GREMLIN Database
Q97XC5 - Uncharacterized protein
UniProt: Q97XC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (299)
Sequences: 6366 (5763)
Seq/√Len: 333.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
220_L223_H3.2351.00
180_S184_E3.0301.00
219_A223_H2.9951.00
226_D230_V2.9211.00
223_H226_D2.8711.00
169_I173_S2.8331.00
169_I172_H2.4041.00
183_I187_T2.3491.00
191_L195_V2.2691.00
220_L226_D2.2491.00
189_A192_M2.0801.00
240_G243_E2.0681.00
113_I117_S2.0581.00
215_L219_A2.0491.00
302_P307_L2.0101.00
57_I61_W1.9131.00
168_R172_H1.9111.00
224_G228_S1.8791.00
192_M196_S1.8271.00
166_S169_I1.8221.00
303_K306_L1.8131.00
18_K22_V1.7811.00
219_A226_D1.7811.00
215_L223_H1.7731.00
35_R38_K1.7591.00
37_T40_E1.7401.00
94_E98_R1.7271.00
31_I35_R1.7171.00
302_P305_V1.7121.00
219_A222_S1.7031.00
190_F194_K1.6811.00
101_E105_I1.6811.00
164_E168_R1.6601.00
223_H230_V1.6531.00
218_E222_S1.6531.00
59_L63_K1.6351.00
220_L230_V1.6271.00
82_S86_E1.6261.00
208_V212_L1.6121.00
226_D229_N1.5961.00
215_L220_L1.5961.00
115_E119_R1.5951.00
310_K316_V1.5781.00
127_L131_S1.5731.00
179_H183_I1.5731.00
80_E84_R1.5631.00
166_S172_H1.5611.00
208_V211_T1.5571.00
302_P306_L1.5411.00
161_R164_E1.5411.00
38_K42_T1.5411.00
58_V61_W1.5371.00
220_L224_G1.5291.00
42_T45_T1.5061.00
274_E278_V1.4981.00
176_L180_S1.4951.00
56_Q59_L1.4891.00
123_H126_I1.4871.00
197_F201_T1.4851.00
166_S170_E1.4821.00
37_T41_E1.4751.00
185_E189_A1.4641.00
182_R185_E1.4471.00
217_K221_K1.4451.00
178_E182_R1.4361.00
17_D20_T1.4341.00
63_K66_E1.4191.00
215_L218_E1.4171.00
233_G237_D1.3961.00
277_I300_S1.3941.00
166_S173_S1.3911.00
84_R87_E1.3861.00
65_D68_E1.3861.00
44_A47_T1.3821.00
70_E73_K1.3821.00
216_Y223_H1.3731.00
105_I108_E1.3681.00
302_P308_K1.3631.00
168_R173_S1.3451.00
134_I138_T1.3431.00
120_I124_S1.3391.00
175_I178_E1.3311.00
209_Q212_L1.3301.00
222_S226_D1.3201.00
122_E126_I1.3081.00
106_L110_S1.3071.00
121_E124_S1.3051.00
162_I165_L1.3031.00
128_E131_S1.3031.00
68_E72_R1.2821.00
92_V96_A1.2801.00
30_D33_L1.2771.00
216_Y220_L1.2761.00
107_E110_S1.2731.00
136_E140_R1.2681.00
85_I89_T1.2681.00
51_Q55_Q1.2631.00
73_K77_I1.2601.00
77_I80_E1.2501.00
141_V145_A1.2491.00
50_V54_N1.2441.00
99_V103_S1.2421.00
219_A230_V1.2391.00
303_K308_K1.2361.00
103_S107_E1.2361.00
186_L189_A1.2351.00
124_S128_E1.2311.00
45_T49_T1.2311.00
158_H162_I1.2271.00
184_E188_K1.2241.00
