GREMLIN Database
Q97X54 - Uncharacterized protein
UniProt: Q97X54 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (214)
Sequences: 692 (657)
Seq/√Len: 44.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_A185_A4.8661.00
203_V210_V4.7331.00
189_D213_G3.7951.00
132_F150_L3.5991.00
156_W206_A3.4641.00
157_S209_E3.4421.00
125_F191_L3.3501.00
156_W185_A3.2791.00
104_V155_V3.1711.00
157_S212_K2.9771.00
161_K182_V2.9601.00
159_S190_S2.7991.00
106_A135_L2.7441.00
222_D245_F2.6881.00
187_A190_S2.5921.00
129_P181_I2.4991.00
201_V210_V2.4831.00
189_D214_A2.4451.00
154_A183_V2.3931.00
104_V201_V2.2881.00
106_A124_A2.1991.00
186_I190_S2.1791.00
132_F135_L2.1631.00
153_N186_I2.1181.00
132_F136_E2.0911.00
159_S186_I2.0780.99
125_F155_V2.0660.99
132_F152_N1.9990.99
153_N184_N1.9910.99
188_L217_T1.9510.99
123_I151_F1.9280.99
103_D200_K1.9150.99
107_Y110_S1.8950.99
208_L239_L1.8770.99
112_T148_V1.8380.99
99_M197_N1.8370.99
151_F191_L1.8150.99
113_I138_N1.8010.98
128_N131_S1.7960.98
121_N149_K1.7100.98
161_K184_N1.6740.98
124_A135_L1.6360.97
207_E226_I1.6290.97
199_L222_D1.6180.97
129_P152_N1.6090.97
163_E182_V1.6010.97
202_D227_E1.5210.96
224_I240_L1.5160.96
198_L225_L1.5080.95
189_D217_T1.4960.95
46_R49_K1.4830.95
98_D120_A1.4520.94
189_D218_L1.4510.94
100_I123_I1.4300.94
101_F122_V1.4090.93
203_V227_E1.4070.93
162_I185_A1.3730.92
164_L181_I1.3650.92
112_T122_V1.3120.91
139_V148_V1.3110.91
213_G229_R1.3090.91
99_M223_K1.3070.91
137_L140_K1.2880.90
139_V150_L1.2710.89
123_I191_L1.2680.89
156_W162_I1.2380.88
155_V210_V1.2360.88
199_L221_T1.2360.88
111_Y229_R1.1980.86
204_E207_E1.1820.85
107_Y227_E1.1820.85
135_L150_L1.1740.85
128_N166_A1.1570.84
203_V206_A1.1560.84
227_E230_K1.1240.82
208_L212_K1.1230.82
59_K62_Y1.0980.81
127_P154_A1.0950.81
239_L243_K1.0940.81
156_W209_E1.0910.80
127_P152_N1.0890.80
213_G222_D1.0730.79
96_E99_M1.0710.79
159_S187_A1.0710.79
98_D119_G1.0410.77
95_F101_F1.0140.75
221_T245_F0.9970.74
104_V210_V0.9960.74
101_F120_A0.9900.74
148_V226_I0.9880.73
125_F213_G0.9870.73
99_M118_R0.9830.73
89_V92_W0.9750.72
154_A162_I0.9750.72
69_V94_S0.9620.71
138_N141_E0.9590.71
188_L214_A0.9550.71
101_F252_T0.9540.71
127_P164_L0.9520.71
199_L214_A0.9420.70
212_K235_N0.9420.70
228_V249_K0.9410.70
63_D66_Y0.9260.68
99_M245_F0.9070.67
95_F98_D0.8940.66
156_W160_G0.8930.66
227_E234_R0.8900.65
95_F119_G0.8870.65
104_V203_V0.8860.65
217_T221_T0.8840.65
113_I142_N0.8620.63
125_F217_T0.8620.63
218_L222_D0.8610.63
201_V227_E0.8590.63
204_E229_R0.8550.62
144_I148_V0.8510.62
136_E150_L0.8500.62
104_V227_E0.8460.61
201_V207_E0.8450.61
125_F151_F0.8430.61
95_F99_M0.8400.61
203_V229_R0.8390.61
133_K136_E0.8360.60
90_R110_S0.8340.60
128_N171_T0.8330.60
105_G205_G0.8290.60
191_L239_L0.8290.60
214_A222_D0.8240.59
211_L239_L0.8190.59
193_L196_V0.8120.58
125_F153_N0.8120.58
101_F229_R0.8090.58
124_A128_N0.8070.58
210_V213_G0.8010.57
99_M120_A0.7990.57
206_A209_E0.7980.57
214_A217_T0.7980.57
155_V185_A0.7960.57
73_N76_H0.7940.56
202_D205_G0.7910.56
125_F188_L0.7910.56
119_G122_V0.7890.56
224_I227_E0.7870.56
54_Y67_W0.7860.56
121_N194_K0.7860.56
189_D221_T0.7830.55
100_I197_N0.7760.55
230_K237_D0.7750.55
185_A206_A0.7730.54
139_V144_I0.7650.54
57_L62_Y0.7610.53
228_V236_I0.7600.53
203_V207_E0.7590.53
120_A197_N0.7460.52
105_G109_G0.7390.51
222_D230_K0.7380.51
193_L220_V0.7370.51
214_A229_R0.7370.51
215_M219_D0.7360.51
123_I194_K0.7320.51
108_I124_A0.7280.50
186_I191_L0.7260.50
61_K65_M0.7250.50
101_F191_L0.7220.50
210_V230_K0.7220.50
199_L224_I0.7200.49
227_E232_F0.7180.49
