Q97XC0 - SULSO - GREMLIN Contacts

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Q97XC0 - Uncharacterized protein

UniProt:	Q97XC0	Sequences: MEKYIKDPIYGNIKVESKLIDNPYFQRLKHIIQNGMAYMIFPSMRHTRFEHSLGTYYIASKMIDRIEGNIDSDFKEIIKKLALYHDIGHFPFSHTFEFALDVLKYLNDDKYKEIIGLTEYKGQLHKFHEMMGIKILKDGLGEKEVADLMENVYTSSNPLDDKIKIAKLIVNSDLDADRLDYLQRDSYYSGAKFGIIDPERIIITMTITPKGYIFPPKAIDDLEHFFLARFHMYSSVYNHPVIEIYNRVMSYFIAFAIHKGLLKIPSNLEEIKTFTDEQVFLALINAKNDNELSHFYFSLVERRKYKRAVLQGSEARTLHKYLTEDEDAKEFYEYILGYKGKVVIGSTELKTSIDNIQIKEKLGKYEYLNNLKEESSVVKPPERFRVHIGVYDDNVAKEISEYFSKNFSITLDFRNLESNP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	420 (363)
Sequences:	1387 (976)
Seq/√Len:	51.2

BACSU - YWFO YDHJ
HALSA - Q9HSK2 Q9HPP4 Q9HMK5
SULSO - Q97XC0 Q97U95 Q7LXZ1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
284_I	289_D	7.991	1.00
286_A	289_D	7.166	1.00
112_K	116_G	5.708	1.00
113_E	116_G	3.863	1.00
284_I	287_K	3.632	1.00
30_H	275_T	3.582	1.00
19_L	80_K	3.521	1.00
252_F	296_Y	3.511	1.00
114_I	118_T	3.249	1.00
62_M	176_A	3.160	1.00
109_D	112_K	3.107	1.00
26_Q	29_K	3.080	1.00
112_K	119_E	2.956	1.00
182_L	232_M	2.897	1.00
60_S	79_K	2.839	1.00
205_M	214_F	2.793	1.00
122_G	125_H	2.750	1.00
84_Y	87_I	2.670	1.00
255_F	291_E	2.641	1.00
64_D	75_K	2.633	1.00
29_K	49_F	2.625	1.00
37_A	242_I	2.611	1.00
294_H	298_S	2.564	1.00
58_I	176_A	2.529	1.00
8_P	43_S	2.510	1.00
121_K	146_A	2.410	1.00
232_M	237_Y	2.313	1.00
123_Q	127_F	2.274	1.00
200_R	239_H	2.229	1.00
298_S	303_R	2.224	1.00
59_A	78_I	2.223	1.00
59_A	82_A	2.210	1.00
109_D	116_G	2.187	1.00
90_F	96_F	2.131	1.00
112_K	120_Y	2.102	1.00
232_M	236_V	2.081	1.00
143_K	147_D	2.055	1.00
5_I	15_V	2.016	1.00
112_K	118_T	1.971	1.00
245_Y	304_K	1.933	0.99
116_G	120_Y	1.925	0.99
55_T	176_A	1.892	0.99
5_I	42_P	1.870	0.99
116_G	119_E	1.816	0.99
111_Y	116_G	1.782	0.99
113_E	120_Y	1.765	0.99
284_I	288_N	1.761	0.99
113_E	119_E	1.741	0.99
6_K	12_N	1.718	0.99
112_K	115_I	1.684	0.98
200_R	302_R	1.659	0.98
19_L	84_Y	1.657	0.98
39_M	245_Y	1.602	0.98
251_Y	254_A	1.598	0.98
109_D	113_E	1.592	0.98
119_E	272_K	1.582	0.98
273_T	288_N	1.578	0.98
61_K	64_D	1.573	0.98
214_F	222_L	1.566	0.98
56_Y	79_K	1.565	0.98
86_D	177_D	1.557	0.97
328_A	331_F	1.549	0.97
218_A	221_D	1.529	0.97
22_N	25_F	1.528	0.97
23_P	123_Q	1.525	0.97
