GREMLIN Database
Q97XA7 - Coenzyme PQQ synthesis protein E (PqqE-4)
UniProt: Q97XA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (309)
Sequences: 8028 (6173)
Seq/√Len: 351.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_D160_N4.0181.00
48_L119_T3.9941.00
71_L104_Y3.3831.00
127_K172_V3.3391.00
167_G200_L3.2381.00
69_E313_R3.0571.00
123_E168_N3.0131.00
75_D104_Y2.9381.00
150_D157_G2.8751.00
66_T69_E2.7571.00
297_D311_N2.7431.00
159_F196_L2.5311.00
47_N117_N2.4681.00
72_G76_E2.3641.00
297_D308_K2.3641.00
67_T100_E2.3481.00
75_D108_K2.2891.00
99_F128_R2.2821.00
144_Y148_F2.1641.00
148_F189_Q2.1511.00
38_V77_M2.1371.00
168_N171_N2.0901.00
316_P319_E2.0731.00
144_Y189_Q2.0311.00
118_G139_I2.0151.00
283_G301_C1.9941.00
127_K131_E1.9791.00
45_K64_G1.9671.00
189_Q192_E1.9671.00
104_Y107_S1.9601.00
191_D235_K1.8851.00
142_D153_R1.8841.00
70_A101_L1.8821.00
71_L100_E1.8531.00
178_L197_A1.8161.00
301_C353_D1.8151.00
128_R132_L1.8051.00
139_I166_I1.7951.00
96_R99_F1.7871.00
184_A228_E1.7861.00
104_Y108_K1.7681.00
123_E171_N1.7261.00
47_N120_L1.7181.00
315_K319_E1.7121.00
103_S107_S1.7111.00
311_N314_E1.7101.00
69_E72_G1.6891.00
74_I105_A1.6861.00
106_R135_S1.6821.00
67_T71_L1.6761.00
293_Y297_D1.6581.00
180_F193_Y1.6441.00
167_G171_N1.6341.00
195_K239_Y1.6311.00
67_T97_D1.6091.00
167_G170_I1.6061.00
161_M164_K1.6011.00
93_L114_L1.5971.00
164_K167_G1.5921.00
151_K185_K1.5911.00
225_T228_E1.5711.00
100_E103_S1.5701.00
122_S125_V1.5661.00
159_F163_V1.5651.00
99_F125_V1.5621.00
123_E172_V1.5611.00
126_A168_N1.5581.00
103_S128_R1.5571.00
130_K172_V1.5521.00
160_N164_K1.5421.00
192_E195_K1.5251.00
71_L75_D1.5021.00
164_K168_N1.4811.00
293_Y299_Y1.4781.00
196_L200_L1.4751.00
195_K199_K1.4741.00
231_S235_K1.4601.00
76_E316_P1.4581.00
64_G95_R1.4531.00
52_H142_D1.4501.00
139_I165_G1.4431.00
145_D150_D1.4281.00
149_H158_A1.4261.00
93_L120_L1.4151.00
51_L151_K1.4141.00
65_L69_E1.4131.00
318_K322_K1.4101.00
168_N172_V1.4061.00
87_M112_L1.4031.00
163_V200_L1.3981.00
87_M105_A1.3791.00
102_A134_F1.3591.00
231_S234_N1.3561.00
180_F205_I1.3541.00
162_T165_G1.3511.00
170_I201_G1.3501.00
143_S148_F1.3331.00
126_A165_G1.3301.00
128_R131_E1.3261.00
97_D100_E1.3251.00
178_L202_V1.3091.00
105_A112_L1.2871.00
298_V320_I1.2861.00
145_D189_Q1.2851.00
115_S138_G1.2731.00
78_A108_K1.2611.00
103_S132_L1.2521.00
163_V196_L1.2521.00
137_V169_A1.2461.00
106_R132_L1.2381.00
42_L87_M1.2291.00
85_I105_A1.2221.00
106_R112_L1.2191.00
