GREMLIN Database
Q97X40 - First ORF in transposon ISC1913
UniProt: Q97X40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (192)
Sequences: 470 (329)
Seq/√Len: 23.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_A124_I4.1131.00
63_A81_L4.0781.00
124_I151_K3.7841.00
85_A126_L3.4711.00
117_V145_F3.0771.00
110_L133_L2.9291.00
10_A14_L2.8560.99
90_Y153_E2.5370.99
20_T24_W2.4630.98
61_I155_V2.4550.98
98_D109_G2.4000.98
5_L10_A2.3570.98
16_I24_W2.3190.98
8_K12_Q2.2670.97
105_T139_E2.1710.96
61_I81_L2.1330.96
118_E148_M2.0930.95
19_S22_L2.0540.95
78_I97_K2.0490.95
113_L122_V2.0360.95
142_E146_S2.0200.94
21_L42_I1.9800.94
126_L139_E1.9350.93
6_R37_G1.9170.93
78_I95_V1.8790.92
25_I40_Y1.8770.92
117_V122_V1.8330.91
80_Y128_T1.8080.90
19_S27_E1.7850.90
84_Y89_G1.7120.88
96_L109_G1.7060.87
117_V125_V1.7040.87
138_F152_I1.6780.87
134_T138_F1.6230.85
10_A47_I1.5870.83
103_L136_F1.5590.82
58_R116_L1.5300.81
94_E116_L1.5220.81
105_T177_S1.5190.80
84_Y88_K1.5030.80
25_I32_V1.4790.79
7_P22_L1.4660.78
59_A151_K1.4520.77
61_I95_V1.4460.77
138_F154_V1.4310.76
17_S23_R1.4280.76
103_L137_G1.4250.76
33_V41_R1.4160.75
116_L121_S1.3970.74
145_F150_V1.3900.74
20_T23_R1.3840.74
73_D76_R1.3750.73
15_G149_G1.3670.73
129_Y169_E1.3510.72
176_T187_S1.3480.72
183_Y186_R1.3470.72
75_E79_N1.3420.71
65_V70_Q1.3330.71
145_F182_I1.3220.70
126_L153_E1.3180.70
34_T40_Y1.3010.69
25_I30_I1.2820.68
23_R26_R1.2600.66
117_V127_I1.2420.65
88_K153_E1.2270.64
6_R41_R1.2250.64
177_S180_G1.2230.64
43_P46_E1.2190.64
29_K36_E1.2030.63
96_L125_V1.1900.62
165_Q169_E1.1890.62
79_N82_T1.1740.61
7_P21_L1.1620.60
30_I33_V1.1320.58
127_I154_V1.1280.58
11_C16_I1.1220.57
10_A30_I1.1140.57
81_L155_V1.1130.57
136_F170_D1.1060.56
18_Y22_L1.1050.56
11_C18_Y1.1040.56
98_D177_S1.0930.55
5_L13_L1.0810.54
145_F179_A1.0810.54
25_I42_I1.0770.54
115_K147_T1.0730.54
128_T188_H1.0720.54
67_S70_Q1.0650.53
30_I46_E1.0620.53
150_V197_V1.0620.53
96_L113_L1.0530.52
87_A126_L1.0280.51
11_C21_L1.0180.50
161_K181_K1.0170.50
174_I184_G0.9990.49
176_T180_G0.9910.48
125_V133_L0.9910.48
59_A126_L0.9820.47
117_V150_V0.9560.46
60_V96_L0.9500.45
137_G179_A0.9490.45
124_I153_E0.9480.45
88_K126_L0.9460.45
61_I85_A0.9320.44
141_I145_F0.9320.44
129_Y161_K0.9270.44
90_Y93_V0.9210.43
17_S182_I0.9200.43
7_P32_V0.9140.43
76_R172_I0.9130.43
60_V78_I0.9090.42
16_I23_R0.9070.42
58_R94_E0.8950.41
166_E178_F0.8950.41
21_L25_I0.8880.41
59_A100_A0.8850.41
11_C181_K0.8810.40
98_D128_T0.8750.40
80_Y98_D0.8710.40
84_Y153_E0.8690.40
80_Y156_F0.8670.39
6_R36_E0.8660.39
105_T134_T0.8640.39
75_E78_I0.8620.39
180_G185_M0.8620.39
10_A21_L0.8600.39
22_L25_I0.8500.38
22_L34_T0.8450.38
78_I114_F0.8410.38
171_L184_G0.8400.38
169_E180_G0.8380.37
22_L42_I0.8360.37
25_I34_T0.8340.37
110_L177_S0.8310.37
60_V122_V0.8300.37
125_V152_I0.8280.37
29_K37_G0.8280.37
134_T141_I0.8270.37
102_G133_L0.8230.36
9_E167_L0.8140.36
138_F141_I0.8130.36
46_E49_K0.8110.36
128_T176_T0.8080.36
107_R134_T0.8060.35
7_P18_Y0.8040.35
8_K37_G0.7970.35
14_L21_L0.7940.35
161_K169_E0.7790.34
100_A162_D0.7790.34
136_F174_I0.7770.34
60_V113_L0.7760.33
31_R46_E0.7720.33
