GREMLIN Database
Q97X50 - Allantoin permease
UniProt: Q97X50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (423)
Sequences: 4788 (3044)
Seq/√Len: 148.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
408_A476_L6.9121.00
419_K422_E6.5181.00
408_A480_L5.6231.00
98_G255_P4.3991.00
446_I478_I4.2231.00
37_K263_S4.1471.00
443_A478_I3.4921.00
77_L284_F3.3491.00
443_A447_G3.2681.00
236_I240_I3.2311.00
211_I215_T3.1931.00
447_G478_I3.0471.00
412_I476_L2.9891.00
447_G475_S2.9371.00
82_I240_I2.9301.00
404_G408_A2.8081.00
443_A482_L2.7441.00
36_S39_S2.7331.00
79_V236_I2.6971.00
409_H414_E2.6201.00
72_G75_I2.5511.00
438_I442_I2.5431.00
450_V474_L2.5241.00
405_V444_M2.4941.00
441_L445_V2.3991.00
412_I480_L2.3721.00
207_G211_I2.3101.00
339_N343_N2.2501.00
86_T244_A2.2071.00
40_K102_G2.1641.00
210_M281_L2.1271.00
95_G258_T2.1061.00
309_N312_N2.0881.00
30_P39_S2.0591.00
404_G472_L2.0451.00
262_R266_D2.0441.00
451_P471_G2.0111.00
478_I482_L1.9861.00
120_I441_L1.9621.00
133_F373_G1.9441.00
474_L478_I1.9421.00
171_L175_L1.9381.00
111_P418_I1.9301.00
377_S380_L1.9061.00
116_R119_R1.8771.00
54_M341_A1.8731.00
137_T180_N1.8731.00
76_A287_V1.8681.00
447_G474_L1.8621.00
181_V370_A1.8481.00
78_T236_I1.8361.00
112_M409_H1.8351.00
477_M481_G1.8271.00
178_L182_L1.8261.00
310_P314_M1.8231.00
133_F339_N1.8161.00
132_W135_V1.8091.00
140_G176_F1.7961.00
73_P77_L1.7941.00
193_K196_L1.7891.00
97_I108_S1.7871.00
469_Y473_F1.7861.00
30_P33_A1.7691.00
265_K269_I1.7571.00
359_L368_V1.7571.00
44_W266_D1.7411.00
404_G475_S1.7251.00
177_W374_L1.7131.00
422_E425_K1.7111.00
186_K190_E1.7031.00
131_F391_V1.6881.00
310_P317_F1.6421.00
422_E429_R1.6241.00
419_K429_R1.6221.00
446_I474_L1.6141.00
376_Y380_L1.6011.00
92_Y272_A1.6011.00
473_F476_L1.5891.00
118_A353_S1.5711.00
180_N339_N1.5521.00
442_I482_L1.5491.00
210_M285_I1.5391.00
405_V443_A1.5281.00
310_P313_I1.5251.00
100_K264_Q1.5171.00
449_S453_I1.4931.00
142_L309_N1.4901.00
46_N196_L1.4891.00
458_P461_A1.4851.00
473_F477_M1.4771.00
74_L78_T1.4631.00
308_V317_F1.4511.00
405_V440_A1.4481.00
204_I208_G1.4431.00
174_F178_L1.4401.00
113_F440_A1.4381.00
476_L480_L1.4361.00
310_P318_T1.4261.00
440_A443_A1.4221.00
269_I273_I1.4211.00
79_V239_G1.4181.00
436_Y441_L1.4011.00
108_S255_P1.3921.00
223_L226_I1.3921.00
145_D172_S1.3801.00
43_T46_N1.3671.00
120_I436_Y1.3631.00
80_I287_V1.3421.00
98_G258_T1.3351.00
445_V449_S1.3321.00
480_L484_K1.3211.00
458_P462_L1.3151.00
401_S471_G1.3101.00
276_P280_L1.3051.00
233_L237_A1.3041.00
71_F79_V1.3011.00
129_A253_N1.2991.00
413_L480_L1.2971.00
30_P35_L1.2901.00
409_H413_L1.2821.00
404_G476_L1.2751.00
266_D270_R1.2691.00
367_I371_I1.2671.00
