GREMLIN Database
HTPX1 - Protease HtpX homolog 1
UniProt: Q97X95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (269)
Sequences: 4769 (3506)
Seq/√Len: 213.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_A303_Y4.5441.00
82_R132_T4.3901.00
140_G222_N4.1641.00
98_D120_L4.1401.00
130_E240_K4.1051.00
70_D81_R3.5881.00
129_D230_G3.5581.00
136_A223_S3.2761.00
224_F302_I3.2481.00
75_W128_V3.1781.00
118_I135_I3.0111.00
217_S297_R2.9701.00
110_R113_G2.6851.00
223_S227_L2.4761.00
77_Y91_P2.4511.00
221_Y225_L2.4461.00
235_A299_A2.2781.00
87_S226_V2.2291.00
42_P46_I2.2111.00
129_D233_A2.1231.00
79_L132_T2.1221.00
242_E296_A2.1141.00
130_E236_T2.1061.00
297_R300_Q2.0761.00
69_N72_Q2.0281.00
46_I50_F2.0261.00
239_A299_A1.9881.00
127_D236_T1.9651.00
81_R85_E1.9571.00
127_D240_K1.9171.00
227_L233_A1.9161.00
294_Y297_R1.9011.00
18_T22_E1.8751.00
14_S18_T1.8721.00
174_A177_L1.8521.00
232_K303_Y1.8461.00
65_E95_F1.8371.00
81_R91_P1.7951.00
146_D218_Y1.7941.00
242_E295_P1.7921.00
230_G233_A1.7731.00
66_V98_D1.7691.00
125_I244_Y1.7511.00
80_V94_V1.7161.00
126_L241_I1.6721.00
235_A303_Y1.6201.00
67_S93_R1.6161.00
57_Y61_R1.6001.00
10_S14_S1.5781.00
105_F117_G1.5781.00
122_L131_L1.5381.00
221_Y301_M1.4691.00
205_Q209_L1.4511.00
79_L128_V1.4401.00
164_S167_L1.4211.00
120_L124_N1.4171.00
300_Q303_Y1.4171.00
74_G77_Y1.4031.00
106_A116_V1.4031.00
114_M142_I1.3941.00
83_I139_V1.3891.00
77_Y81_R1.3871.00
66_V72_Q1.3771.00
146_D215_R1.3741.00
141_H216_E1.3721.00
95_F115_R1.3721.00
78_N82_R1.3711.00
287_D297_R1.3651.00
145_R148_E1.3621.00
100_P124_N1.3611.00
21_S25_V1.3581.00
168_M171_G1.3491.00
73_Y96_V1.3481.00
70_D77_Y1.3421.00
176_F179_A1.3321.00
10_S13_I1.3291.00
301_M304_R1.3181.00
78_N81_R1.2811.00
137_H216_E1.2801.00
234_L302_I1.2791.00
300_Q304_R1.2711.00
133_A234_L1.2601.00
138_E216_E1.2521.00
75_W78_N1.2511.00
132_T230_G1.2471.00
123_L131_L1.2361.00
227_L231_S1.2311.00
50_F54_I1.2251.00
67_S95_F1.2181.00
144_H222_N1.2051.00
54_I58_V1.2001.00
217_S301_M1.1931.00
290_S294_Y1.1641.00
27_I31_S1.1591.00
83_I226_V1.1571.00
184_L187_A1.1391.00
228_G231_S1.1251.00
11_M15_L1.1221.00
10_S18_T1.1011.00
20_I25_V1.0991.00
137_H141_H1.0991.00
60_G105_F1.0891.00
150_G215_R1.0881.00
214_L218_Y1.0861.00
177_L180_D1.0841.00
89_I139_V1.0841.00
118_I123_L1.0821.00
144_H218_Y1.0811.00
47_F51_Q1.0751.00
134_V237_A1.0741.00
20_I24_I1.0541.00
297_R301_M1.0511.00
175_L178_A1.0441.00
185_L188_I1.0331.00
109_N113_G1.0301.00
133_A233_A1.0291.00
23_G28_G1.0271.00
14_S17_L1.0231.00
295_P299_A1.0191.00
296_A300_Q1.0101.00
74_G78_N1.0051.00
242_E246_Q1.0051.00
11_M18_T1.0041.00
48_W51_Q1.0011.00
196_V199_V1.0001.00
218_Y222_N1.0001.00
232_K235_A0.9981.00
24_I27_I0.9831.00
174_A178_A0.9781.00
28_G31_S0.9771.00
78_N128_V0.9751.00
189_A192_A0.9751.00
82_R86_E0.9671.00
167_L170_F0.9651.00
55_S60_G0.9631.00