181_K185_M0.7600.32
39_K42_I0.7590.32
61_I92_V0.7570.32
6_R9_E0.7550.32
70_Q73_D0.7540.32
10_A41_R0.7520.32
17_S25_I0.7500.32
51_L54_R0.7480.32
33_V39_K0.7470.32
22_L39_K0.7460.32
54_R154_V0.7440.31
108_K164_A0.7410.31
5_L41_R0.7380.31
142_E159_E0.7380.31
191_T194_V0.7370.31
100_A173_S0.7360.31
26_R34_T0.7350.31
76_R79_N0.7300.31
65_V74_L0.7280.31
168_V171_L0.7280.31
5_L14_L0.7260.30
103_L140_Y0.7210.30
146_S181_K0.7200.30
57_T150_V0.7180.30
5_L51_L0.7150.30
7_P11_C0.7130.30
71_R189_K0.7130.30
170_D184_G0.7100.29
75_E194_V0.6970.29
118_E144_F0.6940.29
82_T95_V0.6920.28
161_K166_E0.6910.28
104_N148_M0.6910.28
30_I141_I0.6840.28
28_G137_G0.6810.28
167_L176_T0.6800.28
57_T149_G0.6680.27
70_Q76_R0.6680.27
45_S76_R0.6670.27
66_S70_Q0.6570.26
102_G110_L0.6540.26
32_V42_I0.6520.26
92_V155_V0.6510.26
181_K184_G0.6480.26
73_D128_T0.6470.26
53_K114_F0.6470.26
99_I152_I0.6410.26
24_W167_L0.6400.26
9_E60_V0.6400.26
29_K175_I0.6320.25
16_I34_T0.6310.25
11_C127_I0.6300.25
8_K11_C0.6300.25
9_E46_E0.6260.25
96_L116_L0.6230.25
38_G97_K0.6200.24
85_A92_V0.6190.24
26_R108_K0.6160.24
60_V157_G0.6160.24
141_I163_D0.6120.24
67_S76_R0.6100.24
42_I46_E0.6090.24
79_N83_N0.6070.24
106_Q181_K0.6050.24
171_L175_I0.6040.24
7_P10_A0.6010.23
126_L143_E0.5990.23
92_V149_G0.5990.23
107_R163_D0.5950.23
33_V43_P0.5910.23
8_K22_L0.5870.23
12_Q15_G0.5860.23
130_K175_I0.5850.23
162_D188_H0.5790.22
22_L40_Y0.5790.22
13_L97_K0.5780.22
5_L138_F0.5770.22
114_F153_E0.5760.22
80_Y173_S0.5720.22
180_G187_S0.5690.22
90_Y126_L0.5640.22
67_S171_L0.5640.22
98_D152_I0.5610.22
57_T119_G0.5600.21
42_I47_I0.5580.21
31_R50_Y0.5580.21
98_D193_L0.5550.21
111_L141_I0.5550.21
18_Y40_Y0.5530.21
94_E158_E0.5520.21
93_V107_R0.5510.21
66_S135_R0.5460.21
47_I125_V0.5460.21
179_A185_M0.5440.21
37_G120_R0.5410.21
37_G84_Y0.5400.21
14_L98_D0.5370.20
11_C110_L0.5370.20
9_E153_E0.5350.20
29_K54_R0.5350.20
50_Y147_T0.5340.20
9_E13_L0.5330.20
110_L134_T0.5320.20
51_L115_K0.5320.20
170_D174_I0.5300.20
142_E153_E0.5290.20
93_V153_E0.5280.20
67_S127_I0.5260.20
163_D185_M0.5260.20
127_I170_D0.5250.20
136_F184_G0.5240.20
47_I57_T0.5240.20
15_G136_F0.5220.20
90_Y124_I0.5210.20
19_S23_R0.5200.20
84_Y124_I0.5200.20
11_C15_G0.5200.20
118_E140_Y0.5190.20
24_W41_R0.5160.19
148_M152_I0.5150.19
101_S161_K0.5130.19
17_S27_E0.5100.19
81_L150_V0.5100.19
165_Q168_V0.5100.19
127_I149_G0.5090.19
84_Y156_F0.5080.19
100_A151_K0.5080.19
176_T188_H0.5060.19
25_I172_I0.5040.19
42_I177_S0.5030.19
25_I37_G0.5010.19
42_I130_K0.5010.19
5_L22_L0.5010.19
69_D129_Y0.5010.19
125_V154_V0.5000.19
99_I107_R0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhkA 2 0.6854 100 0.605 Contact Map
3ilxA 2 0.6573 100 0.641 Contact Map
3bvpA 4 0.6009 99.9 0.693 Contact Map
3g13A 2 0.7042 99.9 0.694 Contact Map
3guvA 2 0.6573 99.9 0.698 Contact Map
4bqqA 2 0.723 99.9 0.71 Contact Map
2mhcA 1 0.5258 99.9 0.713 Contact Map
2gm5A 4 0.5681 99.9 0.721 Contact Map
1gdtA 2 0.6995 99.9 0.732 Contact Map
3pkzA 4 0.5258 99.8 0.744 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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