GREMLIN Database
Q97XC8 - Uncharacterized protein
UniProt: Q97XC8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (387)
Sequences: 125 (82)
Seq/√Len: 4.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
424_A428_K3.6190.78
194_I197_N3.5310.76
350_S353_F3.3830.73
349_T354_N3.3740.72
349_T353_F3.3160.71
189_G193_I3.1120.66
121_F130_L2.9690.62
193_I196_Y2.9490.61
345_T349_T2.8510.59
185_L188_I2.8360.58
192_R196_Y2.7630.56
342_N349_T2.7080.54
133_F269_F2.5220.49
192_R195_E2.5130.49
233_P238_N2.5060.48
185_L189_G2.4740.47
94_I103_L2.4460.47
350_S354_N2.4070.45
351_L354_N2.4060.45
189_G196_Y2.3920.45
272_R441_G2.3750.45
188_I193_I2.3620.44
199_L351_L2.3400.44
348_Y352_Y2.3340.43
189_G195_E2.3290.43
431_E453_T2.2800.42
328_I386_L2.1890.39
237_F240_L2.1850.39
188_I192_R2.1720.39
407_K410_D2.0870.36
349_T352_Y2.0850.36
343_D346_M2.0780.36
129_L144_N2.0520.35
90_L93_L2.0470.35
234_Y238_N2.0320.35
365_P372_C1.9980.34
338_S348_Y1.9830.34
181_M188_I1.9720.33
124_L252_L1.9400.32
91_S329_L1.9080.32
135_S349_T1.8780.31
189_G192_R1.8720.31
261_V428_K1.8320.30
180_D183_I1.8310.30
367_L445_E1.8090.29
231_Y234_Y1.7600.28
345_T353_F1.7580.28
266_S353_F1.7560.28
236_W430_G1.7410.27
170_S251_L1.7350.27
178_M223_S1.7240.27
234_Y239_G1.7240.27
185_L209_M1.7190.27
165_I329_L1.6970.26
149_G450_N1.6470.25
189_G194_I1.6280.25
342_N345_T1.6240.25
185_L196_Y1.6040.24
63_L94_I1.5960.24
344_P348_Y1.5800.24
107_I269_F1.5800.24
110_K252_L1.5790.24
316_K435_F1.5730.24
185_L192_R1.5620.23
345_T352_Y1.5470.23
192_R197_N1.5420.23
339_I342_N1.5200.23
60_Y64_E1.4880.22
233_P237_F1.4860.22
372_C457_V1.4780.22
241_G269_F1.4750.22
95_I103_L1.4730.22
341_G348_Y1.4710.22
129_L158_F1.4700.22
241_G343_D1.4670.21
251_L334_F1.4520.21
91_S165_I1.4500.21
233_P240_L1.4270.21
185_L193_I1.4250.21
236_W239_G1.4210.21
258_T269_F1.4190.21
342_N348_Y1.4120.20
156_Y256_I1.4110.20
85_T133_F1.4100.20
74_A155_S1.4070.20
246_V323_W1.3980.20
331_V352_Y1.3910.20
339_I350_S1.3890.20
348_Y353_F1.3880.20
124_L134_I1.3870.20
101_Y328_I1.3840.20
338_S349_T1.3780.20
234_Y240_L1.3720.20
178_M185_L1.3690.20
209_M438_V1.3650.20
191_F194_I1.3620.19
381_G439_G1.3520.19
384_N432_F1.3510.19
362_M365_P1.3500.19
154_F256_I1.3450.19
381_G441_G1.3290.19
71_L241_G1.3280.19
224_P227_S1.3240.19
64_E67_S1.3070.18
83_K260_T1.3040.18
93_L126_L1.2990.18
135_S235_M1.2960.18
191_F195_E1.2790.18
66_L246_V1.2760.18
348_Y354_N1.2720.18
60_Y72_I1.2720.18
91_S161_I1.2690.18
311_M334_F1.2680.18
