GREMLIN Database
Q97XB1 - Uncharacterized protein
UniProt: Q97XB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 130 (117)
Sequences: 461 (426)
Seq/√Len: 39.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_E116_R6.1031.00
13_E123_K4.9261.00
15_N41_K3.3591.00
105_K109_T2.8391.00
58_S82_D2.8351.00
42_S119_L2.6101.00
18_S22_N2.5101.00
22_N34_E2.3361.00
30_E34_E2.2491.00
84_N103_Y2.2391.00
11_Q29_E2.2280.99
77_C114_C2.2170.99
43_V59_I2.1050.99
68_I71_P1.9070.98
59_I78_A1.7970.98
63_L78_A1.7710.97
113_E116_R1.6760.96
21_L27_I1.6440.96
15_N34_E1.6150.95
21_L25_N1.6110.95
17_K27_I1.5910.95
39_A81_L1.5540.94
46_L71_P1.5520.94
9_L42_S1.5130.94
11_Q103_Y1.5130.94
71_P121_W1.4700.93
13_E119_L1.4560.92
112_L116_R1.4410.92
84_N111_C1.4400.92
14_R29_E1.4330.92
83_K107_D1.4230.91
28_Y108_A1.3910.90
35_A115_A1.3410.89
38_V112_L1.2740.86
31_T126_V1.2120.83
18_S34_E1.1740.81
12_A76_K1.1550.80
18_S27_I1.1470.79
18_S30_E1.1470.79
15_N22_N1.1410.79
59_I82_D1.1350.78
19_A35_A1.1320.78
35_A113_E1.1270.78
12_A42_S1.1010.76
82_D85_Y1.0970.76
104_S107_D1.0960.76
80_E110_S1.0710.74
23_F108_A1.0700.74
22_N30_E1.0630.74
81_L115_A1.0630.74
32_C111_C1.0400.72
41_K91_P1.0180.70
23_F112_L0.9570.66
46_L67_S0.9480.65
82_D87_P0.9440.65
84_N88_S0.9210.63
9_L45_S0.9190.62
47_L107_D0.9100.62
20_E112_L0.9070.61
113_E117_K0.9020.61
7_D34_E0.9000.61
11_Q99_P0.8970.61
116_R120_A0.8970.61
77_C117_K0.8930.60
10_R101_D0.8920.60
37_Q81_L0.8920.60
14_R22_N0.8890.60
36_Q108_A0.8830.59
11_Q100_L0.8780.59
33_Y85_Y0.8700.58
74_I118_I0.8670.58
120_A124_E0.8550.57
5_Y12_A0.8530.57
41_K55_R0.8400.56
23_F32_C0.8330.55
109_T113_E0.8320.55
16_L115_A0.8310.55
36_Q84_N0.8220.54
22_N41_K0.8090.53
107_D111_C0.8000.52
7_D48_S0.7910.51
19_A112_L0.7900.51
73_W117_K0.7890.51
47_L62_L0.7890.51
16_L20_E0.7780.50
14_R102_Y0.7760.50
51_H82_D0.7750.50
38_V119_L0.7740.50
31_T108_A0.7710.49
10_R70_I0.7690.49
44_K57_H0.7510.47
33_Y89_R0.7480.47
87_P92_D0.7420.47
107_D114_C0.7390.46
32_C107_D0.7300.46
15_N18_S0.7250.45
14_R30_E0.7220.45
16_L51_H0.7200.45
103_Y111_C0.7130.44
83_K104_S0.7130.44
46_L68_I0.7110.44
80_E111_C0.7080.44
70_I121_W0.7070.43
47_L52_K0.7050.43
63_L87_P0.7030.43
39_A118_I0.6990.43
28_Y33_Y0.6990.43
23_F105_K0.6980.43
16_L118_I0.6980.43
7_D56_G0.6950.42
8_W90_Y0.6940.42
63_L71_P0.6890.42
27_I33_Y0.6840.41
112_L119_L0.6830.41
46_L125_I0.6790.41
34_E41_K0.6760.41
11_Q54_M0.6740.41
5_Y45_S0.6690.40
85_Y88_S0.6690.40
12_A38_V0.6660.40
67_S72_D0.6580.39
46_L122_V0.6550.39
33_Y39_A0.6430.38
15_N126_V0.6310.37
119_L123_K0.6300.37
17_K20_E0.6300.37
47_L65_F0.6160.36
110_S113_E0.6140.35
56_G87_P0.6120.35
12_A91_P0.6090.35
41_K99_P0.6070.35
27_I34_E0.6060.35
64_Q70_I0.6040.35
78_A82_D0.6030.34
5_Y49_Y0.6020.34
50_F67_S0.6010.34
85_Y93_V0.5890.33
51_H115_A0.5870.33
46_L50_F0.5740.32
32_C88_S0.5700.32
30_E92_D0.5680.32
106_D118_I0.5680.32
20_E24_E0.5670.32
67_S71_P0.5660.32
11_Q30_E0.5660.32
35_A108_A0.5620.31
63_L74_I0.5590.31
25_N64_Q0.5590.31
33_Y86_I0.5580.31
43_V56_G0.5580.31
82_D86_I0.5570.31
5_Y126_V0.5480.30
49_Y65_F0.5480.30
100_L104_S0.5460.30
72_D106_D0.5450.30
77_C80_E0.5430.30
77_C110_S0.5410.30
22_N62_L0.5360.29
39_A78_A0.5310.29
71_P74_I0.5290.29
24_E68_I0.5280.29
37_Q99_P0.5250.28
39_A69_S0.5230.28
52_K65_F0.5190.28
79_Q103_Y0.5190.28
50_F88_S0.5190.28
73_W118_I0.5170.28
43_V60_T0.5150.28
37_Q115_A0.5120.27
99_P115_A0.5060.27
69_S74_I0.5060.27
37_Q85_Y0.5040.27
27_I30_E0.5020.27
36_Q85_Y0.5010.27
11_Q101_D0.5010.27
28_Y58_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ufbA 3 0.9615 100 0.274 Contact Map
3o10A 2 0.9846 100 0.289 Contact Map
1wolA 1 0.9385 100 0.291 Contact Map
1o3uA 2 0.9077 100 0.338 Contact Map
4nqfA 2 0.9462 100 0.38 Contact Map
2hsbA 2 0.9308 99.9 0.422 Contact Map
2jpuA 1 0.8846 89.5 0.88 Contact Map
3mfnA 2 0.9 32.1 0.923 Contact Map
4uqxA 1 0.7769 31.1 0.924 Contact Map
1knyA 2 0.8385 21.7 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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