GREMLIN Database
Q97XC6 - Sulfurtransferase
UniProt: Q97XC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (264)
Sequences: 4513 (3250)
Seq/√Len: 200.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_T111_R3.3871.00
11_V15_W3.3441.00
154_F157_E3.1031.00
17_L125_L2.7361.00
223_K227_E2.7301.00
74_E139_G2.6981.00
19_H22_D2.6551.00
35_N39_N2.6401.00
119_K123_E2.5701.00
16_V113_L2.5501.00
26_R82_T2.5271.00
179_P183_T2.5111.00
41_W121_A2.4071.00
117_R127_T2.3871.00
180_K186_I2.3641.00
112_I258_F2.3241.00
12_D114_N2.2991.00
15_W19_H2.2791.00
224_S227_E2.2541.00
69_F73_M2.2051.00
41_W129_Q2.1791.00
65_E68_Q2.1421.00
146_V150_N2.0981.00
107_H141_Y2.0731.00
179_P208_S2.0401.00
180_K185_E2.0191.00
28_V78_I1.9261.00
13_N119_K1.8821.00
155_F285_A1.8621.00
12_D15_W1.8491.00
223_K231_L1.8411.00
257_W271_V1.8361.00
225_V229_R1.8301.00
27_I43_I1.8191.00
13_N123_E1.8041.00
70_E74_E1.8021.00
16_V27_I1.7971.00
274_G278_E1.7951.00
128_E132_K1.7831.00
79_S139_G1.7421.00
155_F282_I1.7411.00
50_R53_E1.7381.00
96_V254_S1.7241.00
74_E140_S1.7051.00
13_N125_L1.7011.00
70_E143_V1.6781.00
38_Y42_H1.6611.00
80_N142_K1.6481.00
28_V47_V1.6441.00
153_A158_I1.6401.00
253_A271_V1.6401.00
171_T244_I1.5891.00
229_R233_E1.5711.00
153_A270_R1.5651.00
181_E252_R1.5591.00
63_F101_L1.5551.00
282_I285_A1.5281.00
216_N221_E1.5271.00
119_K221_E1.5161.00
155_F159_L1.5111.00
49_I76_K1.5091.00
79_S82_T1.4691.00
261_K267_P1.4631.00
153_A157_E1.4621.00
161_K244_I1.4541.00
176_V256_T1.4391.00
10_I222_F1.4351.00
26_R136_Y1.4061.00
14_K18_E1.3991.00
203_I206_A1.3961.00
69_F105_Y1.3881.00
209_F231_L1.3741.00
152_R273_D1.3741.00
73_M102_F1.3721.00
83_T109_D1.3691.00
71_K75_S1.3441.00
155_F278_E1.3331.00
218_D221_E1.3261.00
153_A244_I1.3221.00
214_A232_V1.3131.00
30_V86_L1.3101.00
63_F104_A1.3071.00
147_D150_N1.2881.00
209_F235_V1.2821.00
86_L98_A1.2821.00
33_D37_A1.2731.00
161_K171_T1.2721.00
257_W269_V1.2631.00
172_L241_K1.2351.00
245_T260_L1.2251.00
39_N131_P1.2221.00
66_P70_E1.2211.00
159_L285_A1.2131.00
214_A228_L1.1911.00
78_I84_I1.1811.00
79_S140_S1.1781.00
242_E270_R1.1771.00
225_V264_L1.1751.00
11_V19_H1.1641.00
103_K261_K1.1641.00
70_E142_K1.1641.00
238_T241_K1.1511.00
216_N223_K1.1351.00
158_I244_I1.1311.00
199_V280_G1.1231.00
227_E230_R1.1221.00
108_E146_V1.1201.00
199_V287_V1.1171.00
26_R78_I1.1121.00
121_A127_T1.1111.00
242_E268_S1.1101.00
243_I260_L1.1101.00
38_Y132_K1.1061.00
158_I171_T1.0951.00
245_T269_V1.0911.00
158_I161_K1.0881.00
260_L269_V1.0861.00
52_R61_R1.0661.00
259_V264_L1.0601.00
41_W127_T1.0601.00
68_Q71_K1.0461.00
117_R121_A1.0451.00
187_R200_G1.0411.00
276_W280_G1.0321.00
25_V85_V1.0191.00
69_F101_L1.0171.00
19_H25_V1.0161.00
47_V136_Y1.0141.00
203_I246_Y1.0071.00
39_N130_G0.9981.00
36_T40_V0.9941.00
229_R239_S0.9911.00
158_I173_L0.9891.00
