Q97X42 - SULSO - GREMLIN Contacts

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Q97X42 - Uncharacterized protein

UniProt:	Q97X42	Sequences: MMMTVGLFISHGSPTILTEENKWKDLLRNIGKDVMEKYKPDTIIVSSPHFISWSGDYYIENSEKLECIQDYYGFPEETYKYCYEAYNDVELVNEIVMASDGIIKEDNRWGLDHGAWIPLLFMFPEYKPKVVTISITDNSPESHYAIGEKIRNAVEKLGRKVLFLATGSPTHRLDLFYFKITPKPTNFDIILMDMIKSGEFDKILRINELYPKEYQTAMPEGNLNTLYILLGFVKPKRAEILGYDTPWPGVSMLAASFYD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	259 (243)
Sequences:	2052 (1442)
Seq/√Len:	92.5

ECOLI - YGID
SULSO - Q97X42 Q97WR5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
94_E	159_R	7.490	1.00
76_E	80_K	5.629	1.00
39_K	127_K	3.986	1.00
199_E	202_K	3.392	1.00
41_D	160_K	3.310	1.00
186_N	212_K	2.997	1.00
145_A	148_E	2.976	1.00
61_N	105_E	2.890	1.00
141_E	145_A	2.794	1.00
205_R	208_E	2.685	1.00
223_L	227_Y	2.685	1.00
42_T	161_V	2.679	1.00
20_E	25_D	2.643	1.00
88_D	131_V	2.542	1.00
5_V	154_V	2.509	1.00
58_Y	106_D	2.466	1.00
207_N	214_Y	2.422	1.00
68_I	110_G	2.311	1.00
190_I	210_Y	2.305	1.00
139_S	142_S	2.244	1.00
44_I	133_I	2.159	1.00
169_P	191_L	2.158	1.00
163_F	232_F	2.157	1.00
43_I	128_P	2.082	1.00
96_V	105_E	2.004	1.00
89_V	92_V	1.959	1.00
175_L	215_Q	1.947	1.00
81_Y	120_L	1.945	1.00
136_T	143_H	1.937	1.00
46_S	228_I	1.886	1.00
119_L	130_V	1.859	1.00
191_L	223_L	1.826	1.00
57_Y	136_T	1.777	1.00
44_I	163_F	1.772	1.00
144_Y	200_F	1.757	1.00
44_I	95_I	1.672	1.00
165_A	229_L	1.666	1.00
10_S	168_S	1.648	1.00
60_E	132_T	1.642	1.00
59_I	96_V	1.640	1.00
147_G	231_G	1.614	1.00
240_I	243_Y	1.606	1.00
155_E	159_R	1.595	1.00
188_D	253_L	1.588	1.00
206_I	213_E	1.585	1.00
69_Q	82_C	1.558	1.00
51_I	221_G	1.541	1.00
29_N	32_K	1.529	1.00
51_I	219_P	1.512	1.00
45_V	115_A	1.511	1.00
135_I	221_G	1.507	1.00
9_I	164_L	1.496	1.00
147_G	232_F	1.493	1.00
77_E	80_K	1.492	1.00
168_S	252_M	1.489	1.00
48_P	221_G	1.478	1.00
111_L	115_A	1.478	1.00
6_G	232_F	1.471	1.00
194_M	202_K	1.463	1.00
95_I	131_V	1.461	1.00
45_V	119_L	1.403	0.99
51_I	137_D	1.395	0.99
71_Y	116_W	1.387	0.99
58_Y	104_K	1.386	0.99
6_G	229_L	1.385	0.99
190_I	194_M	1.356	0.99
182_P	186_N	1.351	0.99
188_D	251_S	1.333	0.99
4_T	123_F	1.331	0.99
41_D	159_R	1.323	0.99
97_M	102_I	1.320	0.99
59_I	95_I	1.317	0.99
45_V	164_L	1.296	0.99
66_E	109_W	1.288	0.99
38_Y	160_K	1.286	0.99
100_D	149_K	1.271	0.99
