GREMLIN Database
Y1893 - Putative ABC transporter ATP-binding protein SSO1893
UniProt: Q97X60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 530 (467)
Sequences: 1111 (769)
Seq/√Len: 35.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
401_L410_R5.8251.00
11_V46_T5.1241.00
286_S299_N5.0511.00
6_I9_L4.9301.00
128_M137_R4.7891.00
34_V214_I3.8141.00
7_R66_E3.7131.00
8_D23_I3.6561.00
32_E212_R3.6181.00
285_A342_K3.3741.00
379_E411_T3.3231.00
286_S301_K3.2881.00
79_T82_I3.2111.00
242_L246_D3.1941.00
9_L50_V3.1211.00
361_Y436_K2.9931.00
48_V199_V2.8691.00
308_T485_Y2.7861.00
461_E465_K2.7861.00
146_G367_Q2.7791.00
324_L472_V2.7761.00
85_Y163_K2.6821.00
403_I461_E2.6631.00
51_I197_V2.6391.00
5_E27_D2.5661.00
283_L303_S2.5121.00
207_L231_I2.5021.00
245_P250_F2.5001.00
243_E246_D2.4941.00
247_Y250_F2.4171.00
106_V137_R2.4021.00
242_L250_F2.3981.00
129_K134_S2.3811.00
241_G246_D2.3731.00
432_A437_V2.3681.00
246_D250_F2.3390.99
242_L245_P2.2670.99
357_E360_K2.2410.99
22_V220_K2.1770.99
217_E254_S2.1670.99
298_I493_K2.1470.99
316_N320_K2.1450.99
103_I107_A2.1180.99
62_E67_V2.0570.99
320_K474_H2.0370.99
320_K441_D2.0240.98
252_K255_G2.0010.98
26_L214_I1.9690.98
370_D373_F1.9480.98
284_F287_V1.9450.98
270_Y273_P1.9440.98
212_R224_D1.9340.98
311_A483_T1.9170.98
402_R407_D1.9160.98
269_N272_P1.9100.98
241_G245_P1.9070.98
289_V326_A1.8810.97
316_N474_H1.8810.97
245_P248_M1.8590.97
241_G244_I1.8540.97
5_E68_R1.8530.97
9_L67_V1.8460.97
247_Y251_L1.8340.97
175_D320_K1.8230.97
320_K442_E1.8130.97
226_K229_E1.8110.97
391_V397_L1.8030.97
175_D474_H1.7970.97
126_E192_E1.7940.97
398_G410_R1.7940.97
441_D474_H1.7890.97
304_L310_T1.7670.96
243_E250_F1.7570.96
241_G248_M1.7450.96
419_M423_R1.7390.96
250_F254_S1.7270.96
379_E410_R1.7220.96
126_E188_T1.7210.96
374_I381_E1.7100.96
280_G305_K1.7100.96
187_K208_P1.6750.95
250_F253_K1.6630.95
147_G320_K1.6620.95
252_K256_F1.6540.95
21_I47_L1.6470.95
283_L344_I1.6100.94
316_N441_D1.5830.93
384_F388_N1.5770.93
147_G316_N1.5680.93
19_P22_V1.5660.93
297_L322_T1.5620.93
246_D251_L1.5570.93
473_T478_F1.5470.92
454_I458_E1.5320.92
45_S49_S1.5320.92
290_K295_K1.5290.92
239_S242_L1.5230.92
201_H475_D1.5220.92
175_D316_N1.5210.92
145_S474_H1.5120.92
186_V196_L1.5010.91
96_Q112_N1.4960.91
305_K308_T1.4960.91
106_V128_M1.4910.91
103_I106_V1.4890.91
121_I125_E1.4780.91
214_I221_I1.4710.90
244_I253_K1.4700.90
267_T272_P1.4680.90
280_G283_L1.4560.90
