GREMLIN Database
Q97X61 - Uncharacterized protein
UniProt: Q97X61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (249)
Sequences: 3153 (2513)
Seq/√Len: 159.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
286_F291_Y5.7631.00
133_T154_Q4.1161.00
55_K180_T3.6211.00
136_W151_L3.5881.00
215_L259_G3.5391.00
54_T286_F3.4561.00
134_V152_T3.3581.00
52_P284_L3.1211.00
133_T153_L3.1141.00
134_V137_T2.9871.00
50_L293_G2.9761.00
140_S149_Q2.8141.00
45_T48_Y2.7521.00
234_K237_S2.6141.00
58_L297_I2.5521.00
94_K98_V2.5141.00
135_V156_L2.4971.00
291_Y295_A2.4311.00
44_N49_K2.3841.00
217_D221_K2.3531.00
79_L168_P2.2861.00
131_Q154_Q2.2751.00
50_L54_T2.2461.00
55_K179_T2.2441.00
137_T150_Q2.2221.00
219_S223_Q2.2201.00
54_T294_V2.1561.00
85_Y175_L2.1501.00
193_K196_I2.0991.00
189_F194_I2.0951.00
302_V306_L2.0821.00
220_V224_Y2.0521.00
134_V150_Q2.0191.00
288_R292_Y1.9841.00
156_L160_L1.7471.00
274_A277_S1.7441.00
219_S252_T1.7401.00
60_I64_T1.6921.00
59_T176_L1.6701.00
208_M263_L1.6471.00
135_V153_L1.6271.00
115_P159_G1.6061.00
157_I160_L1.5931.00
292_Y296_I1.5821.00
233_P238_S1.5691.00
115_P151_L1.5651.00
113_V117_T1.5451.00
111_W163_S1.5131.00
212_I256_L1.5111.00
194_I198_I1.5081.00
176_L185_I1.5001.00
131_Q134_V1.4471.00
140_S150_Q1.4431.00
49_K289_V1.4121.00
286_F294_V1.4051.00
187_R190_T1.4021.00
200_F204_V1.3931.00
139_P149_Q1.3521.00
189_F193_K1.3441.00
46_F88_L1.3401.00
221_K224_Y1.3351.00
75_A168_P1.3301.00
47_M89_N1.3081.00
233_P237_S1.2991.00
206_I210_P1.2941.00
158_Y162_T1.2911.00
223_Q251_P1.2801.00
116_Y151_L1.2741.00
47_M85_Y1.2461.00
98_V101_L1.2431.00
72_W76_I1.2351.00
137_T140_S1.2131.00
200_F272_F1.2111.00
61_V301_I1.2081.00
265_I268_D1.2011.00
153_L157_I1.1881.00
72_W157_I1.1861.00
236_I243_Y1.1861.00
287_T290_D1.1721.00
62_V172_S1.1711.00
82_L172_S1.1671.00
114_A162_T1.1671.00
157_I161_Q1.1541.00
73_I76_I1.1521.00
43_G46_F1.1361.00
131_Q153_L1.1351.00
199_T210_P1.1301.00
212_I216_L1.1281.00
72_W161_Q1.1001.00
66_A78_T1.0991.00
231_G238_S1.0991.00
87_T90_E1.0991.00
38_T41_E1.0920.99
296_I299_A1.0840.99
136_W139_P1.0830.99
216_L220_V1.0810.99
135_V151_L1.0790.99
297_I301_I1.0790.99
197_A212_I1.0750.99
234_K238_S1.0740.99
131_Q152_T1.0690.99
201_S205_G1.0670.99
71_W74_G1.0600.99
205_G258_R1.0570.99
65_V301_I1.0560.99
233_P244_A1.0550.99
50_L289_V1.0550.99
53_V284_L1.0510.99
139_P150_Q1.0490.99
210_P251_P1.0360.99
46_F289_V1.0290.99
97_Y101_L1.0180.99
73_I77_L1.0160.99
59_T172_S1.0110.99
187_R191_K1.0050.99
138_F150_Q1.0050.99
135_V152_T1.0040.99
210_P264_A1.0010.99
220_V248_A0.9990.99
252_T267_A0.9990.99
288_R291_Y0.9880.99
223_Q244_A0.9850.99
93_R97_Y0.9840.99
106_I166_I0.9840.99
164_F168_P0.9820.99
43_G90_E0.9810.99
