GREMLIN Database
Q97X58 - 2-haloalkanoic acid dehalogenase
UniProt: Q97X58 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (195)
Sequences: 27511 (21856)
Seq/√Len: 1565.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_I156_K2.9921.00
123_E128_V2.9351.00
142_I146_N2.9221.00
175_A182_A2.7371.00
165_G171_D2.6711.00
4_A159_Y2.6561.00
99_E130_Y2.5471.00
152_I155_S2.4241.00
95_I99_E2.3911.00
116_P139_E2.3781.00
107_K132_D2.3251.00
111_V149_I2.2521.00
109_I133_N2.2401.00
116_P119_K2.2341.00
142_I148_K2.1831.00
176_R196_E2.1191.00
199_R203_E2.1131.00
154_I180_L2.0351.00
133_N156_K2.0291.00
172_Y182_A2.0291.00
75_I79_M1.9411.00
7_L108_L1.9221.00
173_I177_R1.9181.00
100_T104_A1.9001.00
181_D196_E1.8841.00
5_I106_L1.8051.00
102_R132_D1.7971.00
6_F163_H1.7941.00
162_L183_V1.7651.00
163_H175_A1.7551.00
102_R130_Y1.7401.00
100_T205_I1.7051.00
108_L131_F1.6941.00
94_V201_L1.6861.00
36_E39_K1.6831.00
4_A157_G1.6181.00
6_F111_V1.5991.00
6_F153_A1.5861.00
186_D199_R1.5771.00
112_S118_T1.5321.00
154_I161_A1.5311.00
76_N80_S1.4961.00
5_I164_I1.4661.00
183_V198_V1.4571.00
5_I101_I1.4451.00
186_D197_K1.4411.00
91_Y187_R1.4261.00
109_I157_G1.3931.00
12_T164_I1.3761.00
74_L77_S1.3741.00
200_D203_E1.3561.00
119_K128_V1.3411.00
64_Y67_S1.3331.00
100_T103_S1.3311.00
72_E76_N1.3271.00
97_F205_I1.3271.00
9_F14_V1.2951.00
93_E96_E1.2841.00
97_F201_L1.2751.00
13_L94_V1.2721.00
9_F110_L1.2601.00
150_F163_H1.2451.00
135_V156_K1.2261.00
90_V127_L1.2241.00
26_I30_E1.1991.00
27_I31_H1.1941.00
147_P151_A1.1551.00
169_E173_I1.1491.00
135_V153_A1.1471.00
74_L78_I1.1451.00
150_F174_G1.1391.00
96_E202_R1.1281.00
9_F114_S1.1181.00
9_F118_T1.1161.00
48_M51_N1.1061.00
111_V153_A1.1041.00
150_F180_L1.0911.00
61_E64_Y1.0851.00
116_P136_L1.0811.00
151_A155_S1.0811.00
10_G16_F1.0781.00
4_A107_K1.0671.00
99_E103_S1.0581.00
22_E26_I1.0501.00
83_I86_G1.0471.00
148_K152_I1.0351.00
120_K124_E1.0341.00
25_Q29_K1.0271.00
176_R182_A1.0181.00
95_I130_Y1.0141.00
72_E79_M1.0121.00
150_F165_G1.0121.00
102_R108_L1.0111.00
76_N79_M1.0101.00
98_L131_F1.0081.00
93_E200_D1.0061.00
126_G129_K1.0061.00
119_K123_E1.0021.00
73_K77_S1.0021.00
63_L66_L0.9981.00
133_N157_G0.9961.00
46_K51_N0.9931.00
26_I29_K0.9911.00
47_A51_N0.9891.00
67_S70_P0.9861.00
30_E74_L0.9811.00
75_I78_I0.9761.00
25_Q37_I0.9641.00
43_A46_K0.9571.00
162_L181_D0.9561.00
110_L131_F0.9551.00
99_E129_K0.9521.00
153_A157_G0.9511.00
72_E75_I0.9501.00
22_E87_E0.9501.00
151_A178_S0.9471.00
116_P138_H0.9461.00
101_I106_L0.9411.00
163_H180_L0.9401.00
96_E99_E0.9391.00
46_K50_I0.9341.00
140_I152_I0.9241.00
164_I183_V0.9221.00
141_G148_K0.9201.00
118_T136_L0.9171.00
28_L33_Y0.9161.00
112_S136_L0.9151.00
10_G114_S0.9081.00
90_V95_I0.9071.00
170_I173_I0.9071.00
6_F157_G0.9031.00
184_L197_K0.8961.00
22_E25_Q0.8921.00
135_V152_I0.8811.00
60_K64_Y0.8791.00
45_V48_M0.8781.00
136_L139_E0.8771.00
74_L79_M0.8771.00
148_K151_A0.8751.00
120_K123_E0.8711.00
172_Y184_L0.8681.00
6_F180_L0.8611.00
10_G112_S0.8591.00
3_R106_L0.8551.00
45_V51_N0.8501.00
182_A196_E0.8481.00
9_F121_L0.8421.00
5_I162_L0.8401.00
149_I153_A0.8381.00
109_I153_A0.8321.00
73_K76_N0.8311.00
108_L130_Y0.8291.00
198_V204_I0.8291.00
