Q97X73 - SULSO - GREMLIN Contacts

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Q97X73 - Uncharacterized protein

UniProt:	Q97X73	Sequences: MQRTTISFLRWIVPLSLFWGFAFPLTKIIAYSASPMIISAFRIGIAAIFFLILGRGLSVGKKQFINGLMNFAFFLILINLGIGLSPDPGLVAVMIYTQPIFVLIIERLLGHKITPKGIVGVLLGVVGVISSATLSFNIGLVFGLLAGILWAGGTIYYSRNLAKEDIVKLNAFMTLTSLPIVLAFTPIDYYFRFSLVTLSLLLLLAILAQILGFYFWFNGVRELGTVYASTGSLLVPVMAYITSFAVLGVAPTLPQIIGSLITLFGVYLTITSRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	274 (260)
Sequences:	33845 (25336)
Seq/√Len:	1571.2

ECOLI - YHBE EAMA YIJE YEDA YDDG YICL RHTA RARD YTFF
BACSU - YDEK YDFC YVBV YBFH YDED YCBK YWFM YXXF YCXC YOAV YETK YRDR YOJE YYAM
HALSA - Q9HHP6 Q9HQ34 Q9HPI0
SULSO - Q97X73 Q97UX3 Q97UE8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_G	143_G	3.281	1.00
11_W	218_N	2.910	1.00
90_L	140_L	2.818	1.00
218_N	222_E	2.723	1.00
243_S	249_V	2.720	1.00
47_A	175_L	2.542	1.00
80_L	142_F	2.484	1.00
25_L	203_L	2.366	1.00
218_N	221_R	2.355	1.00
40_A	182_L	2.326	1.00
120_G	265_G	2.322	1.00
20_G	238_M	2.303	1.00
77_L	145_L	2.259	1.00
92_A	239_A	2.242	1.00
45_I	205_A	2.164	1.00
27_K	249_V	2.137	1.00
26_T	79_N	2.100	1.00
105_I	155_I	2.094	1.00
111_H	158_S	2.061	1.00
12_I	219_G	2.041	1.00
77_L	142_F	2.030	1.00
101_F	147_G	1.996	1.00
195_L	199_S	1.988	1.00
107_R	113_I	1.909	1.00
51_L	171_A	1.886	1.00
20_G	242_T	1.854	1.00
44_G	178_L	1.830	1.00
194_S	197_T	1.808	1.00
73_F	149_L	1.781	1.00
106_E	111_H	1.757	1.00
85_S	140_L	1.739	1.00
205_A	210_I	1.737	1.00
47_A	178_L	1.735	1.00
103_L	121_V	1.732	1.00
102_V	229_S	1.720	1.00
84_L	138_I	1.711	1.00
114_T	117_G	1.697	1.00
21_F	203_L	1.689	1.00
17_L	238_M	1.686	1.00
97_T	101_F	1.679	1.00
32_S	197_T	1.636	1.00
165_D	168_K	1.635	1.00
141_V	145_L	1.633	1.00
179_P	183_A	1.624	1.00
124_G	233_L	1.622	1.00
18_F	207_L	1.620	1.00
33_A	197_T	1.616	1.00
85_S	139_G	1.614	1.00
224_G	227_Y	1.609	1.00
77_L	149_L	1.585	1.00
91_V	143_G	1.568	1.00
101_F	151_A	1.566	1.00
252_T	255_Q	1.543	1.00
46_A	174_T	1.518	1.00
80_L	84_L	1.494	1.00
183_A	186_P	1.484	1.00
15_L	219_G	1.450	1.00
137_N	140_L	1.448	1.00
40_A	178_L	1.446	1.00
29_I	38_I	1.442	1.00
101_F	148_I	1.425	1.00
157_Y	217_F	1.417	1.00
11_W	215_F	1.397	1.00
106_E	109_L	1.389	1.00
80_L	83_G	1.358	1.00
120_G	269_T	1.352	1.00
48_I	52_I	1.334	1.00
195_L	198_L	1.329	1.00
238_M	242_T	1.328	1.00
9_L	231_G	1.328	1.00
85_S	90_L	1.324	1.00
253_L	257_I	1.319	1.00
38_I	204_L	1.312	1.00
24_P	242_T	1.306	1.00
134_L	137_N	1.302	1.00
196_V	199_S	1.290	1.00
28_I	200_L	1.288	1.00
