GREMLIN Database
Q97X55 - NADH oxidase
UniProt: Q97X55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 555 (463)
Sequences: 2499 (1546)
Seq/√Len: 71.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
372_G399_L4.3591.00
149_I201_G3.9531.00
138_K187_E3.7871.00
395_Q438_K3.3871.00
391_T434_K3.2531.00
368_T393_Y3.0751.00
10_I303_V3.0281.00
47_E315_Y2.9871.00
153_I205_K2.9051.00
101_F162_G2.8371.00
426_L433_I2.7651.00
122_I136_M2.7431.00
272_K300_I2.7281.00
93_I100_I2.7181.00
325_P425_E2.6851.00
268_L295_I2.6531.00
21_I317_L2.6301.00
325_P428_R2.5901.00
211_G243_Y2.5841.00
22_A303_V2.5661.00
425_E428_R2.5331.00
80_D154_R2.5331.00
366_E389_A2.5181.00
318_E322_R2.4981.00
46_A96_L2.4541.00
136_M144_V2.4381.00
190_D193_K2.3831.00
7_L321_K2.3371.00
138_K141_I2.2821.00
381_R385_L2.2241.00
379_A453_I2.2121.00
46_A95_A2.1901.00
126_P135_E2.1651.00
172_L194_F2.1571.00
64_N147_D2.1411.00
426_L431_V2.1331.00
272_K276_D2.1161.00
136_M140_D2.1081.00
39_D88_R2.1021.00
389_A432_E2.1011.00
192_V235_R2.0811.00
17_L54_G2.0501.00
153_I157_R2.0441.00
378_E381_R2.0211.00
134_R140_D2.0141.00
5_K297_A2.0041.00
173_I198_I1.9721.00
173_I194_F1.9631.00
11_R16_V1.9341.00
146_N201_G1.9281.00
397_N436_N1.9271.00
437_V443_D1.9081.00
167_G212_I1.9041.00
188_Y197_E1.8911.00
94_H161_D1.8901.00
391_T432_E1.8631.00
53_V310_L1.8591.00
393_Y439_M1.8541.00
368_T449_P1.8531.00
424_R428_R1.8421.00
87_T91_E1.8371.00
104_L151_A1.8231.00
364_R389_A1.8201.00
385_L425_E1.7961.00
173_I195_V1.7961.00
236_L241_I1.7901.00
306_L309_Q1.7831.00
237_E279_K1.7821.00
381_R429_L1.7661.00
372_G392_L1.7581.00
234_K277_T1.7401.00
440_E443_D1.7381.00
22_A283_F1.7331.00
149_I205_K1.7311.00
5_K8_V1.7211.00
290_T316_W1.7141.00
180_A222_G1.7101.00
42_I89_L1.7081.00
165_L202_I1.6951.00
15_V99_K1.6921.00
142_E188_Y1.6851.00
318_E321_K1.6791.00
237_E280_I1.6681.00
50_K96_L1.6631.00
156_K207_R1.6601.00
15_V209_T1.6390.99
463_K468_S1.6180.99
201_G204_E1.6130.99
47_E351_E1.6110.99
142_E187_E1.6070.99
201_G205_K1.5900.99
315_Y318_E1.5830.99
90_T160_F1.5820.99
233_G278_V1.5720.99
434_K437_V1.5640.99
138_K142_E1.5610.99
200_K239_A1.5430.99
284_L301_A1.5390.99
177_L195_V1.5350.99
407_R416_Q1.5160.99
14_D209_T1.5150.99
138_K188_Y1.5080.99
377_L399_L1.5070.99
177_L192_V1.4920.99
392_L399_L1.4830.99
244_I280_I1.4800.99
18_K98_S1.4790.99
86_F160_F1.4760.99
393_Y434_K1.4720.99
295_I301_A1.4720.99
226_P273_V1.4670.99
