GREMLIN Database
Q97X85 - Uncharacterized protein
UniProt: Q97X85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (156)
Sequences: 805 (625)
Seq/√Len: 50.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_L123_F3.8261.00
24_N112_A3.5291.00
66_K134_E3.4121.00
79_E117_K2.9021.00
18_K165_Y2.7261.00
55_E114_H2.3641.00
43_I87_I2.2841.00
51_H55_E2.2261.00
51_H114_H2.1231.00
16_I31_N2.0841.00
55_E80_H1.9861.00
41_D45_N1.9861.00
14_T119_N1.9550.99
133_D137_V1.9370.99
37_K98_E1.9040.99
80_H118_E1.9000.99
17_L115_I1.8660.99
64_E74_Y1.8270.99
19_A42_F1.8190.99
89_R106_S1.8050.99
114_H118_E1.8040.99
41_D157_Y1.7740.99
27_D105_N1.7090.99
44_K91_E1.7060.98
10_M119_N1.6990.98
138_I142_F1.6940.98
25_V28_I1.6790.98
46_F61_D1.6540.98
12_E54_K1.6390.98
107_L110_L1.6340.98
10_M127_E1.6190.98
38_I163_T1.6040.98
150_G154_H1.5930.98
55_E118_E1.5790.97
17_L119_N1.5620.97
51_H118_E1.5520.97
88_N92_A1.5450.97
104_L126_A1.4980.97
69_V72_P1.4920.96
72_P122_L1.4880.96
14_T17_L1.4580.96
91_E95_N1.4340.96
69_V73_I1.4290.95
5_S157_Y1.4270.95
56_E84_R1.4050.95
60_F63_L1.3980.95
115_I119_N1.3940.95
116_D120_N1.3730.94
137_V141_K1.3490.94
16_I47_V1.3400.94
159_E163_T1.2900.92
80_H114_H1.2860.92
59_L63_L1.2850.92
82_K86_I1.2690.92
71_G74_Y1.2400.91
155_E158_I1.2320.90
149_F157_Y1.2290.90
42_F135_N1.2190.90
21_E112_A1.1790.88
52_H107_L1.1760.88
58_V138_I1.1700.88
16_I48_D1.1640.88
161_I165_Y1.1300.86
12_E77_V1.1210.86
131_S134_E1.1210.86
56_E60_F1.1020.85
50_C154_H1.0680.83
63_L104_L1.0550.82
132_D136_K1.0400.81
128_S138_I1.0390.81
69_V74_Y1.0320.80
94_Y100_L1.0260.80
95_N99_E1.0190.80
16_I84_R1.0160.79
100_L104_L1.0100.79
154_H158_I0.9980.78
15_V161_I0.9920.78
41_D156_R0.9750.77
55_E60_F0.9710.76
37_K95_N0.9610.76
101_R105_N0.9560.75
48_D52_H0.9470.74
42_F52_H0.9370.74
121_V125_T0.9350.73
44_K90_I0.9280.73
71_G75_V0.9250.73
75_V121_V0.9200.72
51_H60_F0.9160.72
122_L125_T0.9150.72
153_R156_R0.9100.71
57_K122_L0.9030.71
24_N105_N0.9020.71
86_I106_S0.8980.70
61_D65_H0.8960.70
57_K60_F0.8950.70
7_K14_T0.8940.70
53_V135_N0.8860.69
58_V61_D0.8800.69
156_R159_E0.8750.68
20_L87_I0.8710.68
81_N87_I0.8670.68
117_K121_V0.8660.68
113_S120_N0.8650.68
48_D84_R0.8650.68
34_Q65_H0.8620.67
76_M117_K0.8600.67
45_N157_Y0.8540.67
54_K142_F0.8520.66
40_I99_E0.8490.66
12_E142_F0.8410.65
155_E159_E0.8400.65
157_Y160_L0.8380.65
15_V46_F0.8380.65
63_L126_A0.8340.65
20_L23_L0.8330.65
66_K90_I0.8320.64
114_H124_P0.8310.64
51_H80_H0.8250.64
155_E166_G0.8230.64
22_I39_I0.8140.63
82_K85_D0.8090.62
63_L93_R0.8040.62
99_E131_S0.8040.62
76_M123_F0.7970.61
18_K22_I0.7950.61