4_A109_I0.8241.00
98_L130_Y0.8211.00
38_R42_R0.8161.00
20_F24_L0.8151.00
39_K42_R0.8151.00
91_Y185_L0.8061.00
174_G178_S0.8011.00
91_Y94_V0.8011.00
44_Y48_M0.7981.00
101_I108_L0.7941.00
37_I41_F0.7901.00
21_Y25_Q0.7851.00
113_N143_V0.7791.00
3_R107_K0.7731.00
23_K27_I0.7701.00
59_I62_F0.7701.00
150_F171_D0.7691.00
29_K34_D0.7691.00
122_L128_V0.7681.00
167_I170_I0.7641.00
10_G166_D0.7581.00
95_I129_K0.7571.00
93_E202_R0.7561.00
95_I126_G0.7551.00
3_R159_Y0.7551.00
77_S80_S0.7531.00
61_E65_N0.7521.00
14_V125_L0.7491.00
45_V49_A0.7481.00
161_A180_L0.7421.00
151_A161_A0.7301.00
183_V204_I0.7301.00
163_H171_D0.7291.00
135_V149_I0.7271.00
133_N153_A0.7221.00
20_F114_S0.7171.00
184_L195_K0.7081.00
149_I174_G0.7071.00
187_R201_L0.7031.00
10_G121_L0.7021.00
18_P89_F0.7021.00
173_I176_R0.7011.00
41_F44_Y0.7001.00
139_E156_K0.6991.00
154_I159_Y0.6961.00
201_L205_I0.6921.00
6_F109_I0.6891.00
185_L201_L0.6881.00
147_P177_R0.6871.00
71_D74_L0.6871.00
119_K134_L0.6831.00
202_R205_I0.6771.00
108_L132_D0.6761.00
11_N17_K0.6731.00
164_I204_I0.6711.00
96_E100_T0.6621.00
154_I160_P0.6621.00
14_V88_A0.6581.00
90_V125_L0.6551.00
26_I83_I0.6551.00
163_H174_G0.6541.00
19_A88_A0.6531.00
192_P199_R0.6491.00
48_M52_N0.6491.00
82_D86_G0.6481.00
43_A47_A0.6451.00
113_N170_I0.6431.00
15_G89_F0.6411.00
39_K43_A0.6411.00
12_T185_L0.6371.00
154_I178_S0.6341.00
44_Y51_N0.6331.00
14_V121_L0.6311.00
93_E97_F0.6251.00
85_D120_K0.6191.00
114_S165_G0.6191.00
198_V201_L0.6171.00
47_A50_I0.6171.00
111_V163_H0.6161.00
140_I149_I0.6151.00
94_V97_F0.6141.00
198_V205_I0.6131.00
131_F134_L0.6121.00
107_K159_Y0.6081.00
150_F175_A0.6081.00
30_E77_S0.6031.00
97_F164_I0.6021.00
47_A52_N0.5981.00
18_P22_E0.5961.00
15_G18_P0.5951.00
93_E187_R0.5941.00
92_D202_R0.5921.00
92_D200_D0.5881.00
111_V135_V0.5861.00
31_H74_L0.5841.00
12_T171_D0.5821.00
45_V52_N0.5821.00
21_Y40_V0.5811.00
170_I174_G0.5811.00
6_F150_F0.5791.00
137_S149_I0.5761.00
114_S171_D0.5731.00
43_A51_N0.5711.00
94_V98_L0.5711.00
16_F114_S0.5701.00
123_E129_K0.5681.00
64_Y68_I0.5631.00
24_L28_L0.5601.00
44_Y47_A0.5591.00
99_E102_R0.5571.00
102_R129_K0.5571.00
151_A154_I0.5541.00
186_D191_Y0.5501.00
30_E78_I0.5491.00
190_F193_E0.5451.00
7_L97_F0.5401.00
64_Y71_D0.5391.00
62_F66_L0.5361.00
41_F48_M0.5361.00
15_G91_Y0.5341.00
13_L110_L0.5321.00
22_E83_I0.5291.00
72_E80_S0.5261.00
21_Y37_I0.5231.00
35_V40_V0.5231.00
97_F100_T0.5221.00
27_I30_E0.5201.00
97_F101_I0.5171.00
122_L127_L0.5161.00
191_Y195_K0.5161.00
90_V94_V0.5121.00
172_Y176_R0.5121.00
133_N136_L0.5101.00
97_F198_V0.5051.00
72_E78_I0.5051.00
192_P195_K0.5041.00
5_I108_L0.5011.00
148_K155_S0.5011.00
41_F45_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zg6A 2 0.9481 100 0.274 Contact Map
4uw9A 1 0.9245 100 0.312 Contact Map
3iruA 4 0.9953 100 0.342 Contact Map
1swvA 2 0.9953 100 0.345 Contact Map
3smvA 1 0.9717 100 0.352 Contact Map
2hdoA 1 0.9104 100 0.356 Contact Map
3qxgA 3 0.9575 100 0.357 Contact Map
3nasA 2 0.9104 100 0.358 Contact Map
2no4A 4 0.9717 100 0.358 Contact Map
3k1zA 1 0.9953 100 0.358 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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