34_S	37_I	1.287	1.00
242_T	246_V	1.285	1.00
49_F	210_I	1.266	1.00
89_G	240_Y	1.264	1.00
151_A	155_I	1.262	1.00
88_P	243_S	1.261	1.00
256_I	260_L	1.260	1.00
159_R	162_A	1.258	1.00
130_S	261_I	1.252	1.00
21_F	242_T	1.248	1.00
196_V	200_L	1.247	1.00
116_K	268_L	1.244	1.00
260_L	264_F	1.244	1.00
93_V	259_S	1.238	1.00
234_L	238_M	1.216	1.00
115_P	119_V	1.208	1.00
118_I	122_L	1.205	1.00
130_S	254_P	1.201	1.00
120_G	268_L	1.195	1.00
122_L	126_V	1.191	1.00
55_R	58_S	1.179	1.00
42_R	209_Q	1.177	1.00
19_W	212_G	1.167	1.00
10_R	14_P	1.159	1.00
27_K	31_Y	1.158	1.00
127_G	258_G	1.158	1.00
189_Y	192_R	1.154	1.00
111_H	117_G	1.154	1.00
72_A	180_I	1.147	1.00
84_L	142_F	1.141	1.00
124_G	265_G	1.135	1.00
199_S	203_L	1.130	1.00
105_I	152_G	1.128	1.00
36_M	184_F	1.124	1.00
113_I	118_I	1.123	1.00
25_L	200_L	1.121	1.00
180_I	183_A	1.119	1.00
70_N	152_G	1.117	1.00
159_R	163_K	1.116	1.00
158_S	224_G	1.115	1.00
190_Y	193_F	1.107	1.00
85_S	143_G	1.106	1.00
251_P	256_I	1.104	1.00
72_A	181_V	1.102	1.00
15_L	215_F	1.101	1.00
47_A	171_A	1.098	1.00
32_S	194_S	1.092	1.00
78_I	82_I	1.088	1.00
40_A	185_T	1.087	1.00
40_A	44_G	1.069	1.00
105_I	151_A	1.068	1.00
138_I	142_F	1.054	1.00
115_P	118_I	1.050	1.00
84_L	139_G	1.050	1.00
44_G	182_L	1.046	1.00
29_I	197_T	1.040	1.00
15_L	19_W	1.037	1.00
19_W	216_W	1.036	1.00
86_P	90_L	1.035	1.00
131_S	258_G	1.035	1.00
26_T	82_I	1.031	1.00
82_I	91_V	1.029	1.00
203_L	207_L	1.028	1.00
94_M	147_G	1.027	1.00
102_V	225_T	1.023	1.00
18_F	215_F	1.015	1.00
107_R	112_K	1.014	1.00
8_F	219_G	1.009	1.00
8_F	222_E	1.004	1.00
67_G	70_N	1.004	1.00
199_S	202_L	0.999	1.00
68_L	180_I	0.999	1.00
39_S	79_N	0.997	1.00
220_V	228_A	0.993	1.00
102_V	154_T	0.993	1.00
207_L	211_L	0.988	1.00
109_L	155_I	0.984	1.00
24_P	246_V	0.984	1.00
105_I	108_L	0.982	1.00
237_V	259_S	0.972	1.00
43_I	177_S	0.971	1.00
29_I	200_L	0.969	1.00
183_A	187_I	0.969	1.00
88_P	247_L	0.968	1.00
36_M	76_I	0.967	1.00
138_I	141_V	0.965	1.00
253_L	256_I	0.964	1.00
49_F	206_I	0.959	1.00
97_T	128_V	0.956	1.00
158_S	162_A	0.952	1.00
224_G	228_A	0.950	1.00
93_V	129_I	0.941	1.00
147_G	151_A	0.941	1.00
102_V	151_A	0.939	1.00
198_L	202_L	0.938	1.00
94_M	140_L	0.935	1.00
13_V	238_M	0.934	1.00
94_M	143_G	0.934	1.00
105_I	148_I	0.928	1.00
158_S	225_T	0.927	1.00
223_L	228_A	0.923	1.00
14_P	215_F	0.921	1.00
39_S	181_V	0.919	1.00
184_F	187_I	0.918	1.00
35_P	39_S	0.916	1.00
127_G	262_T	0.913	1.00
16_S	20_G	0.910	1.00
51_L	175_L	0.910	1.00
70_N	153_G	0.901	1.00
201_L	205_A	0.900	1.00
123_L	265_G	0.899	1.00
114_T	118_I	0.899	1.00
