Q97XC5 - SULSO - GREMLIN Contacts

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Q97XC5 - Uncharacterized protein

UniProt:	Q97XC5	Sequences: MSEEIINEIISNPRLLDKITSVIYEKMKNDIILQRLTKLEETVATLTRTVQENNQQIVLIWKKLDEMENEMRKRDSILEEHSKRIEELTKRVEELAKRVEEHSKILEEHSKRIEELSKRIEEHSKILEEHSKRIEELTKRVEELAKRVEEHSKILEEHSKRIEELSKRIEEHSKILEEHSKRIEELTKAFLMLKVSFDSFTSRAGIYVQRTLMELYKEALKSHGVDPSNVKHGYIVDDIGVIEKGRRFEVDFYETNDEIRLFEIKNLGDMDGIEQLIVRRRILESKGNKKQIKMYLVCNSIPKKVLLKAKKEGIVVIAGNILGERSSY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (299)
Sequences:	6366 (5763)
Seq/√Len:	333.3

BACSU - SMC
HALSA - Q9HS95
SULSO - Q97XC5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
220_L	223_H	3.235	1.00
180_S	184_E	3.030	1.00
219_A	223_H	2.995	1.00
226_D	230_V	2.921	1.00
223_H	226_D	2.871	1.00
169_I	173_S	2.833	1.00
169_I	172_H	2.404	1.00
183_I	187_T	2.349	1.00
191_L	195_V	2.269	1.00
220_L	226_D	2.249	1.00
189_A	192_M	2.080	1.00
240_G	243_E	2.068	1.00
113_I	117_S	2.058	1.00
215_L	219_A	2.049	1.00
302_P	307_L	2.010	1.00
57_I	61_W	1.913	1.00
168_R	172_H	1.911	1.00
224_G	228_S	1.879	1.00
192_M	196_S	1.827	1.00
166_S	169_I	1.822	1.00
303_K	306_L	1.813	1.00
18_K	22_V	1.781	1.00
219_A	226_D	1.781	1.00
215_L	223_H	1.773	1.00
35_R	38_K	1.759	1.00
37_T	40_E	1.740	1.00
94_E	98_R	1.727	1.00
31_I	35_R	1.717	1.00
302_P	305_V	1.712	1.00
219_A	222_S	1.703	1.00
190_F	194_K	1.681	1.00
101_E	105_I	1.681	1.00
164_E	168_R	1.660	1.00
223_H	230_V	1.653	1.00
218_E	222_S	1.653	1.00
59_L	63_K	1.635	1.00
220_L	230_V	1.627	1.00
82_S	86_E	1.626	1.00
208_V	212_L	1.612	1.00
226_D	229_N	1.596	1.00
215_L	220_L	1.596	1.00
115_E	119_R	1.595	1.00
310_K	316_V	1.578	1.00
127_L	131_S	1.573	1.00
179_H	183_I	1.573	1.00
80_E	84_R	1.563	1.00
166_S	172_H	1.561	1.00
208_V	211_T	1.557	1.00
302_P	306_L	1.541	1.00
161_R	164_E	1.541	1.00
38_K	42_T	1.541	1.00
58_V	61_W	1.537	1.00
220_L	224_G	1.529	1.00
42_T	45_T	1.506	1.00
274_E	278_V	1.498	1.00
176_L	180_S	1.495	1.00
56_Q	59_L	1.489	1.00
123_H	126_I	1.487	1.00
197_F	201_T	1.485	1.00
166_S	170_E	1.482	1.00
37_T	41_E	1.475	1.00
185_E	189_A	1.464	1.00
182_R	185_E	1.447	1.00
217_K	221_K	1.445	1.00
178_E	182_R	1.436	1.00
17_D	20_T	1.434	1.00
63_K	66_E	1.419	1.00
215_L	218_E	1.417	1.00
233_G	237_D	1.396	1.00
277_I	300_S	1.394	1.00