142_E201_G1.4650.99
322_R325_P1.4630.99
43_A356_L1.4530.99
150_N154_R1.4480.99
365_G451_Y1.4340.99
422_Y426_L1.4290.99
46_A92_L1.4260.99
142_E197_E1.4240.99
443_D446_M1.4220.99
273_V276_D1.4060.98
424_R427_R1.4040.98
393_Y449_P1.3960.98
377_L426_L1.3910.98
39_D43_A1.3870.98
367_V379_A1.3860.98
230_A277_T1.3800.98
368_T439_M1.3760.98
46_A50_K1.3750.98
43_A46_A1.3740.98
325_P424_R1.3640.98
150_N205_K1.3630.98
372_G394_E1.3540.98
5_K296_K1.3390.98
127_I133_V1.3370.98
83_T154_R1.3290.98
361_E364_R1.3280.98
425_E429_L1.3250.98
288_I294_A1.3240.98
145_K188_Y1.3220.98
195_V212_I1.3160.98
180_A220_D1.3160.98
310_L317_L1.3060.97
11_R14_D1.2920.97
156_K208_I1.2910.97
101_F211_G1.2880.97
399_L433_I1.2860.97
265_T293_D1.2860.97
244_I278_V1.2860.97
399_L423_E1.2830.97
423_E427_R1.2800.97
24_S305_V1.2790.97
156_K206_V1.2780.97
243_Y283_F1.2770.97
137_T140_D1.2720.97
357_L360_L1.2540.97
23_M48_R1.2420.97
365_G388_F1.2410.96
444_C449_P1.2380.96
231_E235_R1.2360.96
100_I160_F1.2350.96
381_R425_E1.2340.96
18_K321_K1.2330.96
367_V383_L1.2310.96
77_M151_A1.2260.96
368_T447_A1.2250.96
193_K197_E1.2210.96
196_E239_A1.2210.96
15_V162_G1.2200.96
398_K423_E1.2130.96
393_Y447_A1.2100.96
64_N143_R1.2090.96
203_R210_V1.2040.96
7_L21_I1.2010.96
275_R302_D1.1990.96
91_E95_A1.1930.96
7_L320_A1.1900.96
439_M444_C1.1780.95
440_E444_C1.1750.95
146_N150_N1.1730.95
442_S446_M1.1680.95
61_T102_V1.1600.95
358_P382_V1.1600.95
287_S331_R1.1510.95
368_T444_C1.1510.95
166_H169_H1.1420.94
7_L317_L1.1380.94
295_I300_I1.1370.94
391_T447_A1.1360.94
274_V282_I1.1360.94
196_E200_K1.1350.94
346_C349_N1.1300.94
235_R238_K1.1290.94
288_I295_I1.1230.94
47_E50_K1.1230.94
404_L407_R1.1230.94
169_H247_S1.1220.94
398_K404_L1.1210.94
206_V210_V1.1200.94
392_L431_V1.1120.94
212_I236_L1.1110.94
123_A126_P1.1090.94
385_L429_L1.1070.93
358_P361_E1.1030.93
246_L274_V1.1020.93
236_L244_I1.1000.93
14_D242_D1.0990.93
226_P230_A1.0940.93
51_G318_E1.0930.93
378_E382_V1.0820.93
439_M443_D1.0780.93
127_I183_K1.0740.92
32_T36_Y1.0730.92
366_E447_A1.0730.92
67_D143_R1.0710.92
70_G107_V1.0700.92
136_M141_I1.0680.92
45_L56_I1.0670.92
76_G82_L1.0670.92
265_T295_I1.0630.92
421_Y425_E1.0560.92
109_R175_Q1.0550.92
268_L284_L1.0550.92
399_L435_L1.0550.92
439_M446_M1.0520.92
189_K231_E1.0510.92
162_G209_T1.0510.92
230_A234_K1.0490.91
441_C445_I1.0440.91
306_L316_W1.0420.91
462_E468_S1.0410.91
180_A221_N1.0400.91