56_D	136_T	1.247	0.99
57_Y	146_I	1.234	0.98
210_Y	213_E	1.229	0.98
96_V	103_I	1.228	0.98
21_N	24_K	1.213	0.98
84_E	126_Y	1.212	0.98
4_T	38_Y	1.203	0.98
136_T	142_S	1.198	0.98
194_M	199_E	1.192	0.98
185_T	189_I	1.189	0.98
148_E	200_F	1.182	0.98
67_C	111_L	1.179	0.98
86_Y	89_V	1.171	0.98
4_T	162_L	1.161	0.98
38_Y	123_F	1.159	0.98
192_M	196_K	1.156	0.98
61_N	107_N	1.155	0.98
144_Y	204_L	1.154	0.98
87_N	92_V	1.126	0.97
151_R	234_K	1.104	0.97
23_W	244_D	1.097	0.97
17_L	120_L	1.086	0.96
143_H	228_I	1.083	0.96
44_I	131_V	1.080	0.96
144_Y	230_L	1.079	0.96
42_T	91_L	1.072	0.96
201_D	205_R	1.050	0.96
17_L	121_F	1.044	0.96
115_A	132_T	1.044	0.96
198_G	201_D	1.043	0.95
67_C	85_A	1.042	0.95
188_D	192_M	1.042	0.95
195_I	238_A	1.026	0.95
135_I	224_N	1.024	0.95
144_Y	148_E	1.006	0.95
44_I	161_V	1.004	0.94
98_A	102_I	1.002	0.94
91_L	95_I	1.001	0.94
98_A	101_G	1.000	0.94
88_D	95_I	0.996	0.94
88_D	91_L	0.994	0.94
111_L	130_V	0.990	0.94
59_I	105_E	0.983	0.94
73_G	79_Y	0.981	0.94
59_I	133_I	0.977	0.94
175_L	183_K	0.977	0.94
50_F	132_T	0.975	0.94
46_S	150_I	0.962	0.93
91_L	131_V	0.961	0.93
78_T	116_W	0.960	0.93
181_T	249_G	0.956	0.93
39_K	128_P	0.943	0.92
74_F	79_Y	0.943	0.92
189_I	193_D	0.938	0.92
15_T	78_T	0.938	0.92
9_I	27_L	0.931	0.92
9_I	118_P	0.927	0.92
4_T	160_K	0.923	0.92
90_E	93_N	0.921	0.91
40_P	123_F	0.920	0.91
123_F	162_L	0.920	0.91
25_D	28_R	0.916	0.91
72_Y	76_E	0.915	0.91
140_P	206_I	0.914	0.91
180_I	185_T	0.911	0.91
188_D	243_Y	0.910	0.91
24_K	28_R	0.902	0.91
26_L	29_N	0.898	0.90
24_K	121_F	0.895	0.90
93_N	96_V	0.895	0.90
221_G	224_N	0.889	0.90
40_P	128_P	0.886	0.90
46_S	133_I	0.884	0.90
240_I	253_L	0.882	0.90
193_D	197_S	0.872	0.89
17_L	117_I	0.870	0.89
13_S	16_I	0.867	0.89
145_A	149_K	0.865	0.89
67_C	82_C	0.852	0.88
10_S	217_A	0.851	0.88
28_R	32_K	0.845	0.88
43_I	83_Y	0.845	0.88
148_E	151_R	0.840	0.87
27_L	121_F	0.839	0.87
30_I	34_V	0.834	0.87
31_G	34_V	0.827	0.86
123_F	127_K	0.826	0.86
55_G	138_N	0.824	0.86
61_N	96_V	0.818	0.86
200_F	204_L	0.818	0.86
18_T	78_T	0.801	0.85
61_N	106_D	0.800	0.85
76_E	79_Y	0.792	0.84
141_E	204_L	0.790	0.84
93_N	105_E	0.786	0.83
57_Y	133_I	0.785	0.83
6_G	154_V	0.783	0.83
75_P	79_Y	0.780	0.83
47_S	60_E	0.780	0.83
183_K	215_Q	0.778	0.83
220_E	224_N	0.778	0.83
7_L	33_D	0.773	0.82
71_Y	78_T	0.772	0.82
241_L	244_D	0.770	0.82
