GREMLIN Database
Q97X49 - Amino acid transporter related protein
UniProt: Q97X49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 616 (470)
Sequences: 2883 (1910)
Seq/√Len: 88.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_I384_L6.8811.00
319_A323_V5.1491.00
152_I381_I4.1281.00
351_S361_K4.1201.00
155_L384_L3.6621.00
222_L225_I3.6061.00
410_I439_T3.4701.00
80_V353_E3.3471.00
57_I437_V3.2111.00
360_F375_G3.1841.00
159_F377_L3.1011.00
221_M224_A3.0971.00
374_V378_I3.0211.00
475_K479_L2.9951.00
90_Y471_N2.9881.00
152_I156_F2.8521.00
414_T417_K2.8501.00
189_I193_F2.8191.00
148_L152_I2.7511.00
65_A435_A2.6791.00
205_G208_P2.6431.00
84_F92_G2.5341.00
419_A423_K2.4441.00
480_K485_V2.4191.00
471_N475_K2.3611.00
107_P380_S2.2951.00
473_A476_V2.2301.00
413_Q436_P2.2281.00
406_I443_L2.2121.00
221_M225_I2.1981.00
206_I209_Q2.1941.00
465_I469_W2.1851.00
418_T421_D2.1601.00
420_P423_K2.1541.00
418_T422_L2.1251.00
457_I460_I2.1131.00
354_E358_S2.1081.00
433_L437_V2.1031.00
204_G207_F2.0981.00
118_L329_I2.0751.00
281_N284_S2.0551.00
438_A442_S2.0331.00
478_G481_K2.0271.00
359_I371_W2.0121.00
461_L466_P2.0011.00
347_L356_F1.9791.00
100_L376_S1.9661.00
15_L170_G1.9651.00
146_P149_L1.9551.00
223_Y226_P1.9311.00
47_S206_I1.9301.00
406_I439_T1.9301.00
20_L247_A1.9291.00
458_V465_I1.9261.00
474_V478_G1.9221.00
219_V223_Y1.9151.00
42_S45_G1.8731.00
46_P277_I1.8651.00
88_G472_Y1.8541.00
191_L275_A1.8541.00
471_N474_V1.8501.00
460_I464_G1.8331.00
214_N218_P1.8331.00
284_S311_A1.8291.00
22_F264_I1.8181.00
443_L447_Y1.8111.00
436_P440_I1.8011.00
65_A409_G1.7821.00
459_S464_G1.7521.00
246_E345_R1.7451.00
462_F465_I1.7281.00
104_I376_S1.7241.00
419_A422_L1.7221.00
477_L481_K1.7031.00
213_S216_V1.6921.00
371_W374_V1.6851.00
252_K256_R1.6751.00
481_K484_G1.6741.00
491_Q495_N1.6581.00
460_I465_I1.6561.00
413_Q439_T1.6541.00
214_N217_G1.6501.00
220_G223_Y1.6461.00
461_L465_I1.6451.00
205_G209_Q1.6381.00
215_Y219_V1.6301.00
222_L226_P1.6241.00
466_P470_V1.6171.00
217_G220_G1.6081.00
122_N125_L1.5951.00
182_I323_V1.5931.00
216_V219_V1.5531.00
343_S376_S1.5491.00
183_I323_V1.5451.00
454_L458_V1.5421.00
97_F356_F1.5301.00
188_F271_F1.5241.00
163_Y374_V1.5181.00
409_G438_A1.5101.00
149_L153_L1.5031.00
461_L464_G1.4971.00
418_T423_K1.4821.00
202_N205_G1.4790.99
309_L314_I1.4730.99
63_G262_I1.4710.99
87_H91_T1.4670.99
459_S462_F1.4610.99
61_F437_V1.4530.99
475_K482_W1.4510.99
458_V462_F1.4450.99
208_P212_A1.4430.99