261_V424_A1.2620.18
188_I196_Y1.2570.18
202_K328_I1.2560.18
203_I258_T1.2560.18
264_I301_K1.2530.18
419_L436_K1.2480.17
59_P65_I1.2480.17
124_L293_M1.2480.17
254_G421_D1.2430.17
165_I187_V1.2270.17
140_L185_L1.2250.17
368_G393_F1.2190.17
422_M425_W1.2170.17
194_I219_L1.2150.17
194_I256_I1.2150.17
140_L167_A1.2020.17
233_P239_G1.2010.17
85_T119_V1.1980.17
209_M213_A1.1930.17
251_L254_G1.1870.16
188_I194_I1.1820.16
190_I193_I1.1760.16
191_F196_Y1.1760.16
60_Y63_L1.1730.16
386_L435_F1.1700.16
227_S246_V1.1610.16
331_V335_L1.1590.16
194_I239_G1.1530.16
188_I195_E1.1520.16
119_V126_L1.1500.16
88_V328_I1.1480.16
130_L218_Y1.1370.16
85_T108_K1.1280.15
184_W209_M1.1270.15
163_N176_W1.1250.15
89_F328_I1.1170.15
193_I197_N1.1160.15
144_N260_T1.1110.15
236_W240_L1.0980.15
96_I444_V1.0870.15
258_T333_S1.0860.15
65_I73_Y1.0850.15
59_P72_I1.0840.15
95_I148_F1.0740.15
108_K193_I1.0730.15
318_V336_K1.0720.15
212_Y422_M1.0700.15
93_L97_S1.0670.15
87_I140_L1.0650.15
182_G232_I1.0560.14
372_C428_K1.0540.14
90_L104_K1.0540.14
178_M259_F1.0540.14
318_V387_F1.0470.14
235_M238_N1.0460.14
234_Y243_Y1.0430.14
206_L232_I1.0350.14
340_L343_D1.0300.14
216_S412_A1.0220.14
110_K191_F1.0190.14
361_F423_R1.0150.14
371_A416_P1.0140.14
116_N176_W1.0120.14
201_N445_E1.0100.14
185_L190_I1.0090.14
212_Y412_A1.0090.14
235_M258_T1.0060.14
341_G344_P0.9930.14
404_L425_W0.9860.13
406_C447_C0.9820.13
279_C415_C0.9820.13
403_C415_C0.9820.13
406_C443_C0.9820.13
275_C411_C0.9820.13
411_C415_C0.9820.13
279_C378_C0.9820.13
406_C437_C0.9820.13
275_C447_C0.9820.13
411_C437_C0.9820.13
275_C406_C0.9820.13
275_C403_C0.9820.13
275_C378_C0.9820.13
279_C406_C0.9820.13
279_C443_C0.9820.13
275_C415_C0.9820.13
275_C279_C0.9820.13
279_C403_C0.9820.13
275_C437_C0.9820.13
279_C447_C0.9820.13
279_C437_C0.9820.13
275_C443_C0.9820.13
270_G447_C0.9820.13
270_G443_C0.9820.13
270_G437_C0.9820.13
279_C411_C0.9820.13
415_C443_C0.9820.13
378_C403_C0.9820.13
415_C447_C0.9820.13
403_C406_C0.9820.13
378_C406_C0.9820.13
378_C411_C0.9820.13
378_C415_C0.9820.13
437_C443_C0.9820.13
437_C447_C0.9820.13
378_C437_C0.9820.13
378_C443_C0.9820.13
443_C447_C0.9820.13
403_C411_C0.9820.13
403_C437_C0.9820.13
403_C443_C0.9820.13
406_C415_C0.9820.13
406_C411_C0.9820.13
270_G415_C0.9820.13
411_C443_C0.9820.13
411_C447_C0.9820.13
415_C437_C0.9820.13
270_G411_C0.9820.13
270_G403_C0.9820.13
270_G378_C0.9820.13
403_C447_C0.9820.13
270_G279_C0.9820.13
270_G406_C0.9820.13