442_E474_H1.4530.90
66_E75_K1.4510.90
241_G250_F1.4410.89
49_S55_I1.4330.89
147_G474_H1.3880.88
249_L253_K1.3830.87
473_T479_V1.3700.87
8_D25_K1.3620.87
321_T441_D1.3560.86
285_A301_K1.3550.86
107_A124_V1.3520.86
267_T270_Y1.3520.86
373_F381_E1.3510.86
316_N442_E1.3450.86
175_D441_D1.3440.86
106_V159_A1.3430.86
249_L252_K1.3350.85
117_R121_I1.3350.85
300_T489_M1.3350.85
145_S320_K1.3250.85
38_G43_G1.3240.85
38_G44_K1.3240.85
101_T104_D1.3190.85
108_F112_N1.3180.85
269_N274_S1.3040.84
248_M253_K1.2980.84
397_L432_A1.2830.83
304_L470_L1.2690.82
397_L400_I1.2500.81
78_P81_E1.2460.81
307_G466_G1.2420.81
401_L437_V1.2410.81
145_S316_N1.2370.81
225_I229_E1.2300.80
122_N126_E1.2290.80
147_G175_D1.2270.80
28_I34_V1.2200.80
48_V166_I1.2190.80
242_L248_M1.2170.80
285_A344_I1.2100.79
66_E73_D1.1970.79
77_T81_E1.1970.79
279_K306_Q1.1940.78
242_L247_Y1.1930.78
179_T202_K1.1920.78
239_S245_P1.1910.78
425_V429_S1.1910.78
248_M254_S1.1880.78
240_L244_I1.1860.78
103_I121_I1.1840.78
245_P251_L1.1770.77
49_S54_V1.1760.77
64_K402_R1.1700.77
253_K258_R1.1690.77
81_E398_G1.1690.77
284_F327_I1.1680.77
89_L93_P1.1650.77
223_V230_I1.1570.76
316_N440_M1.1520.76
351_S354_K1.1520.76
97_A105_E1.1440.75
247_Y254_S1.1430.75
105_E381_E1.1390.75
400_I431_I1.1380.75
201_H418_S1.1320.74
151_R178_G1.1210.74
271_K274_S1.1130.73
269_N273_P1.1130.73
322_T474_H1.1120.73
6_I51_I1.1120.73
268_Y271_K1.1110.73
316_N322_T1.1110.73
244_I252_K1.1080.73
35_L210_I1.1080.73
239_S244_I1.1010.72
363_A435_A1.1000.72
250_F257_R1.0990.72
145_S175_D1.0970.72
103_I137_R1.0870.71
6_I26_L1.0750.71
45_S55_I1.0690.70
243_E249_L1.0690.70
12_T22_V1.0680.70
147_G317_G1.0670.70
376_R381_E1.0560.69
87_G92_D1.0550.69
297_L489_M1.0530.69
105_E112_N1.0440.68
166_I199_V1.0430.68
246_D256_F1.0290.67
200_E206_V1.0270.67
248_M251_L1.0260.67
284_F302_I1.0260.67
342_K349_D1.0230.67
207_L496_L1.0210.67
445_S452_R1.0200.66
246_D254_S1.0150.66
93_P97_A1.0130.66
244_I247_Y1.0110.66
102_V105_E1.0100.66
253_K257_R1.0090.66
268_Y273_P1.0080.66
150_Q423_R1.0040.65
90_L94_D1.0030.65
221_I303_S0.9960.65
23_I220_K0.9910.64
241_G247_Y0.9880.64
375_K381_E0.9870.64
33_S195_S0.9860.64
243_E251_L0.9850.64
195_S212_R0.9830.64
150_Q172_S0.9810.63
377_T380_D0.9790.63
247_Y253_K0.9760.63
349_D352_K0.9760.63
83_S87_G0.9740.63
145_S441_D0.9730.63
287_V326_A0.9700.63
377_T381_E0.9660.62
24_D437_V0.9640.62
245_P253_K0.9620.62
197_V460_L0.9620.62
235_D239_S0.9590.62
