GREMLIN Database
Q97X39 - Second ORF in transposon ISC1913
UniProt: Q97X39 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (346)
Sequences: 4575 (3002)
Seq/√Len: 161.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_D248_K5.2441.00
326_P359_V4.3341.00
270_P276_H4.1721.00
306_A313_V3.7671.00
266_L302_I3.0681.00
265_V368_A3.0411.00
299_K315_L2.9551.00
189_V298_M2.9051.00
297_S301_A2.7931.00
251_K255_K2.6961.00
339_G342_P2.6821.00
3_R308_E2.5881.00
150_A162_F2.5041.00
320_H323_T2.4851.00
297_S300_N2.3861.00
208_T288_L2.3751.00
324_V331_K2.3491.00
303_I315_L2.3331.00
316_V364_L2.3161.00
254_V306_A2.2851.00
298_M302_I2.2451.00
247_R304_E2.2371.00
264_I306_A2.2011.00
283_D287_R2.1491.00
321_T364_L2.1401.00
35_N39_S2.1291.00
367_R370_D2.1271.00
247_R301_A2.0851.00
278_I291_Y2.0751.00
207_I241_K2.0741.00
147_A167_K2.0631.00
346_V353_K2.0561.00
12_D15_T2.0481.00
38_L95_K2.0231.00
229_V233_L2.0041.00
323_T333_V1.9831.00
323_T338_G1.9741.00
266_L313_V1.9621.00
20_K154_L1.9531.00
33_A72_C1.9331.00
328_H350_G1.9241.00
34_I75_A1.8831.00
214_R229_V1.8801.00
243_V297_S1.8631.00
246_R301_A1.8401.00
250_A301_A1.8381.00
343_R356_R1.8311.00
284_S287_R1.8311.00
325_C328_H1.8301.00
247_R305_K1.8241.00
328_H347_C1.8241.00
247_R250_A1.7891.00
189_V245_I1.7851.00
262_S311_V1.7691.00
21_E62_D1.7411.00
227_R230_R1.7391.00
20_K160_V1.7301.00
327_V352_E1.7201.00
182_V190_S1.7151.00
303_I307_R1.7091.00
325_C347_C1.7031.00
347_C350_G1.7021.00
8_R159_V1.6881.00
345_G354_W1.6741.00
325_C350_G1.6571.00
246_R297_S1.6031.00
217_A221_G1.5861.00
19_L160_V1.5831.00
266_L315_L1.5791.00
267_E318_P1.5311.00
224_T227_R1.5101.00
332_I338_G1.4931.00
266_L299_K1.4791.00
23_E160_V1.4751.00
17_S21_E1.4581.00
338_G342_P1.4571.00
345_G352_E1.4541.00
85_L93_T1.4421.00
191_V358_V1.4341.00
192_L196_K1.4201.00
74_D111_K1.4181.00
188_S191_V1.4181.00
268_D315_L1.4121.00
221_G229_V1.4031.00
86_K93_T1.4031.00
362_Y366_R1.3991.00
250_A304_E1.3821.00
332_I345_G1.3811.00
4_T163_Y1.3771.00
33_A75_A1.3691.00
218_I230_R1.3561.00
179_F365_A1.3541.00
16_Y20_K1.3531.00
330_T348_E1.3521.00
250_A305_K1.3411.00
344_V353_K1.3411.00
214_R217_A1.3401.00
340_D343_R1.3391.00
180_I192_L1.3341.00
214_R236_L1.2901.00
303_I313_V1.2801.00
81_S93_T1.2651.00
79_L95_K1.2651.00
76_S80_D1.2641.00
70_T73_E1.2591.00
26_Y71_A1.2431.00
290_I295_F1.2381.00
332_I348_E1.2331.00
254_V309_F1.2331.00
207_I238_E1.2261.00
358_V362_Y1.2131.00
80_D84_K1.2061.00
210_G214_R1.2041.00
332_I337_D1.1991.00
250_A298_M1.1971.00
54_K57_R1.1871.00
339_G343_R1.1801.00
193_V361_L1.1761.00
246_R298_M1.1761.00
66_H113_N1.1721.00
218_I229_V1.1671.00
13_Y16_Y1.1621.00
326_P362_Y1.1601.00
326_P354_W1.1561.00
182_V192_L1.1431.00
46_T49_K1.1381.00
179_F263_V1.1281.00
