GREMLIN Database
Q97XA6 - Coenzyme PQQ synthesis protein E (PqqE-5)
UniProt: Q97XA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (288)
Sequences: 10313 (7975)
Seq/√Len: 469.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_S132_N4.4381.00
20_L92_S4.0581.00
44_K77_Y3.4641.00
139_E172_L3.3411.00
48_E77_Y2.6451.00
100_M144_Y2.5871.00
123_D129_G2.5651.00
39_S42_E2.5311.00
42_E292_R2.4881.00
19_P90_S2.3531.00
263_T281_S2.2681.00
277_D290_N2.2091.00
140_L143_K2.2051.00
10_V50_I2.1601.00
121_T161_E2.1371.00
72_F101_K2.1331.00
45_K49_D2.1291.00
96_R140_L2.1081.00
277_D287_Y2.0871.00
72_F98_E2.0601.00
48_E81_L2.0591.00
295_S298_D2.0181.00
79_K108_R2.0101.00
131_Y168_L1.9971.00
152_T165_L1.9711.00
100_M104_S1.9681.00
95_L98_E1.9391.00
161_E164_F1.8661.00
131_Y135_L1.8401.00
167_K209_T1.8151.00
117_A121_T1.7951.00
47_L78_A1.7931.00
43_S74_I1.7851.00
17_A37_E1.7611.00
115_D126_R1.7551.00
139_E142_L1.7411.00
150_V169_L1.7261.00
77_Y80_S1.7251.00
91_P112_I1.7151.00
117_A161_E1.7131.00
40_T70_D1.6901.00
98_E101_K1.6801.00
290_N293_K1.6751.00
294_E298_D1.6651.00
19_P93_Y1.6611.00
163_P205_F1.6581.00
139_E143_K1.6571.00
24_H115_D1.6551.00
112_I138_I1.6381.00
167_K171_E1.6331.00
101_K104_S1.6281.00
70_D73_E1.6131.00
136_R139_E1.5981.00
76_E80_S1.5961.00
133_Y136_R1.5861.00
66_L87_I1.5801.00
140_L144_Y1.5781.00
132_N136_R1.5651.00
40_T44_K1.5561.00
273_G277_D1.5371.00
273_G279_Y1.5361.00
60_F78_A1.5351.00
112_I137_G1.5311.00
168_L172_L1.5211.00
77_Y81_L1.5181.00
44_K48_E1.5151.00
73_E76_E1.5091.00
201_D205_F1.4981.00
124_W157_K1.4891.00
119_S123_D1.4791.00
222_P225_R1.4671.00
156_K198_K1.4651.00
51_A81_L1.4581.00
42_E45_K1.4511.00
23_K124_W1.4411.00
51_A83_L1.4371.00
200_K204_D1.4171.00
69_S72_F1.3991.00
164_F167_K1.3931.00
119_S129_G1.3851.00
195_P198_K1.3811.00
116_G121_T1.3801.00
40_T73_E1.3801.00
66_L93_Y1.3231.00
220_E223_F1.3071.00
119_S131_Y1.2921.00
142_L173_G1.2801.00
44_K73_E1.2751.00
58_I78_A1.2691.00
79_K85_V1.2691.00
99_T103_I1.2651.00
206_L210_T1.2571.00
121_T160_S1.2511.00
110_M141_G1.2511.00
134_A137_G1.2501.00
14_V60_F1.2491.00
135_L139_E1.2431.00
60_F85_V1.2401.00
49_D295_S1.2251.00
76_E101_K1.2181.00
122_H130_S1.2181.00
205_F208_E1.2011.00
136_R140_L1.1941.00
304_E308_I1.1841.00
103_I144_Y1.1821.00
12_W43_S1.1811.00
38_L42_E1.1711.00
194_I198_K1.1701.00
8_H56_V1.1621.00
88_A111_S1.1501.00
78_A85_V1.1491.00
201_D204_D1.1471.00
96_R136_R1.1431.00
219_V222_P1.1421.00
199_Y202_V1.1411.00
167_K170_K1.1381.00
101_K105_N1.1371.00
37_E68_R1.1341.00
142_L172_L1.1181.00
122_H134_A1.1141.00
75_M107_A1.1101.00
68_R74_I1.1081.00
103_I146_I1.1071.00
298_D302_K1.1051.00
278_V299_I1.1051.00
135_L168_L1.1041.00
150_V174_V1.0931.00
95_L100_M1.0901.00
96_R143_K1.0841.00
198_K201_D1.0681.00
12_W272_I1.0551.00
218_T221_A1.0541.00
99_T137_G1.0481.00
297_V301_R1.0461.00
14_V71_I1.0441.00
120_Q124_W1.0431.00
204_D208_E1.0351.00
220_E224_F1.0311.00
205_F209_T1.0281.00
219_V223_F1.0281.00
57_V84_I1.0261.00
221_A224_F1.0261.00
163_P167_K1.0251.00
99_T140_L1.0231.00
