GREMLIN Database
Y1861 - UPF0273 protein SSO1861
UniProt: Q97X93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (218)
Sequences: 8609 (4743)
Seq/√Len: 321.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_G129_T3.7771.00
174_G177_G3.6991.00
5_K12_D3.3491.00
51_E129_T3.3051.00
46_G130_R2.9181.00
6_T19_I2.8631.00
43_L132_V2.7831.00
39_G168_V2.7021.00
21_E162_G2.4811.00
9_P232_V2.4421.00
43_L53_G2.4261.00
54_V122_A2.3231.00
24_I155_K2.3161.00
23_H64_S2.2681.00
192_R209_W2.2651.00
7_Y12_D2.1991.00
75_D78_K2.1721.00
119_I131_I2.1601.00
39_G132_V2.1341.00
25_V189_G2.1191.00
21_E129_T2.0551.00
15_L189_G2.0331.00
151_V186_A2.0321.00
11_L191_I1.9851.00
197_E202_M1.9691.00
26_L187_V1.9271.00
124_K161_L1.9121.00
224_D231_I1.8821.00
29_G193_L1.7801.00
45_N49_K1.7331.00
158_I165_A1.6991.00
78_K89_D1.6901.00
123_I131_I1.6801.00
19_I42_F1.6681.00
211_M214_T1.6591.00
40_K69_F1.6511.00
131_I165_A1.6381.00
10_G13_E1.6351.00
32_G213_D1.6351.00
45_N48_T1.6181.00
123_I127_N1.6161.00
14_I217_S1.6061.00
131_I163_C1.5981.00
52_G127_N1.5831.00
44_Y48_T1.5811.00
203_Y220_R1.5731.00
226_T231_I1.5461.00
132_V166_I1.5311.00
54_V128_A1.5251.00
33_T198_V1.5211.00
130_R166_I1.5061.00
157_V161_L1.4971.00
19_I166_I1.4941.00
191_I206_I1.4711.00
122_A125_D1.4581.00
222_P233_Q1.4321.00
189_G211_M1.4211.00
38_L42_F1.4201.00
43_L55_F1.4121.00
121_A125_D1.3801.00
88_I92_T1.3701.00
9_P13_E1.3551.00
6_T12_D1.3531.00
193_L206_I1.3431.00
44_Y73_K1.3351.00
46_G53_G1.3001.00
29_G33_T1.2931.00
25_V164_T1.2931.00
11_L15_L1.2791.00
151_V167_F1.2531.00
122_A126_I1.2411.00
119_I161_L1.2241.00
24_I151_V1.2161.00
143_K146_M1.2101.00
46_G51_E1.2051.00
33_T199_E1.2041.00
59_E170_Q1.1951.00
40_K65_V1.1951.00
112_V153_Q1.1861.00
19_I164_T1.1671.00
54_V119_I1.1601.00
203_Y222_P1.1601.00
130_R164_T1.1571.00
57_A65_V1.1551.00
143_K179_G1.1441.00
14_I208_I1.1391.00
22_R162_G1.1371.00
205_S220_R1.1241.00
148_R182_G1.1021.00
137_S169_S1.1011.00
123_I128_A1.0901.00
194_D199_E1.0871.00
89_D92_T1.0861.00
27_V38_L1.0821.00
118_N121_A1.0781.00
43_L47_L1.0681.00
115_L139_L1.0651.00
47_L53_G1.0631.00
187_V190_I1.0621.00
181_P184_E1.0541.00
44_Y72_F1.0451.00
10_G232_V1.0451.00
32_G210_K1.0441.00
51_E130_R1.0271.00
36_S65_V1.0211.00
211_M215_K1.0211.00
20_P23_H1.0181.00
37_I68_S1.0131.00
77_R81_R1.0081.00
38_L206_I1.0051.00
8_I232_V1.0011.00
153_Q156_R0.9961.00
32_G216_I0.9891.00
127_N161_L0.9821.00
77_R82_E0.9781.00
55_F132_V0.9771.00
23_H213_D0.9771.00
157_V163_C0.9741.00
173_V181_P0.9701.00
64_S68_S0.9641.00
41_Q45_N0.9601.00
90_T93_G0.9591.00
38_L193_L0.9581.00
87_I92_T0.9571.00
26_L183_V0.9551.00
110_D114_E0.9461.00
11_L208_I0.9431.00
194_D207_I0.9401.00
228_N231_I0.9391.00
37_I225_I0.9351.00
224_D227_D0.9341.00
144_P148_R0.9341.00
66_R70_E0.9341.00
8_I221_H0.9321.00
86_A89_D0.9191.00
42_F46_G0.9161.00
42_F130_R0.9101.00
58_L138_T0.9091.00
53_G130_R0.9071.00
27_V191_I0.9051.00
61_H64_S0.9051.00
8_I41_Q0.8951.00
40_K55_F0.8931.00
62_P66_R0.8921.00
8_I12_D0.8921.00
152_M156_R0.8911.00
36_S40_K0.8871.00
60_E212_R0.8861.00
24_I154_L0.8841.00
149_S153_Q0.8721.00
54_V131_I0.8681.00
116_S153_Q0.8471.00
123_I162_G0.8471.00
154_L165_A0.8391.00
26_L190_I0.8371.00
136_V183_V0.8331.00
20_P211_M0.8331.00
196_D205_S0.8301.00
156_R159_S0.8281.00
53_G132_V0.8271.00
52_G126_I0.8221.00
119_I123_I0.8181.00
178_F181_P0.8171.00
19_I25_V0.8151.00
120_R157_V0.8091.00
191_I208_I0.8081.00
135_S168_V0.8081.00
193_L204_R0.8071.00
151_V183_V0.8061.00
11_L206_I0.7951.00
14_I211_M0.7941.00
