GREMLIN Database
Q97XA4 - Transposase ISC1316
UniProt: Q97XA4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 376 (331)
Sequences: 4592 (2896)
Seq/√Len: 159.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_D242_K5.2531.00
260_H263_Q4.2521.00
312_A342_N4.1981.00
292_L299_L3.5201.00
179_L284_L2.9961.00
285_R301_L2.9601.00
255_V351_S2.9491.00
256_M288_I2.9111.00
245_K249_E2.8971.00
283_E287_L2.7611.00
322_S325_D2.7101.00
139_V151_I2.5881.00
265_I277_S2.4661.00
198_L274_R2.4361.00
283_E286_D2.3591.00
248_A292_L2.3391.00
306_Y309_K2.3251.00
310_T317_V2.3171.00
350_G353_S2.2991.00
289_K301_L2.2971.00
302_V347_I2.2241.00
204_L221_A2.1541.00
284_L288_I2.1391.00
254_V292_L2.1381.00
137_K156_E2.1311.00
329_V336_I2.1021.00
307_T347_I2.0391.00
241_M290_Y2.0361.00
241_M287_L2.0331.00
311_C314_C2.0031.00
11_L57_A1.9971.00
197_A235_L1.9941.00
13_W17_Y1.9861.00
28_Q32_R1.9861.00
314_C333_C1.9611.00
309_K321_L1.9561.00
256_M299_L1.9521.00
237_T283_E1.9471.00
270_R273_R1.9331.00
314_C330_C1.9121.00
29_T32_R1.9011.00
244_G287_L1.8961.00
28_Q58_D1.8801.00
221_A225_L1.8541.00
16_I74_F1.8431.00
252_D297_K1.8131.00
241_M291_Q1.8041.00
289_K293_E1.7981.00
326_R339_R1.7871.00
330_C333_C1.7741.00
313_R335_W1.7671.00
216_N219_F1.7611.00
179_L239_L1.7511.00
241_M244_G1.7491.00
311_C330_C1.7151.00
240_Y287_L1.7091.00
311_C333_C1.6871.00
240_Y283_E1.6511.00
6_K44_E1.6301.00
328_F337_A1.6281.00
208_L222_K1.6151.00
211_K221_A1.6131.00
12_R60_Y1.5971.00
258_D301_L1.5961.00
59_R87_V1.5871.00
256_M301_L1.5801.00
115_L151_I1.5631.00
172_I180_I1.5531.00
70_G73_R1.5461.00
256_M285_R1.5231.00
219_F222_K1.5161.00
16_I20_Q1.5011.00
328_F335_W1.4971.00
51_Q90_Q1.4811.00
244_G290_Y1.4601.00
321_L325_D1.4561.00
327_V336_I1.4461.00
207_E211_K1.4371.00
61_Y65_Q1.4351.00
345_L349_R1.4211.00
257_E304_P1.4121.00
51_Q89_P1.4061.00
181_V341_Y1.3791.00
66_R72_A1.3661.00
169_V348_L1.3581.00
170_V182_T1.3581.00
64_R74_F1.3481.00
316_Y331_S1.3441.00
244_G291_Q1.3331.00
204_L207_E1.3281.00
17_Y21_R1.3211.00
244_G284_L1.3041.00
276_L281_F1.2941.00
214_L218_W1.2901.00
323_L326_R1.2891.00
15_D31_L1.2781.00
170_V251_Y1.2771.00
178_K181_V1.2761.00
11_L60_Y1.2651.00
29_T33_Q1.2621.00
148_R230_E1.2621.00
182_T186_E1.2581.00
312_A345_L1.2531.00
289_K299_L1.2511.00
146_S230_E1.2421.00
248_A295_Y1.2411.00
318_K328_F1.2401.00
27_T30_E1.2351.00
200_K204_L1.2341.00
230_E234_N1.2291.00
187_Y338_D1.2241.00
318_K321_L1.2081.00
201_V225_L1.2011.00
32_R58_D1.1961.00
144_T147_E1.1821.00
309_K320_D1.1801.00
169_V253_V1.1771.00
172_I182_T1.1681.00
201_V229_Y1.1611.00
197_A232_L1.1551.00
55_Q58_D1.1541.00