34_S	188_D	0.895	1.00
240_Y	251_P	0.888	1.00
16_S	238_M	0.884	1.00
220_V	224_G	0.879	1.00
88_P	249_V	0.879	1.00
139_G	143_G	0.878	1.00
16_S	234_L	0.877	1.00
76_I	80_L	0.862	1.00
223_L	227_Y	0.860	1.00
71_F	153_G	0.857	1.00
103_L	113_I	0.853	1.00
128_V	132_A	0.850	1.00
202_L	206_I	0.850	1.00
37_I	185_T	0.849	1.00
133_T	136_F	0.847	1.00
244_F	251_P	0.847	1.00
202_L	205_A	0.846	1.00
72_A	76_I	0.841	1.00
84_L	136_F	0.831	1.00
112_K	116_K	0.829	1.00
102_V	155_I	0.828	1.00
24_P	243_S	0.821	1.00
24_P	88_P	0.820	1.00
137_N	141_V	0.818	1.00
112_K	115_P	0.813	1.00
211_L	215_F	0.810	1.00
50_F	210_I	0.807	1.00
240_Y	259_S	0.806	1.00
103_L	117_G	0.802	1.00
172_F	176_T	0.800	1.00
243_S	247_L	0.800	1.00
254_P	257_I	0.797	1.00
41_F	45_I	0.796	1.00
194_S	198_L	0.796	1.00
63_Q	163_K	0.794	1.00
244_F	250_A	0.793	1.00
126_V	130_S	0.793	1.00
130_S	257_I	0.792	1.00
55_R	59_V	0.790	1.00
100_I	124_G	0.789	1.00
64_F	176_T	0.789	1.00
9_L	227_Y	0.786	1.00
49_F	205_A	0.784	1.00
68_L	72_A	0.782	1.00
49_F	52_I	0.773	1.00
143_G	147_G	0.773	1.00
259_S	263_L	0.770	1.00
44_G	48_I	0.769	1.00
219_G	228_A	0.758	1.00
126_V	261_I	0.758	1.00
176_T	180_I	0.756	1.00
104_I	108_L	0.756	1.00
164_E	169_L	0.756	1.00
23_F	78_I	0.756	1.00
70_N	149_L	0.750	1.00
55_R	60_G	0.741	1.00
12_I	231_G	0.739	1.00
178_L	182_L	0.737	1.00
70_N	156_Y	0.732	1.00
257_I	261_I	0.731	1.00
23_F	92_A	0.730	1.00
68_L	71_F	0.728	1.00
81_G	91_V	0.719	1.00
33_A	37_I	0.716	1.00
54_G	171_A	0.713	1.00
150_W	154_T	0.713	1.00
175_L	179_P	0.711	1.00
111_H	226_V	0.707	1.00
107_R	110_G	0.703	1.00
170_N	173_M	0.703	1.00
234_L	237_V	0.703	1.00
136_F	140_L	0.695	1.00
37_I	41_F	0.692	1.00
166_I	170_N	0.689	1.00
176_T	179_P	0.688	1.00
200_L	203_L	0.686	1.00
8_F	223_L	0.686	1.00
74_F	149_L	0.685	1.00
18_F	208_A	0.683	1.00
171_A	175_L	0.683	1.00
153_G	217_F	0.682	1.00
240_Y	244_F	0.680	1.00
168_K	172_F	0.678	1.00
33_A	38_I	0.677	1.00
119_V	123_L	0.676	1.00
26_T	30_A	0.671	1.00
60_G	63_Q	0.670	1.00
170_N	217_F	0.670	1.00
214_Y	218_N	0.669	1.00
266_V	269_T	0.669	1.00
12_I	223_L	0.669	1.00
101_F	144_L	0.668	1.00
251_P	255_Q	0.668	1.00
47_A	51_L	0.666	1.00
96_Y	128_V	0.666	1.00
45_I	201_L	0.665	1.00
152_G	156_Y	0.665	1.00
85_S	91_V	0.664	1.00
53_L	167_V	0.655	1.00
197_T	200_L	0.651	1.00
41_F	201_L	0.651	1.00
22_A	208_A	0.649	1.00
81_G	139_G	0.649	1.00
74_F	153_G	0.648	1.00
103_L	107_R	0.647	1.00
264_F	268_L	0.643	1.00
150_W	216_W	0.641	1.00
68_L	176_T	0.631	1.00
45_I	49_F	0.630	1.00
71_F	173_M	0.627	1.00
113_I	117_G	0.627	1.00