217_K220_L1.2131.00
227_P230_V1.2111.00
78_L82_S1.2071.00
135_E139_K1.2061.00
119_R122_E1.2051.00
112_R115_E1.2041.00
87_E91_R1.1901.00
167_K170_E1.1881.00
62_K66_E1.1861.00
44_A48_R1.1861.00
109_H112_R1.1851.00
39_L42_T1.1821.00
86_E89_T1.1781.00
187_T191_L1.1771.00
64_L68_E1.1721.00
43_V47_T1.1671.00
229_N282_I1.1671.00
177_E181_K1.1551.00
51_Q54_N1.1531.00
207_Y211_T1.1491.00
15_L18_K1.1441.00
221_K225_V1.1431.00
70_E74_R1.1401.00
100_E103_S1.1361.00
108_E112_R1.1341.00
251_D257_D1.1341.00
30_D34_Q1.1201.00
98_R101_E1.1201.00
201_T205_G1.1131.00
148_V152_S1.1121.00
301_I304_K1.1111.00
126_I129_E1.1081.00
25_E29_N1.1081.00
219_A227_P1.1071.00
174_K178_E1.1031.00
167_K171_E1.1001.00
49_T53_N1.0971.00
26_K29_N1.0951.00
47_T51_Q1.0931.00
157_E161_R1.0901.00
225_V229_N1.0861.00
42_T46_L1.0811.00
35_R39_L1.0801.00
298_C306_L1.0771.00
165_L169_I1.0711.00
117_S121_E1.0701.00
66_E70_E1.0681.00
45_T48_R1.0671.00
177_E180_S1.0571.00
131_S135_E1.0571.00
207_Y210_R1.0561.00
40_E44_A1.0551.00
36_L40_E1.0521.00
170_E173_S1.0501.00
79_E82_S1.0471.00
129_E133_R1.0441.00
162_I166_S1.0431.00
281_R284_E1.0421.00
189_A193_L1.0351.00
265_K279_R1.0351.00
198_D202_S1.0331.00
204_A208_V1.0301.00
21_S25_E1.0291.00
142_E146_K1.0241.00
205_G209_Q1.0221.00
214_E218_E1.0221.00
125_K129_E1.0211.00
191_L194_K1.0201.00
104_K108_E1.0191.00
135_E138_T1.0181.00
24_Y28_K1.0161.00
105_I109_H1.0121.00
72_R75_D1.0091.00
23_I27_M1.0061.00
272_G297_V1.0031.00
220_L232_H1.0001.00
231_K235_I0.9991.00
234_Y249_E0.9961.00
61_W65_D0.9951.00
186_L193_L0.9891.00
264_I300_S0.9861.00
58_V62_K0.9831.00
190_F193_L0.9831.00
15_L19_I0.9751.00
19_I23_I0.9711.00
110_S114_E0.9701.00
147_R150_E0.9611.00
137_L140_R0.9581.00
83_K87_E0.9561.00
102_H105_I0.9531.00
114_E117_S0.9511.00
52_E56_Q0.9511.00
142_E145_A0.9501.00
24_Y27_M0.9491.00
196_S199_S0.9481.00
162_I169_I0.9481.00
22_V26_K0.9481.00
29_N32_I0.9381.00
279_R300_S0.9371.00
187_T190_F0.9371.00
215_L230_V0.9351.00
273_I300_S0.9291.00
265_K300_S0.9281.00
32_I35_R0.9271.00
27_M30_D0.9251.00
53_N57_I0.9231.00
96_A100_E0.9231.00
34_Q37_T0.9231.00
160_K164_E0.9221.00
188_K191_L0.9191.00
273_I277_I0.9141.00
199_S203_R0.9111.00
270_M274_E0.9061.00
21_S24_Y0.9041.00
259_I264_I0.9041.00
221_K224_G0.9011.00
75_D79_E0.8951.00
88_L91_R0.8951.00
273_I294_M0.8921.00
25_E28_K0.8901.00
303_K307_L0.8861.00
220_L227_P0.8861.00
