GREMLIN Database
UPPP - Undecaprenyl-diphosphatase
UniProt: Q97X94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (259)
Sequences: 4107 (2716)
Seq/√Len: 168.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_E189_K3.6031.00
92_V190_L3.3521.00
158_A176_A3.0111.00
13_V31_V2.8341.00
66_I196_I2.7511.00
97_G201_G2.6991.00
3_Y6_I2.6551.00
136_K254_V2.5791.00
8_V232_V2.5451.00
125_L264_A2.4561.00
108_I206_T2.3821.00
129_I133_L2.3731.00
183_K186_E2.3661.00
14_Q54_T2.3401.00
93_T198_A2.3261.00
177_L182_V2.3251.00
128_G261_G2.2591.00
246_R250_T2.2421.00
204_S208_L2.2111.00
96_T198_A2.0781.00
12_I236_V2.0351.00
205_V209_F1.9551.00
104_Y206_T1.9521.00
153_I157_I1.9501.00
264_A268_G1.8571.00
11_G232_V1.8541.00
121_G264_A1.8221.00
91_I149_L1.8151.00
58_A241_I1.8091.00
63_R67_S1.8031.00
122_V126_I1.7911.00
246_R249_R1.7831.00
4_I228_I1.7781.00
96_T160_G1.7581.00
28_V47_G1.7281.00
99_V160_G1.7181.00
201_G205_V1.7061.00
92_V194_S1.7031.00
7_G11_G1.6921.00
54_T237_S1.6881.00
56_A234_T1.6621.00
116_P119_V1.6571.00
30_I267_S1.6461.00
26_T120_L1.6391.00
185_E249_R1.6301.00
150_R154_I1.6281.00
258_I262_I1.6251.00
142_K146_D1.6161.00
121_G267_S1.6001.00
68_G82_D1.5971.00
148_K151_D1.5951.00
232_V236_V1.5731.00
10_L28_V1.5641.00
61_Y242_N1.5481.00
103_L106_F1.5431.00
10_L31_V1.5241.00
123_V164_L1.5121.00
265_I269_I1.5081.00
52_I203_I1.5041.00
133_L137_N1.5031.00
69_L86_L1.4711.00
121_G268_G1.4611.00
132_Y254_V1.4511.00
84_L88_F1.4451.00
71_K75_R1.4271.00
200_L204_S1.4261.00
254_V258_I1.4241.00
266_I270_L1.4041.00
97_G101_V1.4021.00
104_Y108_I1.3871.00
142_K151_D1.3801.00
103_L107_V1.3731.00
67_S71_K1.3621.00
206_T209_F1.3461.00
90_V94_I1.3421.00
60_F234_T1.3261.00
205_V208_L1.3161.00
132_Y257_V1.2991.00
43_A47_G1.2981.00
151_D180_L1.2911.00
125_L268_G1.2871.00
130_V175_S1.2851.00
247_F251_N1.2781.00
45_S210_S1.2771.00
7_G46_F1.2771.00
123_V126_I1.2751.00
236_V240_F1.2691.00
88_F149_L1.2631.00
17_S22_I1.2451.00
118_T268_G1.2451.00
235_F239_F1.2421.00
45_S49_F1.2031.00
118_T271_S1.1981.00
7_G225_G1.1981.00
143_G146_D1.1821.00
119_V123_V1.1811.00
151_D182_V1.1801.00
4_I224_S1.1801.00
97_G100_G1.1781.00
104_Y209_F1.1751.00
51_E199_A1.1751.00
62_F245_L1.1741.00
173_T191_S1.1711.00
167_V172_M1.1701.00
8_V12_I1.1671.00
118_T122_V1.1631.00
93_T97_G1.1621.00
106_F109_S1.1581.00
7_G228_I1.1491.00
99_V103_L1.1441.00
234_T238_I1.1421.00
223_L227_L1.1391.00
83_Y87_K1.1381.00
242_N246_R1.1301.00
135_R184_P1.1251.00
154_I176_A1.1231.00
247_F255_L1.1221.00
227_L231_V1.1131.00
9_I13_V1.1121.00
154_I180_L1.1031.00
27_Q259_I1.1001.00
88_F152_I1.1001.00
122_V268_G1.0851.00
132_Y136_K1.0781.00
201_G204_S1.0711.00
30_I117_M1.0631.00
64_S68_G1.0610.99
149_L153_I1.0520.99
60_F63_R1.0520.99
155_V182_V1.0460.99