24_S307_G1.0400.91
209_T243_Y1.0400.91
37_P85_K1.0350.91
268_L300_I1.0340.91
417_A420_D1.0300.91
15_V101_F1.0240.90
364_R388_F1.0220.90
90_T100_I1.0200.90
135_E185_G1.0170.90
465_L468_S1.0120.90
233_G244_I1.0060.90
22_A57_I1.0060.90
149_I204_E1.0010.89
382_V386_R0.9990.89
52_G318_E0.9970.89
216_V246_L0.9920.89
143_R147_D0.9910.89
55_L101_F0.9900.89
393_Y437_V0.9890.89
391_T449_P0.9870.89
40_A343_E0.9860.89
57_I101_F0.9810.88
192_V232_I0.9780.88
377_L381_R0.9740.88
141_I145_K0.9720.88
140_D143_R0.9690.88
237_E278_V0.9670.88
196_E241_I0.9660.88
273_V277_T0.9650.88
312_A348_V0.9620.87
17_L303_V0.9570.87
212_I241_I0.9570.87
283_F303_V0.9420.86
58_T100_I0.9330.86
150_N153_I0.9310.86
328_P420_D0.9310.86
246_L271_A0.9230.85
202_I210_V0.9210.85
311_L352_L0.9160.85
370_V454_P0.9150.85
166_H247_S0.9140.85
12_V209_T0.9120.85
50_K315_Y0.9110.84
264_R414_E0.9110.84
367_V451_Y0.9070.84
42_I92_L0.9070.84
167_G195_V0.9070.84
153_I156_K0.9060.84
113_K131_D0.9060.84
122_I134_R0.9060.84
372_G433_I0.9060.84
103_Q164_E0.9020.84
91_E94_H0.8950.83
426_L429_L0.8940.83
226_P277_T0.8930.83
377_L392_L0.8920.83
21_I316_W0.8910.83
393_Y443_D0.8900.83
290_T293_D0.8890.83
434_K447_A0.8890.83
52_G321_K0.8880.83
379_A383_L0.8870.83
149_I198_I0.8850.83
192_V195_V0.8850.83
384_A429_L0.8840.83
26_M307_G0.8830.83
53_V317_L0.8830.83
30_L40_A0.8820.83
328_P417_A0.8790.82
418_L422_Y0.8790.82
123_A133_V0.8770.82
94_H99_K0.8700.82
382_V385_L0.8640.81
316_W320_A0.8620.81
35_G38_S0.8540.80
388_F450_D0.8490.80
55_L99_K0.8490.80
346_C350_P0.8450.80
144_V172_L0.8430.80
442_S445_I0.8410.79
51_G317_L0.8400.79
361_E388_F0.8400.79
328_P418_L0.8390.79
196_E235_R0.8390.79
90_T158_A0.8390.79
192_V196_E0.8390.79
18_K97_G0.8380.79
162_G211_G0.8370.79
18_K99_K0.8340.79
80_D84_P0.8340.79
444_C454_P0.8340.79
92_L96_L0.8340.79
17_L55_L0.8280.78
122_I144_V0.8260.78
327_R421_Y0.8250.78
149_I202_I0.8250.78
440_E446_M0.8250.78
227_E273_V0.8240.78
394_E458_D0.8230.78
168_A247_S0.8210.78
372_G377_L0.8210.78
101_F209_T0.8200.78
319_K326_I0.8170.77
32_T38_S0.8160.77
443_D447_A0.8150.77
23_M26_M0.8150.77
30_L353_G0.8150.77
149_I206_V0.8140.77
25_P245_H0.8110.77
26_M311_L0.8090.77
384_A431_V0.8070.77
199_L239_A0.8070.77
366_E391_T0.8060.76
145_K149_I0.8050.76
187_E193_K0.8010.76
199_L236_L0.8000.76
185_G190_D0.7990.76
188_Y200_K0.7960.76
83_T158_A0.7880.75
146_N205_K0.7860.75
102_V155_A0.7840.74
414_E417_A0.7840.74