319_E323_N1.2191.00
121_I126_A1.2081.00
125_V129_L1.1941.00
95_R101_L1.1911.00
227_E231_S1.1861.00
40_W70_A1.1731.00
130_K173_G1.1621.00
102_A132_L1.1321.00
163_V167_G1.1291.00
152_F183_T1.1291.00
239_Y242_K1.1281.00
230_V234_N1.1151.00
101_L105_A1.1111.00
44_R294_P1.1051.00
124_S127_K1.1021.00
234_N238_D1.0971.00
125_V128_R1.0931.00
250_E253_L1.0871.00
150_D158_A1.0851.00
324_I327_L1.0821.00
72_G313_R1.0781.00
65_L70_A1.0741.00
249_I253_L1.0651.00
239_Y243_L1.0651.00
84_L111_K1.0601.00
123_E127_K1.0581.00
100_E104_Y1.0531.00
63_D295_N1.0461.00
138_G179_R1.0361.00
77_M85_I1.0291.00
144_Y192_E1.0261.00
78_A110_I1.0261.00
228_E231_S1.0251.00
93_L165_G1.0221.00
126_A172_V1.0181.00
161_M165_G1.0111.00
72_G75_D1.0091.00
38_V290_I1.0081.00
36_P83_P1.0051.00
299_Y308_K1.0041.00
73_L292_I1.0001.00
47_N91_E0.9991.00
236_M240_A0.9961.00
338_R341_D0.9961.00
48_L158_A0.9961.00
308_K311_N0.9941.00
141_L178_L0.9851.00
51_L152_F0.9831.00
317_L321_I0.9811.00
43_T64_G0.9751.00
147_E151_K0.9741.00
149_H157_G0.9731.00
137_V174_L0.9721.00
54_Y88_S0.9701.00
235_K239_Y0.9691.00
126_A130_K0.9691.00
75_D79_E0.9661.00
149_H162_T0.9631.00
121_I165_G0.9621.00
139_I169_A0.9621.00
93_L125_V0.9591.00
198_L243_L0.9591.00
76_E80_M0.9581.00
283_G353_D0.9511.00
76_E318_K0.9491.00
74_I108_K0.9481.00
144_Y196_L0.9471.00
327_L331_T0.9461.00
143_S159_F0.9401.00
165_G168_N0.9401.00
84_L113_A0.9401.00
114_L129_L0.9391.00
191_D195_K0.9351.00
197_A202_V0.9341.00
140_S181_T0.9251.00
47_N119_T0.9191.00
52_H152_F0.9181.00
149_H159_F0.9171.00
195_K198_L0.9161.00
254_G257_D0.9071.00
310_G320_I0.9051.00
354_R357_A0.8931.00
166_I176_V0.8891.00
254_G258_G0.8831.00
255_Q259_V0.8821.00
248_E251_T0.8811.00
226_L230_V0.8801.00
148_F151_K0.8791.00
324_I328_F0.8791.00
191_D239_Y0.8731.00
170_I176_V0.8721.00
143_S153_R0.8681.00
122_S164_K0.8671.00
250_E254_G0.8651.00
95_R98_F0.8651.00
178_L205_I0.8591.00
114_L137_V0.8581.00
310_G315_K0.8551.00
150_D153_R0.8531.00
169_A174_L0.8531.00
304_I355_A0.8521.00
124_S128_R0.8491.00
315_K320_I0.8481.00
290_I321_I0.8381.00
170_I200_L0.8351.00
252_T255_Q0.8321.00
251_T254_G0.8281.00
145_D159_F0.8181.00
65_L73_L0.8161.00
194_M198_L0.8161.00
98_F102_A0.8161.00
111_K135_S0.8121.00
40_W73_L0.8121.00
193_Y197_A0.8111.00
188_H228_E0.8071.00
130_K174_L0.8041.00
166_I202_V0.8011.00
121_I169_A0.8001.00
196_L199_K0.8001.00
290_I317_L0.7981.00
42_L95_R0.7951.00
280_E283_G0.7921.00
93_L98_F0.7901.00
166_I178_L0.7891.00
