Q97XA6 - SULSO - GREMLIN Contacts

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Q97XA6 - Coenzyme PQQ synthesis protein E (PqqE-5)

UniProt:	Q97XA6	Sequences: MPFENAPHLVFWEVTKACPLSCKHCRANAIDKPLPGELSTEESKKLLEDIARFGKVVIVFTGGDPLSRSDIFEIMEYAKSLGLIVSIAPSPSYRLRDETMKMISNYARYMSISIDGATSQTHDWLRGLGSYNYALRGIELGLKYGIQVQVNTLVWKKSYSELPFLVKLLKELGVKVWEVFFLIPVGRGVIELDIPKEKYKDVIDFLVETTRYDLVVRTVEAPFFRRAKLEYTPSTIKSNELVSKLRELLGEPVKDVDKSVLPTRDGSGVIFIGYNGDVYPSGFLPLYLGNVRKESIVDIYRKSEVLKIIKDGRFDGKCGVCKFNNICGGSRARAFAVYNNPFAEDPMCPY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	350 (288)
Sequences:	10313 (7975)
Seq/√Len:	469.9

ECOLI - ASLB YDEM MOAA
BACSU - ALBA SKFB MOAA YYDG
HALSA - Q9HQF5 MOAA Q9HQF7
SULSO - Q97XA6 Q97XS8 Q97XA7 Q97XS7 Q7LXV3 Q97XZ2 Q97Y04 Q97WK5 Q97WC3 MOAA Q980E0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
119_S	132_N	4.438	1.00
20_L	92_S	4.058	1.00
44_K	77_Y	3.464	1.00
139_E	172_L	3.341	1.00
48_E	77_Y	2.645	1.00
100_M	144_Y	2.587	1.00
123_D	129_G	2.565	1.00
39_S	42_E	2.531	1.00
42_E	292_R	2.488	1.00
19_P	90_S	2.353	1.00
263_T	281_S	2.268	1.00
277_D	290_N	2.209	1.00
140_L	143_K	2.205	1.00
10_V	50_I	2.160	1.00
121_T	161_E	2.137	1.00
72_F	101_K	2.133	1.00
45_K	49_D	2.129	1.00
96_R	140_L	2.108	1.00
277_D	287_Y	2.087	1.00
72_F	98_E	2.060	1.00
48_E	81_L	2.059	1.00
295_S	298_D	2.018	1.00
79_K	108_R	2.010	1.00
131_Y	168_L	1.997	1.00
152_T	165_L	1.971	1.00
100_M	104_S	1.968	1.00
95_L	98_E	1.939	1.00
161_E	164_F	1.866	1.00
131_Y	135_L	1.840	1.00
167_K	209_T	1.815	1.00
117_A	121_T	1.795	1.00
47_L	78_A	1.793	1.00
43_S	74_I	1.785	1.00
17_A	37_E	1.761	1.00
115_D	126_R	1.755	1.00
139_E	142_L	1.741	1.00
150_V	169_L	1.726	1.00
77_Y	80_S	1.725	1.00
91_P	112_I	1.715	1.00
117_A	161_E	1.713	1.00
40_T	70_D	1.690	1.00
98_E	101_K	1.680	1.00
290_N	293_K	1.675	1.00
294_E	298_D	1.665	1.00
19_P	93_Y	1.661	1.00
163_P	205_F	1.658	1.00
139_E	143_K	1.657	1.00
24_H	115_D	1.655	1.00
112_I	138_I	1.638	1.00
167_K	171_E	1.633	1.00
101_K	104_S	1.628	1.00
70_D	73_E	1.613	1.00
136_R	139_E	1.598	1.00
76_E	80_S	1.596	1.00
133_Y	136_R	1.586	1.00
66_L	87_I	1.580	1.00
140_L	144_Y	1.578	1.00
132_N	136_R	1.565	1.00
40_T	44_K	1.556	1.00
273_G	277_D	1.537	1.00
273_G	279_Y	1.536	1.00
