GREMLIN Database
Q97X91 - Microsomal dipeptidase
UniProt: Q97X91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (289)
Sequences: 3065 (2120)
Seq/√Len: 124.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
262_D299_E5.6091.00
170_L173_K4.8071.00
105_E310_K3.8961.00
298_E303_K3.4531.00
128_Y170_L3.3771.00
290_T301_L3.1731.00
261_W296_H2.9791.00
222_E258_S2.8761.00
99_R103_D2.8041.00
189_L223_A2.7641.00
254_Y258_S2.7051.00
207_T211_Q2.7041.00
233_I255_L2.5291.00
172_N195_S2.4721.00
246_S292_A2.3981.00
131_K136_L2.3861.00
185_K207_T2.1801.00
148_F167_L2.1481.00
183_A187_T2.1121.00
188_V220_E2.1071.00
206_F255_L2.0921.00
32_S35_M2.0891.00
241_K247_G2.0261.00
281_E285_K2.0221.00
224_I231_I1.9951.00
98_V110_K1.9871.00
206_F254_Y1.8961.00
180_L201_D1.8521.00
221_I231_I1.8381.00
249_V292_A1.8111.00
193_S223_A1.7951.00
96_K108_G1.7441.00
256_G264_V1.7401.00
307_R311_E1.7291.00
96_K106_K1.7191.00
37_K94_L1.7191.00
160_L168_V1.7141.00
294_E298_E1.7101.00
79_F130_L1.7061.00
221_I255_L1.7061.00
138_L171_A1.7001.00
127_I174_L1.6981.00
228_K263_Y1.6921.00
100_S103_D1.6891.00
165_E194_T1.6871.00
181_A204_T1.6591.00
217_D220_E1.6371.00
192_T199_V1.6261.00
189_L220_E1.6051.00
261_W299_E1.6051.00
189_L219_E1.5981.00
87_Y133_L1.5891.00
233_I252_I1.5771.00
141_T149_A1.5391.00
256_G261_W1.5331.00
131_K176_I1.5301.00
185_K217_D1.5251.00
10_L305_A1.5231.00
10_L265_A1.5101.00
145_D161_T1.4911.00
228_K311_E1.4781.00
162_S165_E1.4691.00
79_F120_V1.4671.00
256_G296_H1.4381.00
80_L133_L1.4341.00
247_G250_E1.4251.00
149_A187_T1.4221.00
218_D254_Y1.4171.00
135_V176_I1.4171.00
103_D106_K1.4101.00
98_V104_L1.4041.00
285_K288_E1.3931.00
208_R254_Y1.3871.00
10_L232_G1.3701.00
115_L130_L1.3701.00
148_F163_E1.3641.00
178_I194_T1.3641.00
169_R196_K1.3571.00
253_K257_E1.3391.00
102_N106_K1.3351.00
221_I259_F1.3341.00
128_Y132_E1.3281.00
124_Y163_E1.3251.00
118_A138_L1.3221.00
114_S137_N1.3081.00
296_H299_E1.3041.00
76_I126_D1.3021.00
223_A226_K1.3021.00
165_E193_S1.2981.00
166_E169_R1.2971.00
163_E167_L1.2871.00
195_S227_T1.2801.00
249_V252_I1.2781.00
127_I167_L1.2731.00
273_I276_A1.2701.00
87_Y132_E1.2521.00
178_I191_V1.2501.00
230_V308_V1.2501.00
118_A148_F1.2491.00
143_N239_T1.2300.99
39_F284_L1.2290.99
31_S36_L1.2010.99
171_A176_I1.1990.99
225_V259_F1.1950.99
150_S157_D1.1940.99
128_Y174_L1.1900.99
181_A201_D1.1900.99
131_K174_L1.1900.99
205_N234_T1.1770.99
288_E291_K1.1720.99
235_A268_T1.1660.99
230_V265_A1.1620.99
80_L129_L1.1540.99
43_V48_F1.1520.99
39_F283_I1.1510.99
282_N285_K1.1500.99
265_A305_A1.1450.99
150_S158_Y1.1440.99
170_L174_L1.1420.99
95_V111_L1.1360.99
231_I255_L1.1310.99
169_R194_T1.1290.99
101_A310_K1.1270.99
180_L199_V1.1200.99
192_T223_A1.1150.99
104_L112_L1.1100.99
86_Y113_L1.1060.99
84_K133_L1.1040.99
222_E225_V1.0950.99
259_F263_Y1.0860.99
185_K189_L1.0850.99
45_A111_L1.0710.99
207_T217_D1.0690.98
35_M282_N1.0640.98
172_N197_K1.0520.98
84_K128_Y1.0430.98
290_T297_E1.0370.98
45_A48_F1.0280.98
113_L135_V1.0250.98
206_F209_L1.0210.98
183_A191_V1.0170.98
165_E190_D1.0120.98
200_I308_V1.0100.98
98_V103_D1.0090.98