199_N202_N1.4310.99
476_V479_L1.4310.99
280_I284_S1.4280.99
358_S361_K1.4180.99
154_L333_T1.4160.99
190_L314_I1.4160.99
122_N126_S1.4130.99
47_S205_G1.4130.99
207_F211_V1.4120.99
219_V224_A1.4050.99
281_N311_A1.4040.99
47_S50_F1.3990.99
459_S463_I1.3930.99
458_V461_L1.3920.99
475_K478_G1.3710.99
159_F374_V1.3710.99
219_V222_L1.3700.99
240_P258_I1.3690.99
48_G51_S1.3640.99
204_G209_Q1.3560.99
186_V320_W1.3500.99
364_N370_I1.3480.99
483_V486_S1.3470.99
204_G208_P1.3390.99
478_G484_G1.3250.99
190_L194_A1.3220.99
184_P269_Y1.3070.99
190_L309_L1.2900.99
181_L185_V1.2870.99
106_T110_E1.2800.99
340_T373_L1.2770.98
471_N478_G1.2700.98
362_K371_W1.2680.98
470_V474_V1.2520.98
459_S466_P1.2510.98
192_F196_K1.2500.98
100_L104_I1.2450.98
93_F97_F1.2430.98
303_S307_S1.2390.98
277_I284_S1.2380.98
359_I362_K1.2330.98
457_I464_G1.2270.98
421_D424_R1.2270.98
480_K483_V1.2250.98
152_I385_L1.2240.98
304_P307_S1.2160.98
492_L496_I1.2100.98
156_F381_I1.1980.98
56_G234_Y1.1890.98
220_G225_I1.1890.98
111_A336_G1.1850.98
434_V438_A1.1830.98
488_G491_Q1.1820.98
114_T154_L1.1810.97
249_N255_W1.1780.97
242_E342_T1.1700.97
439_T443_L1.1660.97
412_L416_R1.1650.97
90_Y472_Y1.1520.97
214_N225_I1.1480.97
24_S27_A1.1450.97
182_I186_V1.1430.97
286_R310_E1.1410.97
123_P126_S1.1390.97
474_V477_L1.1390.97
110_E335_T1.1370.97
457_I465_I1.1350.97
345_R363_L1.1340.97
115_I150_L1.1320.97
235_L401_T1.1320.97
41_A48_G1.1310.97
186_V190_L1.1260.97
457_I461_L1.1220.97
210_S213_S1.1200.97
104_I379_A1.1170.96
16_S248_K1.1150.96
347_L351_S1.1130.96
222_L448_W1.1070.96
213_S217_G1.1060.96
481_K486_S1.1060.96
459_S465_I1.0950.96
11_L363_L1.0910.96
198_N202_N1.0900.96
148_L384_L1.0890.96
306_Y321_G1.0890.96
406_I442_S1.0860.96
460_I467_I1.0850.96
61_F438_A1.0840.96
274_I278_G1.0830.96
151_S384_L1.0800.96
95_I407_M1.0710.96
110_E339_Y1.0700.96
478_G485_V1.0680.95
340_T344_A1.0680.95
199_N203_Y1.0650.95
155_L380_S1.0610.95
117_Y328_A1.0600.95
436_P439_T1.0600.95
256_R260_L1.0600.95
309_L324_L1.0570.95
111_A158_Y1.0550.95
406_I410_I1.0500.95
62_I409_G1.0490.95
465_I468_F1.0470.95
417_K432_S1.0430.95
32_G36_A1.0380.95
508_L511_D1.0330.95
77_G80_V1.0330.95
419_A424_R1.0270.94
126_S149_L1.0250.94
468_F479_L1.0170.94
481_K485_V1.0160.94
478_G483_V1.0130.94
30_G34_L1.0130.94
269_Y272_L1.0110.94
100_L347_L1.0090.94
240_P337_L1.0040.94
203_Y207_F0.9960.93
420_P424_R0.9930.93
61_F434_V0.9910.93
118_L150_L0.9910.93
216_V220_G0.9880.93
29_I34_L0.9870.93
49_V274_I0.9870.93