60_F	78_A	1.535	1.00
112_I	137_G	1.531	1.00
168_L	172_L	1.521	1.00
77_Y	81_L	1.518	1.00
44_K	48_E	1.515	1.00
73_E	76_E	1.509	1.00
201_D	205_F	1.498	1.00
124_W	157_K	1.489	1.00
119_S	123_D	1.479	1.00
222_P	225_R	1.467	1.00
156_K	198_K	1.465	1.00
51_A	81_L	1.458	1.00
42_E	45_K	1.451	1.00
23_K	124_W	1.441	1.00
51_A	83_L	1.437	1.00
200_K	204_D	1.417	1.00
69_S	72_F	1.399	1.00
164_F	167_K	1.393	1.00
119_S	129_G	1.385	1.00
195_P	198_K	1.381	1.00
116_G	121_T	1.380	1.00
40_T	73_E	1.380	1.00
66_L	93_Y	1.323	1.00
220_E	223_F	1.307	1.00
119_S	131_Y	1.292	1.00
142_L	173_G	1.280	1.00
44_K	73_E	1.275	1.00
58_I	78_A	1.269	1.00
79_K	85_V	1.269	1.00
99_T	103_I	1.265	1.00
206_L	210_T	1.257	1.00
121_T	160_S	1.251	1.00
110_M	141_G	1.251	1.00
134_A	137_G	1.250	1.00
14_V	60_F	1.249	1.00
135_L	139_E	1.243	1.00
60_F	85_V	1.240	1.00
49_D	295_S	1.225	1.00
76_E	101_K	1.218	1.00
122_H	130_S	1.218	1.00
205_F	208_E	1.201	1.00
136_R	140_L	1.194	1.00
304_E	308_I	1.184	1.00
103_I	144_Y	1.182	1.00
12_W	43_S	1.181	1.00
38_L	42_E	1.171	1.00
194_I	198_K	1.170	1.00
8_H	56_V	1.162	1.00
88_A	111_S	1.150	1.00
78_A	85_V	1.149	1.00
201_D	204_D	1.147	1.00
96_R	136_R	1.143	1.00
219_V	222_P	1.142	1.00
199_Y	202_V	1.141	1.00
167_K	170_K	1.138	1.00
101_K	105_N	1.137	1.00
37_E	68_R	1.134	1.00
142_L	172_L	1.118	1.00
122_H	134_A	1.114	1.00
75_M	107_A	1.110	1.00
68_R	74_I	1.108	1.00
103_I	146_I	1.107	1.00
298_D	302_K	1.105	1.00
278_V	299_I	1.105	1.00
135_L	168_L	1.104	1.00
150_V	174_V	1.093	1.00
95_L	100_M	1.090	1.00
96_R	143_K	1.084	1.00
198_K	201_D	1.068	1.00
12_W	272_I	1.055	1.00
218_T	221_A	1.054	1.00
99_T	137_G	1.048	1.00
297_V	301_R	1.046	1.00
14_V	71_I	1.044	1.00
120_Q	124_W	1.043	1.00
204_D	208_E	1.035	1.00
220_E	224_F	1.031	1.00
205_F	209_T	1.028	1.00
219_V	223_F	1.028	1.00
57_V	84_I	1.026	1.00
221_A	224_F	1.026	1.00
163_P	167_K	1.025	1.00
99_T	140_L	1.023	1.00
117_A	168_L	1.021	1.00
123_D	130_S	1.016	1.00
16_K	274_Y	1.012	1.00
163_P	209_T	1.009	1.00
47_L	58_I	1.008	1.00
221_A	225_R	1.005	1.00
135_L	172_L	1.002	1.00
36_G	275_N	1.002	1.00
142_L	148_V	0.995	1.00
112_I	141_G	0.992	1.00
60_F	75_M	0.992	1.00
142_L	174_V	0.992	1.00
287_Y	290_N	0.989	1.00
49_D	53_F	0.986	1.00
116_G	131_Y	0.985	1.00