46_L49_T0.8831.00
76_S80_E0.8811.00
89_T93_E0.8771.00
133_R136_E0.8751.00
241_V244_K0.8731.00
28_K31_I0.8711.00
174_K177_E0.8661.00
276_L299_N0.8631.00
133_R137_L0.8571.00
304_K307_L0.8561.00
118_K121_E0.8531.00
20_T24_Y0.8511.00
91_R95_L0.8501.00
168_R171_E0.8501.00
206_I210_R0.8461.00
222_S225_V0.8451.00
215_L226_D0.8441.00
207_Y212_L0.8431.00
238_D244_K0.8321.00
305_V308_K0.8321.00
74_R77_I0.8291.00
259_I287_G0.8291.00
194_K198_D0.8271.00
223_H227_P0.8271.00
179_H182_R0.8181.00
261_L280_R0.8131.00
22_V25_E0.8121.00
103_S106_L0.8111.00
39_L43_V0.8101.00
125_K128_E0.8061.00
77_I81_H0.8061.00
151_H154_I0.8031.00
69_N73_K0.8001.00
259_I265_K0.7971.00
145_A149_E0.7971.00
90_K94_E0.7931.00
17_D21_S0.7911.00
219_A228_S0.7891.00
202_S206_I0.7861.00
158_H165_L0.7861.00
280_R296_L0.7801.00
126_I130_H0.7751.00
20_T23_I0.7731.00
140_R143_E0.7701.00
209_Q213_M0.7691.00
91_R94_E0.7671.00
132_K135_E0.7651.00
63_K67_M0.7621.00
56_Q60_I0.7591.00
97_K101_E0.7571.00
176_L179_H0.7561.00
276_L300_S0.7531.00
259_I276_L0.7531.00
53_N56_Q0.7510.99
215_L222_S0.7490.99
49_T52_E0.7480.99
48_R52_E0.7470.99
260_R264_I0.7450.99
277_I301_I0.7440.99
259_I299_N0.7440.99
110_S113_I0.7440.99
156_E159_S0.7400.99
93_E96_A0.7390.99
216_Y219_A0.7370.99
33_L36_L0.7360.99
182_R192_M0.7350.99
304_K308_K0.7340.99
283_L299_N0.7340.99
71_M75_D0.7340.99
83_K86_E0.7330.99
237_D240_G0.7330.99
121_E125_K0.7320.99
267_L277_I0.7300.99
216_Y224_G0.7250.99
182_R186_L0.7230.99
215_L228_S0.7220.99
33_L37_T0.7220.99
197_F204_A0.7180.99
310_K315_V0.7120.99
196_S203_R0.7050.99
16_L20_T0.7040.99
186_L190_F0.7010.99
215_L227_P0.6930.99
259_I294_M0.6920.99
159_S162_I0.6910.99
311_K315_V0.6910.99
14_R18_K0.6900.99
149_E152_S0.6880.99
196_S200_F0.6880.99
265_K294_M0.6870.99
276_L297_V0.6840.99
267_L300_S0.6820.99
222_S230_V0.6810.99
270_M299_N0.6810.99
265_K276_L0.6790.99
114_E118_K0.6750.99
216_Y222_S0.6740.99
282_I285_S0.6720.99
264_I276_L0.6720.99
220_L228_S0.6680.99
273_I279_R0.6670.99
143_E147_R0.6590.99
200_F204_A0.6580.99
128_E132_K0.6580.99
276_L294_M0.6580.99
101_E104_K0.6570.99
223_H228_S0.6560.99
34_Q38_K0.6550.99
283_L316_V0.6520.99
195_V199_S0.6510.99
98_R102_H0.6480.99
224_G232_H0.6460.98
197_F200_F0.6440.98
149_E153_K0.6410.98
242_I248_F0.6400.98
79_E83_K0.6400.98
175_I179_H0.6360.98
267_L279_R0.6350.98
301_I308_K0.6290.98
298_C305_V0.6260.98
95_L98_R0.6260.98