91_I153_I1.0440.99
64_S67_S1.0430.99
4_I225_G1.0360.99
188_F248_A1.0350.99
61_Y245_L1.0260.99
255_L258_I1.0170.99
52_I199_A1.0170.99
147_L182_V1.0040.99
19_W237_S0.9990.99
208_L212_H0.9980.99
222_S225_G0.9930.99
244_L251_N0.9920.99
98_L102_P0.9860.99
12_I16_I0.9840.99
121_G271_S0.9830.99
4_I8_V0.9810.99
188_F245_L0.9800.99
127_D161_L0.9730.99
50_M229_S0.9730.99
177_L187_A0.9720.99
48_L206_T0.9670.99
6_I36_L0.9640.99
64_S71_K0.9630.99
219_H222_S0.9620.99
220_S224_S0.9510.99
160_G163_A0.9470.99
29_L120_L0.9460.99
59_I66_I0.9400.99
101_V201_G0.9390.99
85_L193_I0.9330.99
30_I124_L0.9310.99
22_I244_L0.9250.99
240_F243_A0.9240.99
32_S38_L0.9210.99
245_L248_A0.9200.99
119_V164_L0.9200.99
157_I161_L0.9150.98
48_L202_A0.9140.98
73_L86_L0.9110.98
151_D177_L0.9040.98
80_R83_Y0.9030.98
151_D154_I0.9000.98
228_I232_V0.8930.98
73_L87_K0.8920.98
127_D260_L0.8900.98
53_G230_I0.8860.98
96_T163_A0.8850.98
107_V163_A0.8810.98
7_G232_V0.8800.98
8_V228_I0.8760.98
99_V163_A0.8740.98
261_G265_I0.8690.98
130_V134_S0.8690.98
134_S179_L0.8620.98
31_V36_L0.8610.98
34_T117_M0.8590.98
117_M267_S0.8570.98
143_G186_E0.8520.98
62_F189_K0.8510.98
155_V194_S0.8510.98
188_F244_L0.8500.98
78_S83_Y0.8460.97
38_L43_A0.8450.97
61_Y238_I0.8410.97
224_S227_L0.8400.97
238_I242_N0.8380.97
117_M271_S0.8350.97
30_I263_M0.8310.97
86_L90_V0.8310.97
125_L261_G0.8240.97
175_S257_V0.8170.97
144_L186_E0.8130.97
155_V177_L0.8120.97
16_I22_I0.8110.97
262_I266_I0.8100.97
206_T210_S0.8020.97
239_F242_N0.7990.96
132_Y261_G0.7970.96
136_K139_F0.7950.96
137_N141_R0.7920.96
224_S228_I0.7910.96
157_I160_G0.7870.96
222_S226_L0.7760.96
49_F203_I0.7740.96
134_S175_S0.7710.96
72_A82_D0.7680.96
96_T100_G0.7640.95
120_L123_V0.7610.95
17_S27_Q0.7580.95
25_K55_I0.7540.95
80_R84_L0.7500.95
99_V157_I0.7490.95
28_V233_A0.7480.95
131_I135_R0.7480.95
131_I171_G0.7470.95
99_V102_P0.7440.95
221_V224_S0.7430.95
131_I175_S0.7430.95
260_L267_S0.7430.95
98_L101_V0.7400.95
25_K51_E0.7400.95
119_V122_V0.7390.95
81_E84_L0.7380.95
5_L9_I0.7360.94
55_I196_I0.7270.94
113_L119_V0.7260.94
44_Y47_G0.7240.94
87_K90_V0.7240.94
127_D167_V0.7230.94
59_I200_L0.7220.94
76_M83_Y0.7190.94
49_F230_I0.7180.94
194_S198_A0.7140.93
105_L108_I0.7130.93
9_I31_V0.7120.93
171_G178_I0.7110.93
154_I157_I0.7100.93
7_G229_S0.7090.93
44_Y51_E0.7080.93
135_R253_V0.7080.93
39_S43_A0.7070.93
147_L186_E0.7060.93
9_I36_L0.7040.93
124_L260_L0.6990.93
125_L129_I0.6960.93
66_I70_L0.6920.92
88_F92_V0.6900.92
85_L144_L0.6820.92
14_Q25_K0.6790.92
263_M266_I0.6750.91
25_K28_V0.6750.91
207_V211_K0.6740.91
39_S42_V0.6720.91
89_L193_I0.6720.91
208_L211_K0.6700.91
84_L87_K0.6650.91
50_M233_A0.6650.91
73_L83_Y0.6570.90
189_K193_I0.6570.90
195_L199_A0.6560.90
147_L151_D0.6520.90
81_E145_H0.6510.90