236_I239_G1.2671.00
141_G172_S1.2571.00
134_S373_G1.2531.00
79_V240_I1.2491.00
80_I283_S1.2491.00
405_V447_G1.2491.00
131_F392_I1.2461.00
30_P36_S1.2451.00
422_E428_G1.2381.00
403_A407_I1.2361.00
89_I93_L1.2361.00
78_T82_I1.2301.00
481_G484_K1.2281.00
183_V194_F1.2261.00
407_I411_W1.2211.00
82_I236_I1.2201.00
170_A174_F1.2111.00
366_A370_A1.2081.00
136_E343_N1.2081.00
440_A479_Y1.2041.00
308_V313_I1.2011.00
281_L285_I1.2001.00
96_H100_K1.1981.00
133_F370_A1.1911.00
313_I317_F1.1811.00
257_F346_S1.1681.00
360_N364_K1.1611.00
94_N406_M1.1601.00
52_A278_L1.1541.00
479_Y483_E1.1381.00
136_E339_N1.1371.00
248_A400_G1.1360.99
430_Y435_G1.1350.99
112_M406_M1.1320.99
425_K428_G1.1300.99
83_A240_I1.1240.99
260_F349_Y1.1220.99
81_A280_L1.1200.99
28_Y33_A1.1180.99
83_A243_M1.1140.99
312_N318_T1.1120.99
237_A241_S1.1070.99
84_Y283_S1.1000.99
439_N442_I1.0820.99
90_A251_V1.0780.99
184_L370_A1.0730.99
375_L379_W1.0690.99
93_L411_W1.0690.99
240_I244_A1.0660.99
97_I101_W1.0660.99
471_G475_S1.0630.99
374_L377_S1.0560.99
88_L92_Y1.0550.99
110_R118_A1.0530.99
459_Q462_L1.0530.99
255_P258_T1.0500.99
334_A338_V1.0490.99
347_P369_S1.0480.99
113_F117_G1.0460.99
454_G470_L1.0440.99
80_I84_Y1.0440.99
208_G211_I1.0410.99
312_N316_L1.0370.99
58_V335_T1.0360.99
439_N443_A1.0320.99
124_M399_L1.0320.99
126_A351_L1.0300.99
116_R435_G1.0300.99
439_N483_E1.0270.99
236_I243_M1.0230.99
373_G376_Y1.0210.99
312_N315_F1.0180.99
47_Y258_T1.0130.99
111_P423_L1.0090.99
474_L477_M1.0090.99
478_I481_G1.0060.99
450_V470_L0.9990.99
147_L325_L0.9960.99
193_K197_I0.9930.99
378_P381_W0.9910.99
101_W418_I0.9900.99
87_L247_W0.9890.99
358_R364_K0.9810.99
113_F121_P0.9760.98
141_G145_D0.9730.98
145_D168_H0.9690.98
65_G139_A0.9680.98
424_F430_Y0.9680.98
210_M289_L0.9630.98
137_T177_W0.9630.98
132_W392_I0.9610.98
380_L383_N0.9610.98
107_S110_R0.9600.98
77_L81_A0.9590.98
85_F276_P0.9570.98
466_Y470_L0.9560.98
408_A413_L0.9550.98
147_L328_G0.9500.98
133_F344_I0.9490.98
95_G98_G0.9450.98
477_M480_L0.9450.98
334_A337_S0.9430.98
96_H416_T0.9420.98
200_P203_I0.9410.98
412_I415_K0.9400.98
457_V462_L0.9380.98
463_L470_L0.9370.98
86_T240_I0.9360.98
446_I453_I0.9350.98
96_H411_W0.9320.98
346_S350_D0.9290.98
251_V403_A0.9250.98
280_L284_F0.9190.98
136_E335_T0.9170.98
75_I78_T0.9160.98
115_I426_P0.9160.98
184_L366_A0.9140.98
359_L364_K0.9140.98
263_S266_D0.9130.98
59_P141_G0.9120.98
457_V461_A0.9110.98
79_V83_A0.9100.98
284_F288_G0.9080.98
285_I289_L0.9050.97
189_D193_K0.9030.97
117_G441_L0.9030.97
443_A476_L0.9020.97
220_L223_L0.8950.97
442_I446_I0.8870.97
200_P204_I0.8870.97
218_N222_P0.8870.97
376_Y381_W0.8850.97
51_W106_P0.8820.97
275_L279_T0.8810.97