215_R219_T1.1261.00
181_S365_A1.1211.00
271_R296_S1.1211.00
251_K309_F1.1191.00
66_H114_L1.1161.00
270_P318_P1.1151.00
77_E81_S1.1141.00
339_G356_R1.1121.00
184_L295_F1.1011.00
301_A304_E1.0971.00
53_Y58_E1.0951.00
44_S47_R1.0951.00
226_D230_R1.0931.00
340_D356_R1.0901.00
243_V301_A1.0891.00
252_L256_E1.0881.00
255_K309_F1.0840.99
176_P262_S1.0790.99
316_V367_R1.0790.99
230_R234_K1.0780.99
81_S85_L1.0750.99
125_R133_P1.0680.99
30_L71_A1.0660.99
120_S127_L1.0650.99
136_F139_Y1.0650.99
55_T59_K1.0630.99
155_L159_V1.0580.99
81_S86_K1.0580.99
126_I162_F1.0570.99
354_W362_Y1.0360.99
11_V15_T1.0320.99
74_D151_R1.0310.99
324_V367_R1.0280.99
246_R250_A1.0230.99
43_T46_T1.0210.99
50_A54_K1.0180.99
11_V19_L1.0180.99
153_K163_Y1.0140.99
197_P355_H1.0140.99
179_F369_G1.0090.99
305_K308_E1.0010.99
254_V311_V1.0000.99
321_T367_R1.0000.99
128_I152_F0.9960.99
34_I79_L0.9940.99
250_A302_I0.9920.99
256_E261_R0.9910.99
330_T349_K0.9890.99
186_E293_A0.9840.99
212_E216_K0.9800.99
28_E32_E0.9760.99
268_D318_P0.9760.99
64_P67_Y0.9740.99
38_L79_L0.9730.99
326_P352_E0.9730.99
253_I264_I0.9720.99
316_V368_A0.9720.99
118_S127_L0.9670.99
136_F140_Y0.9630.99
278_I283_D0.9610.99
184_L299_K0.9580.99
44_S48_I0.9570.99
263_V312_P0.9480.99
6_K155_L0.9400.99
211_Y233_L0.9400.99
326_P366_R0.9360.98
354_W358_V0.9350.98
323_T331_K0.9340.98
237_R241_K0.9340.98
66_H70_T0.9330.98
239_R243_V0.9320.98
53_Y57_R0.9280.98
180_I193_V0.9240.98
338_G345_G0.9230.98
82_F95_K0.9190.98
69_Y73_E0.9100.98
5_V166_F0.9080.98
218_I233_L0.9080.98
265_V364_L0.9040.98
140_Y144_W0.9030.98
190_S249_L0.9020.98
358_V361_L0.9000.98
211_Y219_T0.8990.98
360_A363_N0.8980.98
36_Y40_N0.8970.98
343_R355_H0.8950.98
254_V264_I0.8890.98
82_F96_P0.8870.98
51_G54_K0.8870.98
36_Y52_V0.8860.98
342_P345_G0.8840.98
53_Y56_E0.8780.98
113_N116_R0.8740.98
37_G79_L0.8720.98
85_L94_E0.8700.98
333_V337_D0.8690.98
203_N241_K0.8670.98
342_P356_R0.8610.97
300_N303_I0.8580.97
318_P321_T0.8580.97
57_R68_I0.8570.97
306_A311_V0.8570.97
30_L75_A0.8550.97
296_S300_N0.8520.97
44_S49_K0.8510.97
63_L66_H0.8510.97
326_P360_A0.8470.97
198_M245_I0.8470.97
112_F115_D0.8460.97
45_F49_K0.8460.97
152_F162_F0.8450.97
212_E215_R0.8360.97
37_G76_S0.8350.97
211_Y238_E0.8310.97
110_W114_L0.8290.97
283_D286_L0.8270.97
81_S84_K0.8250.97
359_V363_N0.8230.97
344_V354_W0.8230.97
246_R294_A0.8220.97
154_L160_V0.8220.97
217_A220_T0.8210.97
279_K283_D0.8160.96
106_D110_W0.8140.96
117_I121_T0.8100.96
323_T339_G0.8090.96
184_L190_S0.8080.96
271_R295_F0.8060.96
179_F265_V0.8010.96
188_S197_P0.7990.96
24_K27_R0.7990.96
345_G356_R0.7970.96
327_V362_Y0.7970.96
203_N207_I0.7970.96
187_N191_V0.7960.96
191_V197_P0.7950.96
41_K79_L0.7940.96
332_I339_G0.7910.96
9_V162_F0.7900.96