89_T92_V0.6250.98
72_R76_S0.6250.98
41_E45_T0.6230.98
181_K185_E0.6190.98
14_R17_D0.6190.98
259_I270_M0.6170.98
180_S183_I0.6160.98
283_L301_I0.6100.98
267_L276_L0.6100.98
283_L300_S0.6090.98
48_R51_Q0.6090.98
52_E55_Q0.6070.98
156_E160_K0.6060.98
217_K224_G0.6050.98
116_L120_I0.6050.98
249_E258_E0.6040.98
143_E146_K0.6030.98
159_S163_E0.6030.98
118_K122_E0.6000.98
146_K150_E0.5940.97
204_A207_Y0.5940.97
161_R165_L0.5930.97
19_I22_V0.5890.97
116_L119_R0.5890.97
115_E118_K0.5880.97
175_I189_A0.5880.97
81_H85_I0.5860.97
163_E166_S0.5850.97
176_L183_I0.5800.97
270_M276_L0.5790.97
162_I173_S0.5780.97
201_T204_A0.5770.97
148_V155_L0.5770.97
234_Y237_D0.5770.97
92_V95_L0.5750.97
40_E43_V0.5750.97
301_I306_L0.5750.97
164_E171_E0.5730.97
111_K114_E0.5720.97
150_E153_K0.5720.97
134_I137_L0.5720.97
196_S204_A0.5700.97
287_G300_S0.5690.97
233_G236_V0.5690.97
88_L92_V0.5670.97
272_G275_Q0.5650.97
216_Y226_D0.5640.96
301_I305_V0.5630.96
140_R144_L0.5590.96
219_A224_G0.5590.96
278_V281_R0.5580.96
108_E111_K0.5580.96
279_R283_L0.5570.96
232_H249_E0.5570.96
86_E90_K0.5540.96
163_E167_K0.5540.96
147_R151_H0.5520.96
242_I245_G0.5510.96
306_L309_A0.5510.96
107_E111_K0.5490.96
130_H134_I0.5490.96
185_E192_M0.5470.96
296_L300_S0.5460.96
137_L141_V0.5450.96
265_K299_N0.5440.96
113_I120_I0.5440.96
202_S205_G0.5440.96
270_M277_I0.5420.96
245_G248_F0.5420.96
129_E132_K0.5410.96
183_I197_F0.5400.96
249_E257_D0.5360.95
279_R294_M0.5350.95
141_V144_L0.5330.95
132_K136_E0.5320.95
204_A211_T0.5280.95
36_L39_L0.5270.95
310_K313_G0.5270.95
284_E287_G0.5250.95
266_N299_N0.5240.95
280_R283_L0.5230.95
162_I172_H0.5230.95
245_G253_Y0.5200.95
90_K93_E0.5200.95
65_D69_N0.5180.94
263_E269_D0.5160.94
112_R116_L0.5140.94
69_N72_R0.5140.94
200_F207_Y0.5110.94
271_D275_Q0.5060.94
167_K173_S0.5050.94
246_R250_V0.5030.93
64_L67_M0.5020.93
272_G299_N0.5010.93
109_H113_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.0884 99.2 0.676 Contact Map
1c1gA 2 0.7988 98.6 0.739 Contact Map
4ux3A 1 0.8659 98.6 0.739 Contact Map
3ktaB 1 0.3598 98.6 0.74 Contact Map
3zgxA 2 0.7104 97.7 0.795 Contact Map
2dfsA 2 0.4756 97.4 0.805 Contact Map
4linA 5 0.7073 97.3 0.81 Contact Map
4ad8A 1 0.8262 97.1 0.814 Contact Map
3na7A 1 0.7226 96.9 0.82 Contact Map
4uxvA 1 0.8963 96.9 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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