GREMLIN Database
Q97XB6 - Second ORF in transposon ISC1904
UniProt: Q97XB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (345)
Sequences: 4412 (2822)
Seq/√Len: 151.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_D267_K5.2831.00
287_N290_S4.3741.00
339_P366_N4.2261.00
319_A326_V3.6171.00
282_A375_M3.0541.00
205_L311_I2.9881.00
312_H328_E2.9361.00
283_V315_L2.8851.00
19_F321_L2.8771.00
310_S314_V2.7661.00
270_N274_D2.7011.00
310_S313_R2.4001.00
333_L336_R2.3741.00
172_P181_L2.3431.00
316_K328_E2.3231.00
311_I315_L2.3171.00
329_V371_I2.2271.00
273_L319_A2.2191.00
225_K301_R2.2111.00
292_F304_S2.1551.00
170_G186_K2.1521.00
281_F319_A2.1251.00
266_H317_Y2.1091.00
54_K119_K2.1011.00
266_H314_V2.0781.00
334_T371_I2.0641.00
283_V326_V2.0571.00
224_L260_R2.0371.00
231_K246_G2.0061.00
353_E360_K2.0031.00
338_C341_C2.0011.00
341_C357_C1.9771.00
374_K377_G1.9571.00
51_N55_I1.9501.00
28_R31_S1.9351.00
345_S348_V1.9321.00
277_P324_S1.9081.00
36_K179_V1.9051.00
350_K363_R1.9041.00
297_D300_S1.8921.00
316_K320_P1.8851.00
345_S349_G1.8791.00
269_V314_V1.8791.00
205_L264_F1.8761.00
49_L96_I1.8721.00
337_S344_V1.8481.00
262_L310_S1.8341.00
341_C354_C1.8271.00
354_C357_C1.7701.00
37_E86_H1.7691.00
265_V314_V1.7581.00
352_F361_L1.7541.00
246_G250_M1.7381.00
266_H318_K1.7321.00
67_L71_K1.7251.00
338_C357_C1.7231.00
50_W99_A1.7021.00
241_K244_K1.6861.00
336_R346_R1.6831.00
266_H269_V1.6701.00
283_V328_E1.6521.00
338_C354_C1.6471.00
340_R359_F1.6461.00
244_K247_R1.6181.00
265_V310_S1.6001.00
35_I179_V1.5931.00
231_K234_K1.5811.00
44_K83_K1.5611.00
198_I206_D1.5301.00
65_I70_K1.5281.00
143_I181_L1.5271.00
195_F372_Y1.5271.00
20_T182_P1.5131.00
33_E37_E1.5091.00
285_K328_E1.5041.00
283_V312_H1.5011.00
346_R349_G1.4991.00
351_T360_K1.4821.00
68_P71_K1.4671.00
176_E255_H1.4541.00
352_F359_F1.4461.00
207_A365_L1.4341.00
343_F355_E1.4261.00
284_E331_P1.4011.00
49_L99_A1.3861.00
109_R117_I1.3821.00
110_A117_I1.3821.00
144_T150_Y1.3791.00
65_I69_K1.3791.00
32_K36_K1.3731.00
39_R179_V1.3711.00
269_V317_Y1.3651.00
235_V247_R1.3531.00
100_F104_T1.3491.00
105_S117_I1.3491.00
316_K326_V1.3421.00
238_F246_G1.3411.00
204_T207_A1.3411.00
369_L373_L1.3381.00
178_K255_H1.3351.00
208_Y212_K1.3231.00
349_G363_R1.3161.00
269_V318_K1.3151.00
255_H259_N1.3041.00
294_D300_S1.3021.00
104_T108_K1.2991.00
303_I308_W1.2831.00
90_H130_K1.2791.00
196_L208_Y1.2631.00
68_P72_E1.2441.00
66_T69_K1.2331.00
24_K178_K1.2081.00
228_M250_M1.2081.00
90_H132_T1.2001.00
228_M254_S1.2001.00
195_F280_F1.1961.00
269_V311_I1.1951.00
231_K253_Y1.1941.00
103_L119_K1.1901.00
42_L95_A1.1871.00
75_K78_R1.1841.00
98_D128_R1.1731.00
232_R236_Q1.1651.00
339_P369_L1.1641.00
101_S105_S1.1601.00
271_T275_L1.1551.00