223_S226_D0.7880.96
214_R233_L0.7880.96
30_L78_R0.7870.96
16_Y160_V0.7860.96
32_E36_Y0.7850.96
207_I211_Y0.7840.96
328_H332_I0.7830.95
186_E289_R0.7820.95
314_V368_A0.7820.95
200_L203_N0.7820.95
79_L82_F0.7790.95
54_K72_C0.7780.95
35_N98_V0.7780.95
251_K305_K0.7770.95
180_I264_I0.7760.95
72_C76_S0.7750.95
175_E178_G0.7720.95
188_S199_L0.7710.95
54_K60_H0.7710.95
368_A372_S0.7690.95
245_I249_L0.7680.95
137_W140_Y0.7680.95
269_L318_P0.7650.95
110_W113_N0.7650.95
362_Y365_A0.7620.95
22_V63_L0.7620.95
25_E28_E0.7610.95
263_V314_V0.7580.95
320_H367_R0.7560.95
70_T74_D0.7550.95
132_F135_I0.7550.95
338_G356_R0.7550.95
7_L162_F0.7550.95
116_R129_S0.7540.94
127_L133_P0.7540.94
324_V363_N0.7540.94
151_R163_Y0.7500.94
40_N44_S0.7480.94
177_K262_S0.7480.94
215_R233_L0.7460.94
117_I129_S0.7450.94
110_W119_I0.7450.94
330_T333_V0.7430.94
337_D342_P0.7400.94
66_H115_D0.7390.94
29_V71_A0.7380.94
225_K228_E0.7350.94
102_T108_H0.7340.94
24_K28_E0.7330.94
108_H111_K0.7320.94
8_R161_E0.7300.93
178_G262_S0.7290.93
286_L290_I0.7270.93
36_Y39_S0.7260.93
18_A22_V0.7240.93
268_D299_K0.7240.93
63_L68_I0.7240.93
6_K153_K0.7230.93
138_R142_K0.7230.93
200_L293_A0.7220.93
322_S338_G0.7200.93
227_R231_R0.7170.93
367_R371_V0.7170.93
193_V358_V0.7170.93
189_V250_A0.7140.93
52_V56_E0.7140.93
102_T106_D0.7120.93
183_D357_D0.7120.93
196_K252_L0.7110.93
148_S165_I0.7070.92
229_V232_K0.7070.92
213_Y217_A0.7040.92
323_T332_I0.7040.92
284_S291_Y0.7030.92
43_T48_I0.7010.92
218_I221_G0.7010.92
185_N191_V0.7010.92
323_T337_D0.7000.92
137_W141_N0.6990.92
22_V26_Y0.6990.92
131_T134_K0.6970.92
304_E308_E0.6940.92
138_R141_N0.6930.92
178_G261_R0.6920.92
66_H69_Y0.6910.91
52_V55_T0.6870.91
79_L83_E0.6860.91
54_K59_K0.6850.91
75_A79_L0.6850.91
249_L252_L0.6790.91
144_W166_F0.6770.91
278_I287_R0.6770.91
340_D355_H0.6770.91
302_I313_V0.6770.91
50_A72_C0.6750.91
21_E25_E0.6740.90
265_V365_A0.6730.90
226_D229_V0.6720.90
25_E63_L0.6700.90
53_Y69_Y0.6690.90
111_K115_D0.6690.90
190_S298_M0.6670.90
265_V314_V0.6670.90
54_K58_E0.6660.90
13_Y17_S0.6660.90
338_G343_R0.6650.90
128_I132_F0.6650.90
71_A75_A0.6600.90
82_F85_L0.6580.89
221_G225_K0.6530.89
330_T345_G0.6530.89
159_V240_N0.6530.89
238_E292_R0.6510.89
189_V293_A0.6430.88
255_K263_V0.6430.88
207_I237_R0.6420.88
264_I302_I0.6410.88
204_T207_I0.6370.88
243_V247_R0.6360.88
126_I129_S0.6330.87
242_K292_R0.6330.87
204_T208_T0.6330.87
112_F116_R0.6300.87
41_K82_F0.6290.87
190_S198_M0.6290.87
14_K17_S0.6280.87
333_V338_G0.6250.87
72_C75_A0.6240.87
322_S339_G0.6190.86
354_W359_V0.6160.86
320_H331_K0.6160.86
36_Y55_T0.6160.86
271_R290_I0.6110.86
129_S134_K0.6110.86
265_V367_R0.6090.85
113_N117_I0.6090.85
145_R167_K0.6090.85
110_W116_R0.6060.85
57_R60_H0.6050.85