198_Q280_G0.9891.00
35_N53_E0.9891.00
260_L266_Y0.9851.00
173_L246_Y0.9841.00
44_P120_W0.9821.00
249_I277_A0.9771.00
104_A151_H0.9771.00
33_D36_T0.9740.99
11_V111_R0.9710.99
74_E138_K0.9650.99
86_L102_F0.9600.99
222_F255_H0.9590.99
80_N141_Y0.9570.99
239_S266_Y0.9520.99
96_V258_F0.9510.99
222_F263_L0.9510.99
214_A256_T0.9510.99
47_V132_K0.9500.99
73_M78_I0.9440.99
25_V83_T0.9410.99
69_F102_F0.9350.99
99_F257_W0.9350.99
36_T39_N0.9320.99
93_W252_R0.9300.99
213_Q231_L0.9290.99
71_K138_K0.9250.99
178_S186_I0.9240.99
31_D89_D0.9240.99
9_V261_K0.9230.99
230_R234_N0.9180.99
86_L99_F0.9170.99
78_I82_T0.9100.99
258_F263_L0.9060.99
28_V98_A0.9030.99
247_C275_S0.8990.99
68_Q72_L0.8960.99
158_I162_V0.8900.99
214_A231_L0.8810.99
19_H83_T0.8740.99
272_Y278_E0.8710.99
181_E249_I0.8710.99
35_N48_L0.8690.99
24_N83_T0.8670.99
10_I114_N0.8670.99
232_V260_L0.8670.99
99_F261_K0.8660.99
118_T122_K0.8630.99
181_E248_R0.8610.99
103_K257_W0.8590.99
88_G95_A0.8590.99
161_K173_L0.8570.99
17_L126_P0.8550.99
26_R47_V0.8490.99
80_N144_K0.8480.99
266_Y269_V0.8440.99
223_K228_L0.8430.99
70_E139_G0.8390.98
153_A161_K0.8380.98
80_N140_S0.8380.98
28_V49_I0.8370.98
72_L75_S0.8370.98
41_W117_R0.8350.98
51_W251_E0.8330.98
214_A255_H0.8320.98
188_A200_G0.8290.98
157_E161_K0.8290.98
153_A171_T0.8260.98
55_L59_V0.8230.98
28_V76_K0.8230.98
11_V16_V0.8220.98
182_F202_H0.8210.98
230_R233_E0.8170.98
222_F259_V0.8010.98
209_F214_A0.7990.98
128_E131_P0.7980.98
179_P213_Q0.7960.98
32_Y48_L0.7940.98
25_V82_T0.7930.98
199_V285_A0.7920.98
228_L232_V0.7900.98
61_R249_I0.7900.98
172_L238_T0.7860.98
172_L207_I0.7840.98
178_S212_A0.7790.98
162_V205_G0.7770.98
172_L243_I0.7770.98
209_F232_V0.7720.97
99_F103_K0.7710.97
210_P213_Q0.7690.97
276_W287_V0.7680.97
180_K183_T0.7680.97
178_S181_E0.7650.97
61_R181_E0.7620.97
157_E160_Q0.7590.97
35_N50_R0.7500.97
43_I120_W0.7490.97
47_V76_K0.7460.97
161_K242_E0.7440.97
211_W215_V0.7440.97
16_V25_V0.7420.97
278_E281_N0.7410.97
64_I97_Y0.7400.97
245_T257_W0.7330.96
280_G287_V0.7330.96
61_R251_E0.7330.96
10_I258_F0.7260.96
63_F152_R0.7240.96
184_G201_G0.7240.96
202_H206_A0.7230.96
80_N107_H0.7210.96
232_V256_T0.7190.96
91_N215_V0.7130.96
92_N222_F0.7110.96
226_E229_R0.7070.96
272_Y275_S0.7000.95
60_L197_T0.6990.95
254_S271_V0.6990.95
49_I72_L0.6990.95
228_L231_L0.6940.95
42_H87_Y0.6920.95
118_T121_A0.6910.95
203_I288_K0.6890.95
73_M141_Y0.6880.95
151_H270_R0.6870.95
276_W286_P0.6860.95
92_N95_A0.6850.95
38_Y130_G0.6850.95
103_K108_E0.6850.95
92_N255_H0.6830.95
78_I102_F0.6820.95
206_A246_Y0.6820.95
37_A40_V0.6810.95
182_F206_A0.6810.95
243_I266_Y0.6780.95
261_K269_V0.6780.95
8_G111_R0.6770.95
74_E79_S0.6770.95
75_S138_K0.6760.94
231_L235_V0.6750.94
146_V151_H0.6740.94
66_P145_K0.6730.94
99_F110_V0.6700.94
256_T259_V0.6690.94
17_L21_K0.6660.94
16_V85_V0.6640.94
