GREMLIN Database
Q97X57 - Uncharacterized protein
UniProt: Q97X57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (151)
Sequences: 16804 (13035)
Seq/√Len: 1060.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E95_V2.7611.00
50_C68_A2.7091.00
44_T65_T2.6581.00
49_G117_M2.5641.00
132_K171_V2.5211.00
69_I96_A2.3761.00
104_I109_I2.1801.00
79_L93_P2.1371.00
67_Y109_I2.0781.00
46_V109_I2.0591.00
112_V131_I2.0471.00
110_D136_K2.0101.00
135_L139_G1.9941.00
130_E133_R1.9801.00
40_K43_Y1.9721.00
65_T92_I1.9281.00
131_I141_A1.8941.00
125_D168_Q1.8901.00
123_D126_G1.8751.00
56_T66_V1.8591.00
76_I93_P1.8371.00
73_E77_S1.8041.00
48_L98_A1.7971.00
48_L131_I1.7541.00
125_D129_R1.7141.00
71_P97_P1.6251.00
67_Y94_Y1.6191.00
78_K81_E1.6031.00
43_Y111_F1.5971.00
112_V135_L1.5891.00
50_C56_T1.5861.00
96_A102_E1.5741.00
163_K167_S1.5741.00
76_I95_V1.5701.00
44_T67_Y1.5411.00
61_R86_L1.5281.00
117_M121_T1.5251.00
45_I59_L1.4961.00
83_V93_P1.4751.00
119_C145_V1.4751.00
57_T82_K1.4651.00
130_E134_I1.4611.00
135_L141_A1.4261.00
116_L119_C1.3941.00
44_T136_K1.3911.00
105_R108_S1.3701.00
94_Y104_I1.3491.00
44_T109_I1.3481.00
121_T127_A1.3471.00
56_T68_A1.3431.00
45_I111_F1.3401.00
158_S161_E1.3241.00
70_D76_I1.3081.00
114_S117_M1.3061.00
39_L43_Y1.3001.00
116_L120_C1.2831.00
57_T83_V1.2731.00
120_C145_V1.2691.00
125_D165_I1.2471.00
164_E168_Q1.2181.00
67_Y92_I1.2091.00
124_H165_I1.2031.00
106_D133_R1.1801.00
70_D75_A1.1641.00
44_T110_D1.1381.00
128_L166_L1.1341.00
47_D50_C1.1111.00
68_A93_P1.1091.00
135_L171_V1.1091.00
98_A121_T1.1021.00
44_T108_S1.1001.00
126_G129_R1.0791.00
58_V61_R1.0731.00
74_R77_S1.0681.00
101_L134_I1.0671.00
68_A79_L1.0631.00
60_A90_N1.0531.00
67_Y104_I1.0431.00
118_L121_T1.0391.00
101_L130_E1.0351.00
98_A117_M1.0311.00
59_L113_F1.0111.00
72_D75_A1.0101.00
76_I80_K0.9941.00
57_T86_L0.9771.00
112_V134_I0.9701.00
164_E167_S0.9691.00
50_C79_L0.9681.00
52_P75_A0.9581.00
125_D169_F0.9491.00
77_S80_K0.9371.00
55_F115_N0.9291.00
56_T93_P0.9231.00
127_A131_I0.9211.00
49_G114_S0.9171.00
115_N144_S0.9041.00
53_G79_L0.9011.00
101_L104_I0.8931.00
30_K33_S0.8821.00
57_T61_R0.8801.00
116_L146_T0.8671.00
116_L144_S0.8661.00
118_L128_L0.8651.00
102_E130_E0.8561.00
99_Q123_D0.8551.00
56_T91_V0.8541.00
46_V112_V0.8481.00
83_V91_V0.8421.00
39_L42_D0.8391.00
75_A116_L0.8361.00
46_V134_I0.8231.00
30_K34_R0.8201.00
132_K169_F0.8161.00
163_K176_K0.8151.00
118_L127_A0.8101.00
100_K126_G0.8031.00
50_C76_I0.7971.00
97_P100_K0.7971.00
24_L27_S0.7821.00
29_N33_S0.7781.00