137_G	140_L	0.980	1.00
95_L	101_K	0.973	1.00
121_T	124_W	0.973	1.00
95_L	103_I	0.972	1.00
203_I	207_V	0.968	1.00
74_I	78_A	0.964	1.00
141_G	146_I	0.961	1.00
122_H	126_R	0.959	1.00
191_E	194_I	0.959	1.00
190_I	193_D	0.958	1.00
218_T	222_P	0.955	1.00
123_D	126_R	0.951	1.00
279_Y	287_Y	0.951	1.00
294_E	302_K	0.950	1.00
194_I	197_E	0.948	1.00
204_D	207_V	0.946	1.00
19_P	64_D	0.942	1.00
79_K	106_Y	0.941	1.00
47_L	81_L	0.941	1.00
152_T	177_W	0.938	1.00
66_L	137_G	0.933	1.00
15_T	37_E	0.932	1.00
57_V	86_S	0.932	1.00
46_L	272_I	0.925	1.00
197_E	201_D	0.924	1.00
125_L	155_W	0.922	1.00
169_L	174_V	0.921	1.00
10_V	270_I	0.921	1.00
66_L	71_I	0.916	1.00
19_P	92_S	0.915	1.00
133_Y	137_G	0.910	1.00
306_L	310_K	0.909	1.00
99_T	144_Y	0.906	1.00
110_M	146_I	0.902	1.00
97_D	100_M	0.899	1.00
111_S	151_N	0.894	1.00
23_K	125_L	0.890	1.00
73_E	77_Y	0.888	1.00
40_T	77_Y	0.888	1.00
260_V	263_T	0.882	1.00
141_G	148_V	0.876	1.00
50_I	58_I	0.876	1.00
300_Y	310_K	0.875	1.00
45_K	292_R	0.875	1.00
304_E	307_K	0.873	1.00
197_E	200_K	0.873	1.00
75_M	105_N	0.872	1.00
150_V	177_W	0.872	1.00
84_I	109_Y	0.870	1.00
38_L	43_S	0.869	1.00
130_S	133_Y	0.868	1.00
219_V	224_F	0.866	1.00
286_L	289_G	0.863	1.00
100_M	140_L	0.862	1.00
117_A	164_F	0.860	1.00
147_Q	175_K	0.859	1.00
316_G	319_G	0.856	1.00
113_S	153_L	0.850	1.00
116_G	126_R	0.844	1.00
10_V	272_I	0.841	1.00
72_F	105_N	0.839	1.00
40_T	74_I	0.839	1.00
219_V	225_R	0.838	1.00
114_I	150_V	0.831	1.00
138_I	174_V	0.829	1.00
305_V	308_I	0.820	1.00
207_V	210_T	0.819	1.00
14_V	68_R	0.819	1.00
45_K	48_E	0.815	1.00
89_P	112_I	0.813	1.00
96_R	144_Y	0.812	1.00
44_K	81_L	0.809	1.00
209_T	212_Y	0.807	1.00
13_E	61_T	0.801	1.00
24_H	125_L	0.796	1.00
97_D	101_K	0.795	1.00
138_I	148_V	0.793	1.00
84_I	108_R	0.791	1.00
71_I	75_M	0.784	1.00
289_G	294_E	0.780	1.00
90_S	93_Y	0.780	1.00
168_L	171_E	0.779	1.00
122_H	129_G	0.777	1.00
26_R	61_T	0.772	1.00
203_I	206_L	0.772	1.00
50_I	55_K	0.769	1.00
116_G	161_E	0.768	1.00
20_L	130_S	0.767	1.00
8_H	268_G	0.765	1.00
196_K	199_Y	0.763	1.00
14_V	74_I	0.763	1.00
48_E	52_R	0.762	1.00
189_V	192_L	0.760	1.00
296_I	300_Y	0.760	1.00
163_P	208_E	0.752	1.00
100_M	103_I	0.751	1.00
208_E	211_R	0.751	1.00
95_L	137_G	0.750	1.00