479_L482_W0.9840.93
282_W285_A0.9840.93
57_I61_F0.9840.93
219_V226_P0.9830.93
490_T493_I0.9760.93
468_F472_Y0.9760.93
41_A45_G0.9690.92
468_F474_V0.9680.92
371_W375_G0.9650.92
203_Y206_I0.9640.92
500_I503_Y0.9570.92
395_G398_S0.9570.92
171_K175_A0.9560.92
156_F377_L0.9530.92
216_V223_Y0.9490.92
185_V189_I0.9430.91
479_L483_V0.9400.91
458_V464_G0.9390.91
71_S252_K0.9360.91
462_F466_P0.9360.91
215_Y218_P0.9330.91
90_Y94_V0.9320.91
153_L156_F0.9310.91
254_V258_I0.9310.91
270_T274_I0.9300.91
478_G482_W0.9210.90
17_L21_T0.9210.90
509_N512_S0.9180.90
435_A438_A0.9170.90
39_S43_L0.9170.90
58_M402_V0.9150.90
282_W286_R0.9140.90
241_I408_G0.9100.90
111_A154_L0.9020.89
112_L386_P0.9010.89
208_P213_S0.9000.89
209_Q213_S0.8990.89
455_F458_V0.8970.89
438_A453_T0.8960.89
158_Y336_G0.8950.89
454_L457_I0.8930.89
155_L381_I0.8880.89
498_L501_F0.8860.89
198_N201_T0.8860.89
449_A453_T0.8830.88
187_T272_L0.8810.88
435_A439_T0.8810.88
508_L512_S0.8810.88
265_A269_Y0.8770.88
448_W452_T0.8750.88
183_I324_L0.8690.88
263_V267_L0.8690.88
211_V215_Y0.8680.88
25_L181_L0.8670.88
80_V96_A0.8660.87
431_A435_A0.8620.87
96_A350_L0.8610.87
435_A453_T0.8610.87
188_F191_L0.8600.87
207_F282_W0.8600.87
179_W183_I0.8590.87
92_G236_G0.8580.87
178_V182_I0.8570.87
50_F54_I0.8570.87
257_A265_A0.8570.87
161_I172_T0.8560.87
340_T377_L0.8550.87
436_P450_G0.8540.87
60_M259_I0.8530.87
506_L509_N0.8520.87
83_P353_E0.8500.87
170_G337_L0.8470.86
454_L471_N0.8450.86
75_K81_R0.8450.86
207_F210_S0.8440.86
250_P255_W0.8430.86
450_G453_T0.8410.86
444_L447_Y0.8390.86
494_V497_A0.8390.86
348_Y363_L0.8370.86
248_K253_N0.8360.86
216_V326_I0.8360.86
77_G81_R0.8320.85
302_N306_Y0.8300.85
215_Y220_G0.8290.85
412_L435_A0.8290.85
474_V481_K0.8280.85
477_L485_V0.8260.85
319_A322_Y0.8260.85
307_S311_A0.8260.85
417_K482_W0.8250.85
507_V511_D0.8230.85
157_I333_T0.8220.85
84_F89_S0.8220.85
363_L367_R0.8210.85
314_I321_G0.8190.84
120_S306_Y0.8150.84
66_Y82_Y0.8150.84
360_F372_S0.8140.84
56_G266_I0.8140.84
203_Y282_W0.8130.84
162_N337_L0.8120.84
432_S435_A0.8110.84
52_W55_A0.8110.84
71_S256_R0.8100.84
425_G428_I0.8080.84
497_A501_F0.8070.84
358_S443_L0.8060.83
218_P225_I0.8060.83
304_P312_E0.8060.83
455_F462_F0.8030.83
352_A367_R0.8020.83
440_I444_L0.8020.83
205_G210_S0.7970.83
486_S489_I0.7950.83
63_G263_V0.7940.83
168_I172_T0.7910.82
275_A279_A0.7890.82
192_F350_L0.7890.82
320_W323_V0.7850.82
68_E416_R0.7830.82
88_G477_L0.7820.82
125_L149_L0.7820.82