328_P421_Y0.7800.74
28_S44_Y0.7800.74
33_P37_P0.7790.74
124_P127_I0.7760.74
87_T157_R0.7730.73
377_L433_I0.7730.73
200_K204_E0.7720.73
215_S218_E0.7720.73
109_R170_G0.7720.73
165_L199_L0.7710.73
197_E200_K0.7710.73
203_R206_V0.7700.73
123_A127_I0.7680.73
335_S339_V0.7680.73
37_P41_H0.7640.73
276_D282_I0.7630.72
224_L229_V0.7610.72
149_I153_I0.7580.72
211_G245_H0.7580.72
426_L430_N0.7570.72
134_R137_T0.7570.72
241_I280_I0.7570.72
214_I244_I0.7560.72
214_I233_G0.7520.71
77_M102_V0.7510.71
216_V274_V0.7500.71
195_V232_I0.7480.71
291_P320_A0.7480.71
213_R245_H0.7460.71
230_A273_V0.7460.71
142_E146_N0.7450.71
34_E37_P0.7450.71
21_I53_V0.7440.71
77_M82_L0.7430.70
92_L95_A0.7430.70
444_C452_E0.7420.70
79_S82_L0.7390.70
6_L291_P0.7380.70
12_V242_D0.7380.70
187_E190_D0.7350.70
135_E183_K0.7350.70
409_P412_V0.7340.69
394_E407_R0.7340.69
80_D83_T0.7310.69
419_I423_E0.7280.69
26_M48_R0.7240.68
138_K145_K0.7240.68
3_L292_Q0.7230.68
269_E272_K0.7220.68
421_Y429_L0.7210.68
268_L301_A0.7190.68
37_P75_L0.7150.67
392_L432_E0.7130.67
282_I285_V0.7130.67
289_I331_R0.7120.67
245_H285_V0.7110.67
367_V453_I0.7100.67
203_R242_D0.7090.67
77_M155_A0.7090.67
230_A274_V0.7080.67
196_E236_L0.7080.67
145_K198_I0.7070.67
392_L435_L0.7050.66
369_V390_V0.7020.66
87_T90_T0.7020.66
444_C448_I0.7010.66
145_K201_G0.7000.66
202_I205_K0.6990.66
218_E224_L0.6990.66
335_S338_G0.6970.66
291_P326_I0.6950.65
301_A304_V0.6950.65
55_L97_G0.6930.65
330_I347_D0.6910.65
79_S83_T0.6890.65
309_Q316_W0.6890.65
145_K194_F0.6880.65
33_P36_Y0.6870.64
295_I298_R0.6860.64
109_R181_T0.6860.64
268_L293_D0.6850.64
225_T228_I0.6830.64
99_K161_D0.6790.63
336_C339_V0.6790.63
335_S345_R0.6780.63
83_T157_R0.6760.63
42_I46_A0.6750.63
141_I188_Y0.6740.63
122_I140_D0.6720.63
189_K193_K0.6700.62
13_G242_D0.6690.62
162_G243_Y0.6680.62
327_R418_L0.6680.62
39_D42_I0.6680.62
60_Y105_V0.6670.62
443_D449_P0.6650.62
357_L361_E0.6650.62
18_K96_L0.6600.61
44_Y48_R0.6590.61
53_V56_I0.6590.61
63_V148_F0.6590.61
288_I306_L0.6580.61
365_G450_D0.6580.61
41_H45_L0.6580.61
3_L291_P0.6570.61
269_E300_I0.6570.61
136_M172_L0.6550.61
77_M104_L0.6550.61
40_A356_L0.6550.61
420_D423_E0.6550.61
227_E357_L0.6540.61
61_T77_M0.6530.60
316_W326_I0.6520.60
142_E145_K0.6520.60
24_S245_H0.6510.60
370_V439_M0.6470.60
109_R133_V0.6460.60
209_T242_D0.6450.60
10_I17_L0.6450.60
199_L241_I0.6430.59
287_S414_E0.6410.59
241_I244_I0.6400.59
