GREMLIN Database
Q97XC0 - Uncharacterized protein
UniProt: Q97XC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (363)
Sequences: 1387 (976)
Seq/√Len: 51.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
284_I289_D7.9911.00
286_A289_D7.1661.00
112_K116_G5.7081.00
113_E116_G3.8631.00
284_I287_K3.6321.00
30_H275_T3.5821.00
19_L80_K3.5211.00
252_F296_Y3.5111.00
114_I118_T3.2491.00
62_M176_A3.1601.00
109_D112_K3.1071.00
26_Q29_K3.0801.00
112_K119_E2.9561.00
182_L232_M2.8971.00
60_S79_K2.8391.00
205_M214_F2.7931.00
122_G125_H2.7501.00
84_Y87_I2.6701.00
255_F291_E2.6411.00
64_D75_K2.6331.00
29_K49_F2.6251.00
37_A242_I2.6111.00
294_H298_S2.5641.00
58_I176_A2.5291.00
8_P43_S2.5101.00
121_K146_A2.4101.00
232_M237_Y2.3131.00
123_Q127_F2.2741.00
200_R239_H2.2291.00
298_S303_R2.2241.00
59_A78_I2.2231.00
59_A82_A2.2101.00
109_D116_G2.1871.00
90_F96_F2.1311.00
112_K120_Y2.1021.00
232_M236_V2.0811.00
143_K147_D2.0551.00
5_I15_V2.0161.00
112_K118_T1.9711.00
245_Y304_K1.9330.99
116_G120_Y1.9250.99
55_T176_A1.8920.99
5_I42_P1.8700.99
116_G119_E1.8160.99
111_Y116_G1.7820.99
113_E120_Y1.7650.99
284_I288_N1.7610.99
113_E119_E1.7410.99
6_K12_N1.7180.99
112_K115_I1.6840.98
200_R302_R1.6590.98
19_L84_Y1.6570.98
39_M245_Y1.6020.98
251_Y254_A1.5980.98
109_D113_E1.5920.98
119_E272_K1.5820.98
273_T288_N1.5780.98
61_K64_D1.5730.98
214_F222_L1.5660.98
56_Y79_K1.5650.98
86_D177_D1.5570.97
328_A331_F1.5490.97
218_A221_D1.5290.97
22_N25_F1.5280.97
23_P123_Q1.5250.97
248_V304_K1.5230.97
11_G199_E1.5210.97
92_F280_F1.4980.97
270_E273_T1.4760.96
292_L295_F1.4650.96
112_K117_L1.4640.96
77_I144_E1.4640.96
267_N270_E1.4560.96
85_H177_D1.4420.96
24_Y126_K1.4310.96
196_I226_F1.4290.96
10_Y183_Q1.4290.96
73_D144_E1.4270.96
9_I13_I1.4260.96
148_L166_A1.4210.96
8_P187_Y1.4130.95
94_H177_D1.4060.95
78_I166_A1.4060.95
211_G357_Q1.3920.95
9_I187_Y1.3870.95
122_G126_K1.3830.95
144_E153_Y1.3810.95
175_D178_R1.3790.95
170_V178_R1.3610.94
84_Y120_Y1.3610.94
62_M205_M1.3480.94
26_Q49_F1.3320.94
319_H322_L1.3230.94
147_D152_V1.3190.93
321_Y327_D1.3030.93
252_F283_L1.2900.93
55_T82_A1.2860.93
21_D29_K1.2790.92
63_I79_K1.2750.92
110_K115_I1.2740.92
49_F239_H1.2720.92
189_S236_V1.2680.92
193_F230_F1.2670.92
179_L196_I1.2640.92
216_P360_E1.2580.92
146_A149_M1.2560.92
331_F335_I1.2520.92
137_K140_L1.2480.91
61_K199_E1.2340.91
4_Y12_N1.2340.91
372_K376_S1.2330.91
297_F303_R1.2330.91
337_G341_K1.2320.91
293_S297_F1.2130.90
87_I376_S1.2120.90
38_Y47_T1.2000.90
182_L228_A1.1990.90
48_R51_H1.1970.90
339_K344_I1.1940.89
373_E382_E1.1820.89
208_T213_I1.1780.89
310_L389_G1.1770.89
20_I25_F1.1760.89
366_E371_L1.1690.88
302_R306_K1.1510.88
271_I274_F1.1500.88
78_I170_V1.1470.88
332_Y335_I1.1450.87
110_K113_E1.1410.87
37_A41_F1.1360.87
336_L344_I1.1350.87
63_I67_E1.1350.87
57_Y60_S1.1270.87
85_H89_H1.1260.87