105_T109_G0.9760.99
83_L87_T0.9610.99
58_L293_G0.9590.99
155_A159_G0.9570.99
267_A272_F0.9500.99
237_S243_Y0.9320.98
287_T291_Y0.9260.98
291_Y294_V0.9230.98
43_G48_Y0.9200.98
54_T293_G0.9160.98
197_A272_F0.9120.98
183_S188_M0.9110.98
66_A172_S0.9090.98
65_V69_T0.9090.98
295_A302_V0.9060.98
53_V188_M0.9040.98
96_G171_L0.8990.98
162_T209_I0.8970.98
160_L163_S0.8970.98
218_T262_N0.8970.98
84_S88_L0.8960.98
78_T300_L0.8920.98
186_F190_T0.8920.98
227_G251_P0.8880.98
135_V154_Q0.8870.98
289_V292_Y0.8830.98
154_Q158_Y0.8830.98
87_T303_M0.8820.98
92_V95_F0.8800.98
286_F290_D0.8790.98
303_M306_L0.8720.97
207_R252_T0.8690.97
65_V300_L0.8590.97
186_F189_F0.8570.97
192_I195_P0.8550.97
66_A168_P0.8550.97
64_T67_A0.8480.97
54_T291_Y0.8450.97
61_V305_I0.8440.97
197_A274_A0.8410.97
77_L80_I0.8410.97
285_K288_R0.8400.97
39_R214_E0.8350.97
159_G189_F0.8350.97
207_R263_L0.8330.97
51_N284_L0.8250.97
90_E288_R0.8200.96
295_A298_I0.8140.96
296_I300_L0.8070.96
79_L83_L0.8020.96
212_I263_L0.8010.96
259_G262_N0.8000.96
302_V305_I0.7990.96
50_L290_D0.7910.96
58_L85_Y0.7870.95
182_G210_P0.7840.95
215_L218_T0.7830.95
213_F296_I0.7810.95
255_Y268_D0.7780.95
182_G212_I0.7770.95
173_A199_T0.7760.95
189_F196_I0.7730.95
65_V74_G0.7710.95
108_G111_W0.7700.95
59_T163_S0.7700.95
76_I80_I0.7680.95
62_V297_I0.7670.95
99_S178_T0.7670.95
79_L164_F0.7660.95
165_R216_L0.7640.95
87_T306_L0.7600.94
94_K97_Y0.7580.94
80_I83_L0.7570.94
211_R263_L0.7570.94
77_L300_L0.7550.94
219_S235_L0.7550.94
70_V75_A0.7510.94
190_T193_K0.7490.94
62_V66_A0.7420.94
293_G297_I0.7420.94
45_T49_K0.7400.94
177_I272_F0.7370.94
47_M88_L0.7340.93
46_F288_R0.7330.93
133_T137_T0.7300.93
225_M269_T0.7280.93
105_T194_I0.7280.93
115_P155_A0.7240.93
303_M307_A0.7230.93
136_W140_S0.7220.93
190_T196_I0.7190.93
138_F149_Q0.7160.93
130_K134_V0.7160.93
185_I252_T0.7160.93
223_Q247_E0.7160.93
114_A159_G0.7130.92
96_G175_L0.7110.92
138_F160_L0.7040.92
69_T74_G0.7040.92
295_A306_L0.7030.92
229_G257_F0.7020.92
132_F154_Q0.6980.92
135_V138_F0.6970.92
100_F103_L0.6910.91
154_Q157_I0.6830.91
168_P172_S0.6830.91
188_M272_F0.6820.91
288_R302_V0.6810.91
197_A200_F0.6780.90
246_F249_I0.6780.90
105_T108_G0.6750.90
91_G178_T0.6750.90
114_A209_I0.6740.90
172_S175_L0.6720.90
110_T117_T0.6690.90
300_L304_A0.6670.90
298_I301_I0.6650.90
57_I189_F0.6650.90
166_I200_F0.6600.89
111_W159_G0.6600.89
85_Y138_F0.6600.89
46_F78_T0.6570.89
74_G113_V0.6570.89
39_R265_I0.6530.89
114_A155_A0.6510.89
298_I302_V0.6500.88
237_S244_A0.6480.88
111_W155_A0.6450.88
198_I248_A0.6440.88
102_T105_T0.6430.88
201_S259_G0.6430.88
257_F264_A0.6380.88
188_M192_I0.6370.87
46_F83_L0.6360.87
87_T302_V0.6350.87
78_T299_A0.6350.87
132_F153_L0.6330.87
