Q97XA7 - SULSO - GREMLIN Contacts

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Q97XA7 - Coenzyme PQQ synthesis protein E (PqqE-4)

UniProt:	Q97XA7	Sequences: MIPISVLVTNAGTVSFHIKGEYNRDRPSKFSDVFRPVVTWNLTRKCNLKCLHCYINASPEGEDGLTTEEALGLIDEMAEMKIPLIIMSGGEPLMRRDFFELASYARSKGIKLALSTNGTLISESVAKRLKELDFSYVGISLDSYDPEFHDKFRGLNGAFNMTVKGIGNAINVGLNVGLRFTITAKNIHQVDEYMKLALKLGVKRITFYHLSASGRGRELREWMYTLEEYVSFINKMIDYAIKLSGKIEIETTLGQFDGVYIAKKLARNEEELEKYLKFVENSGGCGRKMISIYPNGDVYPCQFIDFYKLGNVREKPLKEIIKNIPDLFINTDKYLKGRYCDKCEYKSACKGGDRARAYYWNEDIYGDDPLCPLKTLHI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	378 (309)
Sequences:	8028 (6173)
Seq/√Len:	351.2

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XA7 Q97XS7 Q97XS8 Q97XA6 Q7LXV3 Q97XZ2 Q97WC3 Q97Y04 Q97WK5 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
145_D	160_N	4.018	1.00
48_L	119_T	3.994	1.00
71_L	104_Y	3.383	1.00
127_K	172_V	3.339	1.00
167_G	200_L	3.238	1.00
69_E	313_R	3.057	1.00
123_E	168_N	3.013	1.00
75_D	104_Y	2.938	1.00
150_D	157_G	2.875	1.00
66_T	69_E	2.757	1.00
297_D	311_N	2.743	1.00
159_F	196_L	2.531	1.00
47_N	117_N	2.468	1.00
72_G	76_E	2.364	1.00
297_D	308_K	2.364	1.00
67_T	100_E	2.348	1.00
75_D	108_K	2.289	1.00
99_F	128_R	2.282	1.00
144_Y	148_F	2.164	1.00
148_F	189_Q	2.151	1.00
38_V	77_M	2.137	1.00
168_N	171_N	2.090	1.00
316_P	319_E	2.073	1.00
144_Y	189_Q	2.031	1.00
118_G	139_I	2.015	1.00
283_G	301_C	1.994	1.00
127_K	131_E	1.979	1.00
45_K	64_G	1.967	1.00
189_Q	192_E	1.967	1.00
104_Y	107_S	1.960	1.00
191_D	235_K	1.885	1.00
142_D	153_R	1.884	1.00
70_A	101_L	1.882	1.00
71_L	100_E	1.853	1.00
178_L	197_A	1.816	1.00
301_C	353_D	1.815	1.00
128_R	132_L	1.805	1.00
139_I	166_I	1.795	1.00
96_R	99_F	1.787	1.00
184_A	228_E	1.786	1.00
104_Y	108_K	1.768	1.00
123_E	171_N	1.726	1.00
47_N	120_L	1.718	1.00
315_K	319_E	1.712	1.00
103_S	107_S	1.711	1.00
311_N	314_E	1.710	1.00
69_E	72_G	1.689	1.00
74_I	105_A	1.686	1.00
106_R	135_S	1.682	1.00
67_T	71_L	1.676	1.00
293_Y	297_D	1.658	1.00
180_F	193_Y	1.644	1.00
167_G	171_N	1.634	1.00
195_K	239_Y	1.631	1.00
67_T	97_D	1.609	1.00
167_G	170_I	1.606	1.00
161_M	164_K	1.601	1.00
93_L	114_L	1.597	1.00
164_K	167_G	1.592	1.00
151_K	185_K	1.591	1.00
225_T	228_E	1.571	1.00
100_E	103_S	1.570	1.00
122_S	125_V	1.566	1.00
159_F	163_V	1.565	1.00
99_F	125_V	1.562	1.00
123_E	172_V	1.561	1.00
126_A	168_N	1.558	1.00
103_S	128_R	1.557	1.00
