HTPX1 - SULSO - GREMLIN Contacts

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HTPX1 - Protease HtpX homolog 1

UniProt:	Q97X95	Sequences: MDVRQRLISSMVISLGLTIISEGIVLIGIASLLHISLFFIFPALVIFWLFQWIISPYVVGRGGYEVSPNDPQYGWLYNLVRRIAEESKIKPPRVFVIDAPYPNAFAYGNRLGGMRVGITLPLLNILDVDELTAVIAHEVGHIKHRDVEIGMTIGLIPTVLGYISTLLMNFGYLALFLAADEIELLFAIAALAIGFVIFVVTFILQIFVLWFNRLRESYADYNSFLVLGEGSKALATALAKIEIYMQNIRIDPFTGIIVTAPPVKVEEKDPHLLVEQWLRTKVSAFKDILSTHPYPARRAQMIYRLIYGSNI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (269)
Sequences:	4769 (3506)
Seq/√Len:	213.8

ECOLI - HTPX LOIP YCAL BEPA
BACSU - YHFN HTPX YXKI
HALSA - HTPX Q9HSA2 Q9HS47
SULSO - HTPX1 HTPX2 Q97VD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_A	303_Y	4.544	1.00
82_R	132_T	4.390	1.00
140_G	222_N	4.164	1.00
98_D	120_L	4.140	1.00
130_E	240_K	4.105	1.00
70_D	81_R	3.588	1.00
129_D	230_G	3.558	1.00
136_A	223_S	3.276	1.00
224_F	302_I	3.248	1.00
75_W	128_V	3.178	1.00
118_I	135_I	3.011	1.00
217_S	297_R	2.970	1.00
110_R	113_G	2.685	1.00
223_S	227_L	2.476	1.00
77_Y	91_P	2.451	1.00
221_Y	225_L	2.446	1.00
235_A	299_A	2.278	1.00
87_S	226_V	2.229	1.00
42_P	46_I	2.211	1.00
129_D	233_A	2.123	1.00
79_L	132_T	2.122	1.00
242_E	296_A	2.114	1.00
130_E	236_T	2.106	1.00
297_R	300_Q	2.076	1.00
69_N	72_Q	2.028	1.00
46_I	50_F	2.026	1.00
239_A	299_A	1.988	1.00
127_D	236_T	1.965	1.00
81_R	85_E	1.957	1.00
127_D	240_K	1.917	1.00
227_L	233_A	1.916	1.00
294_Y	297_R	1.901	1.00
18_T	22_E	1.875	1.00
14_S	18_T	1.872	1.00
174_A	177_L	1.852	1.00
232_K	303_Y	1.846	1.00
65_E	95_F	1.837	1.00
81_R	91_P	1.795	1.00
146_D	218_Y	1.794	1.00
242_E	295_P	1.792	1.00
230_G	233_A	1.773	1.00
66_V	98_D	1.769	1.00
125_I	244_Y	1.751	1.00
80_V	94_V	1.716	1.00
126_L	241_I	1.672	1.00
235_A	303_Y	1.620	1.00
67_S	93_R	1.616	1.00
57_Y	61_R	1.600	1.00
10_S	14_S	1.578	1.00
105_F	117_G	1.578	1.00
122_L	131_L	1.538	1.00
221_Y	301_M	1.469	1.00
205_Q	209_L	1.451	1.00
79_L	128_V	1.440	1.00
164_S	167_L	1.421	1.00
120_L	124_N	1.417	1.00
300_Q	303_Y	1.417	1.00
74_G	77_Y	1.403	1.00
106_A	116_V	1.403	1.00
114_M	142_I	1.394	1.00
83_I	139_V	1.389	1.00
77_Y	81_R	1.387	1.00
66_V	72_Q	1.377	1.00
146_D	215_R	1.374	1.00
141_H	216_E	1.372	1.00
95_F	115_R	1.372	1.00
78_N	82_R	1.371	1.00
287_D	297_R	1.365	1.00
145_R	148_E	1.362	1.00
100_P	124_N	1.361	1.00
21_S	25_V	1.358	1.00
168_M	171_G	1.349	1.00
73_Y	96_V	1.348	1.00
70_D	77_Y	1.342	1.00
176_F	179_A	1.332	1.00
10_S	13_I	1.329	1.00
301_M	304_R	1.318	1.00
78_N	81_R	1.281	1.00
137_H	216_E	1.280	1.00
234_L	302_I	1.279	1.00
300_Q	304_R	1.271	1.00
133_A	234_L	1.260	1.00