44_K	80_S	0.749	1.00
307_K	311_D	0.749	1.00
116_G	122_H	0.745	1.00
132_N	135_L	0.744	1.00
13_E	274_Y	0.743	1.00
123_D	128_L	0.739	1.00
218_T	223_F	0.738	1.00
12_W	47_L	0.737	1.00
308_I	311_D	0.734	1.00
38_L	46_L	0.733	1.00
96_R	100_M	0.731	1.00
220_E	225_R	0.724	1.00
87_I	110_M	0.718	1.00
137_G	141_G	0.716	1.00
175_K	251_E	0.715	1.00
13_E	271_F	0.712	1.00
123_D	131_Y	0.709	1.00
41_E	44_K	0.709	1.00
70_D	74_I	0.706	1.00
58_I	83_L	0.706	1.00
43_S	68_R	0.705	1.00
78_A	81_L	0.705	1.00
75_M	85_V	0.705	1.00
96_R	99_T	0.702	1.00
64_D	90_S	0.700	1.00
206_L	209_T	0.698	1.00
193_D	196_K	0.697	1.00
68_R	71_I	0.697	1.00
95_L	99_T	0.697	1.00
180_F	183_I	0.696	1.00
64_D	67_S	0.695	1.00
202_V	210_T	0.692	1.00
207_V	211_R	0.692	1.00
316_G	320_V	0.691	1.00
200_K	203_I	0.690	1.00
138_I	150_V	0.688	1.00
154_V	162_L	0.688	1.00
288_L	306_L	0.684	1.00
46_L	50_I	0.681	1.00
165_L	169_L	0.680	1.00
87_I	107_A	0.680	1.00
122_H	131_Y	0.680	1.00
12_W	46_L	0.679	1.00
306_L	309_I	0.678	1.00
199_Y	203_I	0.673	1.00
270_I	296_I	0.670	1.00
11_F	269_V	0.670	1.00
15_T	68_R	0.669	1.00
148_V	174_V	0.666	1.00
76_E	104_S	0.665	1.00
294_E	299_I	0.662	1.00
292_R	295_S	0.659	1.00
49_D	297_V	0.656	1.00
166_V	170_K	0.656	1.00
182_L	188_G	0.652	1.00
245_L	249_L	0.651	1.00
246_R	249_L	0.650	1.00
47_L	60_F	0.650	1.00
61_T	282_G	0.649	1.00
289_G	299_I	0.649	1.00
23_K	127_G	0.649	1.00
103_I	145_G	0.647	1.00
49_D	52_R	0.646	1.00
270_I	300_Y	0.643	1.00
98_E	102_M	0.643	1.00
196_K	200_K	0.640	1.00
76_E	105_N	0.640	1.00
166_V	177_W	0.637	1.00
58_I	85_V	0.636	1.00
24_H	126_R	0.636	1.00
163_P	166_V	0.635	1.00
278_V	296_I	0.634	1.00
88_A	282_G	0.634	1.00
142_L	175_K	0.632	1.00
199_Y	206_L	0.628	0.99
43_S	46_L	0.627	0.99
59_V	86_S	0.625	0.99
191_E	196_K	0.624	0.99
111_S	149_Q	0.624	0.99
287_Y	292_R	0.624	0.99
289_G	292_R	0.623	0.99
40_T	68_R	0.621	0.99
103_I	108_R	0.620	0.99
76_E	106_Y	0.618	0.99
85_V	108_R	0.618	0.99
28_N	127_G	0.615	0.99
280_P	284_L	0.610	0.99
114_I	134_A	0.609	0.99
95_L	105_N	0.609	0.99
92_S	137_G	0.608	0.99
19_P	67_S	0.606	0.99
116_G	119_S	0.603	0.99
20_L	122_H	0.602	0.99
61_T	88_A	0.602	0.99
59_V	88_A	0.600	0.99
287_Y	291_V	0.596	0.99
198_K	207_V	0.592	0.99
75_M	78_A	0.588	0.99
22_C	25_C	0.587	0.99