138_E141_H0.9611.00
193_I197_I0.9551.00
122_L126_L0.9551.00
216_E219_A0.9541.00
76_L118_I0.9531.00
299_A303_Y0.9441.00
12_V16_G0.9431.00
231_S234_L0.9390.99
215_R218_Y0.9320.99
207_F211_F0.9310.99
233_A236_T0.9310.99
129_D236_T0.9200.99
73_Y77_Y0.9170.99
56_P60_G0.9150.99
11_M14_S0.9130.99
19_I23_G0.9080.99
174_A179_A0.8990.99
248_I251_D0.8960.99
21_S24_I0.8960.99
234_L238_L0.8890.99
137_H219_A0.8870.99
118_I122_L0.8870.99
82_R85_E0.8860.99
154_G158_T0.8820.99
53_I109_N0.8800.99
11_M16_G0.8800.99
196_V200_V0.8750.99
166_L170_F0.8740.99
24_I29_I0.8680.99
36_S40_I0.8680.99
187_A190_A0.8620.99
37_L41_F0.8600.99
26_L30_A0.8600.99
269_D273_L0.8570.99
16_G20_I0.8570.99
209_L291_T0.8540.99
190_A194_G0.8520.99
232_K236_T0.8490.99
187_A191_L0.8480.99
102_P244_Y0.8480.99
116_V135_I0.8460.99
190_A193_I0.8440.99
15_L18_T0.8410.99
18_T25_V0.8390.99
149_I215_R0.8380.99
293_P298_R0.8380.99
126_L240_K0.8340.99
271_H274_V0.8310.99
86_E228_G0.8260.99
149_I218_Y0.8220.99
48_W52_W0.8210.99
45_V155_L0.8190.99
63_G273_L0.8150.99
218_Y221_Y0.8140.99
89_I143_K0.8130.99
12_V19_I0.8090.98
212_N291_T0.8080.98
14_S22_E0.8030.98
140_G226_V0.8030.98
38_F42_P0.8030.98
184_L188_I0.8000.98
40_I161_G0.7990.98
70_D74_G0.7980.98
172_Y175_L0.7980.98
68_P76_L0.7970.98
18_T21_S0.7940.98
79_L83_I0.7930.98
68_P96_V0.7930.98
110_R114_M0.7920.98
49_L53_I0.7860.98
186_F190_A0.7840.98
100_P120_L0.7750.98
186_F189_A0.7740.98
127_D130_E0.7740.98
176_F180_D0.7710.98
76_L94_V0.7700.98
150_G212_N0.7690.98
239_A243_I0.7680.98
83_I135_I0.7650.98
21_S28_G0.7620.98
56_P93_R0.7610.98
84_A139_V0.7520.98
15_L23_G0.7520.98
166_L169_N0.7500.98
18_T23_G0.7480.97
170_F174_A0.7470.97
23_G27_I0.7430.97
96_V123_L0.7400.97
139_V142_I0.7400.97
26_L29_I0.7380.97
107_Y147_V0.7370.97
97_I119_T0.7370.97
216_E292_H0.7360.97
236_T240_K0.7340.97
41_F45_V0.7330.97
54_I57_Y0.7330.97
20_I23_G0.7290.97
188_I192_A0.7270.97
102_P125_I0.7270.97
270_P273_L0.7250.97
147_V151_M0.7220.97
165_T169_N0.7210.97
23_G26_L0.7210.97
10_S15_L0.7170.97
14_S24_I0.7170.97
167_L171_G0.7120.97
286_K297_R0.7120.97
25_V28_G0.7120.97
143_K222_N0.7090.96
80_V135_I0.7060.96
13_I18_T0.7060.96
84_A91_P0.7060.96
14_S26_L0.7060.96
15_L19_I0.7040.96
73_Y76_L0.7030.96
85_E88_K0.7010.96
14_S21_S0.7000.96
15_L24_I0.6990.96
68_P73_Y0.6980.96
172_Y176_F0.6960.96
241_I275_E0.6960.96
194_G198_F0.6960.96
19_I22_E0.6950.96
152_T159_V0.6890.96
165_T168_M0.6890.96
128_V132_T0.6880.96
17_L20_I0.6880.96
64_Y98_D0.6860.96
63_G269_D0.6830.96
18_T26_L0.6800.96
235_A239_A0.6790.96
10_S17_L0.6790.96
244_Y247_N0.6790.96
239_A242_E0.6770.95
241_I245_M0.6760.95
228_G233_A0.6740.95
22_E26_L0.6730.95
35_I38_F0.6720.95
175_L180_D0.6720.95
162_Y165_T0.6700.95
14_S25_V0.6670.95
103_N137_H0.6650.95
133_A235_A0.6620.95
199_V202_F0.6610.95
175_L179_A0.6600.95
103_N106_A0.6580.95
153_I211_F0.6550.95
202_F205_Q0.6540.95