166_S	173_S	1.391	1.00
84_R	87_E	1.386	1.00
65_D	68_E	1.386	1.00
44_A	47_T	1.382	1.00
70_E	73_K	1.382	1.00
216_Y	223_H	1.373	1.00
105_I	108_E	1.368	1.00
302_P	308_K	1.363	1.00
168_R	173_S	1.345	1.00
134_I	138_T	1.343	1.00
120_I	124_S	1.339	1.00
175_I	178_E	1.331	1.00
209_Q	212_L	1.330	1.00
222_S	226_D	1.320	1.00
122_E	126_I	1.308	1.00
106_L	110_S	1.307	1.00
121_E	124_S	1.305	1.00
162_I	165_L	1.303	1.00
128_E	131_S	1.303	1.00
68_E	72_R	1.282	1.00
92_V	96_A	1.280	1.00
30_D	33_L	1.277	1.00
216_Y	220_L	1.276	1.00
107_E	110_S	1.273	1.00
136_E	140_R	1.268	1.00
85_I	89_T	1.268	1.00
51_Q	55_Q	1.263	1.00
73_K	77_I	1.260	1.00
77_I	80_E	1.250	1.00
141_V	145_A	1.249	1.00
50_V	54_N	1.244	1.00
99_V	103_S	1.242	1.00
219_A	230_V	1.239	1.00
303_K	308_K	1.236	1.00
103_S	107_E	1.236	1.00
186_L	189_A	1.235	1.00
124_S	128_E	1.231	1.00
45_T	49_T	1.231	1.00
158_H	162_I	1.227	1.00
184_E	188_K	1.224	1.00
217_K	220_L	1.213	1.00
227_P	230_V	1.211	1.00
78_L	82_S	1.207	1.00
135_E	139_K	1.206	1.00
119_R	122_E	1.205	1.00
112_R	115_E	1.204	1.00
87_E	91_R	1.190	1.00
167_K	170_E	1.188	1.00
62_K	66_E	1.186	1.00
44_A	48_R	1.186	1.00
109_H	112_R	1.185	1.00
39_L	42_T	1.182	1.00
86_E	89_T	1.178	1.00
187_T	191_L	1.177	1.00
64_L	68_E	1.172	1.00
43_V	47_T	1.167	1.00
229_N	282_I	1.167	1.00
177_E	181_K	1.155	1.00
51_Q	54_N	1.153	1.00
207_Y	211_T	1.149	1.00
15_L	18_K	1.144	1.00
221_K	225_V	1.143	1.00
70_E	74_R	1.140	1.00
100_E	103_S	1.136	1.00
108_E	112_R	1.134	1.00
251_D	257_D	1.134	1.00
30_D	34_Q	1.120	1.00
98_R	101_E	1.120	1.00
201_T	205_G	1.113	1.00
148_V	152_S	1.112	1.00
301_I	304_K	1.111	1.00
126_I	129_E	1.108	1.00
25_E	29_N	1.108	1.00
219_A	227_P	1.107	1.00
174_K	178_E	1.103	1.00
167_K	171_E	1.100	1.00
49_T	53_N	1.097	1.00
26_K	29_N	1.095	1.00
47_T	51_Q	1.093	1.00
157_E	161_R	1.090	1.00
225_V	229_N	1.086	1.00
42_T	46_L	1.081	1.00
35_R	39_L	1.080	1.00
298_C	306_L	1.077	1.00
165_L	169_I	1.071	1.00
117_S	121_E	1.070	1.00
66_E	70_E	1.068	1.00
45_T	48_R	1.067	1.00
177_E	180_S	1.057	1.00
131_S	135_E	1.057	1.00
207_Y	210_R	1.056	1.00
40_E	44_A	1.055	1.00
36_L	40_E	1.052	1.00
170_E	173_S	1.050	1.00
79_E	82_S	1.047	1.00
129_E	133_R	1.044	1.00
162_I	166_S	1.043	1.00
281_R	284_E	1.042	1.00
189_A	193_L	1.035	1.00
265_K	279_R	1.035	1.00
198_D	202_S	1.033	1.00