270_G275_C0.9820.13
378_C447_C0.9820.13
266_S339_I0.9820.13
185_L227_S0.9790.13
444_V457_V0.9780.13
266_S350_S0.9780.13
347_F354_N0.9760.13
137_F252_L0.9660.13
361_F381_G0.9660.13
156_Y192_R0.9650.13
112_N133_F0.9610.13
344_P350_S0.9590.13
148_F227_S0.9520.13
366_F369_N0.9490.13
340_L344_P0.9460.13
133_F315_Y0.9430.13
234_Y237_F0.9320.13
362_M366_F0.9300.13
85_T185_L0.9290.13
216_S402_Q0.9280.13
144_N161_I0.9280.13
320_S324_I0.9250.13
345_T350_S0.9250.13
161_I331_V0.9250.13
190_I195_E0.9220.13
241_G360_Q0.9200.13
404_L422_M0.9170.12
161_I165_I0.9140.12
278_T385_Q0.9090.12
204_R276_S0.9070.12
266_S417_V0.9060.12
261_V302_V0.8990.12
272_R439_G0.8980.12
96_I289_F0.8960.12
130_L265_L0.8930.12
274_I377_I0.8930.12
190_I196_Y0.8910.12
148_F161_I0.8910.12
325_S329_L0.8890.12
209_M229_V0.8870.12
177_F418_G0.8860.12
142_Q145_F0.8840.12
230_Q243_Y0.8840.12
124_L338_S0.8830.12
209_M259_F0.8800.12
65_I69_L0.8770.12
422_M429_K0.8770.12
135_S354_N0.8730.12
213_A352_Y0.8730.12
260_T435_F0.8680.12
62_V67_S0.8660.12
281_A298_R0.8650.12
361_F441_G0.8650.12
209_M214_F0.8650.12
111_T168_F0.8600.12
202_K435_F0.8600.12
338_S341_G0.8590.12
138_L180_D0.8590.12
197_N362_M0.8590.12
253_D383_F0.8580.12
161_I260_T0.8570.12
346_M349_T0.8530.12
110_K314_W0.8430.12
326_L445_E0.8430.12
87_I94_I0.8430.12
137_F158_F0.8420.12
140_L301_K0.8420.12
312_S317_W0.8390.12
180_D184_W0.8380.11
76_Q88_V0.8370.11
342_N346_M0.8350.11
139_D430_G0.8330.11
410_D422_M0.8310.11
235_M239_G0.8300.11
110_K264_I0.8280.11
125_L265_L0.8260.11
296_Y434_S0.8250.11
257_G390_L0.8250.11
231_Y327_I0.8230.11
134_I158_F0.8160.11
272_R361_F0.8120.11
103_L252_L0.8110.11
152_G245_P0.8100.11
177_F236_W0.8070.11
271_S282_P0.8060.11
227_S234_Y0.8050.11
157_P390_L0.8040.11
172_T224_P0.8020.11
84_A161_I0.8020.11
59_P69_L0.8010.11
85_T256_I0.8010.11
267_F371_A0.8010.11
117_S264_I0.7990.11
368_G448_P0.7980.11
393_F448_P0.7980.11
191_F333_S0.7930.11
147_V360_Q0.7920.11
314_W342_N0.7910.11
200_E286_Q0.7910.11
254_G267_F0.7900.11
231_Y235_M0.7880.11
339_I346_M0.7860.11
91_S140_L0.7840.11
74_A81_L0.7820.11
212_Y391_G0.7790.11
372_C430_G0.7790.11
303_G386_L0.7780.11
137_F367_L0.7770.11
88_V122_T0.7750.11
223_S250_Y0.7750.11
291_N294_K0.7740.11
182_G442_D0.7730.11
192_R202_K0.7710.11
286_Q294_K0.7710.11
87_I109_K0.7700.11
277_V286_Q0.7680.11
260_T428_K0.7670.11
97_S188_I0.7670.11
207_L384_N0.7670.11
124_L360_Q0.7640.11
121_F218_Y0.7630.11
373_V428_K0.7630.11
203_I246_V0.7620.11