299_N340_E0.9570.61
239_S243_E0.9510.61
324_L439_L0.9510.61
243_E247_Y0.9490.61
173_N445_S0.9480.61
46_T49_S0.9460.61
268_Y272_P0.9420.60
146_G175_D0.9420.60
453_Q481_R0.9410.60
72_L77_T0.9380.60
385_S388_N0.9370.60
377_T382_V0.9370.60
409_Y412_E0.9350.60
246_D253_K0.9310.59
100_Y105_E0.9270.59
51_I333_K0.9260.59
33_S431_I0.9250.59
51_I69_V0.9250.59
378_V382_V0.9230.59
105_E108_F0.9230.59
459_L494_I0.9220.59
158_L165_L0.9160.58
220_K405_S0.9060.57
317_G320_K0.9050.57
459_L469_I0.9050.57
154_L167_L0.9030.57
188_T192_E0.9030.57
454_I457_K0.9030.57
6_I50_V0.9010.57
184_E191_S0.9000.57
119_E123_R0.8980.57
90_L96_Q0.8970.56
244_I248_M0.8950.56
8_D220_K0.8920.56
286_S457_K0.8910.56
91_Q97_A0.8900.56
267_T273_P0.8860.55
90_L98_F0.8860.55
462_L467_Y0.8850.55
198_L424_R0.8840.55
40_S447_Q0.8840.55
244_I250_F0.8830.55
8_D118_E0.8820.55
251_L254_S0.8810.55
303_S399_E0.8800.55
250_F255_G0.8800.55
309_I459_L0.8740.54
178_G488_V0.8740.54
248_M252_K0.8700.54
253_K256_F0.8700.54
383_K387_K0.8690.54
10_Q23_I0.8620.53
133_I151_R0.8620.53
187_K191_S0.8600.53
456_G478_F0.8590.53
98_F105_E0.8590.53
286_S412_E0.8580.53
286_S340_E0.8520.53
45_S48_V0.8510.52
114_M119_E0.8490.52
146_G320_K0.8480.52
406_L424_R0.8480.52
321_T474_H0.8450.52
247_Y252_K0.8420.52
254_S258_R0.8410.52
146_G474_H0.8410.52
8_D19_P0.8390.51
186_V211_D0.8370.51
151_R452_R0.8330.51
29_E32_E0.8310.51
129_K220_K0.8300.51
67_V74_I0.8280.50
205_R478_F0.8220.50
174_I418_S0.8220.50
175_D442_E0.8210.50
11_V49_S0.8200.50
384_F389_R0.8190.50
145_S442_E0.8190.50
240_L252_K0.8170.50
165_L194_I0.8170.50
107_A128_M0.8160.49
348_K357_E0.8140.49
202_K477_R0.8110.49
247_Y258_R0.8110.49
103_I110_V0.8080.49
31_G193_G0.8070.49
40_S370_D0.8060.49
72_L79_T0.8050.49
196_L428_A0.8050.49
206_V452_R0.8030.48
119_E122_N0.8010.48
352_K400_I0.8000.48
79_T83_S0.7990.48
46_T50_V0.7980.48
7_R25_K0.7980.48
38_G41_G0.7980.48
8_D12_T0.7970.48
89_L94_D0.7970.48
179_T452_R0.7970.48
108_F160_M0.7900.47
12_T19_P0.7890.47
252_K258_R0.7860.47
105_E156_S0.7810.46
204_E207_L0.7800.46
375_K380_D0.7790.46
146_G316_N0.7790.46
398_G402_R0.7750.46
173_N452_R0.7720.46
311_A479_V0.7710.46
35_L365_L0.7710.46
192_E390_G0.7700.45
232_D402_R0.7700.45
376_R380_D0.7690.45
246_D257_R0.7680.45
320_K367_Q0.7680.45
163_K194_I0.7660.45
354_K357_E0.7640.45
132_G135_H0.7630.45
90_L112_N0.7610.45
54_V497_E0.7610.45
201_H419_M0.7600.45
96_Q108_F0.7590.45
134_S270_Y0.7560.44