143_N152_C1.0090.98
185_K220_E1.0050.98
41_S44_F0.9980.98
253_K256_G0.9950.98
180_L191_V0.9910.98
250_E292_A0.9900.98
245_I249_V0.9900.98
118_A167_L0.9780.97
123_D126_D0.9740.97
44_F114_S0.9700.97
168_V191_V0.9680.97
102_N310_K0.9680.97
235_A286_V0.9540.97
30_Q276_A0.9470.97
252_I293_I0.9430.97
145_D156_K0.9410.97
180_L183_A0.9410.97
222_E226_K0.9370.97
158_Y186_R0.9370.97
181_A239_T0.9320.96
303_K307_R0.9310.96
150_S161_T0.9310.96
177_I308_V0.9300.96
87_Y97_I0.9270.96
295_G303_K0.9210.96
34_R38_E0.9200.96
145_D150_S0.9190.96
128_Y173_K0.9180.96
231_I259_F0.9180.96
192_T227_T0.9150.96
240_L248_I0.9080.96
129_L133_L0.9070.96
76_I80_L0.9050.96
116_E182_H0.9050.96
185_K219_E0.9020.96
120_V130_L0.8990.96
47_I50_H0.8970.96
137_N202_S0.8930.95
96_K110_K0.8920.95
222_E259_F0.8920.95
76_I130_L0.8820.95
104_L306_F0.8820.95
268_T271_L0.8810.95
105_E303_K0.8810.95
201_D204_T0.8800.95
206_F221_I0.8790.95
115_L135_V0.8770.95
36_L43_V0.8760.95
186_R190_D0.8740.95
249_V293_I0.8700.95
193_S196_K0.8690.95
36_L109_V0.8670.95
29_R35_M0.8640.95
162_S166_E0.8630.95
235_A280_F0.8600.94
79_F83_V0.8560.94
128_Y133_L0.8530.94
126_D129_L0.8480.94
235_A248_I0.8470.94
298_E302_W0.8450.94
209_L251_S0.8430.94
201_D224_I0.8380.94
17_S21_G0.8340.93
254_Y257_E0.8280.93
177_I309_I0.8260.93
8_I110_K0.8260.93
42_L112_L0.8250.93
46_S50_H0.8240.93
189_L217_D0.8170.93
235_A266_I0.8120.93
219_E222_E0.8120.93
115_L120_V0.8120.93
25_I38_E0.8110.93
293_I297_E0.8110.93
234_T239_T0.8110.93
233_I248_I0.8110.93
79_F115_L0.8080.92
244_S247_G0.8070.92
43_V47_I0.8030.92
188_V217_D0.8010.92
302_W306_F0.8000.92
119_D144_Y0.7940.92
83_V87_Y0.7930.92
102_N105_E0.7930.92
268_T286_V0.7910.92
248_I280_F0.7910.92
138_L167_L0.7890.91
48_F51_V0.7860.91
43_V46_S0.7800.91
244_S278_K0.7770.91
228_K262_D0.7740.91
189_L193_S0.7730.91
121_L138_L0.7700.90
128_Y131_K0.7660.90
8_I302_W0.7650.90
101_A104_L0.7640.90
201_D216_L0.7610.90
145_D154_S0.7590.90
221_I225_V0.7590.90
172_N196_K0.7580.90
177_I200_I0.7570.90
299_E303_K0.7560.90
182_H269_D0.7560.90
216_L220_E0.7560.90
243_A247_G0.7460.89
41_S47_I0.7460.89
116_E272_G0.7420.89
48_F142_W0.7410.89
141_T187_T0.7390.89
83_V135_V0.7350.88
190_D193_S0.7340.88
76_I122_R0.7300.88
203_H269_D0.7270.88
279_G288_E0.7260.88
250_E253_K0.7250.88
253_K300_V0.7240.88
112_L309_I0.7240.88
178_I195_S0.7200.87
145_D151_S0.7180.87
129_L132_E0.7110.87
204_T234_T0.7090.86
39_F287_K0.7080.86
8_I42_L0.7070.86
140_L149_A0.7070.86
236_I273_I0.7030.86
131_K171_A0.7020.86
189_L192_T0.7020.86
297_E301_L0.6990.86
202_S230_V0.6960.85
246_S250_E0.6950.85
100_S104_L0.6940.85
33_I94_L0.6940.85
12_E31_S0.6930.85
126_D130_L0.6920.85
140_L191_V0.6850.85
184_G187_T0.6830.84
150_S184_G0.6810.84
255_L258_S0.6810.84
42_L98_V0.6810.84
83_V113_L0.6790.84
24_V27_G0.6710.83
183_A188_V0.6710.83
171_A174_L0.6690.83
33_I37_K0.6680.83
44_F137_N0.6660.83
87_Y129_L0.6640.83
232_G265_A0.6640.83
206_F251_S0.6630.83
255_L259_F0.6620.82
124_Y167_L0.6600.82
222_E254_Y0.6590.82
6_K302_W0.6560.82
80_L84_K0.6540.82
18_N21_G0.6530.82
101_A309_I0.6510.81
41_S45_A0.6500.81
278_K281_E0.6490.81