176_N219_D0.7130.49
189_D229_R0.7030.48
155_V214_A0.7020.48
189_D216_N0.7000.47
88_E92_W0.6980.47
176_N246_K0.6980.47
84_H90_R0.6970.47
104_V187_A0.6970.47
136_E140_K0.6940.47
230_K234_R0.6930.47
172_S178_G0.6920.47
157_S206_A0.6900.46
145_E177_K0.6890.46
104_V225_L0.6880.46
241_R244_G0.6870.46
98_D169_D0.6820.46
209_E212_K0.6810.46
193_L197_N0.6800.45
100_I158_R0.6790.45
112_T139_V0.6770.45
126_E132_F0.6760.45
214_A218_L0.6730.45
198_L223_K0.6720.45
107_Y111_Y0.6690.44
135_L139_V0.6660.44
154_A160_G0.6660.44
189_D222_D0.6660.44
54_Y57_L0.6560.43
79_W83_L0.6540.43
160_G166_A0.6510.43
148_V169_D0.6500.43
101_F112_T0.6480.42
69_V113_I0.6480.42
86_E111_Y0.6440.42
107_Y131_S0.6440.42
229_R237_D0.6440.42
112_T142_N0.6440.42
115_A142_N0.6420.42
203_V213_G0.6420.42
90_R93_I0.6410.42
53_G66_Y0.6400.42
214_A221_T0.6400.42
102_V188_L0.6390.42
102_V123_I0.6390.42
83_L90_R0.6380.41
160_G206_A0.6360.41
69_V76_H0.6300.41
230_K233_E0.6290.41
96_E120_A0.6290.41
106_A144_I0.6260.40
145_E150_L0.6250.40
138_N142_N0.6250.40
96_E197_N0.6250.40
133_K246_K0.6240.40
57_L70_R0.6220.40
155_V186_I0.6210.40
118_R188_L0.6200.40
62_Y70_R0.6200.40
59_K70_R0.6200.40
64_G160_G0.6130.39
122_V142_N0.6080.39
187_A213_G0.6060.38
115_A120_A0.6050.38
212_K215_M0.6050.38
232_F236_I0.6030.38
102_V155_V0.6020.38
104_V125_F0.6020.38
164_L171_T0.6010.38
208_L213_G0.6010.38
155_V201_V0.5990.38
127_P207_E0.5980.38
89_V225_L0.5960.38
124_A148_V0.5950.37
118_R122_V0.5950.37
102_V196_V0.5950.37
232_F237_D0.5940.37
229_R247_L0.5930.37
222_D248_S0.5890.37
56_K63_D0.5860.37
229_R232_F0.5860.37
154_A188_L0.5860.37
62_Y66_Y0.5840.36
84_H137_L0.5770.36
111_Y115_A0.5760.36
42_R46_R0.5760.36
197_N222_D0.5740.36
102_V225_L0.5740.36
93_I137_L0.5720.35
107_Y234_R0.5710.35
104_V208_L0.5710.35
59_K63_D0.5700.35
42_R50_I0.5690.35
227_E237_D0.5680.35
94_S169_D0.5680.35
104_V226_I0.5670.35
128_N164_L0.5650.35
44_F48_P0.5650.35
218_L221_T0.5640.35
132_F159_S0.5640.35
115_A144_I0.5630.35
116_G137_L0.5630.35
234_R237_D0.5630.35
195_R198_L0.5620.35
99_M250_V0.5620.35
213_G218_L0.5620.35
125_F166_A0.5590.34
166_A242_S0.5580.34
195_R216_N0.5560.34
123_I149_K0.5560.34
106_A138_N0.5540.34
49_K67_W0.5510.34
174_Y246_K0.5490.33
195_R220_V0.5430.33
208_L245_F0.5430.33
83_L88_E0.5420.33
53_G133_K0.5390.33
57_L164_L0.5380.32
79_W86_E0.5380.32
154_A233_E0.5340.32
188_L239_L0.5320.32
143_E238_D0.5300.32
157_S218_L0.5270.32
98_D197_N0.5250.31
56_K241_R0.5240.31
149_K191_L0.5240.31
64_G96_E0.5230.31
128_N226_I0.5230.31
97_K190_S0.5230.31
199_L245_F0.5210.31
107_Y237_D0.5210.31
170_M218_L0.5200.31
220_V245_F0.5190.31
173_A182_V0.5190.31
201_V226_I0.5180.31
88_E93_I0.5180.31
212_K240_L0.5170.31
105_G126_E0.5170.31
189_D239_L0.5140.30
173_A178_G0.5140.30
122_V148_V0.5130.30
81_I88_E0.5120.30
208_L232_F0.5110.30
54_Y124_A0.5090.30
231_E235_N0.5090.30
173_A177_K0.5090.30
135_L203_V0.5080.30
65_M70_R0.5070.30
72_E76_H0.5070.30
112_T115_A0.5070.30
110_S120_A0.5040.30
57_L79_W0.5030.30
199_L213_G0.5010.29
183_V198_L0.5000.29
115_A118_R0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2py6A 4 0.9323 100 0.402 Contact Map
3k6rA 1 0.8083 97.7 0.853 Contact Map
2b3tA 1 0.9398 97.7 0.855 Contact Map
4dzrA 2 0.5564 97.6 0.855 Contact Map
3dh0A 1 0.6541 97.6 0.858 Contact Map
3v97A 1 0.8308 97.5 0.858 Contact Map
3a27A 1 0.718 97.5 0.858 Contact Map
1uwvA 1 0.891 97.5 0.859 Contact Map
4qdjA 1 0.7481 97.4 0.86 Contact Map
2yx1A 2 0.8008 97.4 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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