114_G	132_T	0.767	0.82
142_S	145_A	0.766	0.82
27_L	31_G	0.760	0.81
18_T	77_E	0.759	0.81
23_W	26_L	0.757	0.81
20_E	24_K	0.757	0.81
198_G	238_A	0.755	0.81
206_I	214_Y	0.744	0.80
169_P	253_L	0.742	0.80
23_W	27_L	0.740	0.80
47_S	115_A	0.738	0.79
251_S	254_A	0.738	0.79
26_L	254_A	0.734	0.79
27_L	34_V	0.732	0.79
52_S	56_D	0.731	0.79
245_T	251_S	0.726	0.78
241_L	253_L	0.724	0.78
62_S	111_L	0.722	0.78
200_F	230_L	0.722	0.78
60_E	111_L	0.712	0.77
51_I	135_I	0.711	0.77
72_Y	75_P	0.709	0.77
43_I	162_L	0.705	0.76
140_P	220_E	0.704	0.76
44_I	153_A	0.704	0.76
64_K	84_E	0.703	0.76
125_E	145_A	0.699	0.76
117_I	120_L	0.699	0.76
11_H	14_P	0.694	0.75
31_G	123_F	0.693	0.75
22_K	244_D	0.692	0.75
183_K	216_T	0.690	0.75
207_N	220_E	0.685	0.74
52_S	58_Y	0.685	0.74
93_N	148_E	0.685	0.74
55_G	137_D	0.685	0.74
191_L	226_L	0.683	0.74
245_T	253_L	0.680	0.74
238_A	241_L	0.678	0.73
170_T	216_T	0.678	0.73
151_R	235_P	0.673	0.73
85_A	111_L	0.673	0.73
154_V	160_K	0.670	0.73
43_I	169_P	0.670	0.73
197_S	202_K	0.669	0.72
152_N	155_E	0.660	0.71
65_L	111_L	0.654	0.71
66_E	108_R	0.652	0.71
186_N	189_I	0.651	0.70
7_L	122_M	0.651	0.70
192_M	240_I	0.650	0.70
95_I	133_I	0.649	0.70
71_Y	170_T	0.649	0.70
192_M	243_Y	0.646	0.70
184_P	245_T	0.644	0.70
15_T	18_T	0.644	0.70
240_I	255_A	0.634	0.68
143_H	224_N	0.632	0.68
170_T	217_A	0.628	0.68
85_A	126_Y	0.626	0.67
40_P	43_I	0.625	0.67
204_L	227_Y	0.624	0.67
16_I	117_I	0.624	0.67
10_S	16_I	0.622	0.67
15_T	19_E	0.622	0.67
26_L	241_L	0.622	0.67
44_I	160_K	0.620	0.67
8_F	12_G	0.618	0.66
50_F	109_W	0.616	0.66
187_F	190_I	0.615	0.66
139_S	143_H	0.615	0.66
152_N	180_I	0.613	0.66
238_A	242_G	0.613	0.66
56_D	104_K	0.612	0.66
48_P	166_T	0.611	0.66
227_Y	230_L	0.611	0.66
14_P	74_F	0.608	0.65
102_I	146_I	0.608	0.65
102_I	149_K	0.605	0.65
43_I	122_M	0.605	0.65
52_S	134_S	0.603	0.65
28_R	121_F	0.603	0.65
29_N	33_D	0.602	0.64
97_M	146_I	0.602	0.64
182_P	185_T	0.602	0.64
72_Y	82_C	0.602	0.64
69_Q	116_W	0.600	0.64
100_D	145_A	0.598	0.64
34_V	122_M	0.597	0.64
64_K	86_Y	0.595	0.64
136_T	146_I	0.594	0.63
68_I	116_W	0.594	0.63
163_F	241_L	0.593	0.63
55_G	72_Y	0.592	0.63
184_P	216_T	0.592	0.63
28_R	148_E	0.590	0.63
11_H	166_T	0.587	0.62
95_I	103_I	0.586	0.62
203_I	230_L	0.583	0.62
116_W	170_T	0.583	0.62
170_T	173_L	0.582	0.62
206_I	220_E	0.581	0.62
249_G	253_L	0.581	0.62
