GREMLIN Database
Q97X37 - Uncharacterized protein
UniProt: Q97X37 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (384)
Sequences: 1468 (1233)
Seq/√Len: 62.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_N47_N7.6711.00
22_S26_E4.6001.00
40_F44_N3.9131.00
197_P200_K3.7361.00
238_I271_I3.4921.00
375_L379_K3.1511.00
46_V96_I3.0561.00
25_L118_V2.9201.00
232_K296_F2.8831.00
20_L45_A2.7441.00
46_V94_I2.6871.00
182_G322_L2.6531.00
274_E344_R2.6291.00
13_L45_A2.6041.00
360_A385_L2.5711.00
42_I132_L2.5661.00
266_E271_I2.5181.00
16_L45_A2.4781.00
234_I261_Y2.4771.00
377_E380_R2.3841.00
166_D169_G2.3721.00
10_E169_G2.3711.00
184_A191_L2.3471.00
244_T249_K2.2951.00
246_G250_D2.2641.00
272_G288_K2.2161.00
27_L131_L2.1981.00
19_R28_I2.1761.00
173_S176_D2.1751.00
16_L28_I2.1731.00
30_I42_I2.1591.00
377_E381_K2.1391.00
153_R156_S2.1311.00
244_T247_E2.1031.00
311_Y315_E2.0891.00
42_I96_I2.0521.00
167_L191_L2.0391.00
178_I329_I2.0151.00
163_K166_D2.0021.00
376_Y379_K1.9901.00
207_K314_K1.9841.00
20_L94_I1.9791.00
196_T204_A1.9681.00
360_A382_V1.9571.00
274_E286_Y1.9241.00
65_F95_I1.9051.00
306_I309_G1.8991.00
370_N374_V1.8881.00
45_A128_K1.8501.00
52_I55_L1.8401.00
17_K49_Y1.8101.00
205_E211_S1.8001.00
318_Y322_L1.7961.00
168_K174_L1.7751.00
34_R99_E1.7550.99
119_D152_R1.7300.99
45_A49_Y1.7100.99
298_F317_E1.7080.99
199_L315_E1.7030.99
99_E134_S1.6830.99
380_R383_E1.6790.99
20_L49_Y1.6720.99
115_Q119_D1.6530.99
14_Q18_K1.6430.99
17_K21_S1.6220.99
82_D85_A1.6140.99
184_A194_A1.6070.99
354_I361_G1.6000.99
30_I159_L1.5950.99
19_R26_E1.5840.99
28_I155_A1.5840.99
15_A155_A1.5560.99
378_L382_V1.5530.99
276_P346_W1.5500.99
158_E269_G1.5430.99
196_T201_W1.5210.99
217_I291_F1.5180.99
175_I179_H1.5170.98
269_G288_K1.5130.98
17_K45_A1.4940.98
305_L309_G1.4910.98
260_S264_K1.4900.98
232_K236_H1.4810.98
79_V82_D1.4800.98
65_F83_W1.4640.98
42_I46_V1.4640.98
162_L166_D1.4530.98
370_N373_K1.4360.98
80_K89_Y1.4310.98
46_V51_F1.4240.98
60_N63_R1.4130.98
327_E364_K1.4100.98
133_G139_M1.4050.98
36_I187_V1.4020.97
114_F117_I1.3940.97
10_E166_D1.3860.97
371_G374_V1.3710.97
109_S113_T1.3560.97
90_L95_I1.3530.97
262_L285_Y1.3450.97
41_L159_L1.3420.97
17_K48_G1.3350.97
20_L128_K1.3260.96
115_Q148_P1.3100.96
330_A363_C1.3050.96
51_F55_L1.3020.96
356_G359_I1.2960.96
66_K80_K1.2960.96
329_I332_E1.2950.96
225_F268_I1.2870.96
372_E376_Y1.2850.96
99_E364_K1.2730.96
101_P135_S1.2700.95
99_E362_E1.2670.95
262_L271_I1.2650.95
231_Y261_Y1.2540.95
187_V190_Y1.2500.95
331_R335_E1.2400.95
362_E381_K1.2300.95
351_E362_E1.2240.94
62_L66_K1.2220.94
289_D294_F1.2200.94
231_Y264_K1.2180.94
6_M44_N1.2120.94
35_R133_G1.2110.94
347_F350_V1.2080.94
242_K247_E1.2070.94
54_Y58_E1.2060.94