42_T45_F0.6050.85
340_D344_V0.6030.85
320_H324_V0.6020.85
33_A52_V0.6010.85
127_L130_P0.6000.85
155_L161_E0.5990.84
38_L42_T0.5990.84
117_I120_S0.5960.84
332_I356_R0.5950.84
114_L117_I0.5930.84
53_Y60_H0.5900.84
192_L198_M0.5900.84
35_N38_L0.5900.84
22_V64_P0.5880.83
214_R232_K0.5880.83
70_T111_K0.5870.83
216_K219_T0.5840.83
6_K243_V0.5840.83
140_Y143_G0.5840.83
219_T233_L0.5820.83
56_E59_K0.5810.83
181_S265_V0.5810.83
109_L115_D0.5800.83
53_Y72_C0.5790.82
119_I128_I0.5790.82
317_N320_H0.5770.82
306_A309_F0.5770.82
205_K289_R0.5750.82
11_V16_Y0.5730.82
240_N244_D0.5730.82
240_N243_V0.5720.82
106_D113_N0.5720.82
246_R249_L0.5720.82
29_V68_I0.5710.82
37_G41_K0.5700.81
126_I150_A0.5690.81
19_L23_E0.5680.81
49_K53_Y0.5670.81
106_D109_L0.5660.81
194_D198_M0.5650.81
4_T165_I0.5650.81
50_A53_Y0.5640.81
366_R369_G0.5640.81
256_E262_S0.5630.81
332_I342_P0.5630.81
4_T153_K0.5630.81
285_Q289_R0.5620.81
43_T47_R0.5580.80
301_A305_K0.5570.80
36_Y56_E0.5550.80
122_K125_R0.5550.80
211_Y215_R0.5540.80
107_D111_K0.5530.80
56_E60_H0.5530.80
369_G372_S0.5520.79
198_M252_L0.5510.79
233_L236_L0.5500.79
83_E86_K0.5490.79
348_E356_R0.5440.78
157_G234_K0.5430.78
346_V352_E0.5430.78
187_N343_R0.5420.78
41_K45_F0.5410.78
205_K208_T0.5410.78
322_S332_I0.5410.78
276_H318_P0.5400.78
286_L289_R0.5400.78
296_S299_K0.5390.78
26_Y67_Y0.5380.78
68_I71_A0.5380.78
18_A21_E0.5380.78
287_R291_Y0.5360.77
84_K93_T0.5350.77
205_K288_L0.5350.77
324_V345_G0.5350.77
283_D291_Y0.5340.77
214_R218_I0.5340.77
32_E59_K0.5340.77
294_A297_S0.5330.77
230_R233_L0.5330.77
338_G341_A0.5330.77
204_T288_L0.5320.77
37_G40_N0.5290.76
106_D112_F0.5280.76
283_D290_I0.5270.76
197_P358_V0.5270.76
183_D322_S0.5260.76
324_V329_G0.5250.76
276_H279_K0.5220.76
52_V57_R0.5220.76
33_A56_E0.5220.76
276_H290_I0.5190.75
248_K251_K0.5190.75
178_G194_D0.5190.75
238_E242_K0.5190.75
173_P176_P0.5150.75
278_I285_Q0.5140.74
212_E288_L0.5140.74
52_V59_K0.5130.74
109_L114_L0.5130.74
364_L367_R0.5120.74
139_Y142_K0.5100.74
50_A57_R0.5100.74
215_R218_I0.5080.74
110_W129_S0.5080.74
137_W142_K0.5060.73
355_H360_A0.5050.73
154_L161_E0.5040.73
181_S193_V0.5040.73
21_E24_K0.5030.73
128_I131_T0.5020.73
181_S361_L0.5020.73
210_G236_L0.5010.73
230_R236_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3186 93.3 0.933 Contact Map
1vhxA 2 0.3358 93 0.934 Contact Map
1iv0A 1 0.2377 88.3 0.941 Contact Map
1ffkW 1 0.1642 86.5 0.942 Contact Map
3j20Y 1 0.1225 84.3 0.944 Contact Map
1qypA 1 0.1201 84.2 0.944 Contact Map
1vq8Z 1 0.1716 82.9 0.945 Contact Map
4aybP 1 0.1078 82 0.946 Contact Map
2k4xA 1 0.1348 82 0.946 Contact Map
1vd4A 1 0.1446 72.9 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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