248_V	304_K	1.523	0.97
11_G	199_E	1.521	0.97
92_F	280_F	1.498	0.97
270_E	273_T	1.476	0.96
292_L	295_F	1.465	0.96
112_K	117_L	1.464	0.96
77_I	144_E	1.464	0.96
267_N	270_E	1.456	0.96
85_H	177_D	1.442	0.96
24_Y	126_K	1.431	0.96
196_I	226_F	1.429	0.96
10_Y	183_Q	1.429	0.96
73_D	144_E	1.427	0.96
9_I	13_I	1.426	0.96
148_L	166_A	1.421	0.96
8_P	187_Y	1.413	0.95
94_H	177_D	1.406	0.95
78_I	166_A	1.406	0.95
211_G	357_Q	1.392	0.95
9_I	187_Y	1.387	0.95
122_G	126_K	1.383	0.95
144_E	153_Y	1.381	0.95
175_D	178_R	1.379	0.95
170_V	178_R	1.361	0.94
84_Y	120_Y	1.361	0.94
62_M	205_M	1.348	0.94
26_Q	49_F	1.332	0.94
319_H	322_L	1.323	0.94
147_D	152_V	1.319	0.93
321_Y	327_D	1.303	0.93
252_F	283_L	1.290	0.93
55_T	82_A	1.286	0.93
21_D	29_K	1.279	0.92
63_I	79_K	1.275	0.92
110_K	115_I	1.274	0.92
49_F	239_H	1.272	0.92
189_S	236_V	1.268	0.92
193_F	230_F	1.267	0.92
179_L	196_I	1.264	0.92
216_P	360_E	1.258	0.92
146_A	149_M	1.256	0.92
331_F	335_I	1.252	0.92
137_K	140_L	1.248	0.91
61_K	199_E	1.234	0.91
4_Y	12_N	1.234	0.91
372_K	376_S	1.233	0.91
297_F	303_R	1.233	0.91
337_G	341_K	1.232	0.91
293_S	297_F	1.213	0.90
87_I	376_S	1.212	0.90
38_Y	47_T	1.200	0.90
182_L	228_A	1.199	0.90
48_R	51_H	1.197	0.90
339_K	344_I	1.194	0.89
373_E	382_E	1.182	0.89
208_T	213_I	1.178	0.89
310_L	389_G	1.177	0.89
20_I	25_F	1.176	0.89
366_E	371_L	1.169	0.88
302_R	306_K	1.151	0.88
271_I	274_F	1.150	0.88
78_I	170_V	1.147	0.88
332_Y	335_I	1.145	0.87
110_K	113_E	1.141	0.87
37_A	41_F	1.136	0.87
336_L	344_I	1.135	0.87
63_I	67_E	1.135	0.87
57_Y	60_S	1.127	0.87
85_H	89_H	1.126	0.87
380_P	383_R	1.119	0.86
338_Y	342_V	1.116	0.86
139_G	143_K	1.114	0.86
183_Q	198_P	1.110	0.86
23_P	301_E	1.107	0.86
262_L	266_S	1.106	0.86
30_H	301_E	1.104	0.85
6_K	41_F	1.101	0.85
33_Q	46_H	1.092	0.85
121_K	125_H	1.085	0.84
95_T	242_I	1.082	0.84
114_I	150_E	1.078	0.84
113_E	118_T	1.068	0.83
57_Y	61_K	1.065	0.83
248_V	305_Y	1.060	0.83
49_F	200_R	1.056	0.83
191_A	232_M	1.046	0.82
351_T	354_D	1.040	0.82
45_R	50_E	1.039	0.82
65_R	202_I	1.038	0.82
200_R	241_V	1.037	0.82
19_L	45_R	1.036	0.82
239_H	302_R	1.032	0.81
115_I	119_E	1.016	0.80
43_S	188_Y	1.016	0.80
40_I	78_I	0.996	0.79
52_S	79_K	0.993	0.79
111_Y	119_E	0.992	0.79
48_R	54_G	0.988	0.78
29_K	39_M	0.984	0.78
204_T	218_A	0.978	0.78