152_T	169_L	0.585	0.99
95_L	102_M	0.584	0.99
97_D	140_L	0.584	0.99
109_Y	149_Q	0.583	0.99
88_A	151_N	0.581	0.99
104_S	144_Y	0.578	0.99
162_L	179_V	0.575	0.99
41_E	77_Y	0.574	0.99
194_I	200_K	0.574	0.99
42_E	46_L	0.573	0.99
285_P	288_L	0.573	0.99
191_E	195_P	0.571	0.99
66_L	98_E	0.571	0.99
69_S	73_E	0.571	0.99
109_Y	147_Q	0.571	0.99
151_N	180_F	0.569	0.99
295_S	299_I	0.568	0.99
27_A	61_T	0.568	0.99
114_I	131_Y	0.567	0.99
78_A	83_L	0.567	0.99
7_P	300_Y	0.565	0.99
72_F	75_M	0.563	0.99
129_G	132_N	0.559	0.99
18_C	22_C	0.559	0.99
114_I	135_L	0.558	0.99
92_S	133_Y	0.558	0.99
112_I	134_A	0.558	0.99
307_K	310_K	0.553	0.99
91_P	137_G	0.552	0.99
29_A	187_R	0.551	0.99
169_L	172_L	0.550	0.99
317_K	320_V	0.550	0.99
87_I	102_M	0.549	0.99
72_F	76_E	0.548	0.99
117_A	131_Y	0.546	0.99
11_F	282_G	0.546	0.99
14_V	43_S	0.545	0.99
24_H	153_L	0.544	0.99
47_L	83_L	0.543	0.99
126_R	129_G	0.543	0.99
73_E	101_K	0.542	0.98
43_S	47_L	0.540	0.98
285_P	291_V	0.539	0.98
286_L	290_N	0.536	0.98
52_R	297_V	0.536	0.98
40_T	43_S	0.535	0.98
152_T	179_V	0.534	0.98
93_Y	96_R	0.534	0.98
82_G	85_V	0.533	0.98
198_K	202_V	0.532	0.98
88_A	283_F	0.531	0.98
71_I	87_I	0.531	0.98
127_G	130_S	0.530	0.98
128_L	131_Y	0.528	0.98
24_H	27_A	0.525	0.98
136_R	143_K	0.525	0.98
302_K	306_L	0.523	0.98
74_I	77_Y	0.522	0.98
18_C	25_C	0.521	0.98
208_E	212_Y	0.521	0.98
155_W	158_S	0.521	0.98
285_P	289_G	0.519	0.98
9_L	57_V	0.517	0.98
13_E	27_A	0.515	0.98
103_I	106_Y	0.513	0.98
189_V	193_D	0.513	0.98
60_F	74_I	0.512	0.98
46_L	49_D	0.511	0.98
11_F	61_T	0.510	0.98
182_L	186_G	0.510	0.98
302_K	308_I	0.508	0.98
64_D	89_P	0.507	0.98
202_V	206_L	0.504	0.98
218_T	224_F	0.503	0.98
17_A	35_P	0.502	0.98
271_F	282_G	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k36A	1	0.9114	100	0.308	Contact Map
1tv8A	2	0.8514	100	0.459	Contact Map
4m7tA	1	0.6629	100	0.466	Contact Map
4rtbA	2	0.8229	100	0.523	Contact Map
4wcxA	1	0.8914	100	0.55	Contact Map
3c8fA	1	0.6086	100	0.569	Contact Map
2yx0A	1	0.6771	100	0.593	Contact Map
2z2uA	1	0.6	99.9	0.607	Contact Map
2qgqA	1	0.7257	99.9	0.614	Contact Map
3rfaA	1	0.6743	99.9	0.623	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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