GREMLIN Database
Q97X97 - Uncharacterized protein
UniProt: Q97X97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (171)
Sequences: 10635 (7021)
Seq/√Len: 536.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_A133_F3.5651.00
86_I157_A3.3371.00
51_Y88_E2.8041.00
142_L153_K2.7201.00
87_A152_F2.5841.00
141_L149_F2.4571.00
120_E171_V2.4011.00
171_V174_W2.3531.00
107_K122_E2.3431.00
93_K134_S2.3071.00
140_V153_K2.2491.00
109_K122_E2.1131.00
111_L144_Y2.1011.00
143_A151_A2.0541.00
87_A92_G1.9201.00
21_L42_I1.9201.00
153_K158_L1.8971.00
23_R173_Q1.8791.00
107_K124_S1.8771.00
83_S159_G1.8721.00
5_A17_L1.8671.00
123_L171_V1.8571.00
141_L144_Y1.8371.00
133_F152_F1.8321.00
124_S170_M1.8141.00
83_S133_F1.7661.00
87_A136_P1.7351.00
174_W177_L1.7261.00
26_E29_A1.6981.00
49_G52_E1.6851.00
134_S144_Y1.6671.00
118_M151_A1.6111.00
135_L141_L1.5971.00
26_E30_E1.5931.00
152_F159_G1.5281.00
27_I30_E1.5241.00
66_I85_L1.5141.00
46_G81_L1.5041.00
109_K144_Y1.4791.00
90_L157_A1.4611.00
50_V88_E1.4351.00
95_I132_T1.4271.00
19_K22_P1.4251.00
41_L65_L1.4171.00
83_S152_F1.3841.00
135_L149_F1.3811.00
3_I40_A1.3711.00
27_I32_L1.3521.00
30_E33_K1.3451.00
139_A152_F1.3441.00
126_F168_S1.3131.00
27_I33_K1.3121.00
68_K72_E1.3091.00
77_L160_V1.2811.00
97_G132_T1.2701.00
27_I31_E1.2651.00
49_G131_D1.2621.00
139_A154_V1.2601.00
106_Q126_F1.2581.00
138_D154_V1.2561.00
101_Q130_G1.2541.00
92_G136_P1.2411.00
79_V160_V1.2221.00
29_A32_L1.2091.00
51_Y131_D1.2061.00
41_L74_K1.2041.00
86_I159_G1.1851.00
48_M52_E1.1691.00
68_K71_K1.1641.00
59_L85_L1.1611.00
123_L175_I1.1611.00
115_K153_K1.1341.00
35_D38_F1.1291.00
101_Q104_G1.1221.00
142_L151_A1.1211.00
112_G140_V1.1131.00
34_G69_G1.1091.00
144_Y148_Y1.1091.00
34_G73_N1.0971.00
116_D153_K1.0971.00
40_A75_R1.0651.00
16_T79_V1.0611.00
108_V143_A1.0481.00
120_E123_L1.0461.00
66_I76_I1.0391.00
61_V89_A1.0371.00
136_P152_F1.0301.00
111_L114_L1.0291.00
102_E105_I1.0261.00
34_G37_Q1.0251.00
4_L40_A1.0201.00
117_F158_L1.0151.00
102_E145_S1.0091.00
29_A33_K1.0001.00
34_G72_E0.9801.00
16_T176_K0.9731.00
142_L158_L0.9691.00
138_D155_K0.9671.00
106_Q127_Q0.9601.00
18_K22_P0.9521.00
118_M162_F0.9471.00
109_K146_N0.9351.00
97_G148_Y0.9131.00
41_L76_I0.9051.00
5_A42_I0.9041.00
4_L27_I0.9031.00
113_E142_L0.8941.00
100_G147_N0.8911.00
116_D119_R0.8891.00
38_F74_K0.8881.00
3_I21_L0.8841.00
21_L24_V0.8801.00
109_K112_G0.8791.00
24_V176_K0.8791.00
71_K157_A0.8771.00
26_E31_E0.8751.00
42_I77_L0.8721.00
49_G96_K0.8671.00
132_T148_Y0.8671.00
28_M33_K0.8591.00
170_M173_Q0.8551.00
43_I60_K0.8541.00
26_E33_K0.8521.00
57_H60_K0.8521.00
20_F173_Q0.8511.00
116_D158_L0.8501.00
19_K23_R0.8471.00
76_I86_I0.8461.00
114_L142_L0.8401.00
57_H85_L0.8171.00
20_F24_V0.8141.00
106_Q124_S0.8111.00
18_K21_L0.8091.00
8_N43_I0.8091.00
95_I134_S0.7921.00