67_C	84_E	0.579	0.61
15_T	75_P	0.577	0.61
189_I	192_M	0.574	0.61
17_L	24_K	0.573	0.61
17_L	78_T	0.572	0.60
196_K	239_E	0.570	0.60
33_D	239_E	0.569	0.60
51_I	220_E	0.566	0.60
82_C	120_L	0.563	0.59
144_Y	227_Y	0.563	0.59
93_N	189_I	0.563	0.59
22_K	26_L	0.563	0.59
16_I	168_S	0.563	0.59
27_L	188_D	0.562	0.59
70_D	74_F	0.559	0.59
65_L	84_E	0.557	0.58
101_G	145_A	0.557	0.58
140_P	224_N	0.555	0.58
67_C	132_T	0.555	0.58
132_T	166_T	0.554	0.58
234_K	238_A	0.552	0.58
48_P	51_I	0.550	0.58
7_L	30_I	0.550	0.58
63_E	89_V	0.549	0.57
10_S	169_P	0.549	0.57
24_K	30_I	0.548	0.57
67_C	116_W	0.547	0.57
31_G	170_T	0.545	0.57
65_L	143_H	0.544	0.57
23_W	30_I	0.543	0.57
212_K	215_Q	0.542	0.56
50_F	135_I	0.541	0.56
169_P	195_I	0.540	0.56
60_E	67_C	0.540	0.56
238_A	243_Y	0.539	0.56
169_P	251_S	0.539	0.56
41_D	88_D	0.539	0.56
202_K	205_R	0.538	0.56
190_I	211_P	0.537	0.56
72_Y	79_Y	0.536	0.56
9_I	122_M	0.535	0.55
6_G	163_F	0.534	0.55
190_I	229_L	0.534	0.55
70_D	73_G	0.533	0.55
61_N	131_V	0.532	0.55
83_Y	124_P	0.532	0.55
17_L	81_Y	0.531	0.55
226_L	255_A	0.529	0.55
43_I	119_L	0.529	0.55
99_S	197_S	0.527	0.54
125_E	208_E	0.526	0.54
193_D	196_K	0.525	0.54
192_M	253_L	0.523	0.54
188_D	245_T	0.520	0.53
194_M	197_S	0.518	0.53
60_E	131_V	0.517	0.53
25_D	29_N	0.515	0.53
10_S	170_T	0.515	0.53
13_S	72_Y	0.514	0.53
101_G	149_K	0.513	0.52
9_I	61_N	0.512	0.52
116_W	183_K	0.512	0.52
201_D	204_L	0.511	0.52
206_I	210_Y	0.511	0.52
195_I	226_L	0.510	0.52
214_Y	220_E	0.509	0.52
140_P	223_L	0.509	0.52
8_F	11_H	0.509	0.52
52_S	57_Y	0.509	0.52
57_Y	143_H	0.508	0.52
198_G	230_L	0.507	0.52
200_F	233_V	0.507	0.52
46_S	135_I	0.504	0.51
59_I	131_V	0.504	0.51
52_S	55_G	0.504	0.51
118_P	121_F	0.503	0.51
42_T	153_A	0.502	0.51
217_A	221_G	0.502	0.51
103_I	146_I	0.502	0.51
172_R	175_L	0.502	0.51
206_I	223_L	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pw6A	2	0.8958	100	0.274	Contact Map
1b4uB	2	0.9382	100	0.545	Contact Map
3wraA	2	0.9189	100	0.55	Contact Map
3vsjA	1	0.9653	100	0.56	Contact Map
3vsjB	2	0.9653	100	0.594	Contact Map
3bczA	1	0.8803	100	0.671	Contact Map
2o1sA	2	0.7761	30.6	0.966	Contact Map
3wj2A	4	0.7375	29	0.967	Contact Map
3dahA	5	0.4903	26.4	0.967	Contact Map
4twbA	2	0.4788	25.5	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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