90_Y118_T0.6640.94
38_Y47_V0.6620.94
162_V173_L0.6600.94
32_Y52_R0.6550.94
86_L110_V0.6520.93
84_I102_F0.6510.93
161_K168_G0.6510.93
91_N118_T0.6500.93
216_N227_E0.6470.93
92_N112_I0.6460.93
228_L259_V0.6450.93
24_N81_N0.6450.93
66_P143_V0.6440.93
104_A145_K0.6430.93
49_I98_A0.6420.93
55_L58_P0.6410.93
178_S252_R0.6380.93
9_V258_F0.6340.92
14_K125_L0.6310.92
277_A280_G0.6300.92
80_N108_E0.6270.92
261_K268_S0.6270.92
213_Q235_V0.6220.92
254_S257_W0.6210.92
72_L76_K0.6170.91
24_N82_T0.6140.91
248_R252_R0.6120.91
88_G97_Y0.6110.91
19_H24_N0.6100.91
38_Y46_S0.6100.91
119_K125_L0.6100.91
177_R206_A0.6100.91
227_E231_L0.6070.91
89_D118_T0.6050.91
84_I107_H0.6040.90
156_W159_L0.6020.90
119_K122_K0.6020.90
156_W160_Q0.6010.90
80_N139_G0.5950.90
214_A259_V0.5950.90
92_N215_V0.5930.90
37_A89_D0.5930.90
40_V129_Q0.5920.90
9_V263_L0.5910.90
43_I113_L0.5890.89
157_E270_R0.5890.89
245_T256_T0.5880.89
113_L120_W0.5880.89
233_E238_T0.5870.89
53_E75_S0.5870.89
174_I243_I0.5870.89
155_F162_V0.5850.89
174_I209_F0.5850.89
99_F258_F0.5800.89
150_N270_R0.5780.88
8_G263_L0.5780.88
157_E242_E0.5760.88
61_R248_R0.5760.88
87_Y117_R0.5750.88
86_L112_I0.5750.88
229_R267_P0.5750.88
188_A248_R0.5710.88
19_H23_P0.5680.88
172_L237_I0.5680.88
132_K136_Y0.5670.88
249_I252_R0.5670.88
42_H128_E0.5670.88
160_Q168_G0.5650.87
16_V120_W0.5650.87
104_A152_R0.5640.87
54_D57_H0.5640.87
163_T173_L0.5630.87
13_N17_L0.5600.87
64_I101_L0.5580.87
159_L279_W0.5550.86
211_W214_A0.5530.86
73_M105_Y0.5500.86
207_I235_V0.5490.86
159_L286_P0.5480.86
81_N139_G0.5460.86
174_I237_I0.5460.86
71_K74_E0.5450.85
155_F272_Y0.5440.85
61_R189_P0.5430.85
120_W125_L0.5430.85
14_K123_E0.5390.85
30_V98_A0.5380.85
177_R276_W0.5380.85
105_Y141_Y0.5370.85
174_I256_T0.5340.84
189_P197_T0.5340.84
217_P220_G0.5280.84
172_L242_E0.5270.83
34_P48_L0.5270.83
135_Q138_K0.5270.83
202_H208_S0.5270.83
83_T86_L0.5260.83
63_F97_Y0.5260.83
197_T277_A0.5250.83
239_S242_E0.5250.83
215_V255_H0.5240.83
73_M76_K0.5240.83
31_D117_R0.5220.83
159_L163_T0.5210.83
237_I266_Y0.5200.83
103_K151_H0.5200.83
42_H46_S0.5200.83
211_W252_R0.5170.82
62_D273_D0.5170.82
9_V111_R0.5160.82
10_I112_I0.5160.82
46_S87_Y0.5150.82
252_R271_V0.5140.82
49_I73_M0.5130.82
249_I276_W0.5080.81
13_N113_L0.5060.81
202_H246_Y0.5030.81
205_G288_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uarA 1 0.9317 100 0.289 Contact Map
3hzuA 2 0.9556 100 0.289 Contact Map
3aayA 1 0.942 100 0.294 Contact Map
1urhA 1 0.8601 100 0.296 Contact Map
1e0cA 1 0.9181 100 0.297 Contact Map
1rhsA 1 0.9454 100 0.3 Contact Map
3utnX 1 0.9522 100 0.308 Contact Map
2wlrA 1 0.9522 100 0.318 Contact Map
4jgtA 1 0.9078 100 0.325 Contact Map
1okgA 1 0.9044 100 0.343 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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