440_V452_I0.7610.11
246_V314_W0.7590.11
137_F235_M0.7580.11
375_S379_A0.7580.11
341_G345_T0.7570.11
95_I99_S0.7570.11
281_A294_K0.7570.11
298_R430_G0.7530.11
388_G440_V0.7530.11
124_L137_F0.7530.11
209_M258_T0.7500.10
124_L235_M0.7450.10
197_N394_K0.7440.10
126_L252_L0.7440.10
137_F245_P0.7420.10
339_I352_Y0.7350.10
92_Y265_L0.7330.10
246_V372_C0.7300.10
246_V250_Y0.7250.10
64_E73_Y0.7250.10
63_L67_S0.7240.10
173_A180_D0.7230.10
87_I264_I0.7220.10
102_R138_L0.7210.10
202_K347_F0.7170.10
124_L147_V0.7150.10
264_I351_L0.7130.10
91_S108_K0.7130.10
142_Q394_K0.7120.10
231_Y237_F0.7110.10
298_R386_L0.7070.10
235_M240_L0.7040.10
183_I187_V0.7040.10
214_F258_T0.7040.10
361_F439_G0.7020.10
190_I269_F0.7000.10
146_S149_G0.7000.10
188_I191_F0.6950.10
65_I383_F0.6940.10
246_V337_F0.6940.10
226_Q329_L0.6880.10
449_Y455_Y0.6870.10
113_Y267_F0.6790.10
103_L359_F0.6790.10
345_T354_N0.6790.10
111_T457_V0.6770.10
180_D290_L0.6760.10
330_A387_F0.6760.10
59_P64_E0.6750.10
233_P243_Y0.6750.10
76_Q337_F0.6730.10
331_V334_F0.6700.10
157_P262_T0.6690.10
56_T60_Y0.6670.10
71_L83_K0.6670.10
107_I129_L0.6660.10
130_L133_F0.6650.10
339_I351_L0.6650.10
135_S236_W0.6640.10
126_L249_S0.6640.10
114_L317_W0.6620.10
92_Y185_L0.6620.10
387_F390_L0.6620.10
166_S384_N0.6610.10
223_S227_S0.6600.10
136_G181_M0.6590.10
65_I72_I0.6580.09
354_N359_F0.6580.09
89_F140_L0.6560.09
147_V346_M0.6560.09
284_M451_N0.6540.09
231_Y240_L0.6540.09
246_V249_S0.6530.09
161_I328_I0.6510.09
136_G139_D0.6510.09
249_S390_L0.6500.09
353_F359_F0.6490.09
165_I268_M0.6490.09
212_Y426_F0.6480.09
163_N322_T0.6470.09
82_L246_V0.6450.09
200_E426_F0.6450.09
111_T300_S0.6440.09
110_K372_C0.6430.09
134_I137_F0.6410.09
190_I261_V0.6390.09
101_Y172_T0.6370.09
60_Y67_S0.6350.09
345_T348_Y0.6340.09
354_N417_V0.6330.09
152_G206_L0.6320.09
126_L158_F0.6250.09
370_Y377_I0.6230.09
192_R354_N0.6230.09
96_I108_K0.6230.09
264_I336_K0.6230.09
83_K386_L0.6220.09
132_W144_N0.6210.09
229_V324_I0.6210.09
96_I318_V0.6210.09
258_T261_V0.6200.09
87_I104_K0.6180.09
60_Y71_L0.6180.09
96_I193_I0.6150.09
140_L259_F0.6130.09
121_F124_L0.6110.09
60_Y70_S0.6110.09
96_I348_Y0.6110.09
147_V223_S0.6100.09
261_V372_C0.6100.09
340_L345_T0.6100.09
96_I130_L0.6090.09
152_G218_Y0.6090.09
104_K129_L0.6080.09
201_N208_M0.6080.09
241_G344_P0.6050.09
133_F256_I0.6040.09
199_L256_I0.6040.09
207_L277_V0.6020.09
202_K222_F0.6020.09
344_P352_Y0.6000.09
264_I335_L0.6000.09
116_N413_N0.5990.09
255_I370_Y0.5990.09