16_E	79_K	0.976	0.78
115_I	118_T	0.976	0.78
178_R	226_F	0.975	0.77
44_M	189_S	0.974	0.77
279_V	299_L	0.961	0.76
179_L	183_Q	0.956	0.76
110_K	114_I	0.956	0.76
51_H	54_G	0.952	0.76
90_F	271_I	0.951	0.76
147_D	154_T	0.947	0.75
255_F	292_L	0.946	0.75
26_Q	239_H	0.946	0.75
360_E	366_E	0.943	0.75
120_Y	123_Q	0.939	0.75
67_E	71_D	0.936	0.74
379_K	384_F	0.935	0.74
88_G	93_S	0.933	0.74
34_N	37_A	0.932	0.74
90_F	274_F	0.926	0.74
240_P	307_R	0.925	0.74
93_S	178_R	0.920	0.73
109_D	120_Y	0.918	0.73
185_D	237_Y	0.916	0.73
50_E	188_Y	0.915	0.73
59_A	176_A	0.912	0.73
163_I	210_K	0.910	0.72
89_H	177_D	0.909	0.72
335_I	342_V	0.909	0.72
117_L	150_E	0.907	0.72
93_S	246_N	0.907	0.72
8_P	188_Y	0.906	0.72
23_P	269_E	0.906	0.72
194_G	223_E	0.906	0.72
26_Q	92_F	0.905	0.72
15_V	20_I	0.905	0.72
298_S	305_Y	0.904	0.72
194_G	228_A	0.903	0.72
163_I	166_A	0.900	0.72
297_F	301_E	0.899	0.71
7_D	10_Y	0.896	0.71
59_A	169_I	0.895	0.71
180_D	184_R	0.894	0.71
182_L	194_G	0.894	0.71
182_L	186_S	0.892	0.71
172_S	179_L	0.890	0.71
71_D	163_I	0.887	0.70
316_R	325_D	0.882	0.70
113_E	117_L	0.880	0.70
241_V	306_K	0.878	0.70
30_H	277_E	0.878	0.70
329_K	332_Y	0.876	0.69
121_K	150_E	0.875	0.69
97_E	223_E	0.874	0.69
18_K	21_D	0.873	0.69
216_P	351_T	0.872	0.69
86_D	94_H	0.870	0.69
241_V	302_R	0.869	0.69
233_Y	238_N	0.864	0.68
260_G	263_K	0.859	0.68
66_I	69_N	0.857	0.68
49_F	302_R	0.854	0.67
121_K	124_L	0.850	0.67
67_E	75_K	0.848	0.67
357_Q	362_L	0.847	0.67
75_K	79_K	0.847	0.67
225_F	240_P	0.846	0.67
320_K	324_E	0.843	0.66
201_I	222_L	0.841	0.66
244_I	248_V	0.838	0.66
259_K	266_S	0.834	0.66
119_E	268_L	0.829	0.65
21_D	26_Q	0.827	0.65
287_K	301_E	0.825	0.65
24_Y	127_F	0.821	0.64
126_K	297_F	0.819	0.64
194_G	218_A	0.818	0.64
66_I	91_P	0.815	0.64
32_I	276_D	0.813	0.64
35_G	175_D	0.812	0.64
223_E	232_M	0.809	0.63
65_R	198_P	0.809	0.63
46_H	185_D	0.806	0.63
383_R	388_I	0.805	0.63
35_G	242_I	0.804	0.63
111_Y	114_I	0.804	0.63
95_T	246_N	0.803	0.63
17_S	76_E	0.802	0.63
97_E	227_L	0.801	0.62
173_D	255_F	0.800	0.62
20_I	53_L	0.797	0.62
40_I	242_I	0.795	0.62
172_S	355_N	0.794	0.62
337_G	342_V	0.793	0.62
228_A	232_M	0.793	0.62
89_H	113_E	0.787	0.61
167_K	170_V	0.783	0.61
89_H	112_K	0.782	0.61
73_D	77_I	0.779	0.60
24_Y	82_A	0.778	0.60
227_L	231_H	0.776	0.60
53_L	266_S	0.776	0.60