224_L257_E1.1541.00
339_P361_L1.1501.00
54_K58_R1.1481.00
78_R92_V1.1441.00
273_L322_Y1.1421.00
314_V317_Y1.1391.00
196_L276_Y1.1351.00
94_K97_N1.1241.00
109_R118_E1.1231.00
29_E32_K1.1210.99
269_V315_L1.1200.99
265_V311_I1.1170.99
200_S308_W1.1160.99
27_E31_S1.1150.99
287_N331_P1.1150.99
350_K362_D1.1030.99
337_S374_K1.1010.99
198_I208_Y1.1000.99
262_L314_V1.0950.99
365_L369_L1.0930.99
197_A372_Y1.0900.99
258_R262_L1.0870.99
127_V131_T1.0750.99
202_L306_T1.0680.99
361_L369_L1.0670.99
318_K321_L1.0650.99
270_N322_Y1.0580.99
239_A243_T1.0570.99
57_V61_G1.0510.99
69_K72_E1.0430.99
192_P277_P1.0420.99
200_S312_H1.0380.99
234_K238_F1.0380.99
273_L281_F1.0370.99
212_K271_T1.0370.99
227_S231_K1.0330.99
265_V269_V1.0330.99
274_D322_Y1.0260.99
21_Y185_Y1.0240.99
329_V374_K1.0240.99
195_F376_C1.0230.99
273_L324_S1.0220.99
334_T374_K1.0160.99
313_R316_K1.0130.99
55_I59_K1.0130.99
145_V174_I1.0130.99
105_S109_R1.0070.99
345_S352_F1.0040.99
46_I95_A1.0030.99
339_P359_F1.0010.99
204_T215_T1.0010.99
348_V363_R0.9980.99
329_V375_M0.9970.99
231_K249_L0.9930.99
127_V130_K0.9920.99
207_A213_F0.9920.99
88_A91_Y0.9900.99
231_K250_M0.9860.99
105_S110_A0.9820.99
285_K331_P0.9790.99
294_D298_S0.9780.99
288_K309_R0.9720.99
76_P80_E0.9700.99
235_V250_M0.9680.99
32_K179_V0.9630.98
54_K103_L0.9620.98
336_R348_V0.9610.98
213_F362_D0.9610.98
361_L365_L0.9600.98
343_F352_F0.9590.98
106_W120_P0.9530.98
70_K73_V0.9510.98
243_T247_R0.9510.98
66_T70_K0.9490.98
196_L209_D0.9480.98
232_R250_M0.9480.98
52_L73_V0.9460.98
135_K144_T0.9440.98
72_E75_K0.9410.98
67_L97_N0.9410.98
27_E35_I0.9320.98
40_T43_Q0.9310.98
46_I102_I0.9290.98
50_W103_L0.9270.98
133_L146_R0.9270.98
352_F363_R0.9260.98
282_A371_I0.9200.98
65_I74_Y0.9170.98
106_W119_K0.9160.98
280_F325_F0.9140.98
142_R150_Y0.9130.98
155_W158_S0.9100.98
90_H94_K0.9050.98
249_L252_K0.9030.98
46_I99_A0.8980.98
56_Q60_N0.8960.98
135_K138_G0.8920.97
229_E233_A0.8890.97
294_D297_D0.8880.97
44_K48_H0.8870.97
74_Y78_R0.8860.97
18_Y184_R0.8850.97
217_S306_T0.8850.97
90_H131_T0.8820.97
105_S108_K0.8780.97
351_T361_L0.8770.97
94_K128_R0.8680.97
333_L374_K0.8670.97
365_L368_S0.8610.97
133_L136_V0.8600.97
195_F282_A0.8600.97
272_L281_F0.8590.97
343_F356_R0.8570.97
288_K308_W0.8560.97
84_I92_V0.8540.97
339_P367_A0.8490.97
345_S355_E0.8460.97
265_V307_V0.8420.96
367_A370_N0.8420.96
202_L302_K0.8370.96
256_R260_R0.8360.96
366_N370_N0.8360.96
65_I68_P0.8350.96
41_L83_K0.8350.96
331_P334_T0.8340.96
206_D268_F0.8310.96
319_A324_S0.8300.96
340_R369_L0.8290.96
200_S206_D0.8280.96
128_R171_E0.8230.96
98_D173_I0.8200.96
143_I172_P0.8190.96
292_F300_S0.8170.96
280_F327_K0.8170.96
253_Y257_E0.8160.96
93_D97_N0.8140.96
240_S243_T0.8130.96
48_H52_L0.8110.96
220_Q260_R0.8070.95
