GREMLIN Database
Q97X78 - Uncharacterized protein
UniProt: Q97X78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (245)
Sequences: 535 (435)
Seq/√Len: 27.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_D203_V4.7371.00
4_I29_L4.6491.00
136_I151_I3.8091.00
197_N200_E3.5321.00
111_K115_D3.0361.00
202_S212_Q2.9091.00
15_D22_R2.7201.00
155_I162_I2.6941.00
226_D230_R2.6560.99
227_N230_R2.6260.99
115_D121_F2.5980.99
69_K117_V2.5930.99
11_Y18_I2.5010.99
112_N115_D2.3240.99
15_D170_R2.2750.98
188_I226_D2.1880.98
133_D165_H2.1880.98
110_T115_D2.1570.98
27_L34_L2.1000.97
115_D120_Y2.0410.97
137_V175_I2.0240.97
8_I132_L2.0150.96
112_N123_V1.9700.96
8_I23_I1.9340.95
136_I155_I1.9020.95
52_L175_I1.8870.95
18_I23_I1.8650.94
9_L78_W1.8480.94
12_L17_R1.7840.93
9_L104_D1.7750.93
157_V162_I1.7670.93
16_G177_V1.7660.93
59_F98_D1.7590.92
112_N120_Y1.7520.92
180_Q221_T1.7430.92
139_I154_K1.7410.92
115_D123_V1.7390.92
162_I175_I1.7250.92
51_K238_A1.7240.92
110_T116_P1.7170.92
4_I34_L1.6990.91
85_C90_N1.6950.91
110_T121_F1.6930.91
123_V126_L1.6740.90
20_Q38_F1.6640.90
29_L33_S1.6520.90
21_R185_K1.6130.89
230_R233_K1.6100.89
8_I160_R1.6080.89
79_I187_D1.6020.88
208_C234_Y1.5490.87
201_I244_T1.5470.87
50_F68_F1.5420.86
5_D37_R1.5240.86
142_I154_K1.5170.85
17_R145_R1.4970.85
166_I226_D1.4760.84
82_K183_L1.4590.83
81_F90_N1.4590.83
213_F217_Y1.4470.83
26_L50_F1.4460.83
16_G144_P1.4060.81
2_D5_D1.3730.79
24_A220_I1.3650.79
146_L154_K1.3630.79
131_N134_Q1.3440.78
84_K91_V1.3240.76
139_I142_I1.3180.76
29_L32_A1.3000.75
36_Y212_Q1.3000.75
169_L215_D1.2980.75
112_N121_F1.2980.75
157_V161_I1.2920.75
2_D37_R1.2730.74
10_F19_S1.2710.73
144_P215_D1.2660.73
81_F85_C1.2550.72
34_L230_R1.2500.72
38_F180_Q1.2440.72
8_I41_L1.2280.71
177_V214_T1.2220.70
184_G238_A1.2080.70
11_Y26_L1.2030.69
233_K236_D1.2000.69
81_F92_Y1.1950.69
137_V149_S1.1930.69
80_S89_L1.1920.68
57_N229_E1.1900.68
114_G177_V1.1740.67
93_G102_L1.1690.67
80_S85_C1.1410.65
8_I170_R1.1340.65
97_S134_Q1.1200.64
128_R172_R1.1200.64
23_I205_L1.1170.63
31_P244_T1.1150.63
194_F221_T1.1120.63
201_I242_D1.0920.62
8_I161_I1.0900.61
51_K183_L1.0860.61
17_R144_P1.0860.61
79_I206_Q1.0860.61
86_L92_Y1.0830.61
15_D24_A1.0810.61
50_F144_P1.0640.60
19_S57_N1.0570.59
8_I197_N1.0540.59
86_L248_M1.0500.58
152_S219_G1.0490.58
60_G106_I1.0490.58
39_K201_I1.0390.58
79_I195_S1.0340.57
58_F239_R1.0240.57
111_K117_V1.0230.56
85_C92_Y1.0230.56
16_G145_R1.0230.56
130_S157_V1.0200.56
131_N229_E1.0110.56
21_R31_P1.0070.55
100_T104_D1.0030.55
183_L191_F1.0020.55
33_S86_L0.9990.55
45_G117_V0.9970.55
161_I164_K0.9960.54