176_K179_G0.7911.00
112_G116_D0.7911.00
113_E116_D0.7881.00
28_M31_E0.7831.00
70_Y157_A0.7801.00
56_Y59_L0.7801.00
120_E170_M0.7761.00
113_E140_V0.7731.00
94_V131_D0.7701.00
100_G103_I0.7701.00
125_V169_E0.7621.00
58_F61_V0.7571.00
174_W178_Y0.7571.00
92_G133_F0.7481.00
59_L89_A0.7391.00
66_I86_I0.7391.00
90_L154_V0.7321.00
102_E150_Q0.7261.00
96_K101_Q0.7251.00
60_K68_K0.7251.00
41_L69_G0.7241.00
43_I76_I0.7131.00
160_V164_L0.7091.00
57_H61_V0.7091.00
48_M51_Y0.7061.00
69_G74_K0.7021.00
58_F89_A0.6991.00
103_I128_W0.6981.00
110_L114_L0.6951.00
69_G72_E0.6921.00
70_Y90_L0.6881.00
80_C84_Q0.6881.00
113_E121_D0.6811.00
100_G132_T0.6811.00
9_H30_E0.6801.00
127_Q150_Q0.6731.00
115_K140_V0.6711.00
172_S176_K0.6691.00
85_L89_A0.6671.00
125_V162_F0.6671.00
61_V88_E0.6631.00
59_L81_L0.6591.00
80_C163_H0.6561.00
58_F88_E0.6551.00
112_G115_K0.6551.00
128_W178_Y0.6541.00
88_E93_K0.6541.00
173_Q177_L0.6501.00
108_V162_F0.6501.00
102_E129_H0.6501.00
103_I130_G0.6481.00
109_K121_D0.6441.00
65_L69_G0.6411.00
145_S148_Y0.6401.00
115_K142_L0.6331.00
83_S87_A0.6311.00
49_G88_E0.6301.00
56_Y60_K0.6291.00
100_G104_G0.6221.00
70_Y76_I0.6161.00
9_H12_E0.6151.00
133_F149_F0.6141.00
126_F166_V0.6111.00
134_S137_Q0.6051.00
115_K121_D0.6051.00
7_Y13_T0.6041.00
88_E94_V0.6001.00
26_E32_L0.6001.00
20_F23_R0.5981.00
132_T149_F0.5951.00
14_L17_L0.5931.00
105_I126_F0.5911.00
114_L153_K0.5901.00
168_S172_S0.5870.99
96_K131_D0.5870.99
96_K130_G0.5840.99
110_L122_E0.5830.99
52_E56_Y0.5810.99
8_N44_M0.5750.99
135_L152_F0.5710.99
24_V173_Q0.5700.99
151_A160_V0.5690.99
92_G134_S0.5660.99
6_V65_L0.5590.99
36_E74_K0.5560.99
4_L38_F0.5560.99
14_L18_K0.5560.99
84_Q161_Q0.5550.99
135_L139_A0.5510.99
123_L170_M0.5470.99
151_A158_L0.5440.99
167_N170_M0.5440.99
24_V177_L0.5440.99
90_L139_A0.5400.99
105_I124_S0.5400.99
61_V68_K0.5390.99
95_I98_G0.5380.99
112_G121_D0.5340.99
7_Y12_E0.5320.99
49_G94_V0.5310.99
17_L22_P0.5290.99
113_E153_K0.5280.99
97_G100_G0.5270.99
50_V131_D0.5220.99
71_K90_L0.5180.99
28_M32_L0.5180.99
149_F152_F0.5180.99
16_T21_L0.5130.99
69_G73_N0.5110.99
78_G86_I0.5110.99
32_L65_L0.5100.99
84_Q94_V0.5100.99
43_I66_I0.5100.99
19_K173_Q0.5090.99
15_G19_K0.5070.99
34_G68_K0.5060.98
5_A14_L0.5050.98
107_K146_N0.5040.98
90_L138_D0.5030.98
21_L25_N0.5010.98
177_L180_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m3pA 1 0.9856 100 0.365 Contact Map
1o1yA 2 0.9952 100 0.365 Contact Map
3l7nA 1 0.9952 100 0.378 Contact Map
3tqiA 3 0.8852 100 0.407 Contact Map
1gpmA 3 0.9522 100 0.411 Contact Map
2vdjA 2 0.9904 100 0.418 Contact Map
3uowA 2 0.9665 100 0.422 Contact Map
2vxoA 2 0.933 100 0.426 Contact Map
3r75A 2 0.8708 100 0.427 Contact Map
2ywbA 4 0.9187 100 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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