138_E	216_E	1.252	1.00
75_W	78_N	1.251	1.00
132_T	230_G	1.247	1.00
123_L	131_L	1.236	1.00
227_L	231_S	1.231	1.00
50_F	54_I	1.225	1.00
67_S	95_F	1.218	1.00
144_H	222_N	1.205	1.00
54_I	58_V	1.200	1.00
217_S	301_M	1.193	1.00
290_S	294_Y	1.164	1.00
27_I	31_S	1.159	1.00
83_I	226_V	1.157	1.00
184_L	187_A	1.139	1.00
228_G	231_S	1.125	1.00
11_M	15_L	1.122	1.00
10_S	18_T	1.101	1.00
20_I	25_V	1.099	1.00
137_H	141_H	1.099	1.00
60_G	105_F	1.089	1.00
150_G	215_R	1.088	1.00
214_L	218_Y	1.086	1.00
177_L	180_D	1.084	1.00
89_I	139_V	1.084	1.00
118_I	123_L	1.082	1.00
144_H	218_Y	1.081	1.00
47_F	51_Q	1.075	1.00
134_V	237_A	1.074	1.00
20_I	24_I	1.054	1.00
297_R	301_M	1.051	1.00
175_L	178_A	1.044	1.00
185_L	188_I	1.033	1.00
109_N	113_G	1.030	1.00
133_A	233_A	1.029	1.00
23_G	28_G	1.027	1.00
14_S	17_L	1.023	1.00
295_P	299_A	1.019	1.00
296_A	300_Q	1.010	1.00
74_G	78_N	1.005	1.00
242_E	246_Q	1.005	1.00
11_M	18_T	1.004	1.00
48_W	51_Q	1.001	1.00
196_V	199_V	1.000	1.00
218_Y	222_N	1.000	1.00
232_K	235_A	0.998	1.00
24_I	27_I	0.983	1.00
174_A	178_A	0.978	1.00
28_G	31_S	0.977	1.00
78_N	128_V	0.975	1.00
189_A	192_A	0.975	1.00
82_R	86_E	0.967	1.00
167_L	170_F	0.965	1.00
55_S	60_G	0.963	1.00
138_E	141_H	0.961	1.00
193_I	197_I	0.955	1.00
122_L	126_L	0.955	1.00
216_E	219_A	0.954	1.00
76_L	118_I	0.953	1.00
299_A	303_Y	0.944	1.00
12_V	16_G	0.943	1.00
231_S	234_L	0.939	0.99
215_R	218_Y	0.932	0.99
207_F	211_F	0.931	0.99
233_A	236_T	0.931	0.99
129_D	236_T	0.920	0.99
73_Y	77_Y	0.917	0.99
56_P	60_G	0.915	0.99
11_M	14_S	0.913	0.99
19_I	23_G	0.908	0.99
174_A	179_A	0.899	0.99
248_I	251_D	0.896	0.99
21_S	24_I	0.896	0.99
234_L	238_L	0.889	0.99
137_H	219_A	0.887	0.99
118_I	122_L	0.887	0.99
82_R	85_E	0.886	0.99
154_G	158_T	0.882	0.99
53_I	109_N	0.880	0.99
11_M	16_G	0.880	0.99
196_V	200_V	0.875	0.99
166_L	170_F	0.874	0.99
24_I	29_I	0.868	0.99
36_S	40_I	0.868	0.99
187_A	190_A	0.862	0.99
37_L	41_F	0.860	0.99
26_L	30_A	0.860	0.99
269_D	273_L	0.857	0.99
16_G	20_I	0.857	0.99
209_L	291_T	0.854	0.99
190_A	194_G	0.852	0.99
232_K	236_T	0.849	0.99
187_A	191_L	0.848	0.99
102_P	244_Y	0.848	0.99
116_V	135_I	0.846	0.99
190_A	193_I	0.844	0.99
15_L	18_T	0.841	0.99
18_T	25_V	0.839	0.99
149_I	215_R	0.838	0.99
293_P	298_R	0.838	0.99
126_L	240_K	0.834	0.99
271_H	274_V	0.831	0.99
86_E	228_G	0.826	0.99
149_I	218_Y	0.822	0.99
48_W	52_W	0.821	0.99
45_V	155_L	0.819	0.99
63_G	273_L	0.815	0.99
218_Y	221_Y	0.814	0.99
89_I	143_K	0.813	0.99
12_V	19_I	0.809	0.98
212_N	291_T	0.808	0.98
14_S	22_E	0.803	0.98
140_G	226_V	0.803	0.98
38_F	42_P	0.803	0.98
184_L	188_I	0.800	0.98
40_I	161_G	0.799	0.98