11_M23_G0.6510.94
245_M248_I0.6500.94
106_A114_M0.6500.94
12_V15_L0.6500.94
97_I117_G0.6500.94
126_L134_V0.6480.94
141_H292_H0.6460.94
10_S25_V0.6460.94
143_K225_L0.6400.94
101_Y245_M0.6390.94
157_P201_T0.6370.94
204_L207_F0.6340.94
223_S234_L0.6340.94
141_H219_A0.6320.93
144_H215_R0.6290.93
107_Y115_R0.6250.93
287_D290_S0.6240.93
85_E232_K0.6230.93
222_N225_L0.6180.93
106_A119_T0.6160.93
210_W214_L0.6150.93
93_R115_R0.6140.92
22_E25_V0.6120.92
234_L237_A0.6110.92
91_P94_V0.6110.92
249_R252_P0.6110.92
41_F162_Y0.6100.92
201_T204_L0.6100.92
63_G97_I0.6090.92
65_E68_P0.6090.92
25_V29_I0.6090.92
46_I49_L0.6050.92
269_D272_L0.6040.92
155_L159_V0.6030.92
35_I39_F0.6020.92
136_A226_V0.6010.92
97_I101_Y0.5980.91
14_S28_G0.5950.91
92_P215_R0.5940.91
18_T24_I0.5930.91
70_D78_N0.5870.91
94_V118_I0.5860.91
13_I45_V0.5860.91
68_P77_Y0.5850.91
20_I28_G0.5840.91
206_I289_L0.5820.90
227_L230_G0.5800.90
238_L302_I0.5790.90
183_E186_F0.5780.90
71_P74_G0.5770.90
99_A120_L0.5760.90
152_T157_P0.5740.90
224_F231_S0.5720.90
59_V62_G0.5690.89
82_R228_G0.5680.89
133_A302_I0.5670.89
148_E152_T0.5670.89
236_T239_A0.5660.89
156_I161_G0.5650.89
210_W213_R0.5620.89
102_P121_P0.5610.89
16_G31_S0.5590.89
28_G32_L0.5560.88
154_G157_P0.5560.88
138_E292_H0.5540.88
66_V97_I0.5530.88
41_F48_W0.5520.88
84_A88_K0.5500.88
252_P283_S0.5480.88
287_D294_Y0.5480.88
29_I32_L0.5480.88
132_T136_A0.5480.88
79_L82_R0.5470.87
80_V132_T0.5460.87
76_L123_L0.5460.87
84_A89_I0.5430.87
21_S26_L0.5410.87
102_P234_L0.5390.87
240_K243_I0.5370.87
185_L189_A0.5350.86
97_I147_V0.5340.86
101_Y241_I0.5340.86
121_P146_D0.5320.86
152_T155_L0.5300.86
40_I44_L0.5300.86
13_I22_E0.5290.86
180_D183_E0.5280.86
220_D298_R0.5280.86
241_I295_P0.5260.85
292_H298_R0.5240.85
13_I25_V0.5230.85
77_Y94_V0.5220.85
195_F199_V0.5210.85
23_G30_A0.5190.85
42_P50_F0.5170.84
248_I252_P0.5170.84
80_V87_S0.5160.84
247_N251_D0.5160.84
161_G165_T0.5150.84
13_I20_I0.5150.84
286_K290_S0.5150.84
45_V49_L0.5140.84
238_L295_P0.5130.84
160_L207_F0.5130.84
87_S139_V0.5120.84
51_Q55_S0.5120.84
52_W55_S0.5120.84
111_L145_R0.5090.83
58_V125_I0.5070.83
44_L52_W0.5070.83
185_L190_A0.5070.83
25_V43_A0.5060.83
194_G197_I0.5060.83
154_G203_I0.5040.83
129_D132_T0.5040.83
170_F176_F0.5030.83
84_A90_K0.5020.83
231_S302_I0.5020.83
28_G37_L0.5020.83
55_S105_F0.5010.83
20_I26_L0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.865 100 0.28 Contact Map
4il3A 1 0.8682 100 0.282 Contact Map
3c37A 1 0.6238 100 0.504 Contact Map
3cqbA 4 0.3312 99.8 0.653 Contact Map
4qhjA 2 0.328 97.2 0.875 Contact Map
4jixA 2 0.3441 96.5 0.887 Contact Map
4jiuA 1 0.3248 95.9 0.893 Contact Map
3dteA 2 0.492 94 0.904 Contact Map
2r9rB 3 0.2058 34.8 0.945 Contact Map
1mhsA 2 0.299 9.1 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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