GREMLIN Database
Q97XD7 - Ubiquinone/menaquinone biosynthesis methyltransferase
UniProt: Q97XD7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (214)
Sequences: 4134 (2596)
Seq/√Len: 177.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_S105_C3.4411.00
198_T201_Q3.1721.00
112_F117_F3.0001.00
56_L82_E2.9041.00
133_E208_K2.7231.00
61_A125_A2.6521.00
199_N217_E2.5671.00
90_E104_L2.5581.00
62_S68_S2.4951.00
60_V139_I2.4721.00
18_N91_N2.3991.00
18_N89_A2.3901.00
90_E94_K2.3651.00
140_T210_I2.3481.00
95_M98_I2.3351.00
62_S85_L2.3151.00
10_N106_S2.2961.00
203_K207_E2.2361.00
133_E205_I2.2291.00
143_S210_I2.2191.00
129_S135_V2.1851.00
57_I71_F2.1721.00
58_L117_F2.1551.00
126_L202_H2.1121.00
42_D216_E2.0901.00
138_E141_R2.0051.00
120_V139_I1.9921.00
206_F228_G1.9531.00
69_Y100_D1.9491.00
132_I205_I1.9151.00
133_E137_R1.8901.00
105_C111_P1.8701.00
84_I117_F1.8461.00
143_S147_V1.8381.00
23_A26_R1.8211.00
131_N134_D1.7851.00
204_R207_E1.7751.00
218_R225_F1.7621.00
76_K81_Y1.7591.00
120_V143_S1.6711.00
118_D144_R1.6411.00
46_T216_E1.6291.00
65_G96_A1.6261.00
139_I147_V1.5941.00
94_K97_L1.5891.00
177_V183_A1.5841.00
56_L84_I1.5741.00
29_R37_V1.5621.00
43_L225_F1.5611.00
134_D137_R1.5601.00
43_L67_L1.5011.00
113_R116_T1.4841.00
122_S129_S1.4661.00
106_S109_A1.4561.00
204_R208_K1.4501.00
14_Q18_N1.4381.00
203_K215_Y1.4351.00
93_L104_L1.4211.00
47_I119_I1.4161.00
219_A222_L1.3941.00
43_L148_G1.3941.00
56_L117_F1.3651.00
203_K213_K1.3541.00
138_E142_V1.3421.00
61_A122_S1.3411.00
29_R36_D1.3301.00
35_Q38_K1.3301.00
88_Y106_S1.3241.00
25_D64_K1.2891.00
207_E213_K1.2771.00
160_R220_L1.2761.00
57_I83_I1.2561.00
183_A187_K1.2351.00
68_S83_I1.2221.00
166_I170_Y1.2151.00
200_S215_Y1.2141.00
84_I112_F1.2051.00
182_K185_D1.1771.00
52_K55_K1.1771.00
103_V112_F1.1551.00
42_D46_T1.1401.00
86_S103_V1.1371.00
214_V227_V1.1371.00
133_E209_Y1.1241.00
152_M193_Y1.1191.00
61_A129_S1.1061.00
168_L193_Y1.1051.00
109_A134_D1.1041.00
154_K198_T1.1011.00
58_L120_V1.0951.00
139_I143_S1.0741.00
36_D40_R1.0731.00
45_K74_I1.0501.00
57_I119_I1.0411.00
68_S85_L1.0391.00
30_F179_G1.0391.00
174_Y177_V1.0361.00
168_L190_Y1.0320.99
97_L101_D1.0210.99
124_F223_F1.0190.99
14_Q88_Y1.0170.99
14_Q104_L1.0080.99
201_Q204_R1.0030.99
71_F121_M0.9950.99
114_E141_R0.9940.99
76_K80_N0.9910.99
165_S194_E0.9840.99
93_L96_A0.9770.99
161_R165_S0.9760.99
25_D99_K0.9710.99
69_Y99_K0.9710.99
94_K98_I0.9620.99
41_A70_T0.9570.99
202_H226_V0.9540.99
10_N108_D0.9530.99
147_V228_G0.9520.99
170_Y174_Y0.9480.99
42_D218_R0.9460.99
107_F129_S0.9380.99
124_F150_I0.9360.99
160_R163_Y0.9350.99
31_I222_L0.9310.99
122_S125_A0.9210.99
19_D182_K0.9150.99
75_Y81_Y0.9070.99
148_G227_V0.8990.99
60_V86_S0.8860.98
120_V142_V0.8860.98
22_K95_M0.8810.98
42_D225_F0.8810.98
157_S162_I0.8800.98
58_L142_V0.8760.98
98_I102_K0.8720.98
66_E99_K0.8700.98
35_Q219_A0.8590.98
64_K99_K0.8540.98
108_D131_N0.8520.98
140_T143_S0.8510.98
47_I148_G0.8430.98
84_I103_V0.8390.98
85_L96_A0.8370.98
55_K81_Y0.8350.98
110_L142_V0.8340.98
38_K42_D0.8300.98
46_T225_F0.8280.98
55_K119_I0.8240.97
147_V210_I0.8190.97
27_A31_I0.8190.97
62_S96_A0.8150.97
147_V206_F0.8100.97
55_K146_I0.8080.97
91_N94_K0.8050.97
34_N37_V0.8020.97
12_E15_Q0.7990.97
216_E227_V0.7960.97
17_Y127_H0.7940.97
98_I101_D0.7900.97
26_R30_F0.7880.97
146_I227_V0.7850.97
60_V120_V0.7810.97
56_L116_T0.7810.97
90_E97_L0.7780.96
158_W162_I0.7770.96
169_K194_E0.7760.96
39_W128_A0.7750.96
159_V162_I0.7740.96
123_S150_I0.7740.96
108_D134_D0.7710.96