236_D239_R0.9930.54
57_N205_L0.9890.54
87_E92_Y0.9850.54
16_G158_N0.9720.53
31_P163_E0.9650.52
52_L137_V0.9630.52
78_W227_N0.9440.50
61_K104_D0.9420.50
112_N122_P0.9410.50
162_I220_I0.9370.50
98_D153_K0.9270.49
5_D8_I0.9220.49
146_L211_W0.9220.49
56_P63_Q0.9220.49
67_A89_L0.9210.49
59_F129_A0.9190.49
111_K120_Y0.9130.48
70_N210_L0.9120.48
182_D185_K0.9120.48
162_I234_Y0.9110.48
196_K204_V0.9070.48
109_M156_N0.9050.47
64_I120_Y0.9000.47
113_L120_Y0.8910.46
112_N117_V0.8880.46
39_K51_K0.8860.46
170_R177_V0.8860.46
135_K220_I0.8770.45
82_K90_N0.8770.45
116_P123_V0.8750.45
98_D103_K0.8730.45
202_S232_R0.8690.45
45_G126_L0.8680.45
17_R87_E0.8650.44
8_I25_S0.8600.44
57_N63_Q0.8590.44
25_S29_L0.8580.44
186_T192_S0.8550.44
47_L157_V0.8460.43
47_L216_G0.8440.43
58_F191_F0.8400.43
102_L114_G0.8360.42
188_I243_N0.8340.42
8_I18_I0.8300.42
47_L78_W0.8290.42
160_R241_I0.8270.42
52_L177_V0.8250.41
3_I240_Q0.8220.41
84_K191_F0.8220.41
61_K95_Y0.8210.41
81_F89_L0.8200.41
19_S65_F0.8160.41
117_V121_F0.8080.40
50_F223_C0.8070.40
24_A44_S0.8010.40
149_S236_D0.8000.40
87_E140_L0.8000.40
73_D159_S0.7930.39
98_D242_D0.7930.39
40_K44_S0.7880.39
9_L84_K0.7830.38
163_E220_I0.7810.38
94_I153_K0.7790.38
41_L163_E0.7790.38
8_I21_R0.7770.38
194_F231_A0.7760.38
94_I98_D0.7720.38
175_I219_G0.7710.38
115_D122_P0.7710.38
149_S173_G0.7650.37
97_S203_V0.7640.37
111_K121_F0.7590.37
71_Y116_P0.7590.37
78_W169_L0.7590.37
115_D223_C0.7570.37
34_L156_N0.7570.37
8_I101_E0.7570.37
110_T141_K0.7560.36
182_D193_I0.7540.36
115_D126_L0.7540.36
68_F147_S0.7530.36
140_L169_L0.7490.36
83_L90_N0.7480.36
16_G170_R0.7420.35
105_K110_T0.7420.35
39_K43_D0.7400.35
197_N243_N0.7390.35
151_I169_L0.7390.35
139_I151_I0.7320.35
20_Q187_D0.7260.34
84_K107_S0.7250.34
188_I247_V0.7250.34
68_F150_E0.7250.34
60_G73_D0.7230.34
186_T194_F0.7220.34
16_G24_A0.7210.34
12_L16_G0.7160.34
67_A212_Q0.7150.34
52_L144_P0.7120.33
145_R165_H0.7110.33
88_W234_Y0.7100.33
148_S196_K0.7090.33
40_K75_D0.7080.33
81_F86_L0.7070.33
16_G122_P0.7060.33
5_D156_N0.7050.33
57_N201_I0.7040.33
2_D40_K0.7030.33
38_F234_Y0.6980.32
97_S103_K0.6950.32
111_K196_K0.6950.32
78_W148_S0.6940.32
70_N73_D0.6930.32
153_K213_F0.6910.32
47_L63_Q0.6910.32
233_K242_D0.6910.32
115_D144_P0.6850.32
66_I91_V0.6830.31
188_I196_K0.6820.31
129_A233_K0.6820.31
152_S181_I0.6820.31
122_P179_P0.6820.31
212_Q232_R0.6810.31
19_S114_G0.6800.31
6_K226_D0.6800.31
31_P215_D0.6790.31
150_E238_A0.6780.31
110_T244_T0.6770.31
101_E197_N0.6760.31
41_L249_I0.6740.31
24_A238_A0.6740.31
137_V167_R0.6720.31
63_Q181_I0.6710.31
109_M113_L0.6710.31
2_D6_K0.6680.30
91_V193_I0.6670.30