130_K	172_V	1.552	1.00
160_N	164_K	1.542	1.00
192_E	195_K	1.525	1.00
71_L	75_D	1.502	1.00
164_K	168_N	1.481	1.00
293_Y	299_Y	1.478	1.00
196_L	200_L	1.475	1.00
195_K	199_K	1.474	1.00
231_S	235_K	1.460	1.00
76_E	316_P	1.458	1.00
64_G	95_R	1.453	1.00
52_H	142_D	1.450	1.00
139_I	165_G	1.443	1.00
145_D	150_D	1.428	1.00
149_H	158_A	1.426	1.00
93_L	120_L	1.415	1.00
51_L	151_K	1.414	1.00
65_L	69_E	1.413	1.00
318_K	322_K	1.410	1.00
168_N	172_V	1.406	1.00
87_M	112_L	1.403	1.00
163_V	200_L	1.398	1.00
87_M	105_A	1.379	1.00
102_A	134_F	1.359	1.00
231_S	234_N	1.356	1.00
180_F	205_I	1.354	1.00
162_T	165_G	1.351	1.00
170_I	201_G	1.350	1.00
143_S	148_F	1.333	1.00
126_A	165_G	1.330	1.00
128_R	131_E	1.326	1.00
97_D	100_E	1.325	1.00
178_L	202_V	1.309	1.00
105_A	112_L	1.287	1.00
298_V	320_I	1.286	1.00
145_D	189_Q	1.285	1.00
115_S	138_G	1.273	1.00
78_A	108_K	1.261	1.00
103_S	132_L	1.252	1.00
163_V	196_L	1.252	1.00
137_V	169_A	1.246	1.00
106_R	132_L	1.238	1.00
42_L	87_M	1.229	1.00
85_I	105_A	1.222	1.00
106_R	112_L	1.219	1.00
319_E	323_N	1.219	1.00
121_I	126_A	1.208	1.00
125_V	129_L	1.194	1.00
95_R	101_L	1.191	1.00
227_E	231_S	1.186	1.00
40_W	70_A	1.173	1.00
130_K	173_G	1.162	1.00
102_A	132_L	1.132	1.00
163_V	167_G	1.129	1.00
152_F	183_T	1.129	1.00
239_Y	242_K	1.128	1.00
230_V	234_N	1.115	1.00
101_L	105_A	1.111	1.00
44_R	294_P	1.105	1.00
124_S	127_K	1.102	1.00
234_N	238_D	1.097	1.00
125_V	128_R	1.093	1.00
250_E	253_L	1.087	1.00
150_D	158_A	1.085	1.00
324_I	327_L	1.082	1.00
72_G	313_R	1.078	1.00
65_L	70_A	1.074	1.00
249_I	253_L	1.065	1.00
239_Y	243_L	1.065	1.00
84_L	111_K	1.060	1.00
123_E	127_K	1.058	1.00
100_E	104_Y	1.053	1.00
63_D	295_N	1.046	1.00
138_G	179_R	1.036	1.00
77_M	85_I	1.029	1.00
144_Y	192_E	1.026	1.00
78_A	110_I	1.026	1.00
228_E	231_S	1.025	1.00
93_L	165_G	1.022	1.00
126_A	172_V	1.018	1.00
161_M	165_G	1.011	1.00
72_G	75_D	1.009	1.00
38_V	290_I	1.008	1.00
36_P	83_P	1.005	1.00
299_Y	308_K	1.004	1.00
73_L	292_I	1.000	1.00
47_N	91_E	0.999	1.00
236_M	240_A	0.996	1.00
338_R	341_D	0.996	1.00
48_L	158_A	0.996	1.00
308_K	311_N	0.994	1.00
141_L	178_L	0.985	1.00
51_L	152_F	0.983	1.00
317_L	321_I	0.981	1.00
43_T	64_G	0.975	1.00
147_E	151_K	0.974	1.00
149_H	157_G	0.973	1.00
137_V	174_L	0.972	1.00
54_Y	88_S	0.970	1.00
235_K	239_Y	0.969	1.00
126_A	130_K	0.969	1.00
75_D	79_E	0.966	1.00
149_H	162_T	0.963	1.00
121_I	165_G	0.962	1.00
139_I	169_A	0.962	1.00