396_N436_N0.6400.59
313_D319_K0.6400.59
101_F243_Y0.6390.59
23_M45_L0.6390.59
392_L426_L0.6380.59
64_N67_D0.6380.59
327_R378_E0.6350.58
141_I195_V0.6350.58
42_I88_R0.6350.58
343_E354_W0.6340.58
317_L320_A0.6340.58
55_L98_S0.6340.58
366_E450_D0.6330.58
17_L99_K0.6320.58
141_I193_K0.6320.58
324_L424_R0.6320.58
394_E439_M0.6320.58
285_V305_V0.6310.58
429_L433_I0.6300.58
69_R73_N0.6300.58
283_F305_V0.6300.58
322_R428_R0.6300.58
269_E273_V0.6280.57
106_H133_V0.6280.57
374_V377_L0.6270.57
216_V229_V0.6250.57
13_G203_R0.6220.57
80_D151_A0.6210.57
189_K235_R0.6200.57
403_F418_L0.6190.56
15_V243_Y0.6190.56
75_L82_L0.6180.56
274_V278_V0.6170.56
216_V271_A0.6160.56
384_A430_N0.6150.56
369_V453_I0.6140.56
28_S59_E0.6140.56
17_L22_A0.6140.56
25_P103_Q0.6120.56
4_S320_A0.6110.55
413_N416_Q0.6110.55
258_M286_G0.6110.55
277_T282_I0.6100.55
381_R421_Y0.6100.55
192_V231_E0.6090.55
109_R252_G0.6090.55
10_I13_G0.6080.55
272_K298_R0.6070.55
169_H213_R0.6070.55
264_R417_A0.6070.55
90_T94_H0.6060.55
28_S41_H0.6060.55
378_E421_Y0.6050.55
320_A326_I0.6040.55
124_P135_E0.6040.55
441_C444_C0.6010.54
77_M154_R0.5990.54
152_A206_V0.5990.54
198_I201_G0.5970.54
194_F198_I0.5970.54
177_L224_L0.5970.54
178_S218_E0.5960.54
233_G274_V0.5960.54
89_L93_I0.5950.53
58_T93_I0.5940.53
6_L294_A0.5920.53
7_L316_W0.5920.53
238_K279_K0.5910.53
72_V128_P0.5910.53
289_I414_E0.5890.53
338_G341_Y0.5890.53
151_A154_R0.5880.53
178_S220_D0.5880.53
78_Y82_L0.5870.53
327_R425_E0.5860.52
203_R241_I0.5860.52
313_D326_I0.5860.52
103_Q240_G0.5840.52
125_S135_E0.5840.52
13_G209_T0.5840.52
271_A284_L0.5840.52
334_Q347_D0.5840.52
294_A320_A0.5830.52
446_M449_P0.5810.52
80_D157_R0.5810.52
23_M310_L0.5800.52
234_K237_E0.5770.51
219_F248_A0.5770.51
368_T448_I0.5770.51
248_A267_F0.5760.51
169_H286_G0.5760.51
230_A276_D0.5760.51
328_P348_V0.5750.51
372_G435_L0.5740.51
34_E150_N0.5740.51
128_P132_E0.5740.51
8_V296_K0.5730.51
141_I176_F0.5730.51
23_M56_I0.5700.50
55_L94_H0.5700.50
337_R340_V0.5700.50
27_I166_H0.5700.50
216_V244_I0.5700.50
218_E223_G0.5700.50
34_E38_S0.5690.50
63_V104_L0.5670.50
444_C447_A0.5660.50
102_V160_F0.5650.50
51_G314_P0.5650.50
141_I194_F0.5630.50
28_S344_V0.5630.50
61_T93_I0.5620.49
166_H286_G0.5620.49
275_R282_I0.5610.49
100_I161_D0.5590.49
214_I229_V0.5580.49
368_T446_M0.5580.49
105_V258_M0.5570.49
423_E426_L0.5550.49
416_Q420_D0.5550.49
416_Q419_I0.5540.48
258_M267_F0.5540.48