124_F128_A0.7690.96
75_Y80_N0.7680.96
127_H192_I0.7640.96
126_L129_S0.7630.96
10_N88_Y0.7600.96
114_E142_V0.7410.95
18_N90_E0.7400.95
217_E224_Y0.7390.95
135_V139_I0.7380.95
137_R208_K0.7360.95
28_N128_A0.7360.95
44_V70_T0.7330.95
88_Y108_D0.7300.95
131_N137_R0.7270.95
137_R209_Y0.7260.95
125_A128_A0.7230.95
56_L144_R0.7200.95
86_S110_L0.7170.94
36_D39_W0.7160.94
75_Y83_I0.7150.94
124_F127_H0.7140.94
65_G100_D0.7110.94
35_Q223_F0.7070.94
126_L136_I0.7070.94
70_T74_I0.7030.94
69_Y73_K0.7030.94
187_K190_Y0.7000.94
86_S112_F0.7000.94
201_Q208_K0.6980.94
11_E14_Q0.6970.94
29_R66_E0.6930.93
58_L112_F0.6920.93
218_R223_F0.6880.93
127_H151_A0.6860.93
153_G224_Y0.6840.93
205_I208_K0.6830.93
41_A45_K0.6820.93
38_K41_A0.6790.93
35_Q222_L0.6770.93
46_T214_V0.6750.92
75_Y223_F0.6740.92
87_D92_M0.6730.92
140_T209_Y0.6710.92
32_S168_L0.6690.92
70_T73_K0.6660.92
162_I166_I0.6650.92
128_A192_I0.6650.92
136_I209_Y0.6600.92
31_I152_M0.6600.92
10_N130_D0.6590.92
69_Y101_D0.6570.91
111_P138_E0.6560.91
103_V111_P0.6510.91
94_K113_R0.6490.91
17_Y128_A0.6470.91
46_T227_V0.6390.90
71_F75_Y0.6380.90
174_Y183_A0.6370.90
42_D45_K0.6330.90
166_I171_I0.6320.90
40_R67_L0.6310.90
174_Y178_L0.6280.89
64_K92_M0.6270.89
199_N226_V0.6240.89
61_A121_M0.6230.89
167_Y171_I0.6230.89
58_L86_S0.6230.89
157_S220_L0.6220.89
14_Q91_N0.6210.89
196_V202_H0.6210.89
44_V67_L0.6200.89
128_A186_F0.6180.89
28_N36_D0.6160.89
202_H206_F0.6140.88
44_V71_F0.6120.88
17_Y20_I0.6090.88
54_P81_Y0.6080.88
48_L52_K0.6080.88
31_I172_M0.6060.88
171_I175_I0.6060.88
54_P75_Y0.6050.88
61_A88_Y0.6040.88
126_L135_V0.6020.87
22_K98_I0.5980.87
149_F202_H0.5940.87
80_N83_I0.5920.87
27_A123_S0.5910.86
172_M176_A0.5890.86
171_I174_Y0.5880.86
175_I179_G0.5860.86
205_I209_Y0.5860.86
35_Q39_W0.5850.86
67_L70_T0.5850.86
28_N32_S0.5850.86
206_F210_I0.5840.86
180_G185_D0.5810.86
32_S36_D0.5800.85
127_H150_I0.5790.85
64_K176_A0.5770.85
29_R40_R0.5760.85
11_E227_V0.5750.85
159_V163_Y0.5730.85
218_R222_L0.5730.85
14_Q90_E0.5730.85
200_S207_E0.5720.85
110_L138_E0.5710.85
11_E15_Q0.5660.84
154_K161_R0.5660.84
86_S104_L0.5640.84
56_L118_D0.5620.84
126_L132_I0.5610.84
128_A188_Y0.5610.84
122_S126_L0.5570.83
149_F206_F0.5570.83
128_A151_A0.5550.83
113_R214_V0.5540.83
199_N224_Y0.5540.83
136_I206_F0.5540.83
108_D130_D0.5530.83
207_E211_D0.5530.83
212_I216_E0.5490.82
28_N127_H0.5470.82
152_M222_L0.5460.82
138_E144_R0.5450.82
94_K204_R0.5450.82
168_L172_M0.5410.81
186_F189_I0.5400.81
123_S152_M0.5380.81
199_N215_Y0.5350.81
40_R124_F0.5340.80
190_Y194_E0.5290.80
67_L123_S0.5280.80
32_S152_M0.5270.80
176_A180_G0.5270.80
71_F76_K0.5270.80
124_F168_L0.5260.79
60_V107_F0.5240.79
87_D93_L0.5230.79
206_F209_Y0.5230.79
36_D128_A0.5190.79
53_R80_N0.5180.78
126_L149_F0.5160.78
200_S204_R0.5150.78
125_A135_V0.5140.78
82_E116_T0.5090.77
136_I149_F0.5090.77
47_I71_F0.5090.77
213_K228_G0.5080.77
84_I116_T0.5050.77
176_A189_I0.5050.77
149_F226_V0.5040.77
133_E140_T0.5010.76
44_V74_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.9009 100 0.4 Contact Map
3dtnA 2 0.9181 99.9 0.52 Contact Map
4pneA 2 0.8534 99.9 0.523 Contact Map
2o57A 2 0.8578 99.9 0.53 Contact Map
4azsA 6 0.8664 99.9 0.535 Contact Map
2yqzA 1 0.8578 99.9 0.538 Contact Map
3l8dA 2 0.7543 99.9 0.543 Contact Map
3bkxA 2 0.8922 99.9 0.544 Contact Map
1y8cA 1 0.9052 99.9 0.548 Contact Map
4kdcA 1 0.819 99.9 0.549 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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