34_N	222_L	0.775	0.60
87_I	370_N	0.774	0.60
242_I	246_N	0.773	0.60
109_D	119_E	0.772	0.60
85_H	94_H	0.769	0.59
14_K	203_I	0.767	0.59
34_N	189_S	0.767	0.59
38_Y	242_I	0.767	0.59
18_K	137_K	0.766	0.59
65_R	203_I	0.766	0.59
206_T	213_I	0.764	0.59
111_Y	118_T	0.764	0.59
62_M	169_I	0.762	0.59
234_S	275_T	0.760	0.58
165_I	168_L	0.758	0.58
21_D	239_H	0.757	0.58
77_I	145_V	0.756	0.58
191_A	194_G	0.756	0.58
389_G	392_D	0.752	0.58
193_F	232_M	0.750	0.57
202_I	232_M	0.750	0.57
196_I	348_E	0.750	0.57
63_I	253_I	0.749	0.57
387_H	390_V	0.746	0.57
336_L	339_K	0.746	0.57
189_S	207_I	0.745	0.57
6_K	186_S	0.744	0.57
214_F	218_A	0.744	0.57
58_I	198_P	0.742	0.57
182_L	236_V	0.739	0.56
5_I	20_I	0.737	0.56
202_I	217_K	0.736	0.56
200_R	236_V	0.735	0.56
89_H	94_H	0.734	0.56
37_A	65_R	0.731	0.55
378_V	381_P	0.728	0.55
331_F	337_G	0.728	0.55
145_V	149_M	0.727	0.55
111_Y	120_Y	0.725	0.55
146_A	217_K	0.724	0.55
50_E	201_I	0.724	0.55
40_I	241_V	0.723	0.55
10_Y	29_K	0.722	0.55
261_L	266_S	0.720	0.54
42_P	50_E	0.720	0.54
9_I	43_S	0.717	0.54
308_A	313_S	0.717	0.54
261_L	289_D	0.717	0.54
36_M	96_F	0.714	0.54
322_L	325_D	0.712	0.54
90_F	237_Y	0.711	0.53
361_K	364_K	0.708	0.53
42_P	45_R	0.708	0.53
28_L	33_Q	0.707	0.53
373_E	378_V	0.707	0.53
278_Q	282_A	0.704	0.53
178_R	229_R	0.703	0.53
53_L	58_I	0.703	0.53
248_V	295_F	0.703	0.53
90_F	173_D	0.700	0.52
253_I	278_Q	0.700	0.52
377_V	381_P	0.698	0.52
220_D	235_S	0.697	0.52
53_L	222_L	0.693	0.52
285_N	289_D	0.691	0.51
173_D	182_L	0.691	0.51
91_P	280_F	0.691	0.51
3_K	11_G	0.689	0.51
191_A	228_A	0.686	0.51
61_K	375_S	0.684	0.51
149_M	186_S	0.682	0.50
67_E	72_S	0.682	0.50
15_V	53_L	0.682	0.50
5_I	80_K	0.682	0.50
331_F	340_G	0.681	0.50
224_H	231_H	0.681	0.50
40_I	239_H	0.678	0.50
174_L	196_I	0.677	0.50
206_T	298_S	0.677	0.50
75_K	207_I	0.677	0.50
111_Y	115_I	0.675	0.50
86_D	89_H	0.674	0.50
110_K	116_G	0.672	0.49
368_L	372_K	0.672	0.49
175_D	181_Y	0.671	0.49
342_V	346_S	0.671	0.49
92_F	388_I	0.669	0.49
252_F	292_L	0.669	0.49
14_K	294_H	0.669	0.49
221_D	235_S	0.667	0.49
28_L	52_S	0.667	0.49
16_E	56_Y	0.665	0.49
335_I	339_K	0.664	0.49
348_E	352_S	0.662	0.48
332_Y	336_L	0.662	0.48
193_F	197_D	0.661	0.48
329_K	341_K	0.661	0.48
20_I	236_V	0.660	0.48
94_H	181_Y	0.660	0.48
328_A	332_Y	0.659	0.48