190_V235_K0.7881.00
67_T104_Y0.7851.00
67_T101_L0.7741.00
169_A176_V0.7721.00
313_R316_P0.7721.00
38_V292_I0.7691.00
74_I110_I0.7661.00
298_V317_L0.7641.00
149_H153_R0.7641.00
47_N94_M0.7621.00
41_N88_S0.7611.00
257_D260_Y0.7611.00
127_K130_K0.7571.00
338_R342_K0.7571.00
143_S189_Q0.7551.00
233_I237_I0.7551.00
315_K323_N0.7471.00
249_I254_G0.7451.00
175_N203_K0.7441.00
170_I203_K0.7431.00
141_L159_F0.7411.00
102_A105_A0.7391.00
238_D242_K0.7381.00
183_T186_N0.7371.00
101_L104_Y0.7371.00
141_L163_V0.7361.00
305_D308_K0.7361.00
252_T257_D0.7351.00
43_T95_R0.7341.00
326_D330_N0.7331.00
85_I112_L0.7321.00
210_L216_G0.7310.99
160_N163_V0.7290.99
233_I236_M0.7290.99
119_T165_G0.7260.99
248_E253_L0.7260.99
105_A108_K0.7250.99
41_N291_S0.7240.99
115_S302_Q0.7230.99
327_L330_N0.7220.99
279_V285_C0.7220.99
76_E79_E0.7220.99
42_L98_F0.7140.99
197_A205_I0.7140.99
340_C349_C0.7110.99
195_K236_M0.7090.99
253_L256_F0.7080.99
126_A169_A0.7060.99
86_I113_A0.7050.99
102_A128_R0.7050.99
42_L101_L0.7040.99
70_A95_R0.7040.99
91_E94_M0.7040.99
74_I85_I0.7020.99
180_F197_A0.7010.99
112_L134_F0.6990.99
87_M102_A0.6950.99
88_S302_Q0.6950.99
71_L107_S0.6950.99
255_Q258_G0.6890.99
250_E255_Q0.6880.99
71_L108_K0.6870.99
102_A112_L0.6860.99
237_I241_I0.6850.99
67_T95_R0.6840.99
143_S149_H0.6840.99
41_N294_P0.6830.99
237_I240_A0.6820.99
229_Y233_I0.6820.99
139_I162_T0.6790.99
319_E322_K0.6790.99
279_V282_S0.6750.99
253_L257_D0.6750.99
325_P329_I0.6720.99
148_F188_H0.6680.99
106_R133_D0.6680.99
93_L129_L0.6670.99
144_Y147_E0.6670.99
208_Y211_S0.6670.99
68_E71_L0.6660.99
328_F331_T0.6650.99
70_A73_L0.6650.99
216_G219_L0.6640.99
184_A225_T0.6630.99
253_L258_G0.6630.99
247_I251_T0.6630.99
165_G169_A0.6610.99
352_G357_A0.6610.99
323_N326_D0.6600.99
122_S165_G0.6590.99
121_I139_I0.6560.99
91_E117_N0.6550.99
256_F259_V0.6530.99
95_R100_E0.6510.99
170_I202_V0.6490.99
238_D241_I0.6470.99
52_H153_R0.6470.99
69_E73_L0.6430.99
325_P328_F0.6420.99
179_R208_Y0.6420.99
68_E72_G0.6410.99
39_T289_M0.6390.99
251_T255_Q0.6390.99
115_S179_R0.6380.99
88_S115_S0.6370.99
91_E116_T0.6370.99
227_E230_V0.6360.99
310_G314_E0.6360.99
280_E286_G0.6340.99
182_I190_V0.6340.99
248_E254_G0.6320.99
86_I115_S0.6310.99
117_N120_L0.6270.98
158_A161_M0.6250.98
82_I109_G0.6240.98
138_G177_G0.6240.98
240_A243_L0.6220.98
116_T139_I0.6210.98
256_F260_Y0.6160.98
40_W292_I0.6160.98
336_K346_K0.6130.98
232_F235_K0.6120.98
57_A215_R0.6110.98
339_Y342_K0.6100.98
36_P288_K0.6100.98