105_F255_P0.8800.97
171_L174_F0.8800.97
224_F227_K0.8800.97
88_L276_P0.8740.97
445_V448_F0.8740.97
97_I406_M0.8720.97
450_V453_I0.8710.97
377_S381_W0.8700.97
36_S40_K0.8660.97
443_A479_Y0.8650.97
232_S235_N0.8640.97
308_V311_V0.8540.96
359_L363_S0.8510.96
56_H202_V0.8510.96
448_F451_P0.8490.96
214_A218_N0.8450.96
290_T293_V0.8430.96
207_G446_I0.8420.96
208_G323_I0.8410.96
147_L332_V0.8410.96
345_V349_Y0.8360.96
32_I107_S0.8350.96
113_F444_M0.8320.96
439_N482_L0.8310.96
213_V217_A0.8280.96
448_F453_I0.8270.96
45_V49_T0.8250.96
242_T389_E0.8250.96
203_I207_G0.8190.95
470_L473_F0.8160.95
226_I291_S0.8130.95
243_M246_F0.8130.95
95_G267_Q0.8120.95
123_I354_L0.8120.95
124_M395_I0.8120.95
138_Y141_G0.8110.95
195_E340_V0.8110.95
195_E337_S0.8060.95
438_I441_L0.8040.95
183_V336_I0.8040.95
61_F289_L0.8000.95
266_D269_I0.7990.95
140_G335_T0.7980.95
122_V350_D0.7980.95
133_F136_E0.7970.95
105_F346_S0.7970.95
54_M250_L0.7960.95
147_L329_I0.7900.95
322_Y326_V0.7890.94
347_P350_D0.7870.94
443_A475_S0.7870.94
387_S391_V0.7870.94
359_L365_S0.7850.94
134_S376_Y0.7840.94
366_A369_S0.7820.94
213_V289_L0.7810.94
106_P350_D0.7800.94
249_T399_L0.7800.94
99_V267_Q0.7790.94
91_L94_N0.7760.94
308_V314_M0.7740.94
84_Y279_T0.7740.94
476_L479_Y0.7720.94
84_Y246_F0.7700.94
241_S469_Y0.7700.94
273_I277_I0.7690.94
208_G212_H0.7670.94
110_R353_S0.7670.94
28_Y345_V0.7660.94
58_V61_F0.7650.94
437_N483_E0.7650.94
272_A276_P0.7650.94
397_A455_F0.7630.93
81_A284_F0.7610.93
222_P227_K0.7580.93
170_A378_P0.7580.93
26_N38_N0.7570.93
348_V365_S0.7520.93
32_I110_R0.7510.93
408_A412_I0.7510.93
448_F452_V0.7500.93
420_L424_F0.7460.93
60_A63_L0.7460.93
473_F481_G0.7450.93
442_I445_V0.7440.93
66_L389_E0.7440.93
120_I445_V0.7430.93
253_N257_F0.7430.93
120_I444_M0.7430.93
137_T339_N0.7420.92
202_V338_V0.7400.92
56_H338_V0.7390.92
85_F280_L0.7370.92
88_L335_T0.7360.92
308_V312_N0.7360.92
46_N192_K0.7350.92
261_S264_Q0.7340.92
62_M65_G0.7330.92
185_F367_I0.7310.92
220_L224_F0.7300.92
48_T52_A0.7290.92
43_T262_R0.7270.92
94_N254_I0.7270.92
314_M323_I0.7260.92
99_V261_S0.7250.92
141_G169_M0.7240.92
214_A288_G0.7240.92
447_G451_P0.7230.91
80_I280_L0.7230.91
314_M318_T0.7230.91
125_R253_N0.7230.91
181_V185_F0.7220.91
369_S381_W0.7190.91
234_P237_A0.7170.91
110_R409_H0.7150.91
65_G290_T0.7110.91
405_V475_S0.7070.91
446_I449_S0.7030.90
457_V460_L0.6990.90
363_S367_I0.6980.90
340_V344_I0.6970.90
188_M260_F0.6960.90
357_K360_N0.6950.90
289_L293_V0.6950.90
288_G292_A0.6940.90
460_L463_L0.6940.90
221_S227_K0.6930.90
92_Y95_G0.6920.90
314_M317_F0.6920.90
48_T273_I0.6910.90
331_L335_T0.6900.89
111_P430_Y0.6900.89
412_I416_T0.6890.89
168_H171_L0.6870.89