250_R256_S0.5530.48
170_G252_G0.5530.48
82_L151_A0.5520.48
243_Y303_V0.5520.48
372_G423_E0.5510.48
129_I133_V0.5510.48
146_N448_I0.5500.48
237_E281_P0.5500.48
152_A202_I0.5490.48
24_S306_L0.5490.48
370_V443_D0.5480.48
445_I448_I0.5480.48
181_T218_E0.5480.48
170_G251_D0.5480.48
120_K134_R0.5470.48
346_C355_E0.5470.48
78_Y121_P0.5460.47
23_M171_Y0.5460.47
258_M266_S0.5460.47
125_S183_K0.5460.47
4_S8_V0.5430.47
378_E426_L0.5430.47
366_E434_K0.5410.47
216_V270_E0.5400.47
289_I417_A0.5390.47
110_K251_D0.5390.47
179_P222_G0.5390.47
214_I224_L0.5380.46
276_D366_E0.5370.46
291_P316_W0.5360.46
374_V394_E0.5350.46
94_H100_I0.5340.46
199_L210_V0.5330.46
124_P181_T0.5330.46
440_E445_I0.5310.46
378_E422_Y0.5310.46
164_E211_G0.5310.46
7_L18_K0.5310.46
339_V342_K0.5300.46
166_H251_D0.5300.46
146_N149_I0.5300.46
126_P133_V0.5290.45
56_I100_I0.5290.45
59_E344_V0.5280.45
106_H247_S0.5270.45
80_D150_N0.5260.45
87_T95_A0.5260.45
175_Q215_S0.5260.45
21_I320_A0.5250.45
27_I60_Y0.5250.45
383_L451_Y0.5250.45
244_I274_V0.5250.45
109_R171_Y0.5240.45
231_E234_K0.5230.45
296_K304_V0.5230.45
268_L288_I0.5220.45
314_P317_L0.5210.44
15_V18_K0.5200.44
22_A54_G0.5190.44
64_N144_V0.5190.44
30_L148_F0.5190.44
121_P128_P0.5190.44
213_R247_S0.5180.44
297_A300_I0.5180.44
75_L177_L0.5170.44
150_N201_G0.5170.44
191_G228_I0.5170.44
153_I201_G0.5170.44
362_K388_F0.5150.44
140_D144_V0.5150.44
145_K197_E0.5140.44
402_Q405_L0.5140.44
61_T86_F0.5130.43
321_K369_V0.5130.43
68_A106_H0.5100.43
368_T443_D0.5090.43
69_R113_K0.5090.43
378_E385_L0.5090.43
202_I206_V0.5090.43
175_Q249_G0.5080.43
348_V418_L0.5080.43
344_V353_G0.5070.43
267_F287_S0.5060.43
264_R293_D0.5060.43
296_K299_E0.5060.43
334_Q337_R0.5050.42
290_T328_P0.5040.42
439_M449_P0.5040.42
57_I283_F0.5030.42
349_N355_E0.5030.42
327_R348_V0.5020.42
291_P294_A0.5010.42
347_D402_Q0.5010.42
157_R231_E0.5010.42
69_R111_T0.5010.42
350_P382_V0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k30A 2 0.9856 100 0.485 Contact Map
1o94A 2 0.9784 100 0.489 Contact Map
1ps9A 1 0.9604 100 0.506 Contact Map
3tjlA 2 0.6486 100 0.616 Contact Map
2hsaB 2 0.618 100 0.616 Contact Map
3l5aA 1 0.6396 100 0.619 Contact Map
4qnwA 1 0.6234 100 0.622 Contact Map
4tmbA 2 0.6378 100 0.622 Contact Map
4gbuA 2 0.6378 100 0.622 Contact Map
4e2bA 1 0.6018 100 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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