123_E126_A0.6090.98
82_I110_I0.6090.98
55_I88_S0.6070.98
248_E252_T0.6070.98
252_T258_G0.6070.98
166_I200_L0.6030.98
51_L154_G0.6030.98
321_I330_N0.6010.98
235_K238_D0.5980.98
191_D194_M0.5980.98
176_V202_V0.5980.98
232_F236_M0.5970.98
150_D159_F0.5970.98
39_T302_Q0.5960.98
153_R157_G0.5930.98
74_I87_M0.5920.98
114_L134_F0.5920.98
94_M120_L0.5910.98
187_I228_E0.5910.98
190_V207_F0.5900.98
154_G158_A0.5890.98
121_I129_L0.5860.98
142_D149_H0.5860.98
41_N55_I0.5860.98
251_T257_D0.5840.98
150_D156_N0.5830.98
42_L70_A0.5830.98
79_E318_K0.5820.98
76_E317_L0.5810.97
225_T229_Y0.5810.97
35_R321_I0.5800.97
247_I254_G0.5780.97
307_Y358_Y0.5770.97
247_I252_T0.5760.97
164_K171_N0.5710.97
190_V194_M0.5710.97
102_A108_K0.5700.97
249_I252_T0.5690.97
119_T161_M0.5660.97
282_S286_G0.5660.97
74_I78_A0.5650.97
46_C53_C0.5650.97
279_V283_G0.5620.97
194_M243_L0.5610.97
99_F132_L0.5590.97
252_T256_F0.5580.97
249_I255_Q0.5570.97
251_T256_F0.5570.97
50_C53_C0.5560.97
292_I298_V0.5510.97
77_M82_I0.5500.97
213_S216_G0.5490.96
291_S302_Q0.5490.96
45_K62_E0.5480.96
253_L260_Y0.5470.96
195_K243_L0.5440.96
97_D101_L0.5430.96
82_I111_K0.5430.96
345_Y348_A0.5420.96
115_S303_F0.5420.96
67_T70_A0.5420.96
224_Y229_Y0.5410.96
197_A200_L0.5410.96
136_Y177_G0.5400.96
333_K336_K0.5400.96
215_R218_E0.5400.96
99_F131_E0.5390.96
49_K56_N0.5370.96
247_I250_E0.5360.96
296_G312_V0.5340.96
252_T259_V0.5320.96
52_H181_T0.5320.96
222_W226_L0.5300.96
322_K325_P0.5300.96
37_V86_I0.5290.96
145_D192_E0.5290.96
283_G286_G0.5290.96
144_Y159_F0.5280.96
46_C50_C0.5280.96
70_A74_I0.5280.96
39_T88_S0.5250.95
37_V84_L0.5220.95
85_I110_I0.5210.95
88_S138_G0.5190.95
99_F103_S0.5180.95
36_P42_L0.5180.95
167_G199_K0.5160.95
126_A174_L0.5130.95
161_M168_N0.5110.95
186_N189_Q0.5100.95
55_I291_S0.5100.95
309_L326_D0.5080.95
150_D160_N0.5070.95
300_P303_F0.5070.95
225_T233_I0.5040.94
189_Q193_Y0.5040.94
282_S285_C0.5030.94
340_C343_C0.5020.94
328_F332_D0.5010.94
247_I253_L0.5010.94
343_C349_C0.5000.94
106_R131_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.8651 100 0.313 Contact Map
1tv8A 2 0.8042 100 0.497 Contact Map
4m7tA 1 0.6217 100 0.505 Contact Map
4rtbA 2 0.8545 100 0.541 Contact Map
4wcxA 1 0.9206 100 0.584 Contact Map
3c8fA 1 0.5952 100 0.609 Contact Map
2yx0A 1 0.709 100 0.633 Contact Map
2qgqA 1 0.6772 99.9 0.638 Contact Map
2z2uA 1 0.627 99.9 0.641 Contact Map
3t7vA 1 0.836 99.9 0.657 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.