201_L330_S0.6870.89
129_A343_N0.6870.89
131_F395_I0.6870.89
309_N313_I0.6870.89
59_P335_T0.6840.89
237_A240_I0.6840.89
134_S138_Y0.6840.89
213_V285_I0.6810.89
202_V334_A0.6810.89
423_L430_Y0.6800.89
410_Y413_L0.6800.89
64_A286_A0.6770.89
33_A39_S0.6750.88
146_A312_N0.6740.88
83_A87_L0.6720.88
363_S366_A0.6700.88
103_V108_S0.6700.88
207_G351_L0.6700.88
178_L375_L0.6690.88
239_G243_M0.6680.88
242_T245_G0.6680.88
129_A347_P0.6670.88
447_G471_G0.6670.88
42_W188_M0.6660.88
94_N407_I0.6660.88
250_L388_I0.6650.88
145_D169_M0.6630.88
465_D470_L0.6620.87
91_L249_T0.6610.87
437_N440_A0.6600.87
57_N60_A0.6600.87
54_M335_T0.6600.87
409_H483_E0.6590.87
140_G183_V0.6590.87
133_F181_V0.6580.87
55_I106_P0.6570.87
175_L445_V0.6570.87
195_E341_A0.6570.87
429_R481_G0.6570.87
413_L483_E0.6550.87
96_H264_Q0.6550.87
60_A246_F0.6540.87
209_L317_F0.6500.87
84_Y128_S0.6500.87
55_I279_T0.6500.87
140_G191_I0.6490.86
453_I460_L0.6440.86
269_I272_A0.6440.86
447_G450_V0.6400.86
333_I337_S0.6400.86
205_I330_S0.6400.86
328_G337_S0.6390.86
452_V456_L0.6390.86
126_A250_L0.6390.86
336_I341_A0.6380.86
124_M402_V0.6370.85
222_P225_Q0.6360.85
60_A286_A0.6350.85
427_N478_I0.6340.85
470_L474_L0.6330.85
278_L282_F0.6300.85
175_L182_L0.6300.85
294_I447_G0.6300.85
125_R346_S0.6290.85
291_S295_Y0.6280.85
138_Y142_L0.6270.85
311_V318_T0.6270.85
247_W275_L0.6270.85
344_I370_A0.6270.85
253_N346_S0.6250.84
191_I340_V0.6250.84
54_M247_W0.6250.84
92_Y268_L0.6220.84
274_G278_L0.6210.84
103_V107_S0.6210.84
247_W251_V0.6190.84
81_A175_L0.6190.84
425_K429_R0.6170.84
241_S250_L0.6170.84
48_T277_I0.6170.84
204_I211_I0.6160.83
397_A452_V0.6150.83
334_A341_A0.6150.83
183_V340_V0.6150.83
401_S447_G0.6150.83
75_I236_I0.6140.83
180_N336_I0.6140.83
364_K367_I0.6140.83
109_I118_A0.6140.83
335_T338_V0.6120.83
112_M405_V0.6100.83
179_L182_L0.6100.83
110_R115_I0.6090.83
144_L172_S0.6070.83
270_R274_G0.6040.82
311_V317_F0.6040.82
467_G471_G0.6040.82
128_S392_I0.6020.82
368_V372_L0.6000.82
197_I200_P0.5970.82
273_I442_I0.5960.81
184_L344_I0.5960.81
321_P325_L0.5960.81
193_K198_A0.5960.81
27_Y31_N0.5960.81
430_Y437_N0.5950.81
360_N363_S0.5950.81
236_I441_L0.5940.81
63_L468_W0.5940.81
375_L415_K0.5940.81
375_L438_I0.5930.81
312_N317_F0.5930.81
87_L252_L0.5930.81
309_N314_M0.5880.81
131_F274_G0.5870.80
71_F75_I0.5860.80
109_I402_V0.5850.80
119_R354_L0.5840.80
185_F363_S0.5840.80
253_N256_D0.5830.80
62_M139_A0.5830.80
93_L412_I0.5830.80
447_G476_L0.5790.80
428_G442_I0.5760.79
63_L389_E0.5750.79
311_V327_L0.5750.79
42_W261_S0.5720.79
99_V264_Q0.5710.79
61_F354_L0.5710.79
414_E418_I0.5700.79
387_S390_N0.5690.78
148_I172_S0.5660.78
245_G400_G0.5650.78