380_P383_R1.1190.86
338_Y342_V1.1160.86
139_G143_K1.1140.86
183_Q198_P1.1100.86
23_P301_E1.1070.86
262_L266_S1.1060.86
30_H301_E1.1040.85
6_K41_F1.1010.85
33_Q46_H1.0920.85
121_K125_H1.0850.84
95_T242_I1.0820.84
114_I150_E1.0780.84
113_E118_T1.0680.83
57_Y61_K1.0650.83
248_V305_Y1.0600.83
49_F200_R1.0560.83
191_A232_M1.0460.82
351_T354_D1.0400.82
45_R50_E1.0390.82
65_R202_I1.0380.82
200_R241_V1.0370.82
19_L45_R1.0360.82
239_H302_R1.0320.81
115_I119_E1.0160.80
43_S188_Y1.0160.80
40_I78_I0.9960.79
52_S79_K0.9930.79
111_Y119_E0.9920.79
48_R54_G0.9880.78
29_K39_M0.9840.78
204_T218_A0.9780.78
16_E79_K0.9760.78
115_I118_T0.9760.78
178_R226_F0.9750.77
44_M189_S0.9740.77
279_V299_L0.9610.76
179_L183_Q0.9560.76
110_K114_I0.9560.76
51_H54_G0.9520.76
90_F271_I0.9510.76
147_D154_T0.9470.75
255_F292_L0.9460.75
26_Q239_H0.9460.75
360_E366_E0.9430.75
120_Y123_Q0.9390.75
67_E71_D0.9360.74
379_K384_F0.9350.74
88_G93_S0.9330.74
34_N37_A0.9320.74
90_F274_F0.9260.74
240_P307_R0.9250.74
93_S178_R0.9200.73
109_D120_Y0.9180.73
185_D237_Y0.9160.73
50_E188_Y0.9150.73
59_A176_A0.9120.73
163_I210_K0.9100.72
89_H177_D0.9090.72
335_I342_V0.9090.72
117_L150_E0.9070.72
93_S246_N0.9070.72
8_P188_Y0.9060.72
23_P269_E0.9060.72
194_G223_E0.9060.72
26_Q92_F0.9050.72
15_V20_I0.9050.72
298_S305_Y0.9040.72
194_G228_A0.9030.72
163_I166_A0.9000.72
297_F301_E0.8990.71
7_D10_Y0.8960.71
59_A169_I0.8950.71
180_D184_R0.8940.71
182_L194_G0.8940.71
182_L186_S0.8920.71
172_S179_L0.8900.71
71_D163_I0.8870.70
316_R325_D0.8820.70
113_E117_L0.8800.70
241_V306_K0.8780.70
30_H277_E0.8780.70
329_K332_Y0.8760.69
121_K150_E0.8750.69
97_E223_E0.8740.69
18_K21_D0.8730.69
216_P351_T0.8720.69
86_D94_H0.8700.69
241_V302_R0.8690.69
233_Y238_N0.8640.68
260_G263_K0.8590.68
66_I69_N0.8570.68
49_F302_R0.8540.67
121_K124_L0.8500.67
67_E75_K0.8480.67
357_Q362_L0.8470.67
75_K79_K0.8470.67
225_F240_P0.8460.67
320_K324_E0.8430.66
201_I222_L0.8410.66
244_I248_V0.8380.66
259_K266_S0.8340.66
119_E268_L0.8290.65
21_D26_Q0.8270.65
287_K301_E0.8250.65
24_Y127_F0.8210.64
126_K297_F0.8190.64
194_G218_A0.8180.64
66_I91_P0.8150.64
32_I276_D0.8130.64
35_G175_D0.8120.64
223_E232_M0.8090.63
65_R198_P0.8090.63
46_H185_D0.8060.63
383_R388_I0.8050.63
35_G242_I0.8040.63
111_Y114_I0.8040.63
95_T246_N0.8030.63
17_S76_E0.8020.63
97_E227_L0.8010.62
173_D255_F0.8000.62
20_I53_L0.7970.62
40_I242_I0.7950.62
172_S355_N0.7940.62
337_G342_V0.7930.62
228_A232_M0.7930.62
89_H113_E0.7870.61
167_K170_V0.7830.61
89_H112_K0.7820.61
73_D77_I0.7790.60
24_Y82_A0.7780.60
227_L231_H0.7760.60
53_L266_S0.7760.60
34_N222_L0.7750.60
87_I370_N0.7740.60
242_I246_N0.7730.60
109_D119_E0.7720.60
85_H94_H0.7690.59
14_K203_I0.7670.59
34_N189_S0.7670.59
38_Y242_I0.7670.59
18_K137_K0.7660.59
65_R203_I0.7660.59
206_T213_I0.7640.59
111_Y118_T0.7640.59