204_A	208_V	1.030	1.00
21_S	25_E	1.029	1.00
142_E	146_K	1.024	1.00
205_G	209_Q	1.022	1.00
214_E	218_E	1.022	1.00
125_K	129_E	1.021	1.00
191_L	194_K	1.020	1.00
104_K	108_E	1.019	1.00
135_E	138_T	1.018	1.00
24_Y	28_K	1.016	1.00
105_I	109_H	1.012	1.00
72_R	75_D	1.009	1.00
23_I	27_M	1.006	1.00
272_G	297_V	1.003	1.00
220_L	232_H	1.000	1.00
231_K	235_I	0.999	1.00
234_Y	249_E	0.996	1.00
61_W	65_D	0.995	1.00
186_L	193_L	0.989	1.00
264_I	300_S	0.986	1.00
58_V	62_K	0.983	1.00
190_F	193_L	0.983	1.00
15_L	19_I	0.975	1.00
19_I	23_I	0.971	1.00
110_S	114_E	0.970	1.00
147_R	150_E	0.961	1.00
137_L	140_R	0.958	1.00
83_K	87_E	0.956	1.00
102_H	105_I	0.953	1.00
114_E	117_S	0.951	1.00
52_E	56_Q	0.951	1.00
142_E	145_A	0.950	1.00
24_Y	27_M	0.949	1.00
196_S	199_S	0.948	1.00
162_I	169_I	0.948	1.00
22_V	26_K	0.948	1.00
29_N	32_I	0.938	1.00
279_R	300_S	0.937	1.00
187_T	190_F	0.937	1.00
215_L	230_V	0.935	1.00
273_I	300_S	0.929	1.00
265_K	300_S	0.928	1.00
32_I	35_R	0.927	1.00
27_M	30_D	0.925	1.00
53_N	57_I	0.923	1.00
96_A	100_E	0.923	1.00
34_Q	37_T	0.923	1.00
160_K	164_E	0.922	1.00
188_K	191_L	0.919	1.00
273_I	277_I	0.914	1.00
199_S	203_R	0.911	1.00
270_M	274_E	0.906	1.00
21_S	24_Y	0.904	1.00
259_I	264_I	0.904	1.00
221_K	224_G	0.901	1.00
75_D	79_E	0.895	1.00
88_L	91_R	0.895	1.00
273_I	294_M	0.892	1.00
25_E	28_K	0.890	1.00
303_K	307_L	0.886	1.00
220_L	227_P	0.886	1.00
46_L	49_T	0.883	1.00
76_S	80_E	0.881	1.00
89_T	93_E	0.877	1.00
133_R	136_E	0.875	1.00
241_V	244_K	0.873	1.00
28_K	31_I	0.871	1.00
174_K	177_E	0.866	1.00
276_L	299_N	0.863	1.00
133_R	137_L	0.857	1.00
304_K	307_L	0.856	1.00
118_K	121_E	0.853	1.00
20_T	24_Y	0.851	1.00
91_R	95_L	0.850	1.00
168_R	171_E	0.850	1.00
206_I	210_R	0.846	1.00
222_S	225_V	0.845	1.00
215_L	226_D	0.844	1.00
207_Y	212_L	0.843	1.00
238_D	244_K	0.832	1.00
305_V	308_K	0.832	1.00
74_R	77_I	0.829	1.00
259_I	287_G	0.829	1.00
194_K	198_D	0.827	1.00
223_H	227_P	0.827	1.00
179_H	182_R	0.818	1.00
261_L	280_R	0.813	1.00
22_V	25_E	0.812	1.00
103_S	106_L	0.811	1.00
39_L	43_V	0.810	1.00
125_K	128_E	0.806	1.00
77_I	81_H	0.806	1.00
151_H	154_I	0.803	1.00
69_N	73_K	0.800	1.00
259_I	265_K	0.797	1.00
145_A	149_E	0.797	1.00
90_K	94_E	0.793	1.00
17_D	21_S	0.791	1.00
219_A	228_S	0.789	1.00
202_S	206_I	0.786	1.00
158_H	165_L	0.786	1.00
