GREMLIN Database
Q97X42 - Uncharacterized protein
UniProt: Q97X42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (243)
Sequences: 2052 (1442)
Seq/√Len: 92.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_E159_R7.4901.00
76_E80_K5.6291.00
39_K127_K3.9861.00
199_E202_K3.3921.00
41_D160_K3.3101.00
186_N212_K2.9971.00
145_A148_E2.9761.00
61_N105_E2.8901.00
141_E145_A2.7941.00
205_R208_E2.6851.00
223_L227_Y2.6851.00
42_T161_V2.6791.00
20_E25_D2.6431.00
88_D131_V2.5421.00
5_V154_V2.5091.00
58_Y106_D2.4661.00
207_N214_Y2.4221.00
68_I110_G2.3111.00
190_I210_Y2.3051.00
139_S142_S2.2441.00
44_I133_I2.1591.00
169_P191_L2.1581.00
163_F232_F2.1571.00
43_I128_P2.0821.00
96_V105_E2.0041.00
89_V92_V1.9591.00
175_L215_Q1.9471.00
81_Y120_L1.9451.00
136_T143_H1.9371.00
46_S228_I1.8861.00
119_L130_V1.8591.00
191_L223_L1.8261.00
57_Y136_T1.7771.00
44_I163_F1.7721.00
144_Y200_F1.7571.00
44_I95_I1.6721.00
165_A229_L1.6661.00
10_S168_S1.6481.00
60_E132_T1.6421.00
59_I96_V1.6401.00
147_G231_G1.6141.00
240_I243_Y1.6061.00
155_E159_R1.5951.00
188_D253_L1.5881.00
206_I213_E1.5851.00
69_Q82_C1.5581.00
51_I221_G1.5411.00
29_N32_K1.5291.00
51_I219_P1.5121.00
45_V115_A1.5111.00
135_I221_G1.5071.00
9_I164_L1.4961.00
147_G232_F1.4931.00
77_E80_K1.4921.00
168_S252_M1.4891.00
48_P221_G1.4781.00
111_L115_A1.4781.00
6_G232_F1.4711.00
194_M202_K1.4631.00
95_I131_V1.4611.00
45_V119_L1.4030.99
51_I137_D1.3950.99
71_Y116_W1.3870.99
58_Y104_K1.3860.99
6_G229_L1.3850.99
190_I194_M1.3560.99
182_P186_N1.3510.99
188_D251_S1.3330.99
4_T123_F1.3310.99
41_D159_R1.3230.99
97_M102_I1.3200.99
59_I95_I1.3170.99
45_V164_L1.2960.99
66_E109_W1.2880.99
38_Y160_K1.2860.99
100_D149_K1.2710.99
56_D136_T1.2470.99
57_Y146_I1.2340.98
210_Y213_E1.2290.98
96_V103_I1.2280.98
21_N24_K1.2130.98
84_E126_Y1.2120.98
4_T38_Y1.2030.98
136_T142_S1.1980.98
194_M199_E1.1920.98
185_T189_I1.1890.98
148_E200_F1.1820.98
67_C111_L1.1790.98
86_Y89_V1.1710.98
4_T162_L1.1610.98
38_Y123_F1.1590.98
192_M196_K1.1560.98
61_N107_N1.1550.98
144_Y204_L1.1540.98
87_N92_V1.1260.97
151_R234_K1.1040.97
23_W244_D1.0970.97
17_L120_L1.0860.96
143_H228_I1.0830.96
44_I131_V1.0800.96
144_Y230_L1.0790.96
42_T91_L1.0720.96
201_D205_R1.0500.96
17_L121_F1.0440.96
115_A132_T1.0440.96
198_G201_D1.0430.95
67_C85_A1.0420.95
188_D192_M1.0420.95
195_I238_A1.0260.95
135_I224_N1.0240.95
144_Y148_E1.0060.95
44_I161_V1.0040.94
98_A102_I1.0020.94
91_L95_I1.0010.94
98_A101_G1.0000.94
88_D95_I0.9960.94
88_D91_L0.9940.94
111_L130_V0.9900.94
59_I105_E0.9830.94
73_G79_Y0.9810.94
59_I133_I0.9770.94
175_L183_K0.9770.94