56_Y	240_P	0.658	0.48
93_S	229_R	0.658	0.48
225_F	271_I	0.658	0.48
96_F	169_I	0.656	0.48
170_V	176_A	0.656	0.48
283_L	300_V	0.653	0.47
147_D	254_A	0.653	0.47
252_F	299_L	0.653	0.47
62_M	202_I	0.650	0.47
113_E	177_D	0.650	0.47
74_F	356_I	0.647	0.47
35_G	93_S	0.646	0.47
183_Q	187_Y	0.644	0.46
254_A	297_F	0.642	0.46
35_G	181_Y	0.641	0.46
89_H	181_Y	0.639	0.46
18_K	38_Y	0.639	0.46
188_Y	242_I	0.637	0.46
42_P	217_K	0.637	0.46
63_I	75_K	0.637	0.46
248_V	252_F	0.636	0.46
245_Y	299_L	0.636	0.46
209_P	277_E	0.635	0.46
8_P	238_N	0.633	0.45
373_E	377_V	0.633	0.45
368_L	375_S	0.632	0.45
116_G	123_Q	0.632	0.45
36_M	246_N	0.631	0.45
252_F	295_F	0.631	0.45
5_I	9_I	0.629	0.45
125_H	143_K	0.629	0.45
41_F	304_K	0.629	0.45
21_D	302_R	0.628	0.45
284_I	300_V	0.625	0.45
331_F	344_I	0.623	0.44
96_F	173_D	0.623	0.44
70_I	144_E	0.622	0.44
387_H	391_Y	0.619	0.44
220_D	234_S	0.618	0.44
370_N	376_S	0.617	0.44
330_E	336_L	0.615	0.44
165_I	169_I	0.612	0.43
40_I	44_M	0.609	0.43
179_L	226_F	0.609	0.43
102_V	273_T	0.608	0.43
50_E	200_R	0.607	0.43
178_R	227_L	0.606	0.43
111_Y	271_I	0.605	0.42
192_K	195_I	0.603	0.42
67_E	78_I	0.603	0.42
285_N	288_N	0.603	0.42
19_L	281_L	0.602	0.42
375_S	378_V	0.601	0.42
40_I	66_I	0.600	0.42
74_F	153_Y	0.598	0.42
366_E	370_N	0.595	0.41
244_I	299_L	0.594	0.41
115_I	271_I	0.593	0.41
218_A	223_E	0.590	0.41
33_Q	177_D	0.589	0.41
6_K	230_F	0.589	0.41
323_T	327_D	0.588	0.41
172_S	243_E	0.588	0.41
326_E	329_K	0.588	0.41
64_D	363_G	0.588	0.41
35_G	95_T	0.588	0.41
334_Y	338_Y	0.587	0.41
171_N	226_F	0.587	0.41
319_H	336_L	0.586	0.41
170_V	200_R	0.586	0.41
149_M	171_N	0.584	0.40
193_F	235_S	0.584	0.40
245_Y	251_Y	0.583	0.40
335_I	340_G	0.583	0.40
85_H	113_E	0.583	0.40
32_I	45_R	0.583	0.40
291_E	294_H	0.582	0.40
39_M	78_I	0.581	0.40
371_L	384_F	0.580	0.40
337_G	346_S	0.580	0.40
9_I	325_D	0.578	0.40
99_A	381_P	0.577	0.40
322_L	327_D	0.576	0.40
33_Q	48_R	0.575	0.39
40_I	200_R	0.575	0.39
179_L	307_R	0.574	0.39
329_K	334_Y	0.574	0.39
354_D	357_Q	0.573	0.39
316_R	326_E	0.570	0.39
34_N	95_T	0.569	0.39
177_D	181_Y	0.569	0.39
4_Y	14_K	0.566	0.39
95_T	176_A	0.565	0.38
330_E	339_K	0.564	0.38
8_P	12_N	0.563	0.38
180_D	185_D	0.563	0.38
8_P	190_G	0.563	0.38
224_H	227_L	0.562	0.38
71_D	145_V	0.560	0.38
55_T	241_V	0.560	0.38