93_L	125_V	0.959	1.00
198_L	243_L	0.959	1.00
76_E	80_M	0.958	1.00
283_G	353_D	0.951	1.00
76_E	318_K	0.949	1.00
74_I	108_K	0.948	1.00
144_Y	196_L	0.947	1.00
327_L	331_T	0.946	1.00
143_S	159_F	0.940	1.00
165_G	168_N	0.940	1.00
84_L	113_A	0.940	1.00
114_L	129_L	0.939	1.00
191_D	195_K	0.935	1.00
197_A	202_V	0.934	1.00
140_S	181_T	0.925	1.00
47_N	119_T	0.919	1.00
52_H	152_F	0.918	1.00
149_H	159_F	0.917	1.00
195_K	198_L	0.916	1.00
254_G	257_D	0.907	1.00
310_G	320_I	0.905	1.00
354_R	357_A	0.893	1.00
166_I	176_V	0.889	1.00
254_G	258_G	0.883	1.00
255_Q	259_V	0.882	1.00
248_E	251_T	0.881	1.00
226_L	230_V	0.880	1.00
148_F	151_K	0.879	1.00
324_I	328_F	0.879	1.00
191_D	239_Y	0.873	1.00
170_I	176_V	0.872	1.00
143_S	153_R	0.868	1.00
122_S	164_K	0.867	1.00
250_E	254_G	0.865	1.00
95_R	98_F	0.865	1.00
178_L	205_I	0.859	1.00
114_L	137_V	0.858	1.00
310_G	315_K	0.855	1.00
150_D	153_R	0.853	1.00
169_A	174_L	0.853	1.00
304_I	355_A	0.852	1.00
124_S	128_R	0.849	1.00
315_K	320_I	0.848	1.00
290_I	321_I	0.838	1.00
170_I	200_L	0.835	1.00
252_T	255_Q	0.832	1.00
251_T	254_G	0.828	1.00
145_D	159_F	0.818	1.00
65_L	73_L	0.816	1.00
194_M	198_L	0.816	1.00
98_F	102_A	0.816	1.00
111_K	135_S	0.812	1.00
40_W	73_L	0.812	1.00
193_Y	197_A	0.811	1.00
188_H	228_E	0.807	1.00
130_K	174_L	0.804	1.00
166_I	202_V	0.801	1.00
121_I	169_A	0.800	1.00
196_L	199_K	0.800	1.00
290_I	317_L	0.798	1.00
42_L	95_R	0.795	1.00
280_E	283_G	0.792	1.00
93_L	98_F	0.790	1.00
166_I	178_L	0.789	1.00
190_V	235_K	0.788	1.00
67_T	104_Y	0.785	1.00
67_T	101_L	0.774	1.00
169_A	176_V	0.772	1.00
313_R	316_P	0.772	1.00
38_V	292_I	0.769	1.00
74_I	110_I	0.766	1.00
298_V	317_L	0.764	1.00
149_H	153_R	0.764	1.00
47_N	94_M	0.762	1.00
41_N	88_S	0.761	1.00
257_D	260_Y	0.761	1.00
127_K	130_K	0.757	1.00
338_R	342_K	0.757	1.00
143_S	189_Q	0.755	1.00
233_I	237_I	0.755	1.00
315_K	323_N	0.747	1.00
249_I	254_G	0.745	1.00
175_N	203_K	0.744	1.00
170_I	203_K	0.743	1.00
141_L	159_F	0.741	1.00
102_A	105_A	0.739	1.00
238_D	242_K	0.738	1.00
183_T	186_N	0.737	1.00
101_L	104_Y	0.737	1.00
141_L	163_V	0.736	1.00
305_D	308_K	0.736	1.00
252_T	257_D	0.735	1.00
43_T	95_R	0.734	1.00
326_D	330_N	0.733	1.00
85_I	112_L	0.732	1.00
210_L	216_G	0.731	0.99
160_N	163_V	0.729	0.99
233_I	236_M	0.729	0.99
119_T	165_G	0.726	0.99
248_E	253_L	0.726	0.99
105_A	108_K	0.725	0.99
41_N	291_S	0.724	0.99
115_S	302_Q	0.723	0.99
327_L	330_N	0.722	0.99