117_A168_L1.0211.00
123_D130_S1.0161.00
16_K274_Y1.0121.00
163_P209_T1.0091.00
47_L58_I1.0081.00
221_A225_R1.0051.00
135_L172_L1.0021.00
36_G275_N1.0021.00
142_L148_V0.9951.00
112_I141_G0.9921.00
60_F75_M0.9921.00
142_L174_V0.9921.00
287_Y290_N0.9891.00
49_D53_F0.9861.00
116_G131_Y0.9851.00
137_G140_L0.9801.00
95_L101_K0.9731.00
121_T124_W0.9731.00
95_L103_I0.9721.00
203_I207_V0.9681.00
74_I78_A0.9641.00
141_G146_I0.9611.00
122_H126_R0.9591.00
191_E194_I0.9591.00
190_I193_D0.9581.00
218_T222_P0.9551.00
123_D126_R0.9511.00
279_Y287_Y0.9511.00
294_E302_K0.9501.00
194_I197_E0.9481.00
204_D207_V0.9461.00
19_P64_D0.9421.00
79_K106_Y0.9411.00
47_L81_L0.9411.00
152_T177_W0.9381.00
66_L137_G0.9331.00
15_T37_E0.9321.00
57_V86_S0.9321.00
46_L272_I0.9251.00
197_E201_D0.9241.00
125_L155_W0.9221.00
169_L174_V0.9211.00
10_V270_I0.9211.00
66_L71_I0.9161.00
19_P92_S0.9151.00
133_Y137_G0.9101.00
306_L310_K0.9091.00
99_T144_Y0.9061.00
110_M146_I0.9021.00
97_D100_M0.8991.00
111_S151_N0.8941.00
23_K125_L0.8901.00
73_E77_Y0.8881.00
40_T77_Y0.8881.00
260_V263_T0.8821.00
141_G148_V0.8761.00
50_I58_I0.8761.00
300_Y310_K0.8751.00
45_K292_R0.8751.00
304_E307_K0.8731.00
197_E200_K0.8731.00
75_M105_N0.8721.00
150_V177_W0.8721.00
84_I109_Y0.8701.00
38_L43_S0.8691.00
130_S133_Y0.8681.00
219_V224_F0.8661.00
286_L289_G0.8631.00
100_M140_L0.8621.00
117_A164_F0.8601.00
147_Q175_K0.8591.00
316_G319_G0.8561.00
113_S153_L0.8501.00
116_G126_R0.8441.00
10_V272_I0.8411.00
72_F105_N0.8391.00
40_T74_I0.8391.00
219_V225_R0.8381.00
114_I150_V0.8311.00
138_I174_V0.8291.00
305_V308_I0.8201.00
207_V210_T0.8191.00
14_V68_R0.8191.00
45_K48_E0.8151.00
89_P112_I0.8131.00
96_R144_Y0.8121.00
44_K81_L0.8091.00
209_T212_Y0.8071.00
13_E61_T0.8011.00
24_H125_L0.7961.00
97_D101_K0.7951.00
138_I148_V0.7931.00
84_I108_R0.7911.00
71_I75_M0.7841.00
289_G294_E0.7801.00
90_S93_Y0.7801.00
168_L171_E0.7791.00
122_H129_G0.7771.00
26_R61_T0.7721.00
203_I206_L0.7721.00
50_I55_K0.7691.00
116_G161_E0.7681.00
20_L130_S0.7671.00
8_H268_G0.7651.00
196_K199_Y0.7631.00
14_V74_I0.7631.00
48_E52_R0.7621.00
189_V192_L0.7601.00
296_I300_Y0.7601.00
163_P208_E0.7521.00
100_M103_I0.7511.00
208_E211_R0.7511.00
95_L137_G0.7501.00
44_K80_S0.7491.00
307_K311_D0.7491.00
116_G122_H0.7451.00
132_N135_L0.7441.00
13_E274_Y0.7431.00
123_D128_L0.7391.00
218_T223_F0.7381.00
12_W47_L0.7371.00
308_I311_D0.7341.00
38_L46_L0.7331.00
96_R100_M0.7311.00
220_E225_R0.7241.00
87_I110_M0.7181.00
137_G141_G0.7161.00
175_K251_E0.7151.00
13_E271_F0.7121.00
123_D131_Y0.7091.00
41_E44_K0.7091.00
70_D74_I0.7061.00
58_I83_L0.7061.00
43_S68_R0.7051.00
78_A81_L0.7051.00
75_M85_V0.7051.00
96_R99_T0.7021.00
64_D90_S0.7001.00
206_L209_T0.6981.00
193_D196_K0.6971.00
68_R71_I0.6971.00
95_L99_T0.6971.00
180_F183_I0.6961.00
64_D67_S0.6951.00
202_V210_T0.6921.00
207_V211_R0.6921.00
316_G320_V0.6911.00
200_K203_I0.6901.00
138_I150_V0.6881.00
154_V162_L0.6881.00
288_L306_L0.6841.00
46_L50_I0.6811.00
165_L169_L0.6801.00
87_I107_A0.6801.00
122_H131_Y0.6801.00
12_W46_L0.6791.00
306_L309_I0.6781.00