280_R	296_L	0.780	1.00
126_I	130_H	0.775	1.00
20_T	23_I	0.773	1.00
140_R	143_E	0.770	1.00
209_Q	213_M	0.769	1.00
91_R	94_E	0.767	1.00
132_K	135_E	0.765	1.00
63_K	67_M	0.762	1.00
56_Q	60_I	0.759	1.00
97_K	101_E	0.757	1.00
176_L	179_H	0.756	1.00
276_L	300_S	0.753	1.00
259_I	276_L	0.753	1.00
53_N	56_Q	0.751	0.99
215_L	222_S	0.749	0.99
49_T	52_E	0.748	0.99
48_R	52_E	0.747	0.99
260_R	264_I	0.745	0.99
277_I	301_I	0.744	0.99
259_I	299_N	0.744	0.99
110_S	113_I	0.744	0.99
156_E	159_S	0.740	0.99
93_E	96_A	0.739	0.99
216_Y	219_A	0.737	0.99
33_L	36_L	0.736	0.99
182_R	192_M	0.735	0.99
304_K	308_K	0.734	0.99
283_L	299_N	0.734	0.99
71_M	75_D	0.734	0.99
83_K	86_E	0.733	0.99
237_D	240_G	0.733	0.99
121_E	125_K	0.732	0.99
267_L	277_I	0.730	0.99
216_Y	224_G	0.725	0.99
182_R	186_L	0.723	0.99
215_L	228_S	0.722	0.99
33_L	37_T	0.722	0.99
197_F	204_A	0.718	0.99
310_K	315_V	0.712	0.99
196_S	203_R	0.705	0.99
16_L	20_T	0.704	0.99
186_L	190_F	0.701	0.99
215_L	227_P	0.693	0.99
259_I	294_M	0.692	0.99
159_S	162_I	0.691	0.99
311_K	315_V	0.691	0.99
14_R	18_K	0.690	0.99
149_E	152_S	0.688	0.99
196_S	200_F	0.688	0.99
265_K	294_M	0.687	0.99
276_L	297_V	0.684	0.99
267_L	300_S	0.682	0.99
222_S	230_V	0.681	0.99
270_M	299_N	0.681	0.99
265_K	276_L	0.679	0.99
114_E	118_K	0.675	0.99
216_Y	222_S	0.674	0.99
282_I	285_S	0.672	0.99
264_I	276_L	0.672	0.99
220_L	228_S	0.668	0.99
273_I	279_R	0.667	0.99
143_E	147_R	0.659	0.99
200_F	204_A	0.658	0.99
128_E	132_K	0.658	0.99
276_L	294_M	0.658	0.99
101_E	104_K	0.657	0.99
223_H	228_S	0.656	0.99
34_Q	38_K	0.655	0.99
283_L	316_V	0.652	0.99
195_V	199_S	0.651	0.99
98_R	102_H	0.648	0.99
224_G	232_H	0.646	0.98
197_F	200_F	0.644	0.98
149_E	153_K	0.641	0.98
242_I	248_F	0.640	0.98
79_E	83_K	0.640	0.98
175_I	179_H	0.636	0.98
267_L	279_R	0.635	0.98
301_I	308_K	0.629	0.98
298_C	305_V	0.626	0.98
95_L	98_R	0.626	0.98
89_T	92_V	0.625	0.98
72_R	76_S	0.625	0.98
41_E	45_T	0.623	0.98
181_K	185_E	0.619	0.98
14_R	17_D	0.619	0.98
259_I	270_M	0.617	0.98
180_S	183_I	0.616	0.98
283_L	301_I	0.610	0.98
267_L	276_L	0.610	0.98
283_L	300_S	0.609	0.98
48_R	51_Q	0.609	0.98
52_E	55_Q	0.607	0.98
156_E	160_K	0.606	0.98
217_K	224_G	0.605	0.98
116_L	120_I	0.605	0.98
249_E	258_E	0.604	0.98
143_E	146_K	0.603	0.98
159_S	163_E	0.603	0.98
118_K	122_E	0.600	0.98
