GREMLIN Database
Q97XB5 - First ORF in transposon ISC1904
UniProt: Q97XB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (183)
Sequences: 482 (339)
Seq/√Len: 25.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_V117_R4.0811.00
60_A78_L4.0531.00
82_V119_V3.5801.00
117_R144_E3.3131.00
58_L148_I2.6700.99
7_A11_L2.6650.99
103_F126_L2.6320.99
110_I138_C2.5570.99
91_D102_G2.3980.98
17_T21_Y2.3720.98
13_I21_Y2.3010.98
5_K9_Q2.2490.97
135_E139_K2.2450.97
85_Y146_V2.1780.97
18_L39_F2.1720.97
106_L115_V2.1250.96
16_A19_R2.0770.96
96_L129_F1.9390.94
22_V37_W1.9280.94
55_K109_M1.9150.94
98_M132_E1.8870.93
111_L141_H1.8740.93
2_L7_A1.8580.93
75_V88_V1.8490.92
3_R34_S1.7560.90
77_Y121_A1.7500.90
131_F145_I1.7470.90
119_V132_E1.7440.90
75_V90_T1.7330.90
138_C143_C1.6960.89
87_Q109_M1.6940.89
58_L78_L1.6910.88
110_I115_V1.6790.88
58_L88_V1.6400.87
22_V29_P1.6200.86
109_M114_E1.5590.84
110_I118_V1.5580.84
89_I102_G1.5540.84
166_V177_S1.5230.82
131_F147_V1.5010.82
72_V76_K1.4930.81
4_P19_R1.4700.80
12_G142_G1.4570.80
127_V131_F1.4430.79
98_M167_S1.4390.79
57_I75_V1.3930.76
155_E159_E1.3820.76
167_S170_G1.3680.75
96_L130_G1.3430.74
40_R43_D1.3430.74
26_Y33_Q1.3400.73
31_I37_W1.3290.73
4_P18_L1.3260.73
16_A24_K1.3250.73
138_C172_L1.3190.72
110_I120_V1.3080.72
7_A27_I1.3050.71
17_T20_E1.2840.70
122_Y159_E1.2820.70
166_V170_G1.2620.69
56_V144_E1.2620.69
27_I30_V1.2540.68
8_C13_I1.2440.68
70_D73_N1.2270.67
7_A44_V1.2110.66
8_C15_Y1.2110.66
89_I118_V1.2070.65
119_V146_V1.2030.65
121_A178_H1.1690.63
170_G175_M1.1650.62
64_S67_Q1.1610.62
58_L82_V1.1570.62
20_E23_K1.1470.61
91_D167_S1.1450.61
22_V27_I1.1410.61
22_V39_F1.1370.61
14_S20_E1.1310.60
15_Y19_R1.1310.60
62_V67_Q1.1110.59
159_E170_G1.0830.57
95_K126_L1.0790.56
131_F134_L1.0620.55
62_V71_L1.0340.53
170_G177_S1.0330.53
43_D46_R1.0310.53
85_Y148_I1.0270.53
67_Q70_D1.0200.52
78_L148_I1.0150.52
164_I174_G1.0140.52
27_I134_L1.0100.51
26_Y34_S1.0070.51
91_D121_A1.0040.51
89_I106_L1.0020.51
4_P29_P0.9970.51
117_R146_V0.9940.50
3_R38_R0.9900.50
173_Y176_R0.9880.50
2_L38_R0.9870.50
76_K79_E0.9850.50
57_I89_I0.9800.49
22_V31_I0.9650.48
13_I20_E0.9460.47
98_M127_V0.9400.46
56_V119_V0.9310.46
155_E158_V0.9220.45
11_L18_L0.9190.45
28_K43_D0.9180.45
8_C18_L0.9180.45
75_V107_L0.9110.44
161_L165_L0.9100.44
72_V75_V0.9060.44
138_C169_S0.9050.44
7_A18_L0.9030.44
157_L166_V0.9000.44
56_V93_G0.8930.43
14_S172_L0.8890.43
85_Y121_A0.8880.43
127_V134_L0.8850.42
77_Y149_N0.8820.42
95_K103_F0.8770.42
166_V178_H0.8760.42
19_R39_F0.8660.41
18_L22_V0.8600.41
3_R33_Q0.8560.40
4_P15_Y0.8550.40
108_R140_A0.8460.40
8_C171_K0.8420.39
156_E168_F0.8400.39
2_L11_L0.8390.39
19_R22_V0.8280.38
54_R142_G0.8260.38
158_V161_L0.8230.38
181_E185_K0.8130.37
148_I154_E0.8110.37
42_E73_N0.8100.37
153_K175_M0.8050.37
177_S183_V0.8030.37
129_F160_D0.8020.37
63_S67_Q0.8010.37
171_K175_M0.8000.37
110_I143_C0.7960.36
19_R31_I0.7910.36
30_V38_R0.7900.36
82_V85_Y0.7880.36