177_I182_G0.6300.87
199_T264_A0.6300.87
103_L167_A0.6280.87
62_V82_L0.6280.87
253_M257_F0.6220.86
76_I236_I0.6190.86
47_M170_L0.6180.86
43_G95_F0.6170.86
84_S288_R0.6160.86
208_M264_A0.6160.86
44_N90_E0.6140.85
45_T89_N0.6140.85
184_D280_S0.6120.85
112_S116_Y0.6110.85
89_N179_T0.6100.85
93_R303_M0.6080.85
60_I135_V0.6040.85
65_V297_I0.6040.85
216_L252_T0.6020.84
153_L158_Y0.6010.84
190_T204_V0.6010.84
205_G267_A0.5990.84
41_E92_V0.5960.84
278_R290_D0.5950.84
69_T304_A0.5950.84
82_L171_L0.5930.83
173_A209_I0.5910.83
78_T168_P0.5890.83
65_V135_V0.5870.83
259_G267_A0.5870.83
165_R222_M0.5870.83
255_Y261_K0.5860.83
218_T259_G0.5840.83
199_T256_L0.5830.82
271_G274_A0.5810.82
77_L256_L0.5780.82
107_L111_W0.5780.82
193_K199_T0.5770.82
57_I76_I0.5760.82
292_Y302_V0.5750.82
62_V85_Y0.5730.81
57_I294_V0.5730.81
111_W173_A0.5720.81
112_S151_L0.5680.81
61_V65_V0.5670.81
94_K101_L0.5630.80
210_P215_L0.5620.80
271_G281_L0.5610.80
196_I269_T0.5590.80
217_D296_I0.5590.80
58_L62_V0.5580.80
103_L107_L0.5570.80
112_S299_A0.5570.80
149_Q155_A0.5570.80
103_L205_G0.5500.79
204_V263_L0.5480.78
190_T253_M0.5450.78
84_S87_T0.5450.78
175_L179_T0.5440.78
231_G236_I0.5430.78
85_Y307_A0.5420.78
289_V306_L0.5410.78
227_G272_F0.5410.78
72_W136_W0.5400.77
203_L282_V0.5390.77
292_Y306_L0.5390.77
162_T242_V0.5380.77
189_F202_V0.5370.77
47_M50_L0.5350.77
298_I306_L0.5350.77
289_V303_M0.5340.77
236_I295_A0.5280.76
174_L178_T0.5270.76
199_T202_V0.5260.76
73_I307_A0.5230.75
191_K283_E0.5230.75
84_S300_L0.5220.75
83_L86_L0.5220.75
214_E217_D0.5200.75
155_A265_I0.5190.75
67_A206_I0.5180.74
193_K261_K0.5180.74
184_D187_R0.5170.74
266_S279_T0.5170.74
136_W153_L0.5170.74
48_Y165_R0.5170.74
192_I276_P0.5170.74
292_Y295_A0.5160.74
65_V306_L0.5130.74
208_M211_R0.5130.74
268_D279_T0.5120.74
226_R266_S0.5120.74
289_V299_A0.5120.74
292_Y303_M0.5110.73
175_L180_T0.5110.73
287_T303_M0.5100.73
163_S169_V0.5080.73
203_L219_S0.5080.73
258_R263_L0.5070.73
74_G308_N0.5070.73
187_R194_I0.5060.73
254_V257_F0.5060.73
196_I200_F0.5050.73
215_L255_Y0.5050.73
63_M114_A0.5040.72
86_L96_G0.5040.72
77_L303_M0.5040.72
79_L172_S0.5020.72
37_I100_F0.5010.72
197_A253_M0.5010.72
212_I228_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4huqT 1 0.7383 100 0.371 Contact Map
2l0eA 1 0.0966 11.3 0.964 Contact Map
1rh5C 1 0.0997 8.7 0.966 Contact Map
3hd7A 1 0.2555 4.2 0.97 Contact Map
1r2dA 1 0.1807 2.5 0.974 Contact Map
1n7lA 1 0.1651 2 0.975 Contact Map
2ww9C 1 0.0654 1.9 0.975 Contact Map
2kixA 3 0.1028 1.8 0.976 Contact Map
2a5yA 1 0.2181 1.8 0.976 Contact Map
4p4hI 3 0.296 1.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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