35_A57_A1.1531.00
14_A34_L1.1481.00
237_T287_L1.1381.00
174_V281_F1.1361.00
260_H304_P1.1271.00
65_Q69_E1.1271.00
246_W250_H1.1261.00
181_V187_Y1.1211.00
341_Y345_L1.1211.00
309_K319_E1.1201.00
312_A337_A1.1151.00
62_E66_R1.1071.00
208_L221_A1.1011.00
240_Y284_L1.0940.99
176_I279_V1.0910.99
33_Q36_L1.0910.99
337_A345_L1.0750.99
183_S344_S1.0750.99
32_R57_A1.0720.99
208_L225_L1.0700.99
204_L228_A1.0670.99
144_T148_R1.0660.99
245_K295_Y1.0550.99
49_Y52_V1.0550.99
142_K152_T1.0520.99
28_Q57_A1.0480.99
4_A56_I1.0470.99
323_L339_R1.0450.99
287_L290_Y1.0390.99
39_R53_V1.0300.99
265_I273_R1.0290.99
244_G288_I1.0280.99
322_S339_R1.0270.99
94_K116_K1.0220.99
318_K331_S1.0210.99
174_V285_R1.0200.99
94_K97_Q1.0180.99
88_Y91_Y1.0140.99
171_A348_L1.0120.99
114_T122_T1.0120.99
6_K10_T1.0120.99
55_Q89_P1.0110.99
51_Q55_Q1.0110.99
66_R69_E1.0070.99
248_A254_V1.0060.99
291_Q294_K1.0040.99
302_V350_G0.9980.99
166_T252_D0.9970.99
337_A341_Y0.9880.99
178_K189_P0.9870.99
249_E295_Y0.9860.99
322_S326_R0.9860.99
307_T350_G0.9850.99
248_A297_K0.9850.99
8_Y56_I0.9810.99
18_F22_D0.9810.99
66_R71_L0.9720.99
240_Y244_G0.9670.99
10_T14_A0.9660.99
310_T350_G0.9640.99
18_F26_L0.9580.99
87_V138_R0.9520.99
318_K322_S0.9510.99
67_F74_F0.9510.99
321_L328_F0.9430.98
36_L39_R0.9410.98
286_D289_K0.9350.98
12_R64_R0.9340.98
51_Q91_Y0.9340.98
258_D304_P0.9340.98
16_I64_R0.9300.98
59_R140_V0.9290.98
302_V351_S0.9270.98
19_Y23_G0.9240.98
292_L297_K0.9220.98
205_H209_S0.9210.98
141_V151_I0.9200.98
341_Y344_S0.9200.98
144_T230_E0.9140.98
255_V347_I0.9080.98
233_K237_T0.9060.98
272_L276_L0.9050.98
45_Y53_V0.9050.98
316_Y332_N0.9040.98
247_F254_V0.9020.98
81_H84_Y0.9000.98
48_L51_Q0.9000.98
261_V282_S0.8980.98
207_E210_R0.8960.98
325_D328_F0.8950.98
92_G118_S0.8930.98
11_L31_L0.8930.98
178_K187_Y0.8900.98
218_W222_K0.8880.98
114_T117_L0.8870.98
187_Y341_Y0.8870.98
54_Q58_D0.8830.98
231_H235_L0.8810.98
67_F75_P0.8800.98
309_K317_V0.8790.98
240_Y280_A0.8740.98
350_G354_E0.8710.97
201_V209_S0.8700.97
55_Q59_R0.8700.97
202_K205_H0.8680.97
312_A335_W0.8670.97
205_H229_Y0.8640.97
116_K122_T0.8630.97
87_V140_V0.8570.97
282_S286_D0.8540.97
201_V232_L0.8530.97
204_L225_L0.8530.97
325_D339_R0.8520.97
224_K227_R0.8490.97
312_A349_R0.8450.97
193_P235_L0.8430.97
168_K252_D0.8410.97
205_H225_L0.8380.97
253_V298_K0.8380.97
190_N193_P0.8360.97
208_L218_W0.8350.97
186_E246_W0.8350.97
140_V152_T0.8320.97
169_V352_G0.8310.97
312_A343_A0.8310.97
55_Q87_V0.8280.97
211_K217_N0.8220.96
327_V337_A0.8220.96
112_L117_L0.8220.96
13_W77_E0.8210.96
39_R43_D0.8190.96
345_L348_L0.8190.96
180_I243_L0.8170.96