476_V483_V0.7800.81
216_V225_I0.7790.81
214_N221_M0.7790.81
205_G211_V0.7780.81
471_N487_L0.7770.81
34_L75_K0.7750.81
85_Y490_T0.7750.81
170_G341_G0.7730.81
458_V473_A0.7710.81
455_F463_I0.7710.81
70_G82_Y0.7700.81
356_F360_F0.7700.81
198_N205_G0.7690.80
181_L463_I0.7660.80
28_M235_L0.7660.80
34_L180_K0.7630.80
24_S28_M0.7610.80
507_V510_N0.7570.79
208_P211_V0.7570.79
345_R369_P0.7560.79
215_Y226_P0.7560.79
494_V498_L0.7550.79
163_Y373_L0.7540.79
504_Y507_V0.7520.79
505_N510_N0.7490.79
474_V487_L0.7480.79
443_L469_W0.7480.79
502_G505_N0.7470.79
471_N477_L0.7460.78
179_W327_D0.7450.78
424_R428_I0.7440.78
119_T147_G0.7440.78
504_Y509_N0.7440.78
433_L436_P0.7370.78
124_T182_I0.7350.77
216_V226_P0.7340.77
303_S306_Y0.7340.77
249_N252_K0.7320.77
303_S320_W0.7300.77
76_T245_G0.7300.77
359_I375_G0.7250.76
80_V349_G0.7240.76
206_I211_V0.7230.76
126_S147_G0.7210.76
28_M239_Q0.7200.76
92_G438_A0.7190.76
81_R85_Y0.7170.76
106_T235_L0.7160.76
459_S468_F0.7150.75
505_N508_L0.7130.75
118_L126_S0.7120.75
91_T94_V0.7110.75
193_F197_S0.7100.75
69_L408_G0.7090.75
189_I205_G0.7090.75
206_I210_S0.7090.75
82_Y346_T0.7080.75
413_Q417_K0.7070.75
359_I374_V0.7070.75
126_S145_L0.7070.75
11_L168_I0.7060.75
498_L502_G0.7050.74
391_Y394_V0.7050.74
257_A261_S0.7010.74
83_P95_I0.7010.74
382_I385_L0.7010.74
440_I465_I0.6990.74
373_L442_S0.6980.74
34_L183_I0.6970.74
73_I86_S0.6960.73
39_S42_S0.6940.73
482_W485_V0.6940.73
84_F353_E0.6920.73
205_G275_A0.6920.73
212_A215_Y0.6910.73
464_G469_W0.6900.73
468_F471_N0.6900.73
45_G52_W0.6880.73
402_V442_S0.6870.73
443_L466_P0.6870.73
22_F27_A0.6870.73
233_S445_I0.6870.73
159_F340_T0.6860.72
472_Y475_K0.6830.72
103_A342_T0.6830.72
273_Q276_F0.6820.72
173_N177_T0.6820.72
29_I32_G0.6820.72
271_F274_I0.6790.72
220_G226_P0.6790.72
272_L275_A0.6790.72
109_I394_V0.6760.71
199_N204_G0.6760.71
505_N509_N0.6750.71
107_P235_L0.6740.71
189_I323_V0.6740.71
44_A48_G0.6740.71
51_S224_A0.6740.71
469_W473_A0.6730.71
120_S322_Y0.6730.71
162_N170_G0.6720.71
470_V473_A0.6710.71
414_T485_V0.6700.71
151_S387_F0.6700.71
477_L480_K0.6690.71
188_F275_A0.6690.71
323_V327_D0.6670.70
106_T397_N0.6670.70
487_L490_T0.6650.70
148_L387_F0.6640.70
118_L121_V0.6640.70
65_A442_S0.6630.70
155_L159_F0.6630.70
54_I58_M0.6620.70
238_R242_E0.6620.70
464_G468_F0.6580.69
488_G508_L0.6580.69
218_P223_Y0.6580.69
245_G348_Y0.6580.69
105_S400_A0.6570.69
364_N368_I0.6560.69
432_S438_A0.6550.69
56_G59_V0.6540.69
239_Q342_T0.6540.69
102_S400_A0.6530.69