53_T100_F0.8070.95
290_S303_I0.8060.95
71_K96_I0.8040.95
285_K312_H0.8030.95
369_L372_Y0.8020.95
220_Q224_L0.7980.95
290_S331_P0.7970.95
232_R254_S0.7960.95
18_Y186_K0.7960.95
228_M257_E0.7880.95
57_V103_L0.7860.95
247_R251_R0.7860.95
71_K75_K0.7820.95
53_T103_L0.7810.95
229_E232_R0.7800.95
52_L56_Q0.7800.95
299_L303_I0.7780.94
137_V140_S0.7760.94
94_K98_D0.7730.94
270_N318_K0.7710.94
204_T213_F0.7690.94
173_I182_P0.7660.94
153_F156_S0.7650.94
23_I181_L0.7640.94
203_Y207_A0.7610.94
70_K74_Y0.7610.94
272_L276_Y0.7570.94
257_E305_R0.7560.94
281_F315_L0.7470.93
228_M236_Q0.7470.93
96_I100_F0.7470.93
196_L281_F0.7440.93
199_D364_Q0.7430.93
235_V246_G0.7380.93
102_I120_P0.7380.93
374_K378_F0.7360.93
35_I39_R0.7350.93
25_N181_L0.7350.93
333_L337_S0.7330.93
174_I181_L0.7320.92
41_L87_L0.7300.92
194_N210_G0.7290.92
346_R352_F0.7260.92
228_M232_R0.7260.92
229_E236_Q0.7260.92
48_H77_L0.7240.92
309_R313_R0.7240.92
129_I145_V0.7230.92
268_F271_T0.7220.92
38_Y42_L0.7200.92
264_F268_F0.7190.92
286_L331_P0.7170.92
148_Y151_I0.7160.92
34_L38_Y0.7150.92
94_K130_K0.7140.92
336_R344_V0.7130.91
87_L90_H0.7100.91
224_L256_R0.7100.91
45_A95_A0.7100.91
337_S370_N0.7080.91
24_K180_Y0.7080.91
29_E33_E0.7060.91
339_P373_L0.7060.91
191_T194_N0.7030.91
282_A372_Y0.7030.91
217_S220_Q0.7030.91
103_L107_R0.6990.91
58_R61_G0.6990.91
67_L72_E0.6980.91
99_A103_L0.6950.90
67_L70_K0.6930.90
214_V264_F0.6920.90
40_T44_K0.6910.90
282_A327_K0.6900.90
41_L44_K0.6900.90
171_E184_R0.6900.90
168_E186_K0.6860.90
201_N207_A0.6860.90
327_K375_M0.6850.90
134_R169_L0.6840.90
53_T70_K0.6840.90
205_L306_T0.6830.90
65_I73_V0.6820.90
90_H93_D0.6820.90
315_L326_V0.6810.90
128_R173_I0.6790.89
213_F365_L0.6730.89
132_T135_K0.6710.89
37_E41_L0.6680.89
189_W324_S0.6680.89
203_Y350_K0.6680.89
235_V243_T0.6660.88
75_K79_E0.6610.88
206_D311_I0.6610.88
274_D280_F0.6610.88
126_Y130_K0.6590.88
205_L269_V0.6560.88
234_K246_G0.6560.88
345_S363_R0.6540.88
103_L106_W0.6540.88
69_K74_Y0.6520.87
361_L366_N0.6510.87
22_S182_P0.6510.87
67_L96_I0.6510.87
23_I157_K0.6450.87
137_V144_T0.6450.87
344_V347_K0.6450.87
142_R145_V0.6390.86
294_D303_I0.6390.86
52_L55_I0.6390.86
130_K133_L0.6380.86
236_Q250_M0.6350.86
231_K235_V0.6340.86
145_V148_Y0.6330.86
90_H133_L0.6330.86
74_Y77_L0.6320.86
233_A237_S0.6320.86
189_W192_P0.6320.86
178_K259_N0.6300.86
157_K160_F0.6300.86
355_E363_R0.6290.85
221_L224_L0.6290.85
38_Y88_A0.6280.85
89_S130_K0.6280.85
17_V186_K0.6270.85
224_L228_M0.6260.85
95_A99_A0.6240.85
128_R131_T0.6240.85
30_K33_E0.6220.85
74_Y93_D0.6210.85
96_I99_A0.6210.85
73_V76_P0.6200.85
175_K178_K0.6170.84
276_Y281_F0.6160.84
20_T184_R0.6160.84
202_L293_K0.6160.84
51_N122_V0.6130.84
75_K96_I0.6120.84
261_V305_R0.6120.84