146_K	150_E	0.594	0.97
204_A	207_Y	0.594	0.97
161_R	165_L	0.593	0.97
19_I	22_V	0.589	0.97
116_L	119_R	0.589	0.97
115_E	118_K	0.588	0.97
175_I	189_A	0.588	0.97
81_H	85_I	0.586	0.97
163_E	166_S	0.585	0.97
176_L	183_I	0.580	0.97
270_M	276_L	0.579	0.97
162_I	173_S	0.578	0.97
201_T	204_A	0.577	0.97
148_V	155_L	0.577	0.97
234_Y	237_D	0.577	0.97
92_V	95_L	0.575	0.97
40_E	43_V	0.575	0.97
301_I	306_L	0.575	0.97
164_E	171_E	0.573	0.97
111_K	114_E	0.572	0.97
150_E	153_K	0.572	0.97
134_I	137_L	0.572	0.97
196_S	204_A	0.570	0.97
287_G	300_S	0.569	0.97
233_G	236_V	0.569	0.97
88_L	92_V	0.567	0.97
272_G	275_Q	0.565	0.97
216_Y	226_D	0.564	0.96
301_I	305_V	0.563	0.96
140_R	144_L	0.559	0.96
219_A	224_G	0.559	0.96
278_V	281_R	0.558	0.96
108_E	111_K	0.558	0.96
279_R	283_L	0.557	0.96
232_H	249_E	0.557	0.96
86_E	90_K	0.554	0.96
163_E	167_K	0.554	0.96
147_R	151_H	0.552	0.96
242_I	245_G	0.551	0.96
306_L	309_A	0.551	0.96
107_E	111_K	0.549	0.96
130_H	134_I	0.549	0.96
185_E	192_M	0.547	0.96
296_L	300_S	0.546	0.96
137_L	141_V	0.545	0.96
265_K	299_N	0.544	0.96
113_I	120_I	0.544	0.96
202_S	205_G	0.544	0.96
270_M	277_I	0.542	0.96
245_G	248_F	0.542	0.96
129_E	132_K	0.541	0.96
183_I	197_F	0.540	0.96
249_E	257_D	0.536	0.95
279_R	294_M	0.535	0.95
141_V	144_L	0.533	0.95
132_K	136_E	0.532	0.95
204_A	211_T	0.528	0.95
36_L	39_L	0.527	0.95
310_K	313_G	0.527	0.95
284_E	287_G	0.525	0.95
266_N	299_N	0.524	0.95
280_R	283_L	0.523	0.95
162_I	172_H	0.523	0.95
245_G	253_Y	0.520	0.95
90_K	93_E	0.520	0.95
65_D	69_N	0.518	0.94
263_E	269_D	0.516	0.94
112_R	116_L	0.514	0.94
69_N	72_R	0.514	0.94
200_F	207_Y	0.511	0.94
271_D	275_Q	0.506	0.94
167_K	173_S	0.505	0.94
246_R	250_V	0.503	0.93
64_L	67_M	0.502	0.93
272_G	299_N	0.501	0.93
109_H	113_I	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i84S	2	0.0884	99.2	0.676	Contact Map
1c1gA	2	0.7988	98.6	0.739	Contact Map
4ux3A	1	0.8659	98.6	0.739	Contact Map
3ktaB	1	0.3598	98.6	0.74	Contact Map
3zgxA	2	0.7104	97.7	0.795	Contact Map
2dfsA	2	0.4756	97.4	0.805	Contact Map
4linA	5	0.7073	97.3	0.81	Contact Map
4ad8A	1	0.8262	97.1	0.814	Contact Map
3na7A	1	0.7226	96.9	0.82	Contact Map
4uxvA	1	0.8963	96.9	0.821	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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