70_D	74_G	0.798	0.98
172_Y	175_L	0.798	0.98
68_P	76_L	0.797	0.98
18_T	21_S	0.794	0.98
79_L	83_I	0.793	0.98
68_P	96_V	0.793	0.98
110_R	114_M	0.792	0.98
49_L	53_I	0.786	0.98
186_F	190_A	0.784	0.98
100_P	120_L	0.775	0.98
186_F	189_A	0.774	0.98
127_D	130_E	0.774	0.98
176_F	180_D	0.771	0.98
76_L	94_V	0.770	0.98
150_G	212_N	0.769	0.98
239_A	243_I	0.768	0.98
83_I	135_I	0.765	0.98
21_S	28_G	0.762	0.98
56_P	93_R	0.761	0.98
84_A	139_V	0.752	0.98
15_L	23_G	0.752	0.98
166_L	169_N	0.750	0.98
18_T	23_G	0.748	0.97
170_F	174_A	0.747	0.97
23_G	27_I	0.743	0.97
96_V	123_L	0.740	0.97
139_V	142_I	0.740	0.97
26_L	29_I	0.738	0.97
107_Y	147_V	0.737	0.97
97_I	119_T	0.737	0.97
216_E	292_H	0.736	0.97
236_T	240_K	0.734	0.97
41_F	45_V	0.733	0.97
54_I	57_Y	0.733	0.97
20_I	23_G	0.729	0.97
188_I	192_A	0.727	0.97
102_P	125_I	0.727	0.97
270_P	273_L	0.725	0.97
147_V	151_M	0.722	0.97
165_T	169_N	0.721	0.97
23_G	26_L	0.721	0.97
10_S	15_L	0.717	0.97
14_S	24_I	0.717	0.97
167_L	171_G	0.712	0.97
286_K	297_R	0.712	0.97
25_V	28_G	0.712	0.97
143_K	222_N	0.709	0.96
80_V	135_I	0.706	0.96
13_I	18_T	0.706	0.96
84_A	91_P	0.706	0.96
14_S	26_L	0.706	0.96
15_L	19_I	0.704	0.96
73_Y	76_L	0.703	0.96
85_E	88_K	0.701	0.96
14_S	21_S	0.700	0.96
15_L	24_I	0.699	0.96
68_P	73_Y	0.698	0.96
172_Y	176_F	0.696	0.96
241_I	275_E	0.696	0.96
194_G	198_F	0.696	0.96
19_I	22_E	0.695	0.96
152_T	159_V	0.689	0.96
165_T	168_M	0.689	0.96
128_V	132_T	0.688	0.96
17_L	20_I	0.688	0.96
64_Y	98_D	0.686	0.96
63_G	269_D	0.683	0.96
18_T	26_L	0.680	0.96
235_A	239_A	0.679	0.96
10_S	17_L	0.679	0.96
244_Y	247_N	0.679	0.96
239_A	242_E	0.677	0.95
241_I	245_M	0.676	0.95
228_G	233_A	0.674	0.95
22_E	26_L	0.673	0.95
35_I	38_F	0.672	0.95
175_L	180_D	0.672	0.95
162_Y	165_T	0.670	0.95
14_S	25_V	0.667	0.95
103_N	137_H	0.665	0.95
133_A	235_A	0.662	0.95
199_V	202_F	0.661	0.95
175_L	179_A	0.660	0.95
103_N	106_A	0.658	0.95
153_I	211_F	0.655	0.95
202_F	205_Q	0.654	0.95
11_M	23_G	0.651	0.94
245_M	248_I	0.650	0.94
106_A	114_M	0.650	0.94
12_V	15_L	0.650	0.94
97_I	117_G	0.650	0.94
126_L	134_V	0.648	0.94
141_H	292_H	0.646	0.94
10_S	25_V	0.646	0.94
143_K	225_L	0.640	0.94
101_Y	245_M	0.639	0.94
157_P	201_T	0.637	0.94
204_L	207_F	0.634	0.94
223_S	234_L	0.634	0.94
141_H	219_A	0.632	0.93
144_H	215_R	0.629	0.93
107_Y	115_R	0.625	0.93
287_D	290_S	0.624	0.93
85_E	232_K	0.623	0.93
222_N	225_L	0.618	0.93
106_A	119_T	0.616	0.93
210_W	214_L	0.615	0.93
93_R	115_R	0.614	0.92
22_E	25_V	0.612	0.92
234_L	237_A	0.611	0.92
91_P	94_V	0.611	0.92
249_R	252_P	0.611	0.92
41_F	162_Y	0.610	0.92
201_T	204_L	0.610	0.92