134_L138_C0.7870.36
78_L143_C0.7860.36
55_K87_Q0.7740.35
5_K34_S0.7730.35
93_G163_S0.7710.35
84_E119_V0.7680.34
100_R127_V0.7670.34
81_Q85_Y0.7630.34
39_F43_D0.7630.34
7_A38_R0.7600.34
68_K179_K0.7570.34
160_D174_G0.7540.34
70_D121_A0.7430.33
44_V118_V0.7350.32
81_Q146_V0.7320.32
48_M108_R0.7300.32
157_L160_D0.7250.32
19_R36_K0.7240.32
13_I31_I0.7230.32
76_K80_E0.7210.31
103_F127_V0.7180.31
130_G146_V0.7150.31
92_I100_R0.7030.30
4_P7_A0.7030.30
118_V145_I0.6950.30
19_R37_W0.6860.29
67_Q73_N0.6850.29
96_L133_I0.6840.29
97_N128_R0.6810.29
56_V87_Q0.6790.29
97_N141_H0.6710.28
27_I43_D0.6700.28
64_S73_N0.6670.28
41_E49_G0.6660.28
99_K171_K0.6650.28
54_R143_C0.6640.28
161_L174_G0.6640.28
22_V32_L0.6600.28
81_Q149_N0.6600.28
63_S128_R0.6580.28
147_V165_L0.6540.27
120_V147_V0.6530.27
139_K171_K0.6510.27
73_N162_V0.6470.27
92_I145_I0.6460.27
119_V134_L0.6390.27
161_L164_I0.6380.26
56_V116_S0.6370.26
107_L146_V0.6360.26
51_I147_V0.6320.26
137_V140_A0.6310.26
3_R36_K0.6300.26
14_S22_V0.6250.26
30_V43_D0.6250.26
64_S174_G0.6250.26
121_A166_V0.6230.26
9_Q68_K0.6170.25
12_G129_F0.6160.25
33_Q113_N0.6160.25
15_Y37_W0.6150.25
119_V136_E0.6130.25
6_E43_D0.6120.25
160_D164_I0.6050.25
110_I147_V0.6020.24
85_Y117_R0.6010.24
6_E157_L0.5940.24
107_L111_L0.5940.24
129_F174_G0.5900.24
73_N76_K0.5890.24
157_L168_F0.5880.24
99_K141_H0.5870.24
93_G144_E0.5870.24
77_Y91_D0.5830.23
77_Y163_S0.5820.23
79_E88_V0.5800.23
135_E152_D0.5790.23
103_F167_S0.5760.23
118_V147_V0.5730.23
77_Y178_H0.5700.23
161_L168_F0.5700.23
129_F164_I0.5690.23
54_R112_N0.5660.23
177_S180_Y0.5630.22
57_I150_Q0.5610.22
34_S113_N0.5610.22
98_M118_V0.5570.22
149_N153_K0.5560.22
6_E146_V0.5540.22
170_G178_H0.5530.22
22_V34_S0.5530.22
93_G97_N0.5490.22
110_I145_I0.5490.22
57_I106_L0.5490.22
23_K101_K0.5480.22
120_V145_I0.5470.22
128_R173_Y0.5460.22
8_C12_G0.5450.22
135_E145_I0.5450.22
91_D98_M0.5450.22
39_F167_S0.5430.21
169_S175_M0.5410.21
13_I16_A0.5370.21
8_C103_F0.5350.21
55_K116_S0.5350.21
145_I148_I0.5340.21
45_E48_M0.5280.21
81_Q148_I0.5270.21
97_N106_L0.5260.21
106_L138_C0.5250.21
130_G169_S0.5240.21
63_S129_F0.5230.20
10_R90_T0.5230.20
126_L133_I0.5230.20
103_F116_S0.5210.20
2_L22_V0.5200.20
118_V183_V0.5190.20
6_E10_R0.5190.20
48_M51_I0.5190.20
2_L13_I0.5190.20
6_E57_I0.5150.20
16_A26_Y0.5130.20
118_V126_L0.5080.20
165_L169_S0.5060.20
48_M114_E0.5040.20
107_L118_V0.5020.20
53_K57_I0.5020.20
91_D145_I0.5010.19
170_G174_G0.5010.19
5_K25_G0.5000.19
5_K19_R0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ilxA 2 0.7188 100 0.651 Contact Map
3lhkA 2 0.7292 100 0.654 Contact Map
3g13A 2 0.7292 99.8 0.733 Contact Map
3bvpA 4 0.6458 99.8 0.741 Contact Map
4bqqA 2 0.6979 99.8 0.743 Contact Map
2mhcA 1 0.5625 99.8 0.743 Contact Map
3guvA 2 0.7031 99.8 0.744 Contact Map
2gm5A 4 0.6302 99.8 0.754 Contact Map
1gdtA 2 0.6875 99.7 0.759 Contact Map
3pkzA 4 0.5833 99.7 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.