279_V	285_C	0.722	0.99
76_E	79_E	0.722	0.99
42_L	98_F	0.714	0.99
197_A	205_I	0.714	0.99
340_C	349_C	0.711	0.99
195_K	236_M	0.709	0.99
253_L	256_F	0.708	0.99
126_A	169_A	0.706	0.99
86_I	113_A	0.705	0.99
102_A	128_R	0.705	0.99
42_L	101_L	0.704	0.99
70_A	95_R	0.704	0.99
91_E	94_M	0.704	0.99
74_I	85_I	0.702	0.99
180_F	197_A	0.701	0.99
112_L	134_F	0.699	0.99
87_M	102_A	0.695	0.99
88_S	302_Q	0.695	0.99
71_L	107_S	0.695	0.99
255_Q	258_G	0.689	0.99
250_E	255_Q	0.688	0.99
71_L	108_K	0.687	0.99
102_A	112_L	0.686	0.99
237_I	241_I	0.685	0.99
67_T	95_R	0.684	0.99
143_S	149_H	0.684	0.99
41_N	294_P	0.683	0.99
237_I	240_A	0.682	0.99
229_Y	233_I	0.682	0.99
139_I	162_T	0.679	0.99
319_E	322_K	0.679	0.99
279_V	282_S	0.675	0.99
253_L	257_D	0.675	0.99
325_P	329_I	0.672	0.99
148_F	188_H	0.668	0.99
106_R	133_D	0.668	0.99
93_L	129_L	0.667	0.99
144_Y	147_E	0.667	0.99
208_Y	211_S	0.667	0.99
68_E	71_L	0.666	0.99
328_F	331_T	0.665	0.99
70_A	73_L	0.665	0.99
216_G	219_L	0.664	0.99
184_A	225_T	0.663	0.99
253_L	258_G	0.663	0.99
247_I	251_T	0.663	0.99
165_G	169_A	0.661	0.99
352_G	357_A	0.661	0.99
323_N	326_D	0.660	0.99
122_S	165_G	0.659	0.99
121_I	139_I	0.656	0.99
91_E	117_N	0.655	0.99
256_F	259_V	0.653	0.99
95_R	100_E	0.651	0.99
170_I	202_V	0.649	0.99
238_D	241_I	0.647	0.99
52_H	153_R	0.647	0.99
69_E	73_L	0.643	0.99
325_P	328_F	0.642	0.99
179_R	208_Y	0.642	0.99
68_E	72_G	0.641	0.99
39_T	289_M	0.639	0.99
251_T	255_Q	0.639	0.99
115_S	179_R	0.638	0.99
88_S	115_S	0.637	0.99
91_E	116_T	0.637	0.99
227_E	230_V	0.636	0.99
310_G	314_E	0.636	0.99
280_E	286_G	0.634	0.99
182_I	190_V	0.634	0.99
248_E	254_G	0.632	0.99
86_I	115_S	0.631	0.99
117_N	120_L	0.627	0.98
158_A	161_M	0.625	0.98
82_I	109_G	0.624	0.98
138_G	177_G	0.624	0.98
240_A	243_L	0.622	0.98
116_T	139_I	0.621	0.98
256_F	260_Y	0.616	0.98
40_W	292_I	0.616	0.98
336_K	346_K	0.613	0.98
232_F	235_K	0.612	0.98
57_A	215_R	0.611	0.98
339_Y	342_K	0.610	0.98
36_P	288_K	0.610	0.98
123_E	126_A	0.609	0.98
82_I	110_I	0.609	0.98
55_I	88_S	0.607	0.98
248_E	252_T	0.607	0.98
252_T	258_G	0.607	0.98
166_I	200_L	0.603	0.98
51_L	154_G	0.603	0.98
321_I	330_N	0.601	0.98
235_K	238_D	0.598	0.98
191_D	194_M	0.598	0.98
176_V	202_V	0.598	0.98
232_F	236_M	0.597	0.98
150_D	159_F	0.597	0.98
39_T	302_Q	0.596	0.98
153_R	157_G	0.593	0.98
74_I	87_M	0.592	0.98
114_L	134_F	0.592	0.98
94_M	120_L	0.591	0.98
187_I	228_E	0.591	0.98