63_G	97_I	0.609	0.92
65_E	68_P	0.609	0.92
25_V	29_I	0.609	0.92
46_I	49_L	0.605	0.92
269_D	272_L	0.604	0.92
155_L	159_V	0.603	0.92
35_I	39_F	0.602	0.92
136_A	226_V	0.601	0.92
97_I	101_Y	0.598	0.91
14_S	28_G	0.595	0.91
92_P	215_R	0.594	0.91
18_T	24_I	0.593	0.91
70_D	78_N	0.587	0.91
94_V	118_I	0.586	0.91
13_I	45_V	0.586	0.91
68_P	77_Y	0.585	0.91
20_I	28_G	0.584	0.91
206_I	289_L	0.582	0.90
227_L	230_G	0.580	0.90
238_L	302_I	0.579	0.90
183_E	186_F	0.578	0.90
71_P	74_G	0.577	0.90
99_A	120_L	0.576	0.90
152_T	157_P	0.574	0.90
224_F	231_S	0.572	0.90
59_V	62_G	0.569	0.89
82_R	228_G	0.568	0.89
133_A	302_I	0.567	0.89
148_E	152_T	0.567	0.89
236_T	239_A	0.566	0.89
156_I	161_G	0.565	0.89
210_W	213_R	0.562	0.89
102_P	121_P	0.561	0.89
16_G	31_S	0.559	0.89
28_G	32_L	0.556	0.88
154_G	157_P	0.556	0.88
138_E	292_H	0.554	0.88
66_V	97_I	0.553	0.88
41_F	48_W	0.552	0.88
84_A	88_K	0.550	0.88
252_P	283_S	0.548	0.88
287_D	294_Y	0.548	0.88
29_I	32_L	0.548	0.88
132_T	136_A	0.548	0.88
79_L	82_R	0.547	0.87
80_V	132_T	0.546	0.87
76_L	123_L	0.546	0.87
84_A	89_I	0.543	0.87
21_S	26_L	0.541	0.87
102_P	234_L	0.539	0.87
240_K	243_I	0.537	0.87
185_L	189_A	0.535	0.86
97_I	147_V	0.534	0.86
101_Y	241_I	0.534	0.86
121_P	146_D	0.532	0.86
152_T	155_L	0.530	0.86
40_I	44_L	0.530	0.86
13_I	22_E	0.529	0.86
180_D	183_E	0.528	0.86
220_D	298_R	0.528	0.86
241_I	295_P	0.526	0.85
292_H	298_R	0.524	0.85
13_I	25_V	0.523	0.85
77_Y	94_V	0.522	0.85
195_F	199_V	0.521	0.85
23_G	30_A	0.519	0.85
42_P	50_F	0.517	0.84
248_I	252_P	0.517	0.84
80_V	87_S	0.516	0.84
247_N	251_D	0.516	0.84
161_G	165_T	0.515	0.84
13_I	20_I	0.515	0.84
286_K	290_S	0.515	0.84
45_V	49_L	0.514	0.84
238_L	295_P	0.513	0.84
160_L	207_F	0.513	0.84
87_S	139_V	0.512	0.84
51_Q	55_S	0.512	0.84
52_W	55_S	0.512	0.84
111_L	145_R	0.509	0.83
58_V	125_I	0.507	0.83
44_L	52_W	0.507	0.83
185_L	190_A	0.507	0.83
25_V	43_A	0.506	0.83
194_G	197_I	0.506	0.83
154_G	203_I	0.504	0.83
129_D	132_T	0.504	0.83
170_F	176_F	0.503	0.83
84_A	90_K	0.502	0.83
231_S	302_I	0.502	0.83
28_G	37_L	0.502	0.83
55_S	105_F	0.501	0.83
20_I	26_L	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4aw6A	2	0.865	100	0.28	Contact Map
4il3A	1	0.8682	100	0.282	Contact Map
3c37A	1	0.6238	100	0.504	Contact Map
3cqbA	4	0.3312	99.8	0.653	Contact Map
4qhjA	2	0.328	97.2	0.875	Contact Map
4jixA	2	0.3441	96.5	0.887	Contact Map
4jiuA	1	0.3248	95.9	0.893	Contact Map
3dteA	2	0.492	94	0.904	Contact Map
2r9rB	3	0.2058	34.8	0.945	Contact Map
1mhsA	2	0.299	9.1	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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