146_L151_I0.6660.30
152_S238_A0.6630.30
150_E245_A0.6620.30
220_I223_C0.6610.30
148_S244_T0.6610.30
198_I234_Y0.6590.30
115_D130_S0.6540.30
193_I223_C0.6530.30
4_I240_Q0.6500.29
183_L186_T0.6500.29
24_A205_L0.6490.29
130_S168_Y0.6480.29
111_K116_P0.6470.29
75_D146_L0.6470.29
106_I142_I0.6430.29
31_P161_I0.6400.29
66_I217_Y0.6390.29
3_I127_F0.6310.28
48_K210_L0.6300.28
176_L220_I0.6290.28
21_R112_N0.6280.28
120_Y123_V0.6270.28
235_I238_A0.6240.28
83_L137_V0.6230.28
32_A176_L0.6230.28
64_I234_Y0.6200.27
14_K171_H0.6170.27
214_T218_A0.6160.27
39_K118_L0.6130.27
108_Y112_N0.6100.27
159_S188_I0.6080.27
198_I218_A0.6050.27
3_I199_D0.6030.26
180_Q228_M0.6020.26
21_R34_L0.6000.26
199_D202_S0.5980.26
74_I163_E0.5950.26
87_E145_R0.5930.26
86_L90_N0.5910.26
68_F75_D0.5900.26
51_K71_Y0.5900.26
200_E241_I0.5900.26
3_I63_Q0.5890.26
200_E237_L0.5890.26
139_I160_R0.5870.25
129_A238_A0.5850.25
167_R171_H0.5830.25
39_K170_R0.5780.25
136_I162_I0.5780.25
196_K242_D0.5770.25
167_R236_D0.5740.25
36_Y67_A0.5740.25
149_S155_I0.5730.25
99_N189_I0.5710.25
19_S197_N0.5710.25
36_Y72_S0.5710.25
42_T52_L0.5700.25
9_L191_F0.5680.24
66_I95_Y0.5670.24
90_N93_G0.5650.24
147_S182_D0.5640.24
57_N193_I0.5620.24
96_A136_I0.5610.24
16_G43_D0.5610.24
4_I27_L0.5610.24
149_S230_R0.5600.24
41_L137_V0.5580.24
22_R171_H0.5560.24
15_D165_H0.5550.24
67_A92_Y0.5520.24
56_P61_K0.5510.23
24_A240_Q0.5510.23
128_R166_I0.5500.23
19_S94_I0.5500.23
203_V238_A0.5460.23
100_T188_I0.5460.23
175_I206_Q0.5450.23
102_L130_S0.5430.23
205_L242_D0.5420.23
91_V107_S0.5410.23
177_V218_A0.5410.23
7_R127_F0.5390.23
67_A195_S0.5370.23
65_F220_I0.5360.23
166_I223_C0.5320.22
112_N116_P0.5300.22
97_S102_L0.5300.22
7_R66_I0.5290.22
8_I121_F0.5260.22
36_Y234_Y0.5260.22
59_F126_L0.5250.22
241_I244_T0.5190.22
137_V155_I0.5170.22
53_Y148_S0.5150.22
122_P210_L0.5140.21
27_L105_K0.5100.21
15_D23_I0.5100.21
134_Q153_K0.5100.21
166_I175_I0.5090.21
115_D119_S0.5080.21
112_N126_L0.5070.21
118_L238_A0.5060.21
131_N139_I0.5030.21
130_S239_R0.5010.21
28_N43_D0.5000.21
27_L243_N0.5000.21
24_A135_K0.5000.21
174_L191_F0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9648 100 0.356 Contact Map
4un1B 1 0.5312 99.8 0.696 Contact Map
4un1A 1 0.5 99.8 0.697 Contact Map
2p5vA 5 0.5195 99.8 0.699 Contact Map
4pcqA 2 0.5156 99.8 0.701 Contact Map
2cg4A 6 0.5078 99.8 0.703 Contact Map
2e1cA 1 0.5273 99.8 0.705 Contact Map
2ia0A 2 0.4961 99.8 0.71 Contact Map
2pn6A 5 0.5 99.8 0.717 Contact Map
3i4pA 5 0.4961 99.8 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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