172_S175_E0.7941.00
10_G235_D0.7931.00
110_D115_L0.7921.00
170_Q185_H0.7871.00
42_F45_N0.7871.00
14_I221_H0.7841.00
224_D229_G0.7811.00
204_R230_I0.7811.00
120_R153_Q0.7771.00
115_L118_N0.7761.00
15_L18_G0.7751.00
56_I131_I0.7721.00
3_R214_T0.7701.00
196_D200_G0.7681.00
17_G82_E0.7661.00
68_S213_D0.7430.99
24_I167_F0.7420.99
119_I165_A0.7420.99
38_L230_I0.7420.99
27_V166_I0.7380.99
70_E77_R0.7380.99
4_V46_G0.7380.99
111_D114_E0.7360.99
148_R152_M0.7350.99
85_F93_G0.7340.99
203_Y233_Q0.7230.99
225_I229_G0.7140.99
20_P189_G0.7100.99
123_I126_I0.7100.99
144_P182_G0.7080.99
231_I234_W0.7050.99
37_I228_N0.7030.99
59_E212_R0.7020.99
87_I90_T0.7010.99
19_I130_R0.7000.99
17_G20_P0.6990.99
41_Q44_Y0.6970.99
30_G176_R0.6960.99
178_F185_H0.6950.99
39_G55_F0.6930.99
209_W216_I0.6900.99
71_H79_Y0.6840.99
133_V139_L0.6820.99
147_A180_G0.6800.99
88_I91_F0.6750.99
21_E51_E0.6720.99
87_I91_F0.6700.99
120_R124_K0.6580.98
75_D226_T0.6500.98
64_S213_D0.6490.98
39_G166_I0.6490.98
78_K84_K0.6470.98
156_R160_G0.6440.98
4_V164_T0.6430.98
107_K110_D0.6420.98
30_G33_T0.6420.98
78_K82_E0.6420.98
5_K49_K0.6400.98
22_R61_H0.6400.98
33_T204_R0.6370.98
70_E93_G0.6370.98
155_K167_F0.6360.98
42_F166_I0.6340.98
108_S111_D0.6310.98
14_I219_V0.6220.98
115_L133_V0.6190.98
133_V154_L0.6160.98
28_S192_R0.6130.98
157_V165_A0.6110.98
30_G171_V0.6070.97
30_G181_P0.6060.97
44_Y69_F0.6020.97
193_L230_I0.6010.97
57_A169_S0.5970.97
137_S179_G0.5950.97
31_P187_V0.5940.97
67_R70_E0.5930.97
111_D115_L0.5930.97
41_Q72_F0.5920.97
142_T149_S0.5900.97
204_R225_I0.5900.97
78_K86_A0.5900.97
23_H188_D0.5860.97
113_K153_Q0.5840.97
37_I41_Q0.5820.97
171_V178_F0.5810.97
25_V191_I0.5770.97
119_I128_A0.5750.96
30_G173_V0.5680.96
157_V160_G0.5680.96
170_Q173_V0.5670.96
50_G129_T0.5670.96
206_I221_H0.5650.96
23_H189_G0.5630.96
12_D45_N0.5630.96
179_G183_V0.5610.96
171_V181_P0.5590.96
68_S72_F0.5590.96
36_S213_D0.5580.96
155_K158_I0.5580.96
224_D233_Q0.5550.96
5_K11_L0.5550.96
135_S138_T0.5540.96
140_Y156_R0.5530.96
76_V228_N0.5530.96
141_L149_S0.5510.96
196_D201_V0.5510.96
195_L202_M0.5500.95
56_I119_I0.5490.95
16_Y215_K0.5460.95
188_D212_R0.5460.95
15_L191_I0.5450.95
172_S178_F0.5440.95
158_I164_T0.5430.95
129_T164_T0.5430.95
21_E164_T0.5410.95
81_R211_M0.5400.95
47_L50_G0.5390.95
47_L79_Y0.5380.95
52_G128_A0.5370.95
86_A126_I0.5360.95
222_P225_I0.5340.95
85_F89_D0.5330.95
206_I219_V0.5330.95
136_V150_I0.5320.95
3_R20_P0.5310.95
184_E190_I0.5300.95
120_R161_L0.5290.94
116_S160_G0.5280.94
10_G219_V0.5280.94
47_L85_F0.5260.94
67_R124_K0.5260.94
112_V115_L0.5230.94
116_S120_R0.5230.94
144_P172_S0.5220.94
8_I45_N0.5220.94
10_G221_H0.5220.94
135_S170_Q0.5210.94
181_P185_H0.5210.94
172_S190_I0.5190.94
173_V184_E0.5190.94
3_R17_G0.5180.94
194_D197_E0.5150.94
85_F92_T0.5140.94
7_Y45_N0.5100.93
44_Y74_W0.5090.93
113_K119_I0.5080.93
15_L208_I0.5070.93
19_I46_G0.5060.93
204_R229_G0.5050.93
196_D199_E0.5040.93
24_I165_A0.5040.93
194_D205_S0.5020.93
59_E135_S0.5010.93
12_D232_V0.5000.93
20_P81_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bgwA 3 0.8286 100 0.345 Contact Map
4nmnA 3 0.8286 100 0.365 Contact Map
2q6tA 1 0.8107 100 0.366 Contact Map
3bs4A 1 0.7964 100 0.386 Contact Map
2dr3A 3 0.875 100 0.395 Contact Map
2r6aA 5 0.8143 100 0.422 Contact Map
1n0wA 1 0.6964 100 0.43 Contact Map
3bh0A 1 0.825 100 0.431 Contact Map
3ldaA 1 0.7107 100 0.436 Contact Map
2cvhA 1 0.7393 100 0.438 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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