94_M	144_L	0.626	1.00
97_T	100_I	0.625	1.00
252_T	256_I	0.625	1.00
142_F	145_L	0.619	1.00
66_N	70_N	0.618	1.00
241_I	244_F	0.618	1.00
20_G	235_V	0.615	1.00
241_I	245_A	0.612	1.00
28_I	247_L	0.606	1.00
28_I	31_Y	0.606	1.00
172_F	175_L	0.606	1.00
250_A	255_Q	0.605	1.00
104_I	121_V	0.604	1.00
73_F	77_L	0.604	1.00
154_T	216_W	0.603	1.00
117_G	224_G	0.601	1.00
99_P	233_L	0.597	1.00
30_A	82_I	0.597	1.00
71_F	213_F	0.594	1.00
125_V	233_L	0.593	1.00
242_T	245_A	0.591	1.00
132_A	140_L	0.589	1.00
46_A	210_I	0.586	1.00
68_L	73_F	0.581	1.00
93_V	132_A	0.581	1.00
18_F	212_G	0.580	1.00
46_A	205_A	0.573	1.00
170_N	174_T	0.571	1.00
194_S	199_S	0.570	1.00
66_N	156_Y	0.569	1.00
109_L	158_S	0.564	1.00
78_I	146_A	0.564	1.00
154_T	229_S	0.563	1.00
78_I	91_V	0.562	1.00
123_L	268_L	0.561	1.00
148_I	152_G	0.561	1.00
96_Y	99_P	0.560	1.00
46_A	209_Q	0.558	1.00
30_A	83_G	0.555	1.00
250_A	254_P	0.555	1.00
106_E	226_V	0.555	1.00
133_T	137_N	0.554	1.00
72_A	184_F	0.553	1.00
175_L	178_L	0.553	1.00
84_L	137_N	0.552	1.00
177_S	181_V	0.551	1.00
97_T	147_G	0.550	1.00
153_G	173_M	0.546	1.00
219_G	223_L	0.546	1.00
24_P	239_A	0.545	1.00
22_A	204_L	0.545	1.00
102_V	106_E	0.544	1.00
14_P	18_F	0.543	1.00
21_F	208_A	0.542	1.00
12_I	216_W	0.537	1.00
100_I	121_V	0.536	1.00
22_A	79_N	0.535	1.00
203_L	206_I	0.534	1.00
255_Q	259_S	0.532	1.00
79_N	83_G	0.532	1.00
96_Y	147_G	0.530	1.00
12_I	228_A	0.529	1.00
81_G	85_S	0.528	1.00
43_I	181_V	0.526	1.00
265_G	269_T	0.526	1.00
20_G	239_A	0.525	1.00
119_V	126_V	0.524	1.00
74_F	78_I	0.522	1.00
237_V	263_L	0.521	1.00
127_G	265_G	0.519	1.00
134_L	138_I	0.518	1.00
130_S	255_Q	0.518	1.00
48_I	51_L	0.517	1.00
179_P	182_L	0.514	1.00
182_L	186_P	0.514	1.00
230_T	269_T	0.514	1.00
116_K	119_V	0.508	1.00
54_G	168_K	0.507	1.00
164_E	168_K	0.506	1.00
71_F	75_L	0.505	1.00
11_W	222_E	0.504	1.00
71_F	177_S	0.504	1.00
153_G	157_Y	0.503	1.00
8_F	11_W	0.503	1.00
244_F	248_G	0.503	1.00
28_I	32_S	0.502	1.00
103_L	226_V	0.502	1.00
233_L	266_V	0.502	1.00
245_A	248_G	0.501	1.00
42_R	75_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.281	98.7	0.767	Contact Map
3b5dA	2	0.3686	98.1	0.801	Contact Map
4pgrA	1	0.6898	12.5	0.941	Contact Map
4qndA	2	0.3467	4.1	0.953	Contact Map
2gfpA	2	0.7774	3.8	0.954	Contact Map
4pypA	1	0.5693	3.7	0.954	Contact Map
1pw4A	1	0.8321	3.5	0.955	Contact Map
2nq2A	2	0.1971	3.2	0.955	Contact Map
4j05A	3	0.9526	2.7	0.957	Contact Map
2cfqA	1	0.5985	2.4	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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