269_E	285_N	0.559	0.38
317_T	321_Y	0.559	0.38
288_N	327_D	0.557	0.38
118_T	318_L	0.555	0.38
9_I	366_E	0.553	0.37
22_N	138_D	0.552	0.37
66_I	231_H	0.552	0.37
118_T	121_K	0.551	0.37
188_Y	191_A	0.551	0.37
253_I	276_D	0.551	0.37
85_H	112_K	0.550	0.37
344_I	350_K	0.550	0.37
33_Q	51_H	0.548	0.37
171_N	178_R	0.548	0.37
42_P	46_H	0.547	0.37
191_A	236_V	0.547	0.37
380_P	384_F	0.546	0.37
43_S	215_P	0.545	0.37
24_Y	206_T	0.545	0.37
301_E	311_Q	0.545	0.37
172_S	218_A	0.545	0.37
371_L	376_S	0.544	0.36
337_G	340_G	0.542	0.36
227_L	374_E	0.542	0.36
179_L	203_I	0.539	0.36
35_G	246_N	0.539	0.36
4_Y	203_I	0.539	0.36
239_H	306_K	0.539	0.36
194_G	232_M	0.536	0.36
171_N	175_D	0.535	0.36
172_S	299_L	0.535	0.36
215_P	276_D	0.534	0.35
9_I	99_A	0.533	0.35
269_E	373_E	0.533	0.35
308_A	312_G	0.532	0.35
230_F	234_S	0.532	0.35
8_P	13_I	0.531	0.35
51_H	86_D	0.531	0.35
58_I	71_D	0.531	0.35
294_H	331_F	0.530	0.35
287_K	300_V	0.529	0.35
297_F	320_K	0.529	0.35
182_L	191_A	0.529	0.35
65_R	69_N	0.528	0.35
72_S	269_E	0.527	0.35
40_I	219_I	0.526	0.35
117_L	120_Y	0.523	0.34
189_S	196_I	0.523	0.34
118_T	143_K	0.521	0.34
187_Y	202_I	0.521	0.34
20_I	358_I	0.521	0.34
36_M	249_M	0.521	0.34
316_R	323_T	0.520	0.34
96_F	253_I	0.519	0.34
74_F	246_N	0.518	0.34
9_I	153_Y	0.517	0.34
100_L	151_N	0.515	0.34
78_I	176_A	0.515	0.34
275_T	280_F	0.515	0.34
176_A	252_F	0.514	0.34
213_I	249_M	0.514	0.34
81_L	171_N	0.514	0.34
222_L	241_V	0.513	0.34
51_H	85_H	0.511	0.33
32_I	305_Y	0.511	0.33
61_K	366_E	0.508	0.33
40_I	295_F	0.508	0.33
4_Y	16_E	0.507	0.33
359_K	365_Y	0.507	0.33
31_I	205_M	0.505	0.33
35_G	38_Y	0.504	0.33
266_S	290_N	0.504	0.33
100_L	271_I	0.504	0.33
71_D	74_F	0.502	0.33
47_T	124_L	0.501	0.32
137_K	327_D	0.501	0.32
96_F	278_Q	0.500	0.32
74_F	165_I	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mz7A	4	0.9857	100	0.273	Contact Map
4lrlA	4	0.931	100	0.318	Contact Map
2hekA	4	0.8643	100	0.351	Contact Map
2q14A	4	0.8643	100	0.362	Contact Map
3bg2A	4	0.631	100	0.744	Contact Map
2pgsA	4	0.6881	100	0.749	Contact Map
2dqbA	4	0.6571	100	0.753	Contact Map
4x9eA	4	0.731	100	0.761	Contact Map
2pq7A	2	0.4048	98.6	0.911	Contact Map
3gw7A	2	0.4857	98.5	0.914	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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