62_M169_I0.7620.59
234_S275_T0.7600.58
165_I168_L0.7580.58
21_D239_H0.7570.58
77_I145_V0.7560.58
191_A194_G0.7560.58
389_G392_D0.7520.58
193_F232_M0.7500.57
202_I232_M0.7500.57
196_I348_E0.7500.57
63_I253_I0.7490.57
387_H390_V0.7460.57
336_L339_K0.7460.57
189_S207_I0.7450.57
6_K186_S0.7440.57
214_F218_A0.7440.57
58_I198_P0.7420.57
182_L236_V0.7390.56
5_I20_I0.7370.56
202_I217_K0.7360.56
200_R236_V0.7350.56
89_H94_H0.7340.56
37_A65_R0.7310.55
378_V381_P0.7280.55
331_F337_G0.7280.55
145_V149_M0.7270.55
111_Y120_Y0.7250.55
146_A217_K0.7240.55
50_E201_I0.7240.55
40_I241_V0.7230.55
10_Y29_K0.7220.55
261_L266_S0.7200.54
42_P50_E0.7200.54
9_I43_S0.7170.54
308_A313_S0.7170.54
261_L289_D0.7170.54
36_M96_F0.7140.54
322_L325_D0.7120.54
90_F237_Y0.7110.53
361_K364_K0.7080.53
42_P45_R0.7080.53
28_L33_Q0.7070.53
373_E378_V0.7070.53
278_Q282_A0.7040.53
178_R229_R0.7030.53
53_L58_I0.7030.53
248_V295_F0.7030.53
90_F173_D0.7000.52
253_I278_Q0.7000.52
377_V381_P0.6980.52
220_D235_S0.6970.52
53_L222_L0.6930.52
285_N289_D0.6910.51
173_D182_L0.6910.51
91_P280_F0.6910.51
3_K11_G0.6890.51
191_A228_A0.6860.51
61_K375_S0.6840.51
149_M186_S0.6820.50
67_E72_S0.6820.50
15_V53_L0.6820.50
5_I80_K0.6820.50
331_F340_G0.6810.50
224_H231_H0.6810.50
40_I239_H0.6780.50
174_L196_I0.6770.50
206_T298_S0.6770.50
75_K207_I0.6770.50
111_Y115_I0.6750.50
86_D89_H0.6740.50
110_K116_G0.6720.49
368_L372_K0.6720.49
175_D181_Y0.6710.49
342_V346_S0.6710.49
92_F388_I0.6690.49
252_F292_L0.6690.49
14_K294_H0.6690.49
221_D235_S0.6670.49
28_L52_S0.6670.49
16_E56_Y0.6650.49
335_I339_K0.6640.49
348_E352_S0.6620.48
332_Y336_L0.6620.48
193_F197_D0.6610.48
329_K341_K0.6610.48
20_I236_V0.6600.48
94_H181_Y0.6600.48
328_A332_Y0.6590.48
56_Y240_P0.6580.48
93_S229_R0.6580.48
225_F271_I0.6580.48
96_F169_I0.6560.48
170_V176_A0.6560.48
283_L300_V0.6530.47
147_D254_A0.6530.47
252_F299_L0.6530.47
62_M202_I0.6500.47
113_E177_D0.6500.47
74_F356_I0.6470.47
35_G93_S0.6460.47
183_Q187_Y0.6440.46
254_A297_F0.6420.46
35_G181_Y0.6410.46
89_H181_Y0.6390.46
18_K38_Y0.6390.46
188_Y242_I0.6370.46
42_P217_K0.6370.46
63_I75_K0.6370.46
248_V252_F0.6360.46
245_Y299_L0.6360.46
209_P277_E0.6350.46
8_P238_N0.6330.45
373_E377_V0.6330.45
368_L375_S0.6320.45
116_G123_Q0.6320.45
36_M246_N0.6310.45
252_F295_F0.6310.45
5_I9_I0.6290.45
125_H143_K0.6290.45
41_F304_K0.6290.45
21_D302_R0.6280.45
284_I300_V0.6250.45
331_F344_I0.6230.44
96_F173_D0.6230.44
70_I144_E0.6220.44
387_H391_Y0.6190.44
220_D234_S0.6180.44
370_N376_S0.6170.44
330_E336_L0.6150.44
165_I169_I0.6120.43
40_I44_M0.6090.43
179_L226_F0.6090.43
102_V273_T0.6080.43
50_E200_R0.6070.43
178_R227_L0.6060.43
111_Y271_I0.6050.42
192_K195_I0.6030.42
67_E78_I0.6030.42
285_N288_N0.6030.42
19_L281_L0.6020.42
375_S378_V0.6010.42
40_I66_I0.6000.42
74_F153_Y0.5980.42
366_E370_N0.5950.41
244_I299_L0.5940.41