10_Q19_P0.7560.44
216_V302_I0.7550.44
172_S475_D0.7530.44
118_E122_N0.7530.44
254_S257_R0.7520.44
90_L105_E0.7520.44
40_S96_Q0.7500.44
245_P249_L0.7490.44
109_G159_A0.7490.44
431_I458_E0.7480.44
6_I164_A0.7470.44
87_G90_L0.7440.43
485_Y492_G0.7420.43
399_E403_I0.7420.43
308_T484_D0.7420.43
40_S112_N0.7410.43
51_I83_S0.7390.43
302_I355_L0.7380.43
35_L195_S0.7370.43
309_I423_R0.7370.43
325_K331_I0.7340.42
249_L254_S0.7320.42
367_Q474_H0.7280.42
295_K298_I0.7280.42
148_E206_V0.7280.42
253_K496_L0.7280.42
87_G157_V0.7270.42
317_G441_D0.7250.42
76_T82_I0.7250.42
298_I395_M0.7220.41
242_L251_L0.7190.41
168_D319_G0.7170.41
47_L197_V0.7140.41
90_L99_N0.7140.41
326_A333_K0.7140.41
362_L437_V0.7140.41
116_S119_E0.7120.41
384_F387_K0.7110.40
379_E382_V0.7090.40
125_E134_S0.7080.40
89_L92_D0.7070.40
5_E8_D0.7070.40
52_N166_I0.7070.40
27_D229_E0.7070.40
41_G44_K0.7050.40
427_M486_L0.7040.40
45_S169_E0.7030.40
46_T224_D0.7020.40
412_E416_V0.7000.40
11_V63_V0.7000.40
386_M389_R0.6990.39
33_S186_V0.6990.39
375_K382_V0.6990.39
36_I42_S0.6970.39
83_S93_P0.6970.39
387_K390_G0.6960.39
323_L327_I0.6950.39
366_P372_M0.6940.39
45_S375_K0.6930.39
316_N321_T0.6900.39
100_Y104_D0.6890.39
32_E195_S0.6880.39
110_V120_M0.6870.39
175_D321_T0.6860.38
306_Q468_T0.6860.38
322_T441_D0.6850.38
204_E422_R0.6830.38
42_S327_I0.6820.38
243_E248_M0.6820.38
201_H366_P0.6810.38
43_G420_G0.6810.38
44_K420_G0.6810.38
93_P98_F0.6800.38
166_I301_K0.6800.38
355_L358_R0.6800.38
186_V426_A0.6790.38
328_V439_L0.6770.38
235_D278_G0.6760.38
273_P278_G0.6750.38
148_E183_L0.6750.38
284_F437_V0.6750.38
5_E15_G0.6740.37
48_V444_T0.6740.37
83_S89_L0.6720.37
40_S381_E0.6720.37
86_V121_I0.6700.37
184_E283_L0.6680.37
232_D465_K0.6680.37
309_I439_L0.6680.37
197_V277_E0.6680.37
447_Q475_D0.6670.37
322_T442_E0.6670.37
316_N367_Q0.6630.37
126_E380_D0.6620.36
404_F428_A0.6580.36
232_D257_R0.6580.36
245_P254_S0.6570.36
73_D76_T0.6570.36
321_T442_E0.6560.36
356_V360_K0.6550.36
46_T497_E0.6550.36
93_P111_E0.6530.36
153_V156_S0.6500.36
426_A429_S0.6500.36
280_G303_S0.6490.35
243_E256_F0.6490.35
35_L213_I0.6470.35
13_Y46_T0.6470.35
291_T439_L0.6460.35
6_I204_E0.6460.35
127_S311_A0.6460.35
396_R400_I0.6450.35
324_L489_M0.6440.35
193_G305_K0.6430.35
310_T470_L0.6430.35
287_V479_V0.6400.35
169_E201_H0.6390.35
191_S277_E0.6380.35
202_K446_G0.6370.35
86_V89_L0.6360.34
421_Q471_V0.6360.34
186_V458_E0.6360.34
189_F467_Y0.6360.34
