GREMLIN Database
Q97X73 - Uncharacterized protein
UniProt: Q97X73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 274 (260)
Sequences: 33845 (25336)
Seq/√Len: 1571.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_G143_G3.2811.00
11_W218_N2.9101.00
90_L140_L2.8181.00
218_N222_E2.7231.00
243_S249_V2.7201.00
47_A175_L2.5421.00
80_L142_F2.4841.00
25_L203_L2.3661.00
218_N221_R2.3551.00
40_A182_L2.3261.00
120_G265_G2.3221.00
20_G238_M2.3031.00
77_L145_L2.2591.00
92_A239_A2.2421.00
45_I205_A2.1641.00
27_K249_V2.1371.00
26_T79_N2.1001.00
105_I155_I2.0941.00
111_H158_S2.0611.00
12_I219_G2.0411.00
77_L142_F2.0301.00
101_F147_G1.9961.00
195_L199_S1.9881.00
107_R113_I1.9091.00
51_L171_A1.8861.00
20_G242_T1.8541.00
44_G178_L1.8301.00
194_S197_T1.8081.00
73_F149_L1.7811.00
106_E111_H1.7571.00
85_S140_L1.7391.00
205_A210_I1.7371.00
47_A178_L1.7351.00
103_L121_V1.7321.00
102_V229_S1.7201.00
84_L138_I1.7111.00
114_T117_G1.6971.00
21_F203_L1.6891.00
17_L238_M1.6861.00
97_T101_F1.6791.00
32_S197_T1.6361.00
165_D168_K1.6351.00
141_V145_L1.6331.00
179_P183_A1.6241.00
124_G233_L1.6221.00
18_F207_L1.6201.00
33_A197_T1.6161.00
85_S139_G1.6141.00
224_G227_Y1.6091.00
77_L149_L1.5851.00
91_V143_G1.5681.00
101_F151_A1.5661.00
252_T255_Q1.5431.00
46_A174_T1.5181.00
80_L84_L1.4941.00
183_A186_P1.4841.00
15_L219_G1.4501.00
137_N140_L1.4481.00
40_A178_L1.4461.00
29_I38_I1.4421.00
101_F148_I1.4251.00
157_Y217_F1.4171.00
11_W215_F1.3971.00
106_E109_L1.3891.00
80_L83_G1.3581.00
120_G269_T1.3521.00
48_I52_I1.3341.00
195_L198_L1.3291.00
238_M242_T1.3281.00
9_L231_G1.3281.00
85_S90_L1.3241.00
253_L257_I1.3191.00
38_I204_L1.3121.00
24_P242_T1.3061.00
134_L137_N1.3021.00
196_V199_S1.2901.00
28_I200_L1.2881.00
34_S37_I1.2871.00
242_T246_V1.2851.00
49_F210_I1.2661.00
89_G240_Y1.2641.00
151_A155_I1.2621.00
88_P243_S1.2611.00
256_I260_L1.2601.00
159_R162_A1.2581.00
130_S261_I1.2521.00
21_F242_T1.2481.00
196_V200_L1.2471.00
116_K268_L1.2441.00
260_L264_F1.2441.00
93_V259_S1.2381.00
234_L238_M1.2161.00
115_P119_V1.2081.00
118_I122_L1.2051.00
130_S254_P1.2011.00
120_G268_L1.1951.00
122_L126_V1.1911.00
55_R58_S1.1791.00
42_R209_Q1.1771.00
19_W212_G1.1671.00
10_R14_P1.1591.00
27_K31_Y1.1581.00
127_G258_G1.1581.00
189_Y192_R1.1541.00
111_H117_G1.1541.00
72_A180_I1.1471.00
84_L142_F1.1411.00
124_G265_G1.1351.00
199_S203_L1.1301.00
105_I152_G1.1281.00
36_M184_F1.1241.00
113_I118_I1.1231.00
25_L200_L1.1211.00
180_I183_A1.1191.00
70_N152_G1.1171.00
159_R163_K1.1161.00
158_S224_G1.1151.00
190_Y193_F1.1071.00
85_S143_G1.1061.00
251_P256_I1.1041.00
72_A181_V1.1021.00
15_L215_F1.1011.00
47_A171_A1.0981.00
32_S194_S1.0921.00
78_I82_I1.0881.00
40_A185_T1.0871.00
40_A44_G1.0691.00
105_I151_A1.0681.00
138_I142_F1.0541.00
115_P118_I1.0501.00
84_L139_G1.0501.00