50_F132_T0.9750.94
46_S150_I0.9620.93
91_L131_V0.9610.93
78_T116_W0.9600.93
181_T249_G0.9560.93
39_K128_P0.9430.92
74_F79_Y0.9430.92
189_I193_D0.9380.92
15_T78_T0.9380.92
9_I27_L0.9310.92
9_I118_P0.9270.92
4_T160_K0.9230.92
90_E93_N0.9210.91
40_P123_F0.9200.91
123_F162_L0.9200.91
25_D28_R0.9160.91
72_Y76_E0.9150.91
140_P206_I0.9140.91
180_I185_T0.9110.91
188_D243_Y0.9100.91
24_K28_R0.9020.91
26_L29_N0.8980.90
24_K121_F0.8950.90
93_N96_V0.8950.90
221_G224_N0.8890.90
40_P128_P0.8860.90
46_S133_I0.8840.90
240_I253_L0.8820.90
193_D197_S0.8720.89
17_L117_I0.8700.89
13_S16_I0.8670.89
145_A149_K0.8650.89
67_C82_C0.8520.88
10_S217_A0.8510.88
28_R32_K0.8450.88
43_I83_Y0.8450.88
148_E151_R0.8400.87
27_L121_F0.8390.87
30_I34_V0.8340.87
31_G34_V0.8270.86
123_F127_K0.8260.86
55_G138_N0.8240.86
61_N96_V0.8180.86
200_F204_L0.8180.86
18_T78_T0.8010.85
61_N106_D0.8000.85
76_E79_Y0.7920.84
141_E204_L0.7900.84
93_N105_E0.7860.83
57_Y133_I0.7850.83
6_G154_V0.7830.83
75_P79_Y0.7800.83
47_S60_E0.7800.83
183_K215_Q0.7780.83
220_E224_N0.7780.83
7_L33_D0.7730.82
71_Y78_T0.7720.82
241_L244_D0.7700.82
114_G132_T0.7670.82
142_S145_A0.7660.82
27_L31_G0.7600.81
18_T77_E0.7590.81
23_W26_L0.7570.81
20_E24_K0.7570.81
198_G238_A0.7550.81
206_I214_Y0.7440.80
169_P253_L0.7420.80
23_W27_L0.7400.80
47_S115_A0.7380.79
251_S254_A0.7380.79
26_L254_A0.7340.79
27_L34_V0.7320.79
52_S56_D0.7310.79
245_T251_S0.7260.78
241_L253_L0.7240.78
62_S111_L0.7220.78
200_F230_L0.7220.78
60_E111_L0.7120.77
51_I135_I0.7110.77
72_Y75_P0.7090.77
43_I162_L0.7050.76
140_P220_E0.7040.76
44_I153_A0.7040.76
64_K84_E0.7030.76
125_E145_A0.6990.76
117_I120_L0.6990.76
11_H14_P0.6940.75
31_G123_F0.6930.75
22_K244_D0.6920.75
183_K216_T0.6900.75
207_N220_E0.6850.74
52_S58_Y0.6850.74
93_N148_E0.6850.74
55_G137_D0.6850.74
191_L226_L0.6830.74
245_T253_L0.6800.74
238_A241_L0.6780.73
170_T216_T0.6780.73
151_R235_P0.6730.73
85_A111_L0.6730.73
154_V160_K0.6700.73
43_I169_P0.6700.73
197_S202_K0.6690.72
152_N155_E0.6600.71
65_L111_L0.6540.71
66_E108_R0.6520.71
186_N189_I0.6510.70
7_L122_M0.6510.70
192_M240_I0.6500.70
95_I133_I0.6490.70
71_Y170_T0.6490.70
192_M243_Y0.6460.70
184_P245_T0.6440.70
15_T18_T0.6440.70
240_I255_A0.6340.68
143_H224_N0.6320.68
170_T217_A0.6280.68
85_A126_Y0.6260.67
40_P43_I0.6250.67
204_L227_Y0.6240.67
16_I117_I0.6240.67
10_S16_I0.6220.67
15_T19_E0.6220.67
26_L241_L0.6220.67
44_I160_K0.6200.67
8_F12_G0.6180.66
50_F109_W0.6160.66
187_F190_I0.6150.66
139_S143_H0.6150.66
152_N180_I0.6130.66
238_A242_G0.6130.66
56_D104_K0.6120.66
48_P166_T0.6110.66
227_Y230_L0.6110.66