167_L446_G0.6350.34
106_V321_T0.6340.34
342_K400_I0.6330.34
27_D192_E0.6330.34
255_G258_R0.6330.34
150_Q171_T0.6320.34
311_A423_R0.6320.34
146_G442_E0.6320.34
242_L249_L0.6310.34
249_L255_G0.6290.34
24_D66_E0.6280.34
109_G112_N0.6280.34
93_P105_E0.6270.34
379_E397_L0.6260.34
12_T411_T0.6250.34
247_Y255_G0.6240.33
126_E130_I0.6200.33
354_K358_R0.6180.33
372_M381_E0.6180.33
40_S88_T0.6180.33
175_D322_T0.6170.33
146_G150_Q0.6160.33
367_Q444_T0.6150.33
402_R434_G0.6150.33
6_I132_G0.6140.33
391_V414_P0.6140.33
87_G93_P0.6110.33
244_I254_S0.6100.32
40_S414_P0.6080.32
62_E65_G0.6080.32
424_R445_S0.6070.32
83_S86_V0.6070.32
175_D367_Q0.6070.32
198_L379_E0.6070.32
267_T271_K0.6060.32
21_I50_V0.6060.32
174_I472_V0.6060.32
233_R360_K0.6050.32
169_E329_G0.6040.32
184_E188_T0.6030.32
30_E163_K0.6020.32
333_K341_E0.6020.32
348_K355_L0.6020.32
223_V233_R0.6010.32
15_G18_K0.6010.32
344_I349_D0.6000.32
205_R446_G0.6000.32
130_I188_T0.5970.31
191_S437_V0.5960.31
273_P277_E0.5960.31
228_D305_K0.5940.31
427_M489_M0.5930.31
452_R478_F0.5930.31
122_N186_V0.5930.31
366_P371_V0.5920.31
290_K486_L0.5920.31
18_K64_K0.5920.31
221_I397_L0.5920.31
45_S93_P0.5920.31
304_L318_S0.5910.31
431_I496_L0.5900.31
243_E253_K0.5900.31
475_D478_F0.5900.31
307_G427_M0.5880.31
147_G441_D0.5880.31
247_Y257_R0.5870.31
98_F127_S0.5860.31
394_E465_K0.5860.31
385_S389_R0.5850.31
98_F109_G0.5850.31
204_E365_L0.5850.31
88_T112_N0.5840.30
153_V426_A0.5840.30
66_E436_K0.5820.30
129_K399_E0.5820.30
300_T427_M0.5810.30
40_S452_R0.5810.30
22_V242_L0.5810.30
128_M344_I0.5800.30
35_L203_I0.5780.30
333_K436_K0.5780.30
48_V195_S0.5770.30
125_E129_K0.5760.30
34_V327_I0.5760.30
374_I382_V0.5760.30
50_V67_V0.5750.30
90_L93_P0.5750.30
36_I305_K0.5740.30
38_G420_G0.5740.30
351_S358_R0.5740.30
170_P443_P0.5730.30
152_T377_T0.5730.30
24_D233_R0.5720.30
417_L443_P0.5710.30
315_K320_K0.5700.29
93_P109_G0.5690.29
403_I458_E0.5680.29
182_I487_L0.5680.29
27_D348_K0.5680.29
145_S322_T0.5660.29
377_T454_I0.5660.29
94_D108_F0.5650.29
305_K348_K0.5640.29
36_I214_I0.5640.29
352_K437_V0.5630.29
270_Y276_N0.5630.29
200_E475_D0.5630.29
23_I412_E0.5620.29
301_K348_K0.5620.29
28_I125_E0.5620.29
397_L410_R0.5610.29
313_M479_V0.5580.29
51_I332_D0.5560.28
384_F426_A0.5560.28
6_I208_P0.5560.28
43_G418_S0.5560.28
44_K418_S0.5560.28
162_P438_I0.5560.28
8_D278_G0.5550.28
381_E414_P0.5550.28
107_A121_I0.5550.28
149_L445_S0.5550.28
41_G45_S0.5550.28