55_F113_F0.7721.00
52_P82_K0.7631.00
128_L169_F0.7621.00
80_K84_Q0.7601.00
57_T60_A0.7591.00
104_I134_I0.7551.00
54_F82_K0.7431.00
119_C146_T0.7421.00
45_I66_V0.7411.00
24_L28_P0.7331.00
88_L91_V0.7311.00
43_Y110_D0.7291.00
131_I135_L0.7281.00
128_L165_I0.7281.00
57_T88_L0.7261.00
69_I94_Y0.7251.00
99_Q121_T0.7161.00
58_V62_M0.7161.00
32_I35_F0.7111.00
77_S81_E0.7111.00
159_G163_K0.7071.00
29_N58_V0.6991.00
25_V29_N0.6961.00
48_L112_V0.6961.00
38_Y140_L0.6921.00
82_K86_L0.6841.00
45_I113_F0.6811.00
80_K93_P0.6811.00
114_S121_T0.6781.00
69_I101_L0.6781.00
47_D120_C0.6721.00
45_I64_K0.6711.00
109_I134_I0.6701.00
161_E164_E0.6681.00
42_D64_K0.6671.00
55_F58_V0.6651.00
167_S171_V0.6631.00
126_G130_E0.6601.00
114_S131_I0.6601.00
99_Q127_A0.6591.00
157_V162_W0.6551.00
75_A120_C0.6491.00
114_S143_I0.6471.00
111_F140_L0.6461.00
54_F58_V0.6461.00
55_F119_C0.6461.00
47_D113_F0.6421.00
156_D159_G0.6411.00
81_E84_Q0.6401.00
143_I166_L0.6331.00
129_R169_F0.6321.00
35_F142_Y0.6311.00
173_K176_K0.6311.00
82_K85_K0.6181.00
33_S62_M0.6141.00
63_V66_V0.6071.00
23_F27_S0.6071.00
84_Q89_N0.6001.00
53_G93_P0.5981.00
52_P116_L0.5941.00
120_C146_T0.5931.00
165_I169_F0.5881.00
73_E80_K0.5871.00
115_N145_V0.5861.00
115_N119_C0.5841.00
68_A91_V0.5821.00
31_I142_Y0.5821.00
108_S136_K0.5811.00
99_Q122_S0.5801.00
28_P55_F0.5781.00
48_L127_A0.5771.00
124_H157_V0.5741.00
28_P32_I0.5721.00
147_R150_I0.5631.00
78_K82_K0.5611.00
154_K157_V0.5591.00
167_S173_K0.5531.00
116_L145_V0.5511.00
107_K137_D0.5461.00
148_S158_S0.5461.00
25_V28_P0.5451.00
106_D134_I0.5421.00
99_Q126_G0.5421.00
115_N120_C0.5381.00
141_A166_L0.5361.00
114_S141_A0.5361.00
61_R88_L0.5351.00
118_L143_I0.5351.00
49_G71_P0.5331.00
50_C70_D0.5301.00
23_F26_S0.5281.00
161_E167_S0.5281.00
111_F139_G0.5271.00
47_D66_V0.5201.00
100_K130_E0.5181.00
106_D130_E0.5161.00
60_A91_V0.5141.00
50_C93_P0.5111.00
83_V86_L0.5101.00
52_P78_K0.5091.00
74_R78_K0.5071.00
154_K158_S0.5051.00
160_K163_K0.5051.00
43_Y140_L0.5031.00
76_I79_L0.5011.00
71_P98_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl5A 1 0.8579 100 0.364 Contact Map
4pneA 2 0.9737 100 0.384 Contact Map
1xxlA 1 0.8632 100 0.385 Contact Map
3sm3A 2 0.8474 100 0.388 Contact Map
3dh0A 1 0.9526 100 0.389 Contact Map
4obxA 2 0.9158 100 0.393 Contact Map
2o57A 2 0.9947 100 0.394 Contact Map
2p35A 2 0.8789 100 0.394 Contact Map
4krgA 1 0.9737 100 0.395 Contact Map
3vc1A 5 0.9842 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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