199_Y203_I0.6731.00
270_I296_I0.6701.00
11_F269_V0.6701.00
15_T68_R0.6691.00
148_V174_V0.6661.00
76_E104_S0.6651.00
294_E299_I0.6621.00
292_R295_S0.6591.00
49_D297_V0.6561.00
166_V170_K0.6561.00
182_L188_G0.6521.00
245_L249_L0.6511.00
246_R249_L0.6501.00
47_L60_F0.6501.00
61_T282_G0.6491.00
289_G299_I0.6491.00
23_K127_G0.6491.00
103_I145_G0.6471.00
49_D52_R0.6461.00
270_I300_Y0.6431.00
98_E102_M0.6431.00
196_K200_K0.6401.00
76_E105_N0.6401.00
166_V177_W0.6371.00
58_I85_V0.6361.00
24_H126_R0.6361.00
163_P166_V0.6351.00
278_V296_I0.6341.00
88_A282_G0.6341.00
142_L175_K0.6321.00
199_Y206_L0.6280.99
43_S46_L0.6270.99
59_V86_S0.6250.99
191_E196_K0.6240.99
111_S149_Q0.6240.99
287_Y292_R0.6240.99
289_G292_R0.6230.99
40_T68_R0.6210.99
103_I108_R0.6200.99
76_E106_Y0.6180.99
85_V108_R0.6180.99
28_N127_G0.6150.99
280_P284_L0.6100.99
114_I134_A0.6090.99
95_L105_N0.6090.99
92_S137_G0.6080.99
19_P67_S0.6060.99
116_G119_S0.6030.99
20_L122_H0.6020.99
61_T88_A0.6020.99
59_V88_A0.6000.99
287_Y291_V0.5960.99
198_K207_V0.5920.99
75_M78_A0.5880.99
22_C25_C0.5870.99
152_T169_L0.5850.99
95_L102_M0.5840.99
97_D140_L0.5840.99
109_Y149_Q0.5830.99
88_A151_N0.5810.99
104_S144_Y0.5780.99
162_L179_V0.5750.99
41_E77_Y0.5740.99
194_I200_K0.5740.99
42_E46_L0.5730.99
285_P288_L0.5730.99
191_E195_P0.5710.99
66_L98_E0.5710.99
69_S73_E0.5710.99
109_Y147_Q0.5710.99
151_N180_F0.5690.99
295_S299_I0.5680.99
27_A61_T0.5680.99
114_I131_Y0.5670.99
78_A83_L0.5670.99
7_P300_Y0.5650.99
72_F75_M0.5630.99
129_G132_N0.5590.99
18_C22_C0.5590.99
114_I135_L0.5580.99
92_S133_Y0.5580.99
112_I134_A0.5580.99
307_K310_K0.5530.99
91_P137_G0.5520.99
29_A187_R0.5510.99
169_L172_L0.5500.99
317_K320_V0.5500.99
87_I102_M0.5490.99
72_F76_E0.5480.99
117_A131_Y0.5460.99
11_F282_G0.5460.99
14_V43_S0.5450.99
24_H153_L0.5440.99
47_L83_L0.5430.99
126_R129_G0.5430.99
73_E101_K0.5420.98
43_S47_L0.5400.98
285_P291_V0.5390.98
286_L290_N0.5360.98
52_R297_V0.5360.98
40_T43_S0.5350.98
152_T179_V0.5340.98
93_Y96_R0.5340.98
82_G85_V0.5330.98
198_K202_V0.5320.98
88_A283_F0.5310.98
71_I87_I0.5310.98
127_G130_S0.5300.98
128_L131_Y0.5280.98
24_H27_A0.5250.98
136_R143_K0.5250.98
302_K306_L0.5230.98
74_I77_Y0.5220.98
18_C25_C0.5210.98
208_E212_Y0.5210.98
155_W158_S0.5210.98
285_P289_G0.5190.98
9_L57_V0.5170.98
13_E27_A0.5150.98
103_I106_Y0.5130.98
189_V193_D0.5130.98
60_F74_I0.5120.98
46_L49_D0.5110.98
11_F61_T0.5100.98
182_L186_G0.5100.98
302_K308_I0.5080.98
64_D89_P0.5070.98
202_V206_L0.5040.98
218_T224_F0.5030.98
17_A35_P0.5020.98
271_F282_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9114 100 0.308 Contact Map
1tv8A 2 0.8514 100 0.459 Contact Map
4m7tA 1 0.6629 100 0.466 Contact Map
4rtbA 2 0.8229 100 0.523 Contact Map
4wcxA 1 0.8914 100 0.55 Contact Map
3c8fA 1 0.6086 100 0.569 Contact Map
2yx0A 1 0.6771 100 0.593 Contact Map
2z2uA 1 0.6 99.9 0.607 Contact Map
2qgqA 1 0.7257 99.9 0.614 Contact Map
3rfaA 1 0.6743 99.9 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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