5_S15_V0.7940.61
13_H118_E0.7930.61
7_K127_E0.7820.60
58_V141_K0.7810.60
32_N121_V0.7790.59
122_L129_L0.7740.59
135_N139_Y0.7720.59
93_R97_F0.7690.58
86_I103_D0.7670.58
47_V50_C0.7440.56
16_I42_F0.7390.55
161_I164_L0.7350.55
60_F126_A0.7340.55
40_I44_K0.7330.55
159_E166_G0.7310.55
27_D30_E0.7260.54
26_I37_K0.7260.54
152_E162_D0.7230.54
29_N127_E0.7100.52
46_F142_F0.7080.52
16_I43_I0.7060.52
127_E133_D0.7030.52
9_L83_L0.7030.52
59_L76_M0.7020.52
62_F65_H0.7020.52
75_V113_S0.6920.51
162_D166_G0.6920.51
151_K159_E0.6910.50
37_K48_D0.6900.50
90_I100_L0.6900.50
71_G138_I0.6870.50
96_E99_E0.6840.50
42_F53_V0.6840.50
5_S139_Y0.6830.50
96_E142_F0.6830.50
56_E59_L0.6830.50
123_F126_A0.6820.50
39_I161_I0.6800.49
57_K61_D0.6790.49
5_S39_I0.6760.49
76_M80_H0.6750.49
88_N129_L0.6580.47
150_G156_R0.6560.47
43_I83_L0.6550.47
64_E73_I0.6540.47
52_H118_E0.6510.46
94_Y122_L0.6450.46
28_I138_I0.6440.46
19_A161_I0.6390.45
20_L108_I0.6370.45
44_K100_L0.6340.45
72_P76_M0.6300.44
36_I87_I0.6270.44
48_D107_L0.6270.44
52_H80_H0.6250.44
15_V18_K0.6220.43
19_A39_I0.6180.43
87_I111_L0.6160.43
92_A98_E0.6150.43
151_K166_G0.6100.42
77_V126_A0.6010.41
15_V19_A0.5990.41
63_L78_Y0.5980.41
40_I98_E0.5970.41
59_L65_H0.5960.41
35_D48_D0.5940.41
72_P78_Y0.5920.40
42_F134_E0.5910.40
152_E159_E0.5910.40
40_I104_L0.5890.40
156_R163_T0.5860.40
5_S73_I0.5840.40
88_N91_E0.5830.40
136_K140_E0.5810.39
83_L93_R0.5770.39
153_R157_Y0.5700.38
5_S135_N0.5680.38
33_M98_E0.5670.38
63_L97_F0.5620.37
85_D109_V0.5600.37
47_V52_H0.5500.36
83_L119_N0.5480.36
25_V29_N0.5460.36
42_F56_E0.5420.36
153_R161_I0.5400.35
28_I101_R0.5400.35
48_D104_L0.5380.35
53_V57_K0.5380.35
25_V86_I0.5370.35
15_V54_K0.5370.35
30_E34_Q0.5360.35
81_N85_D0.5340.35
17_L20_L0.5330.35
149_F153_R0.5280.34
110_L125_T0.5270.34
52_H119_N0.5270.34
64_E67_G0.5270.34
24_N108_I0.5260.34
154_H159_E0.5250.34
77_V123_F0.5240.34
102_E105_N0.5190.33
107_L127_E0.5160.33
133_D140_E0.5150.33
62_F126_A0.5130.33
42_F119_N0.5050.32
75_V117_K0.5040.32
34_Q60_F0.5020.32
120_N140_E0.5010.32
77_V104_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3caxA 2 0.9773 99.9 0.506 Contact Map
2p0nA 1 0.8295 99.8 0.557 Contact Map
3u9jA 1 0.8068 87 0.892 Contact Map
4xpxA 1 0.6818 79.9 0.901 Contact Map
3agtA 1 0.6989 63.6 0.913 Contact Map
2hmqA 5 0.5739 27.7 0.93 Contact Map
2mhrA 1 0.6023 22.8 0.933 Contact Map
2lc5A 1 0.3068 14.2 0.939 Contact Map
1j7qA 1 0.3068 8.1 0.945 Contact Map
4gjfA 2 0.3295 7.6 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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