44_G182_L1.0461.00
29_I197_T1.0401.00
15_L19_W1.0371.00
19_W216_W1.0361.00
86_P90_L1.0351.00
131_S258_G1.0351.00
26_T82_I1.0311.00
82_I91_V1.0291.00
203_L207_L1.0281.00
94_M147_G1.0271.00
102_V225_T1.0231.00
18_F215_F1.0151.00
107_R112_K1.0141.00
8_F219_G1.0091.00
8_F222_E1.0041.00
67_G70_N1.0041.00
199_S202_L0.9991.00
68_L180_I0.9991.00
39_S79_N0.9971.00
220_V228_A0.9931.00
102_V154_T0.9931.00
207_L211_L0.9881.00
109_L155_I0.9841.00
24_P246_V0.9841.00
105_I108_L0.9821.00
237_V259_S0.9721.00
43_I177_S0.9711.00
29_I200_L0.9691.00
183_A187_I0.9691.00
88_P247_L0.9681.00
36_M76_I0.9671.00
138_I141_V0.9651.00
253_L256_I0.9641.00
49_F206_I0.9591.00
97_T128_V0.9561.00
158_S162_A0.9521.00
224_G228_A0.9501.00
93_V129_I0.9411.00
147_G151_A0.9411.00
102_V151_A0.9391.00
198_L202_L0.9381.00
94_M140_L0.9351.00
13_V238_M0.9341.00
94_M143_G0.9341.00
105_I148_I0.9281.00
158_S225_T0.9271.00
223_L228_A0.9231.00
14_P215_F0.9211.00
39_S181_V0.9191.00
184_F187_I0.9181.00
35_P39_S0.9161.00
127_G262_T0.9131.00
16_S20_G0.9101.00
51_L175_L0.9101.00
70_N153_G0.9011.00
201_L205_A0.9001.00
123_L265_G0.8991.00
114_T118_I0.8991.00
34_S188_D0.8951.00
240_Y251_P0.8881.00
16_S238_M0.8841.00
220_V224_G0.8791.00
88_P249_V0.8791.00
139_G143_G0.8781.00
16_S234_L0.8771.00
76_I80_L0.8621.00
223_L227_Y0.8601.00
71_F153_G0.8571.00
103_L113_I0.8531.00
128_V132_A0.8501.00
202_L206_I0.8501.00
37_I185_T0.8491.00
133_T136_F0.8471.00
244_F251_P0.8471.00
202_L205_A0.8461.00
72_A76_I0.8411.00
84_L136_F0.8311.00
112_K116_K0.8291.00
102_V155_I0.8281.00
24_P243_S0.8211.00
24_P88_P0.8201.00
137_N141_V0.8181.00
112_K115_P0.8131.00
211_L215_F0.8101.00
50_F210_I0.8071.00
240_Y259_S0.8061.00
103_L117_G0.8021.00
172_F176_T0.8001.00
243_S247_L0.8001.00
254_P257_I0.7971.00
41_F45_I0.7961.00
194_S198_L0.7961.00
63_Q163_K0.7941.00
244_F250_A0.7931.00
126_V130_S0.7931.00
130_S257_I0.7921.00
55_R59_V0.7901.00
100_I124_G0.7891.00
64_F176_T0.7891.00
9_L227_Y0.7861.00
49_F205_A0.7841.00
68_L72_A0.7821.00
49_F52_I0.7731.00
143_G147_G0.7731.00
259_S263_L0.7701.00
44_G48_I0.7691.00
219_G228_A0.7581.00
126_V261_I0.7581.00
176_T180_I0.7561.00
104_I108_L0.7561.00
164_E169_L0.7561.00
23_F78_I0.7561.00
70_N149_L0.7501.00
55_R60_G0.7411.00
12_I231_G0.7391.00
178_L182_L0.7371.00
70_N156_Y0.7321.00
257_I261_I0.7311.00
23_F92_A0.7301.00
68_L71_F0.7281.00
81_G91_V0.7191.00
33_A37_I0.7161.00
54_G171_A0.7131.00
150_W154_T0.7131.00
175_L179_P0.7111.00
111_H226_V0.7071.00
107_R110_G0.7031.00
170_N173_M0.7031.00
234_L237_V0.7031.00
136_F140_L0.6951.00
37_I41_F0.6921.00
166_I170_N0.6891.00
176_T179_P0.6881.00
200_L203_L0.6861.00
8_F223_L0.6861.00
74_F149_L0.6851.00
18_F208_A0.6831.00
171_A175_L0.6831.00
153_G217_F0.6821.00
240_Y244_F0.6801.00
168_K172_F0.6781.00
33_A38_I0.6771.00