358_R471_V0.5550.28
374_I378_V0.5540.28
68_R218_S0.5530.28
23_I228_D0.5530.28
419_M424_R0.5530.28
358_R400_I0.5510.28
116_S268_Y0.5500.28
105_E202_K0.5500.28
149_L370_D0.5500.28
81_E191_S0.5490.28
171_T206_V0.5480.28
210_I459_L0.5460.28
487_L490_S0.5460.28
231_I412_E0.5450.28
11_V213_I0.5450.28
350_L356_V0.5450.28
288_K299_N0.5450.28
28_I405_S0.5440.28
314_G420_G0.5420.27
245_P257_R0.5410.27
89_L174_I0.5410.27
258_R457_K0.5390.27
373_F376_R0.5390.27
101_T105_E0.5380.27
470_L485_Y0.5380.27
13_Y108_F0.5380.27
281_E346_N0.5380.27
374_I379_E0.5380.27
90_L97_A0.5370.27
92_D98_F0.5370.27
88_T93_P0.5360.27
460_L463_R0.5330.27
413_D416_V0.5330.27
244_I258_R0.5330.27
239_S246_D0.5320.27
105_E200_E0.5320.27
177_Q315_K0.5310.27
150_Q446_G0.5300.27
401_L414_P0.5300.27
37_T213_I0.5300.27
174_I447_Q0.5290.27
224_D234_A0.5290.27
201_H447_Q0.5290.27
66_E216_V0.5290.27
32_E211_D0.5280.27
277_E436_K0.5280.27
470_L489_M0.5280.27
134_S137_R0.5270.26
422_R445_S0.5270.26
23_I257_R0.5270.26
26_L126_E0.5270.26
64_K67_V0.5260.26
379_E383_K0.5260.26
77_T228_D0.5250.26
25_K275_R0.5250.26
51_I66_E0.5220.26
24_D392_Y0.5220.26
70_F163_K0.5210.26
10_Q25_K0.5200.26
153_V214_I0.5200.26
6_I497_E0.5200.26
171_T205_R0.5190.26
98_F452_R0.5190.26
173_N206_V0.5190.26
48_V421_Q0.5190.26
104_D109_G0.5180.26
151_R321_T0.5170.26
33_S196_L0.5170.26
348_K352_K0.5170.26
168_D420_G0.5150.26
319_G420_G0.5150.26
318_S324_L0.5150.26
382_V397_L0.5150.26
139_R143_T0.5150.26
291_T326_A0.5150.26
375_K378_V0.5140.26
423_R445_S0.5130.26
171_T204_E0.5120.25
289_V332_D0.5120.25
103_I128_M0.5120.25
193_G274_S0.5110.25
10_Q274_S0.5110.25
67_V161_R0.5110.25
107_A111_E0.5080.25
40_S424_R0.5070.25
320_K421_Q0.5070.25
8_D276_N0.5070.25
374_I413_D0.5070.25
153_V424_R0.5060.25
402_R493_K0.5050.25
45_S87_G0.5040.25
231_I401_L0.5030.25
352_K438_I0.5020.25
105_E113_Y0.5010.25
399_E465_K0.5010.25
206_V366_P0.5010.25
31_G106_V0.5000.25
151_R370_D0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.9245 100 0.308 Contact Map
4f4cA 1 0.9057 100 0.323 Contact Map
4finA 2 0.8906 100 0.325 Contact Map
1yqtA 1 0.9057 100 0.359 Contact Map
2iw3A 2 0.8245 100 0.359 Contact Map
3ozxA 1 0.8887 100 0.36 Contact Map
3bk7A 1 0.917 100 0.36 Contact Map
3j16B 1 0.9075 100 0.375 Contact Map
3ux8A 2 0.8245 100 0.387 Contact Map
2vf7A 2 0.9151 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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