115_I271_I0.5930.41
218_A223_E0.5900.41
33_Q177_D0.5890.41
6_K230_F0.5890.41
323_T327_D0.5880.41
172_S243_E0.5880.41
326_E329_K0.5880.41
64_D363_G0.5880.41
35_G95_T0.5880.41
334_Y338_Y0.5870.41
171_N226_F0.5870.41
319_H336_L0.5860.41
170_V200_R0.5860.41
149_M171_N0.5840.40
193_F235_S0.5840.40
245_Y251_Y0.5830.40
335_I340_G0.5830.40
85_H113_E0.5830.40
32_I45_R0.5830.40
291_E294_H0.5820.40
39_M78_I0.5810.40
371_L384_F0.5800.40
337_G346_S0.5800.40
9_I325_D0.5780.40
99_A381_P0.5770.40
322_L327_D0.5760.40
33_Q48_R0.5750.39
40_I200_R0.5750.39
179_L307_R0.5740.39
329_K334_Y0.5740.39
354_D357_Q0.5730.39
316_R326_E0.5700.39
34_N95_T0.5690.39
177_D181_Y0.5690.39
4_Y14_K0.5660.39
95_T176_A0.5650.38
330_E339_K0.5640.38
8_P12_N0.5630.38
180_D185_D0.5630.38
8_P190_G0.5630.38
224_H227_L0.5620.38
71_D145_V0.5600.38
55_T241_V0.5600.38
269_E285_N0.5590.38
317_T321_Y0.5590.38
288_N327_D0.5570.38
118_T318_L0.5550.38
9_I366_E0.5530.37
22_N138_D0.5520.37
66_I231_H0.5520.37
118_T121_K0.5510.37
188_Y191_A0.5510.37
253_I276_D0.5510.37
85_H112_K0.5500.37
344_I350_K0.5500.37
33_Q51_H0.5480.37
171_N178_R0.5480.37
42_P46_H0.5470.37
191_A236_V0.5470.37
380_P384_F0.5460.37
43_S215_P0.5450.37
24_Y206_T0.5450.37
301_E311_Q0.5450.37
172_S218_A0.5450.37
371_L376_S0.5440.36
337_G340_G0.5420.36
227_L374_E0.5420.36
179_L203_I0.5390.36
35_G246_N0.5390.36
4_Y203_I0.5390.36
239_H306_K0.5390.36
194_G232_M0.5360.36
171_N175_D0.5350.36
172_S299_L0.5350.36
215_P276_D0.5340.35
9_I99_A0.5330.35
269_E373_E0.5330.35
308_A312_G0.5320.35
230_F234_S0.5320.35
8_P13_I0.5310.35
51_H86_D0.5310.35
58_I71_D0.5310.35
294_H331_F0.5300.35
287_K300_V0.5290.35
297_F320_K0.5290.35
182_L191_A0.5290.35
65_R69_N0.5280.35
72_S269_E0.5270.35
40_I219_I0.5260.35
117_L120_Y0.5230.34
189_S196_I0.5230.34
118_T143_K0.5210.34
187_Y202_I0.5210.34
20_I358_I0.5210.34
36_M249_M0.5210.34
316_R323_T0.5200.34
96_F253_I0.5190.34
74_F246_N0.5180.34
9_I153_Y0.5170.34
100_L151_N0.5150.34
78_I176_A0.5150.34
275_T280_F0.5150.34
176_A252_F0.5140.34
213_I249_M0.5140.34
81_L171_N0.5140.34
222_L241_V0.5130.34
51_H85_H0.5110.33
32_I305_Y0.5110.33
61_K366_E0.5080.33
40_I295_F0.5080.33
4_Y16_E0.5070.33
359_K365_Y0.5070.33
31_I205_M0.5050.33
35_G38_Y0.5040.33
266_S290_N0.5040.33
100_L271_I0.5040.33
71_D74_F0.5020.33
47_T124_L0.5010.32
137_K327_D0.5010.32
96_F278_Q0.5000.32
74_F165_I0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mz7A 4 0.9857 100 0.273 Contact Map
4lrlA 4 0.931 100 0.318 Contact Map
2hekA 4 0.8643 100 0.351 Contact Map
2q14A 4 0.8643 100 0.362 Contact Map
3bg2A 4 0.631 100 0.744 Contact Map
2pgsA 4 0.6881 100 0.749 Contact Map
2dqbA 4 0.6571 100 0.753 Contact Map
4x9eA 4 0.731 100 0.761 Contact Map
2pq7A 2 0.4048 98.6 0.911 Contact Map
3gw7A 2 0.4857 98.5 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.