119_V123_L0.6761.00
26_T30_A0.6711.00
60_G63_Q0.6701.00
170_N217_F0.6701.00
214_Y218_N0.6691.00
266_V269_T0.6691.00
12_I223_L0.6691.00
101_F144_L0.6681.00
251_P255_Q0.6681.00
47_A51_L0.6661.00
96_Y128_V0.6661.00
45_I201_L0.6651.00
152_G156_Y0.6651.00
85_S91_V0.6641.00
53_L167_V0.6551.00
197_T200_L0.6511.00
41_F201_L0.6511.00
22_A208_A0.6491.00
81_G139_G0.6491.00
74_F153_G0.6481.00
103_L107_R0.6471.00
264_F268_L0.6431.00
150_W216_W0.6411.00
68_L176_T0.6311.00
45_I49_F0.6301.00
71_F173_M0.6271.00
113_I117_G0.6271.00
94_M144_L0.6261.00
97_T100_I0.6251.00
252_T256_I0.6251.00
142_F145_L0.6191.00
66_N70_N0.6181.00
241_I244_F0.6181.00
20_G235_V0.6151.00
241_I245_A0.6121.00
28_I247_L0.6061.00
28_I31_Y0.6061.00
172_F175_L0.6061.00
250_A255_Q0.6051.00
104_I121_V0.6041.00
73_F77_L0.6041.00
154_T216_W0.6031.00
117_G224_G0.6011.00
99_P233_L0.5971.00
30_A82_I0.5971.00
71_F213_F0.5941.00
125_V233_L0.5931.00
242_T245_A0.5911.00
132_A140_L0.5891.00
46_A210_I0.5861.00
68_L73_F0.5811.00
93_V132_A0.5811.00
18_F212_G0.5801.00
46_A205_A0.5731.00
170_N174_T0.5711.00
194_S199_S0.5701.00
66_N156_Y0.5691.00
109_L158_S0.5641.00
78_I146_A0.5641.00
154_T229_S0.5631.00
78_I91_V0.5621.00
123_L268_L0.5611.00
148_I152_G0.5611.00
96_Y99_P0.5601.00
46_A209_Q0.5581.00
30_A83_G0.5551.00
250_A254_P0.5551.00
106_E226_V0.5551.00
133_T137_N0.5541.00
72_A184_F0.5531.00
175_L178_L0.5531.00
84_L137_N0.5521.00
177_S181_V0.5511.00
97_T147_G0.5501.00
153_G173_M0.5461.00
219_G223_L0.5461.00
24_P239_A0.5451.00
22_A204_L0.5451.00
102_V106_E0.5441.00
14_P18_F0.5431.00
21_F208_A0.5421.00
12_I216_W0.5371.00
100_I121_V0.5361.00
22_A79_N0.5351.00
203_L206_I0.5341.00
255_Q259_S0.5321.00
79_N83_G0.5321.00
96_Y147_G0.5301.00
12_I228_A0.5291.00
81_G85_S0.5281.00
43_I181_V0.5261.00
265_G269_T0.5261.00
20_G239_A0.5251.00
119_V126_V0.5241.00
74_F78_I0.5221.00
237_V263_L0.5211.00
127_G265_G0.5191.00
134_L138_I0.5181.00
130_S255_Q0.5181.00
48_I51_L0.5171.00
179_P182_L0.5141.00
182_L186_P0.5141.00
230_T269_T0.5141.00
116_K119_V0.5081.00
54_G168_K0.5071.00
164_E168_K0.5061.00
71_F75_L0.5051.00
11_W222_E0.5041.00
71_F177_S0.5041.00
153_G157_Y0.5031.00
8_F11_W0.5031.00
244_F248_G0.5031.00
28_I32_S0.5021.00
103_L226_V0.5021.00
233_L266_V0.5021.00
245_A248_G0.5011.00
42_R75_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.281 98.7 0.767 Contact Map
3b5dA 2 0.3686 98.1 0.801 Contact Map
4pgrA 1 0.6898 12.5 0.941 Contact Map
4qndA 2 0.3467 4.1 0.953 Contact Map
2gfpA 2 0.7774 3.8 0.954 Contact Map
4pypA 1 0.5693 3.7 0.954 Contact Map
1pw4A 1 0.8321 3.5 0.955 Contact Map
2nq2A 2 0.1971 3.2 0.955 Contact Map
4j05A 3 0.9526 2.7 0.957 Contact Map
2cfqA 1 0.5985 2.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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