340_R361_L0.6120.84
319_A322_Y0.6100.84
44_K81_L0.6090.84
224_L253_Y0.6090.84
27_E32_K0.6060.83
262_L266_H0.6030.83
60_N63_Y0.6010.83
18_Y170_G0.6010.83
153_F157_K0.5990.83
34_L37_E0.5990.83
233_A236_Q0.5980.83
371_I374_K0.5970.82
106_W109_R0.5960.82
145_V151_I0.5960.82
230_V234_K0.5960.82
234_K237_S0.5950.82
51_N54_K0.5950.82
26_S154_S0.5940.82
288_K303_I0.5920.82
314_V318_K0.5890.82
208_Y214_V0.5880.81
194_N276_Y0.5880.81
134_R138_G0.5870.81
317_Y321_L0.5870.81
38_Y129_I0.5870.81
69_K73_V0.5860.81
234_K249_L0.5840.81
243_T250_M0.5830.81
297_D304_S0.5830.81
244_K248_E0.5830.81
89_S132_T0.5830.81
333_L352_F0.5810.81
38_Y87_L0.5790.80
126_Y129_I0.5770.80
288_K291_M0.5720.80
254_S261_V0.5710.80
52_L77_L0.5700.79
92_V95_A0.5690.79
91_Y127_V0.5690.79
330_N333_L0.5670.79
70_K93_D0.5660.79
89_S133_L0.5650.79
39_R127_V0.5650.79
57_V106_W0.5640.79
222_Y225_K0.5640.79
156_S159_W0.5630.79
312_H316_K0.5620.78
200_S283_V0.5620.78
75_K80_E0.5610.78
108_K117_I0.5600.78
282_A374_K0.5600.78
22_S262_L0.5590.78
337_S352_F0.5580.78
227_S253_Y0.5540.78
207_A215_T0.5530.77
127_V133_L0.5520.77
243_T246_G0.5510.77
49_L77_L0.5500.77
199_D335_S0.5490.77
48_H83_K0.5480.77
268_F311_I0.5480.77
87_L92_V0.5480.77
332_Y336_R0.5460.76
238_F242_H0.5460.76
254_S258_R0.5450.76
209_D365_L0.5440.76
265_V268_F0.5430.76
235_V238_F0.5420.76
242_H245_R0.5420.76
299_L302_K0.5410.76
240_S244_K0.5410.76
205_L265_V0.5390.76
95_A98_D0.5380.75
27_E151_I0.5350.75
373_L378_F0.5330.75
56_Q61_G0.5320.75
289_E309_R0.5320.75
222_Y302_K0.5300.74
229_E297_D0.5300.74
53_T56_Q0.5300.74
267_K270_N0.5280.74
280_F375_M0.5260.74
25_N153_F0.5250.74
160_F166_E0.5250.74
122_V125_A0.5220.73
42_L127_V0.5220.73
21_Y157_K0.5200.73
257_E261_V0.5190.73
134_R140_S0.5190.73
66_T72_E0.5180.73
68_P74_Y0.5170.73
130_K134_R0.5160.72
57_V107_R0.5160.72
74_Y96_I0.5140.72
222_Y301_R0.5130.72
107_R110_A0.5120.72
46_I50_W0.5110.72
259_N263_D0.5100.72
353_E361_L0.5100.72
180_Y255_H0.5090.71
41_L92_V0.5090.71
371_I376_C0.5080.71
229_E301_R0.5080.71
290_S294_D0.5070.71
155_W159_W0.5070.71
270_N314_V0.5060.71
362_D367_A0.5050.71
202_L292_F0.5040.71
30_K34_L0.5030.71
37_E87_L0.5030.71
41_L84_I0.5020.70
88_A146_R0.5010.70
348_V362_D0.5000.70
214_V271_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3103 93.4 0.938 Contact Map
1vhxA 2 0.327 91.7 0.941 Contact Map
1iv0A 1 0.2315 88.8 0.945 Contact Map
3j20Y 1 0.1146 86.7 0.947 Contact Map
4aybP 1 0.0955 86.6 0.947 Contact Map
2k4xA 1 0.1265 85.9 0.947 Contact Map
1qypA 1 0.1026 85.1 0.948 Contact Map
3j3w0 1 0.1265 76 0.952 Contact Map
1ffkW 1 0.1671 75.8 0.953 Contact Map
1vd4A 1 0.1265 69.8 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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