249_V253_K0.6440.81
252_I256_G0.6430.81
98_V112_L0.6420.81
87_Y99_R0.6420.81
225_V258_S0.6410.80
137_N200_I0.6410.80
74_F122_R0.6380.80
157_D161_T0.6370.80
182_H203_H0.6370.80
245_I292_A0.6360.80
42_L48_F0.6350.80
15_A86_Y0.6350.80
199_V227_T0.6340.80
237_V273_I0.6330.80
236_I239_T0.6310.79
246_S249_V0.6300.79
132_E174_L0.6250.79
180_L224_I0.6250.79
45_A50_H0.6240.79
14_L82_Q0.6230.78
7_L301_L0.6220.78
33_I95_V0.6220.78
25_I34_R0.6210.78
253_K296_H0.6210.78
188_V216_L0.6210.78
105_E306_F0.6190.78
118_A121_L0.6180.78
34_R39_F0.6170.78
223_A227_T0.6160.78
308_V311_E0.6150.78
138_L176_I0.6140.77
168_V178_I0.6130.77
224_I229_G0.6130.77
187_T190_D0.6120.77
44_F48_F0.6110.77
101_A105_E0.6100.77
32_S283_I0.6080.77
171_A178_I0.6080.77
173_K196_K0.6060.77
8_I305_A0.6050.76
44_F50_H0.6030.76
245_I288_E0.6020.76
253_K292_A0.6020.76
266_I290_T0.6000.76
7_L39_F0.6000.76
83_V133_L0.5990.76
73_N122_R0.5950.75
159_G190_D0.5930.75
10_L230_V0.5920.75
14_L31_S0.5920.75
125_S128_Y0.5910.75
252_I264_V0.5900.75
7_L290_T0.5880.74
84_K88_Y0.5840.74
295_G298_E0.5830.74
171_A175_G0.5820.74
252_I300_V0.5810.74
46_S49_P0.5790.73
218_D258_S0.5760.73
234_T273_I0.5750.73
248_I289_L0.5740.73
141_T183_A0.5740.73
200_I230_V0.5730.73
74_F77_E0.5730.73
75_S119_D0.5720.72
44_F47_I0.5710.72
51_V54_L0.5700.72
150_S156_K0.5680.72
125_S173_K0.5670.72
116_E203_H0.5670.72
31_S43_V0.5660.72
152_C220_E0.5630.71
305_A309_I0.5630.71
43_V49_P0.5620.71
163_E166_E0.5620.71
18_N22_I0.5610.71
251_S254_Y0.5600.71
92_K95_V0.5600.71
212_H239_T0.5590.71
78_L82_Q0.5590.71
168_V194_T0.5570.70
41_S51_V0.5560.70
254_Y259_F0.5560.70
13_D214_R0.5550.70
266_I300_V0.5530.70
224_I227_T0.5500.69
147_K163_E0.5490.69
209_L264_V0.5470.69
118_A139_G0.5460.69
180_L188_V0.5460.69
122_R147_K0.5450.69
45_A51_V0.5440.69
195_S198_P0.5430.68
191_V195_S0.5400.68
76_I129_L0.5400.68
294_E303_K0.5360.68
46_S114_S0.5360.68
192_T224_I0.5360.68
234_T268_T0.5360.68
281_E284_L0.5340.67
44_F112_L0.5330.67
41_S46_S0.5330.67
37_K109_V0.5330.67
256_G293_I0.5290.67
157_D162_S0.5280.66
233_I264_V0.5270.66
81_D85_F0.5270.66
140_L167_L0.5240.66
47_I51_V0.5230.66
121_L127_I0.5220.65
95_V109_V0.5210.65
47_I79_F0.5210.65
182_H272_G0.5180.65
205_N233_I0.5180.65
210_K241_K0.5180.65
156_K186_R0.5160.65
306_F310_K0.5150.64
205_N240_L0.5130.64
137_N177_I0.5120.64
45_A49_P0.5120.64
283_I286_V0.5100.64
136_L174_L0.5090.64
152_C213_R0.5090.64
44_F309_I0.5080.63
35_M38_E0.5070.63
249_V297_E0.5060.63
47_I83_V0.5050.63
168_V172_N0.5050.63
124_Y170_L0.5050.63
101_A306_F0.5020.63
293_I296_H0.5010.62
192_T195_S0.5010.62
35_M283_I0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ragA 2 0.949 100 0.093 Contact Map
3nehA 1 0.9236 100 0.117 Contact Map
3b40A 1 0.965 100 0.125 Contact Map
3ly0A 1 0.9904 100 0.136 Contact Map
3id7A 1 0.9395 100 0.153 Contact Map
1ituA 2 0.9459 100 0.186 Contact Map
2i5gA 2 0.8885 100 0.201 Contact Map
2ffiA 1 0.8248 99.4 0.842 Contact Map
4mupA 1 0.8248 99.2 0.854 Contact Map
4do7A 1 0.8185 99.2 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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