208_P217_G0.6530.69
275_A278_G0.6520.69
253_N256_R0.6520.69
18_L22_F0.6490.68
212_A216_V0.6490.68
407_M464_G0.6480.68
83_P407_M0.6470.68
167_K170_G0.6410.67
474_V485_V0.6410.67
156_F160_V0.6400.67
322_Y326_I0.6390.67
258_I261_S0.6380.67
502_G507_V0.6370.67
51_S54_I0.6370.67
181_L403_L0.6360.67
183_I327_D0.6360.67
157_I440_I0.6360.67
472_Y476_V0.6360.67
503_Y510_N0.6350.67
157_I161_I0.6340.66
85_Y89_S0.6330.66
77_G165_G0.6330.66
246_E348_Y0.6330.66
99_Y103_A0.6330.66
45_G49_V0.6330.66
76_T324_L0.6330.66
187_T190_L0.6320.66
477_L482_W0.6310.66
202_N206_I0.6310.66
454_L459_S0.6300.66
107_P339_Y0.6290.66
191_L195_F0.6280.66
455_F468_F0.6250.65
464_G472_Y0.6240.65
345_R389_S0.6240.65
121_V321_G0.6230.65
185_V310_E0.6220.65
47_S51_S0.6210.65
114_T333_T0.6200.65
85_Y415_L0.6200.65
101_L166_I0.6200.65
162_N445_I0.6190.65
149_L495_N0.6190.65
391_Y497_A0.6190.65
497_A500_I0.6190.65
16_S19_D0.6190.65
201_T375_G0.6180.64
26_S177_T0.6170.64
385_L392_L0.6160.64
119_T124_T0.6150.64
33_W113_A0.6150.64
45_G51_S0.6150.64
183_I320_W0.6140.64
375_G379_A0.6130.64
346_T404_T0.6120.64
191_L279_A0.6120.64
201_T205_G0.6120.64
29_I180_K0.6120.64
194_A312_E0.6120.64
448_W453_T0.6110.64
309_L320_W0.6110.64
116_E147_G0.6110.64
23_L181_L0.6100.63
211_V216_V0.6090.63
224_A227_S0.6090.63
260_L263_V0.6080.63
253_N257_A0.6080.63
281_N285_A0.6070.63
212_A218_P0.6050.63
86_S346_T0.6050.63
308_E312_E0.6050.63
231_I269_Y0.6030.63
457_I466_P0.6030.63
369_P372_S0.6020.62
474_V482_W0.6000.62
340_T376_S0.5990.62
95_I442_S0.5990.62
464_G467_I0.5970.62
35_L332_P0.5970.62
234_Y237_F0.5960.62
458_V468_F0.5960.62
102_S401_T0.5950.62
216_V224_A0.5950.62
360_F371_W0.5940.61
352_A470_V0.5920.61
83_P411_G0.5920.61
247_A254_V0.5920.61
199_N205_G0.5910.61
58_M441_V0.5900.61
194_A197_S0.5890.61
76_T81_R0.5880.61
93_F467_I0.5870.61
18_L171_K0.5870.61
432_S436_P0.5870.61
267_L271_F0.5860.60
203_Y281_N0.5850.60
303_S309_L0.5840.60
15_L384_L0.5830.60
185_V268_I0.5830.60
80_V346_T0.5820.60
305_F321_G0.5820.60
501_F510_N0.5790.59
89_S355_Y0.5790.59
275_A285_A0.5780.59
331_S336_G0.5770.59
345_R348_Y0.5750.59
343_S347_L0.5750.59
57_I469_W0.5740.59
245_G363_L0.5720.59
116_E119_T0.5710.58
78_G338_V0.5700.58
52_W252_K0.5700.58
114_T338_V0.5700.58
264_I268_I0.5700.58
202_N283_E0.5700.58
231_I334_G0.5690.58
262_I266_I0.5680.58
23_L173_N0.5670.58
179_W330_L0.5660.58
95_I99_Y0.5650.58
18_L174_S0.5640.57
221_M309_L0.5640.57
173_N338_V0.5630.57
108_S235_L0.5630.57
