L114_N0.5590.34
106_Y121_D0.5580.34
25_K67_E0.5580.34
126_R130_E0.5530.34
56_K66_L0.5530.34
117_V128_V0.5520.34
72_I93_L0.5520.34
104_A125_I0.5450.33
65_E119_T0.5440.33
24_S27_A0.5430.33
49_F74_S0.5420.33
18_F95_L0.5390.32
46_I102_Y0.5350.32
14_V41_L0.5350.32
68_E105_A0.5310.32
66_L95_L0.5300.32
79_T82_G0.5290.32
86_I109_L0.5240.31
29_I114_N0.5240.31
70_G92_S0.5230.31
25_K114_N0.5230.31
52_L56_K0.5220.31
55_L66_L0.5180.31
40_D43_A0.5170.31
25_K98_G0.5160.31
18_F123_R0.5150.30
116_K134_V0.5120.30
53_N74_S0.5090.30
22_N57_Y0.5080.30
77_Q83_F0.5030.29
90_M108_A0.5030.29
57_Y66_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fe1A 2 0.8671 99.7 0.593 Contact Map
1v8pA 4 0.8951 99.7 0.597 Contact Map
1w8iA 2 0.9441 99.2 0.694 Contact Map
4chgA 2 0.8671 99.2 0.699 Contact Map
3tndA 3 0.8811 99 0.713 Contact Map
3zvkA 3 0.8951 99 0.715 Contact Map
2h1cA 2 0.9091 98.9 0.724 Contact Map
3ix7A 2 0.8322 98.5 0.765 Contact Map
3h87A 3 0.9021 98.4 0.768 Contact Map
3dboB 1 0.8322 98.4 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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