69_L72_I0.5950.09
286_Q291_N0.5950.09
125_L336_K0.5910.09
341_G346_M0.5910.09
75_A365_P0.5900.09
214_F331_V0.5890.09
85_T367_L0.5880.09
252_L332_L0.5880.09
232_I245_P0.5870.09
266_S348_Y0.5860.09
133_F144_N0.5850.09
236_W373_V0.5830.09
87_I343_D0.5820.09
224_P242_T0.5820.09
277_V282_P0.5810.09
76_Q161_I0.5800.09
272_R381_G0.5790.09
93_L337_F0.5770.09
122_T125_L0.5720.09
110_K117_S0.5720.09
73_Y129_L0.5690.09
97_S104_K0.5690.09
79_T83_K0.5690.09
184_W258_T0.5670.09
168_F232_I0.5670.09
317_W321_I0.5660.09
86_D332_L0.5650.09
153_Y240_L0.5630.09
339_I348_Y0.5630.09
185_L236_W0.5630.09
361_F365_P0.5610.09
57_N300_S0.5600.09
182_G330_A0.5600.09
286_Q426_F0.5600.09
108_K124_L0.5600.09
412_A422_M0.5590.09
167_A315_Y0.5550.08
344_P360_Q0.5550.08
212_Y286_Q0.5550.08
252_L318_V0.5540.08
333_S346_M0.5530.08
204_R439_G0.5530.08
161_I333_S0.5530.08
182_G188_I0.5500.08
107_I121_F0.5500.08
348_Y351_L0.5490.08
222_F257_G0.5480.08
204_R280_T0.5480.08
189_G197_N0.5470.08
57_N69_L0.5470.08
212_Y425_W0.5410.08
126_L227_S0.5400.08
72_I137_F0.5380.08
144_N157_P0.5380.08
370_Y379_A0.5380.08
192_R344_P0.5360.08
84_A428_K0.5360.08
364_M369_N0.5350.08
337_F340_L0.5340.08
126_L161_I0.5330.08
339_I344_P0.5330.08
60_Y65_I0.5320.08
258_T372_C0.5320.08
99_S105_R0.5320.08
138_L148_F0.5320.08
73_Y96_I0.5310.08
96_I372_C0.5310.08
120_A265_L0.5300.08
140_L148_F0.5300.08
88_V121_F0.5300.08
87_I108_K0.5280.08
277_V384_N0.5280.08
124_L135_S0.5280.08
314_W372_C0.5250.08
208_M380_W0.5250.08
161_I337_F0.5240.08
93_L344_P0.5230.08
207_L417_V0.5230.08
273_Q400_L0.5230.08
140_L193_I0.5230.08
262_T390_L0.5210.08
211_A455_Y0.5210.08
121_F160_A0.5190.08
188_I235_M0.5190.08
225_L341_G0.5110.08
271_S277_V0.5110.08
328_I332_L0.5090.08
88_V109_K0.5080.08
135_S386_L0.5080.08
201_N384_N0.5080.08
62_V73_Y0.5080.08
399_D450_N0.5040.08
123_L134_I0.5040.08
419_L422_M0.5030.08
264_I340_L0.5020.08
192_R198_K0.5010.08
140_L365_P0.5010.08
156_Y245_P0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hfeL 2 0.208 98.9 0.933 Contact Map
1jnrB 1 0.1723 98.9 0.933 Contact Map
3gyxB 1 0.1723 98.9 0.933 Contact Map
1rgvA 1 0.1555 98.9 0.934 Contact Map
2zvsA 1 0.1534 98.8 0.936 Contact Map
1iqzA 1 0.1513 98.8 0.936 Contact Map
2v2kA 1 0.1597 98.8 0.936 Contact Map
3eunA 1 0.1555 98.8 0.937 Contact Map
1h98A 1 0.1555 98.8 0.937 Contact Map
7fd1A 1 0.1639 98.8 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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