69_F235_N0.5650.78
379_W385_A0.5640.78
73_P288_G0.5640.78
72_G228_A0.5620.78
170_A446_I0.5610.77
211_I481_G0.5610.77
180_N183_V0.5610.77
202_V337_S0.5600.77
383_N387_S0.5590.77
44_W270_R0.5590.77
129_A346_S0.5580.77
247_W279_T0.5580.77
65_G98_G0.5570.77
195_E338_V0.5570.77
76_A80_I0.5570.77
397_A451_P0.5560.77
264_Q329_I0.5560.77
38_N477_M0.5550.77
411_W416_T0.5510.76
111_P414_E0.5510.76
59_P136_E0.5500.76
60_A136_E0.5500.76
109_I112_M0.5470.76
139_A335_T0.5470.76
125_R129_A0.5460.76
418_I424_F0.5460.76
63_L242_T0.5450.75
57_N246_F0.5450.75
313_I316_L0.5450.75
221_S225_Q0.5450.75
35_L102_G0.5440.75
171_L439_N0.5440.75
122_V353_S0.5430.75
446_I450_V0.5430.75
47_Y95_G0.5410.75
141_G173_F0.5410.75
91_L251_V0.5410.75
56_H203_I0.5410.75
106_P353_S0.5410.75
454_G464_Y0.5410.75
105_F125_R0.5400.75
427_N470_L0.5390.75
57_N61_F0.5390.75
41_T189_D0.5380.74
53_G195_E0.5380.74
39_S189_D0.5380.74
47_Y261_S0.5370.74
37_K329_I0.5360.74
348_V353_S0.5350.74
33_A36_S0.5340.74
120_I171_L0.5330.74
87_L91_L0.5330.74
474_L483_E0.5320.74
143_I311_V0.5320.74
34_P101_W0.5310.74
28_Y31_N0.5300.73
194_F337_S0.5290.73
59_P135_V0.5290.73
106_P125_R0.5290.73
187_G345_V0.5290.73
53_G338_V0.5280.73
81_A85_F0.5260.73
207_G281_L0.5260.73
335_T393_N0.5250.73
136_E337_S0.5250.73
40_K262_R0.5240.73
259_R345_V0.5240.73
147_L330_S0.5220.72
178_L405_V0.5190.72
132_W250_L0.5180.72
127_I391_V0.5170.72
335_T339_N0.5170.72
55_I64_A0.5160.71
212_H216_L0.5160.71
72_G406_M0.5160.71
50_I191_I0.5150.71
228_A232_S0.5150.71
67_L290_T0.5150.71
307_Y310_P0.5150.71
182_L421_A0.5140.71
205_I327_L0.5140.71
119_R356_P0.5140.71
221_S224_F0.5130.71
452_V455_F0.5130.71
468_W472_L0.5130.71
131_F384_N0.5130.71
182_L366_A0.5120.71
315_F318_T0.5120.71
209_L247_W0.5120.71
355_F473_F0.5120.71
133_F180_N0.5110.71
308_V318_T0.5110.71
122_V354_L0.5100.71
418_I423_L0.5100.71
285_I333_I0.5090.70
182_L450_V0.5090.70
176_F336_I0.5090.70
200_P404_G0.5090.70
128_S249_T0.5090.70
182_L186_K0.5080.70
60_A84_Y0.5070.70
43_T266_D0.5070.70
213_V292_A0.5060.70
215_T218_N0.5060.70
346_S349_Y0.5050.70
86_T116_R0.5040.70
168_H172_S0.5020.69
133_F253_N0.5010.69
51_W271_Q0.5000.69
89_I425_K0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.875 100 0.223 Contact Map
4djkA 2 0.8381 99.3 0.864 Contact Map
3l1lA 2 0.8156 99.1 0.876 Contact Map
3dh4A 3 0.8217 99 0.882 Contact Map
3giaA 1 0.832 99 0.885 Contact Map
2xq2A 2 0.8381 98.7 0.894 Contact Map
4wgvA 2 0.7418 98.4 0.904 Contact Map
4us3A 1 0.8258 97.5 0.923 Contact Map
2a65A 2 0.8873 95.2 0.94 Contact Map
4xp4A 1 0.9119 93.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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