280_I283_E0.5630.57
212_A225_I0.5620.57
185_V197_S0.5620.57
17_L253_N0.5600.57
470_V475_K0.5590.57
66_Y343_S0.5580.57
145_L149_L0.5570.57
48_G273_Q0.5560.56
458_V474_V0.5560.56
212_A221_M0.5540.56
221_M226_P0.5540.56
46_P246_E0.5540.56
469_W472_Y0.5530.56
70_G114_T0.5520.56
501_F504_Y0.5510.56
246_E507_V0.5500.56
488_G492_L0.5490.55
408_G412_L0.5490.55
24_S240_P0.5480.55
254_V269_Y0.5480.55
57_I195_F0.5470.55
102_S109_I0.5470.55
410_I414_T0.5460.55
115_I118_L0.5460.55
309_L321_G0.5460.55
440_I463_I0.5430.55
180_K331_S0.5410.54
203_Y208_P0.5410.54
305_F309_L0.5390.54
347_L360_F0.5370.54
437_V462_F0.5370.54
33_W37_S0.5370.54
52_W273_Q0.5360.54
165_G241_I0.5350.54
36_A390_W0.5350.54
54_I441_V0.5350.54
219_V225_I0.5340.53
235_L405_Y0.5340.53
406_I446_V0.5340.53
277_I282_W0.5330.53
96_A156_F0.5330.53
54_I154_L0.5320.53
347_L510_N0.5320.53
335_T338_V0.5320.53
159_F163_Y0.5310.53
500_I506_L0.5310.53
350_L397_N0.5300.53
458_V467_I0.5300.53
45_G92_G0.5300.53
456_Y459_S0.5290.53
161_I382_I0.5290.53
76_T233_S0.5270.52
215_Y222_L0.5260.52
435_A442_S0.5250.52
121_V325_L0.5250.52
221_M228_A0.5240.52
240_P257_A0.5240.52
501_F505_N0.5230.52
50_F281_N0.5230.52
160_V214_N0.5230.52
162_N373_L0.5220.52
158_Y375_G0.5210.52
461_L470_V0.5210.52
268_I433_L0.5190.51
42_S46_P0.5190.51
14_E396_F0.5180.51
125_L150_L0.5180.51
227_S230_I0.5150.51
336_G339_Y0.5150.51
90_Y468_F0.5140.51
476_V482_W0.5130.51
400_A404_T0.5120.50
124_T185_V0.5120.50
205_G467_I0.5120.50
200_F206_I0.5110.50
217_G221_M0.5100.50
360_F478_G0.5100.50
457_I462_F0.5090.50
429_P432_S0.5090.50
385_L388_P0.5090.50
23_L26_S0.5080.50
162_N341_G0.5080.50
474_V484_G0.5080.50
473_A477_L0.5070.50
106_T109_I0.5070.50
212_A219_V0.5070.50
246_E363_L0.5070.50
192_F271_F0.5070.50
214_N220_G0.5040.49
477_L486_S0.5040.49
330_L413_Q0.5030.49
16_S77_G0.5020.49
147_G389_S0.5020.49
482_W486_S0.5010.49
85_Y489_I0.5010.49
51_S59_V0.5010.49
96_A148_L0.5010.49
109_I339_Y0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.6769 100 0.524 Contact Map
3giaA 1 0.6948 100 0.556 Contact Map
4djkA 2 0.6932 100 0.566 Contact Map
2jlnA 1 0.6932 98.8 0.911 Contact Map
3dh4A 3 0.7532 98.3 0.923 Contact Map
2xq2A 2 0.7955 98.2 0.926 Contact Map
4wgvA 2 0.6055 97.8 0.933 Contact Map
4xp4A 1 0.7435 97.3 0.939 Contact Map
4us3A 1 0.6461 96.7 0.944 Contact Map
2a65A 2 0.7175 95.5 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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