310_T346_N0.8160.96
202_K206_R0.8160.96
13_W16_I0.8160.96
326_R338_D0.8090.96
170_V183_S0.8060.96
197_A201_V0.8060.96
258_D285_R0.8020.96
239_L243_L0.8020.96
35_A54_Q0.8000.96
204_L224_K0.8000.96
270_R277_S0.7980.96
117_L141_V0.7980.96
253_V300_I0.7970.96
30_E33_Q0.7950.96
343_A346_N0.7910.96
127_I130_D0.7880.95
228_A232_L0.7870.95
15_D61_Y0.7850.95
14_A17_Y0.7810.95
174_V180_I0.7780.95
170_V254_V0.7780.95
176_I265_I0.7770.95
181_V188_F0.7770.95
245_K291_Q0.7740.95
304_P307_T0.7660.95
255_V300_I0.7620.95
176_I275_R0.7600.94
138_R154_V0.7600.94
93_W97_Q0.7570.94
60_Y64_R0.7570.94
328_F339_R0.7500.94
165_N168_K0.7490.94
310_T319_E0.7480.94
64_R68_F0.7470.94
177_E181_V0.7460.94
51_Q54_Q0.7430.94
15_D18_F0.7410.94
319_E328_F0.7410.94
180_I284_L0.7320.93
217_N220_K0.7320.93
22_D25_G0.7300.93
321_L339_R0.7290.93
64_R67_F0.7280.93
194_Y198_L0.7280.93
309_K318_K0.7280.93
117_L123_F0.7270.93
115_L139_V0.7260.93
188_F243_L0.7240.93
201_V205_H0.7240.93
306_Y350_G0.7180.93
243_L246_W0.7160.93
66_R70_G0.7160.93
222_K226_A0.7150.92
215_S218_W0.7130.92
190_N279_V0.7130.92
14_A18_F0.7070.92
31_L34_L0.7050.92
342_N346_N0.7000.92
313_R345_L0.6990.92
300_I351_S0.6970.92
254_V288_I0.6950.91
263_Q304_P0.6950.91
113_I116_K0.6930.91
179_L279_V0.6930.91
203_H207_E0.6930.91
169_V255_V0.6900.91
51_Q92_G0.6880.91
209_S225_L0.6870.91
249_E253_V0.6860.91
261_V281_F0.6850.91
180_I188_F0.6780.90
116_K120_L0.6730.90
184_D251_Y0.6680.90
135_K156_E0.6680.90
175_G181_V0.6670.90
148_R234_N0.6650.90
194_Y197_A0.6620.89
255_V348_L0.6600.89
167_G252_D0.6590.89
25_G31_L0.6550.89
8_Y60_Y0.6510.89
39_R45_Y0.6480.88
20_Q23_G0.6470.88
197_A231_H0.6460.88
10_T13_W0.6460.88
57_A61_Y0.6460.88
349_R352_G0.6450.88
263_Q276_L0.6440.88
17_Y20_Q0.6430.88
208_L211_K0.6410.88
53_V56_I0.6400.88
308_S321_L0.6380.88
247_F251_Y0.6380.88
26_L31_L0.6360.87
206_R210_R0.6340.87
93_W136_V0.6340.87
36_L50_S0.6340.87
292_L295_Y0.6320.87
207_E221_A0.6320.87
206_R209_S0.6310.87
202_K209_S0.6310.87
18_F24_K0.6300.87
7_I53_V0.6300.87
28_Q31_L0.6290.87
168_K184_D0.6280.87
197_A228_A0.6280.87
16_I19_Y0.6270.87
49_Y88_Y0.6270.87
19_Y64_R0.6240.86
50_S92_G0.6230.86
320_D325_D0.6230.86
52_V86_L0.6230.86
91_Y94_K0.6220.86
24_K30_E0.6220.86
309_K322_S0.6220.86
7_I56_I0.6210.86
86_L90_Q0.6210.86
69_E72_A0.6190.86
25_G61_Y0.6180.86
259_I304_P0.6180.86
306_Y310_T0.6170.86
121_G124_K0.6170.86
163_L166_T0.6160.86
290_Y294_K0.6090.85
120_L123_F0.6070.85
349_R354_E0.6050.85
15_D25_G0.6050.85
168_K251_Y0.6040.85
306_Y317_V0.6020.84
218_W225_L0.6010.84
265_I270_R0.5960.84
232_L278_D0.5950.84
171_A255_V0.5930.83
85_S140_V0.5910.83