14_P74_F0.6080.65
102_I146_I0.6080.65
102_I149_K0.6050.65
43_I122_M0.6050.65
52_S134_S0.6030.65
28_R121_F0.6030.65
29_N33_D0.6020.64
97_M146_I0.6020.64
182_P185_T0.6020.64
72_Y82_C0.6020.64
69_Q116_W0.6000.64
100_D145_A0.5980.64
34_V122_M0.5970.64
64_K86_Y0.5950.64
136_T146_I0.5940.63
68_I116_W0.5940.63
163_F241_L0.5930.63
55_G72_Y0.5920.63
184_P216_T0.5920.63
28_R148_E0.5900.63
11_H166_T0.5870.62
95_I103_I0.5860.62
203_I230_L0.5830.62
116_W170_T0.5830.62
170_T173_L0.5820.62
206_I220_E0.5810.62
249_G253_L0.5810.62
67_C84_E0.5790.61
15_T75_P0.5770.61
189_I192_M0.5740.61
17_L24_K0.5730.61
17_L78_T0.5720.60
196_K239_E0.5700.60
33_D239_E0.5690.60
51_I220_E0.5660.60
82_C120_L0.5630.59
144_Y227_Y0.5630.59
93_N189_I0.5630.59
22_K26_L0.5630.59
16_I168_S0.5630.59
27_L188_D0.5620.59
70_D74_F0.5590.59
65_L84_E0.5570.58
101_G145_A0.5570.58
140_P224_N0.5550.58
67_C132_T0.5550.58
132_T166_T0.5540.58
234_K238_A0.5520.58
48_P51_I0.5500.58
7_L30_I0.5500.58
63_E89_V0.5490.57
10_S169_P0.5490.57
24_K30_I0.5480.57
67_C116_W0.5470.57
31_G170_T0.5450.57
65_L143_H0.5440.57
23_W30_I0.5430.57
212_K215_Q0.5420.56
50_F135_I0.5410.56
169_P195_I0.5400.56
60_E67_C0.5400.56
238_A243_Y0.5390.56
169_P251_S0.5390.56
41_D88_D0.5390.56
202_K205_R0.5380.56
190_I211_P0.5370.56
72_Y79_Y0.5360.56
9_I122_M0.5350.55
6_G163_F0.5340.55
190_I229_L0.5340.55
70_D73_G0.5330.55
61_N131_V0.5320.55
83_Y124_P0.5320.55
17_L81_Y0.5310.55
226_L255_A0.5290.55
43_I119_L0.5290.55
99_S197_S0.5270.54
125_E208_E0.5260.54
193_D196_K0.5250.54
192_M253_L0.5230.54
188_D245_T0.5200.53
194_M197_S0.5180.53
60_E131_V0.5170.53
25_D29_N0.5150.53
10_S170_T0.5150.53
13_S72_Y0.5140.53
101_G149_K0.5130.52
9_I61_N0.5120.52
116_W183_K0.5120.52
201_D204_L0.5110.52
206_I210_Y0.5110.52
195_I226_L0.5100.52
214_Y220_E0.5090.52
140_P223_L0.5090.52
8_F11_H0.5090.52
52_S57_Y0.5090.52
57_Y143_H0.5080.52
198_G230_L0.5070.52
200_F233_V0.5070.52
46_S135_I0.5040.51
59_I131_V0.5040.51
52_S55_G0.5040.51
118_P121_F0.5030.51
42_T153_A0.5020.51
217_A221_G0.5020.51
103_I146_I0.5020.51
172_R175_L0.5020.51
206_I223_L0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pw6A 2 0.8958 100 0.274 Contact Map
1b4uB 2 0.9382 100 0.545 Contact Map
3wraA 2 0.9189 100 0.55 Contact Map
3vsjA 1 0.9653 100 0.56 Contact Map
3vsjB 2 0.9653 100 0.594 Contact Map
3bczA 1 0.8803 100 0.671 Contact Map
2o1sA 2 0.7761 30.6 0.966 Contact Map
3wj2A 4 0.7375 29 0.967 Contact Map
3dahA 5 0.4903 26.4 0.967 Contact Map
4twbA 2 0.4788 25.5 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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