12_I232_V0.6460.90
128_G132_Y0.6400.89
235_F238_I0.6360.89
252_K255_L0.6360.89
154_I158_A0.6350.89
55_I195_L0.6350.89
161_L172_M0.6320.89
60_F238_I0.6300.88
70_L73_L0.6300.88
190_L194_S0.6280.88
175_S178_I0.6270.88
220_S223_L0.6240.88
126_I167_V0.6240.88
45_S48_L0.6220.88
16_I244_L0.6200.88
97_G205_V0.6190.88
51_E54_T0.6180.87
46_F229_S0.6170.87
252_K260_L0.6170.87
41_N115_L0.6170.87
15_G236_V0.6170.87
44_Y108_I0.6160.87
135_R241_I0.6140.87
185_E189_K0.6130.87
105_L109_S0.6130.87
97_G102_P0.6120.87
70_L74_V0.6100.87
32_S37_G0.6090.87
135_R254_V0.6070.87
10_L43_A0.6050.86
233_A236_V0.6040.86
129_I132_Y0.6040.86
72_A80_R0.6030.86
19_W28_V0.6030.86
35_L270_L0.6020.86
227_L230_I0.6000.86
126_I130_V0.5940.85
263_M267_S0.5930.85
51_E55_I0.5920.85
163_A198_A0.5910.85
73_L90_V0.5880.85
254_V257_V0.5870.85
45_S206_T0.5850.84
22_I124_L0.5830.84
14_Q50_M0.5820.84
43_A115_L0.5810.84
125_L265_I0.5780.84
87_K91_I0.5770.84
136_K140_P0.5750.83
257_V261_G0.5720.83
177_L180_L0.5720.83
69_L89_L0.5720.83
32_S43_A0.5710.83
251_N255_L0.5670.83
170_S192_F0.5660.82
107_V164_L0.5660.82
247_F252_K0.5640.82
14_Q55_I0.5640.82
142_K183_K0.5640.82
55_I58_A0.5630.82
158_A161_L0.5590.82
83_Y86_L0.5580.82
137_N140_P0.5580.82
86_L89_L0.5570.81
22_I120_L0.5570.81
129_I261_G0.5560.81
96_T107_V0.5560.81
147_L152_I0.5560.81
155_V190_L0.5550.81
167_V260_L0.5540.81
171_G175_S0.5530.81
257_V260_L0.5510.81
14_Q51_E0.5500.81
175_S194_S0.5490.81
243_A246_R0.5490.81
230_I233_A0.5480.80
135_R178_I0.5480.80
75_R79_R0.5470.80
56_A230_I0.5450.80
164_L167_V0.5380.79
67_S70_L0.5330.79
29_L117_M0.5310.78
143_G183_K0.5310.78
131_I253_V0.5300.78
127_D164_L0.5290.78
34_T39_S0.5280.78
172_M176_A0.5270.78
32_S47_G0.5270.78
115_L164_L0.5270.78
25_K54_T0.5260.78
203_I207_V0.5250.78
84_L149_L0.5240.77
11_G233_A0.5210.77
10_L36_L0.5190.77
212_H218_V0.5180.77
93_T201_G0.5180.77
34_T270_L0.5160.76
6_I38_L0.5150.76
120_L124_L0.5140.76
128_G257_V0.5140.76
132_Y135_R0.5130.76
94_I97_G0.5130.76
26_T30_I0.5110.76
92_V147_L0.5110.76
98_L157_I0.5100.76
135_R252_K0.5100.76
101_V205_V0.5080.75
32_S36_L0.5080.75
75_R80_R0.5080.75
62_F65_E0.5070.75
50_M199_A0.5060.75
184_P248_A0.5050.75
162_A230_I0.5040.75
127_D172_M0.5020.74
160_G164_L0.5010.74
131_I252_K0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w252 1 0.223 13.1 0.966 Contact Map
3mp7B 1 0.1942 10.7 0.968 Contact Map
3ux4A 3 0.3921 9.5 0.968 Contact Map
4x5mA 2 0.3381 8 0.969 Contact Map
2ww9B 1 0.2158 7.3 0.97 Contact Map
1jb0M 1 0.1115 4.9 0.972 Contact Map
1fdmA 1 0.1799 4.1 0.973 Contact Map
1iflA 10 0.1906 3.8 0.974 Contact Map
1ifkA 9 0.1835 2.7 0.976 Contact Map
2a65A 2 0.4856 2.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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