190_V	207_F	0.590	0.98
154_G	158_A	0.589	0.98
121_I	129_L	0.586	0.98
142_D	149_H	0.586	0.98
41_N	55_I	0.586	0.98
251_T	257_D	0.584	0.98
150_D	156_N	0.583	0.98
42_L	70_A	0.583	0.98
79_E	318_K	0.582	0.98
76_E	317_L	0.581	0.97
225_T	229_Y	0.581	0.97
35_R	321_I	0.580	0.97
247_I	254_G	0.578	0.97
307_Y	358_Y	0.577	0.97
247_I	252_T	0.576	0.97
164_K	171_N	0.571	0.97
190_V	194_M	0.571	0.97
102_A	108_K	0.570	0.97
249_I	252_T	0.569	0.97
119_T	161_M	0.566	0.97
282_S	286_G	0.566	0.97
74_I	78_A	0.565	0.97
46_C	53_C	0.565	0.97
279_V	283_G	0.562	0.97
194_M	243_L	0.561	0.97
99_F	132_L	0.559	0.97
252_T	256_F	0.558	0.97
249_I	255_Q	0.557	0.97
251_T	256_F	0.557	0.97
50_C	53_C	0.556	0.97
292_I	298_V	0.551	0.97
77_M	82_I	0.550	0.97
213_S	216_G	0.549	0.96
291_S	302_Q	0.549	0.96
45_K	62_E	0.548	0.96
253_L	260_Y	0.547	0.96
195_K	243_L	0.544	0.96
97_D	101_L	0.543	0.96
82_I	111_K	0.543	0.96
345_Y	348_A	0.542	0.96
115_S	303_F	0.542	0.96
67_T	70_A	0.542	0.96
224_Y	229_Y	0.541	0.96
197_A	200_L	0.541	0.96
136_Y	177_G	0.540	0.96
333_K	336_K	0.540	0.96
215_R	218_E	0.540	0.96
99_F	131_E	0.539	0.96
49_K	56_N	0.537	0.96
247_I	250_E	0.536	0.96
296_G	312_V	0.534	0.96
252_T	259_V	0.532	0.96
52_H	181_T	0.532	0.96
222_W	226_L	0.530	0.96
322_K	325_P	0.530	0.96
37_V	86_I	0.529	0.96
145_D	192_E	0.529	0.96
283_G	286_G	0.529	0.96
144_Y	159_F	0.528	0.96
46_C	50_C	0.528	0.96
70_A	74_I	0.528	0.96
39_T	88_S	0.525	0.95
37_V	84_L	0.522	0.95
85_I	110_I	0.521	0.95
88_S	138_G	0.519	0.95
99_F	103_S	0.518	0.95
36_P	42_L	0.518	0.95
167_G	199_K	0.516	0.95
126_A	174_L	0.513	0.95
161_M	168_N	0.511	0.95
186_N	189_Q	0.510	0.95
55_I	291_S	0.510	0.95
309_L	326_D	0.508	0.95
150_D	160_N	0.507	0.95
300_P	303_F	0.507	0.95
225_T	233_I	0.504	0.94
189_Q	193_Y	0.504	0.94
282_S	285_C	0.503	0.94
340_C	343_C	0.502	0.94
328_F	332_D	0.501	0.94
247_I	253_L	0.501	0.94
343_C	349_C	0.500	0.94
106_R	131_E	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.8651	100	0.313	Contact Map
1tv8A	2	0.8042	100	0.497	Contact Map
4m7tA	1	0.6217	100	0.505	Contact Map
4rtbA	2	0.8545	100	0.541	Contact Map
4wcxA	1	0.9206	100	0.584	Contact Map
3c8fA	1	0.5952	100	0.609	Contact Map
2yx0A	1	0.709	100	0.633	Contact Map
2qgqA	1	0.6772	99.9	0.638	Contact Map
2z2uA	1	0.627	99.9	0.641	Contact Map
3t7vA	1	0.836	99.9	0.657	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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