11_L35_A0.5910.83
35_A39_R0.5900.83
39_R42_D0.5900.83
4_A86_L0.5890.83
36_L57_A0.5890.83
48_L53_V0.5870.83
207_E224_K0.5850.83
193_P197_A0.5850.83
4_A48_L0.5830.82
58_D89_P0.5830.82
273_R277_S0.5810.82
179_L240_Y0.5810.82
90_Q93_W0.5810.82
287_L291_Q0.5810.82
280_A283_E0.5800.82
10_T44_E0.5800.82
229_Y236_R0.5770.82
188_F246_W0.5770.82
337_A342_N0.5750.82
191_L239_L0.5740.81
57_A60_Y0.5740.81
50_S89_P0.5740.81
93_W139_V0.5720.81
308_S322_S0.5710.81
319_E322_S0.5700.81
316_Y328_F0.5690.81
15_D22_D0.5670.81
188_F239_L0.5670.81
89_P93_W0.5670.81
117_L120_L0.5670.81
36_L40_K0.5670.81
34_L38_L0.5660.81
96_L116_K0.5660.81
184_D250_H0.5650.80
310_T315_G0.5630.80
321_L326_R0.5620.80
285_R289_K0.5590.80
196_K199_W0.5580.80
263_Q272_L0.5580.80
92_G95_I0.5570.80
144_T149_I0.5550.79
173_D340_D0.5550.79
347_I350_G0.5550.79
10_T38_L0.5540.79
288_I299_L0.5540.79
14_A31_L0.5540.79
210_R221_A0.5530.79
195_E274_R0.5520.79
32_R36_L0.5520.79
251_Y254_V0.5500.79
242_K245_K0.5490.79
305_A309_K0.5490.79
243_L284_L0.5470.78
10_T31_L0.5460.78
313_R337_A0.5450.78
6_K42_D0.5450.78
115_L118_S0.5430.78
125_V128_H0.5420.78
195_E198_L0.5410.78
88_Y93_W0.5410.78
237_T241_M0.5410.78
129_R132_P0.5410.78
265_I271_S0.5400.77
15_D19_Y0.5400.77
56_I60_Y0.5390.77
323_L338_D0.5390.77
245_K248_A0.5390.77
177_E326_R0.5360.77
177_E338_D0.5350.77
323_L327_V0.5340.77
229_Y233_K0.5340.77
272_L275_R0.5310.76
310_T328_F0.5310.76
264_L276_L0.5300.76
15_D64_R0.5290.76
49_Y90_Q0.5280.76
171_A344_S0.5280.76
163_L297_K0.5270.76
54_Q57_A0.5250.75
88_Y117_L0.5250.75
27_T32_R0.5250.75
234_N238_D0.5240.75
236_R278_D0.5230.75
29_T58_D0.5220.75
183_S341_Y0.5210.75
318_K339_R0.5210.75
171_A183_S0.5210.75
25_G30_E0.5210.75
325_D331_S0.5190.75
329_V335_W0.5190.75
144_T150_Y0.5180.74
130_D134_D0.5180.74
175_G178_K0.5140.74
63_A75_P0.5130.74
178_K338_D0.5120.74
261_V277_S0.5100.73
195_E199_W0.5100.73
195_E275_R0.5090.73
218_W221_A0.5080.73
13_W20_Q0.5060.73
49_Y89_P0.5060.73
79_K82_K0.5050.73
194_Y274_R0.5050.73
8_Y63_A0.5040.72
11_L38_L0.5040.72
14_A38_L0.5020.72
30_E34_L0.5020.72
173_D308_S0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3644 94.7 0.927 Contact Map
1nu0A 1 0.3404 94.1 0.929 Contact Map
1iv0A 1 0.2527 90 0.937 Contact Map
1ffkW 1 0.1676 89.4 0.938 Contact Map
4aybP 1 0.1144 87.5 0.94 Contact Map
1vq8Z 1 0.1941 84.1 0.943 Contact Map
1qypA 1 0.1223 83.2 0.943 Contact Map
1vd4A 1 0.1489 79.3 0.946 Contact Map
3j20Y 1 0.133 79.3 0.946 Contact Map
2k4xA 1 0.1463 78.8 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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