310_I315_E1.2050.94
237_A252_V1.2050.94
273_K283_A1.2050.94
40_F192_T1.2020.94
330_A333_Y1.2000.94
379_K382_V1.1930.94
40_F162_L1.1910.94
380_R384_D1.1900.94
42_I94_I1.1890.94
351_E364_K1.1870.93
344_R351_E1.1840.93
242_K251_F1.1760.93
199_L203_N1.1750.93
9_R12_E1.1730.93
52_I56_A1.1730.93
373_K376_Y1.1530.92
148_P152_R1.1520.92
68_L71_S1.1520.92
297_T300_Y1.1500.92
35_R99_E1.1480.92
237_A251_F1.1440.92
115_Q152_R1.1430.92
112_S115_Q1.1410.92
321_Y325_I1.1350.92
130_I133_G1.1340.92
99_E353_D1.1340.92
378_L384_D1.1250.92
297_T309_G1.1220.91
33_R216_E1.1210.91
50_D92_D1.1210.91
202_I207_K1.1180.91
128_K133_G1.1170.91
245_L249_K1.1070.91
376_Y383_E1.1030.91
19_R155_A1.0980.91
206_L291_F1.0920.90
8_N166_D1.0920.90
6_M40_F1.0920.90
27_L129_L1.0890.90
197_P201_W1.0880.90
374_V381_K1.0870.90
37_G188_P1.0860.90
190_Y216_E1.0820.90
11_R208_E1.0780.90
26_E154_T1.0770.90
99_E152_R1.0690.89
345_L350_V1.0680.89
351_E381_K1.0630.89
180_V194_A1.0620.89
332_E336_D1.0610.89
54_Y57_T1.0580.89
263_N267_K1.0560.89
15_A28_I1.0560.89
331_R342_V1.0520.89
366_S370_N1.0480.88
183_F202_I1.0360.88
354_I363_C1.0300.87
182_G325_I1.0280.87
377_E383_E1.0230.87
277_Y343_E1.0220.87
102_Y111_L1.0220.87
237_A248_I1.0210.87
104_I111_L1.0180.87
168_K177_A1.0150.87
101_P139_M1.0140.87
306_I310_I1.0130.87
43_I120_E1.0130.87
246_G318_Y1.0090.86
94_I130_I1.0080.86
84_E113_T0.9970.86
34_R364_K0.9950.86
127_T133_G0.9920.85
103_M110_I0.9880.85
35_R216_E0.9880.85
331_R361_G0.9860.85
35_R364_K0.9830.85
53_Y56_A0.9820.85
134_S152_R0.9710.84
198_F207_K0.9700.84
295_W299_I0.9680.84
7_V170_F0.9630.84
244_T284_R0.9590.83
305_L308_E0.9580.83
62_L80_K0.9530.83
68_L304_S0.9530.83
382_V388_D0.9520.83
61_N73_Y0.9470.83
133_G152_R0.9450.83
328_K332_E0.9450.83
11_R14_Q0.9430.82
327_E351_E0.9410.82
357_D389_V0.9370.82
178_I322_L0.9360.82
184_A291_F0.9360.82
9_R32_G0.9290.81
28_I128_K0.9270.81
249_K252_V0.9250.81
43_I308_E0.9100.80
99_E133_G0.9100.80
98_D101_P0.9070.80
99_E351_E0.9050.80
234_I271_I0.9040.80
368_G372_E0.9000.79
134_S364_K0.9000.79
294_F298_F0.9000.79
23_N144_S0.8980.79
164_F168_K0.8980.79
163_K336_D0.8950.79
297_T317_E0.8920.79
358_G389_V0.8850.78
12_E157_I0.8840.78
128_K132_L0.8760.77
112_S149_L0.8750.77
303_L309_G0.8720.77
34_R101_P0.8710.77
42_I130_I0.8700.77
80_K86_I0.8640.76
35_R351_E0.8630.76
53_Y114_F0.8620.76
91_R312_E0.8600.76
52_I58_E0.8590.76
36_I161_E0.8560.76
163_K167_L0.8540.76
15_A19_R0.8540.76
172_F180_V0.8510.75
342_V346_W0.8500.75
35_R152_R0.8480.75
263_N282_G0.8480.75
216_E265_L0.8480.75
190_Y294_F0.8460.75
373_K377_E0.8440.75
350_V380_R0.8430.75
33_R289_D0.8420.75
53_Y58_E0.8360.74
98_D290_N0.8340.74
290_N325_I0.8330.74
97_I129_L0.8330.74
98_D133_G0.8330.74
383_E386_G0.8300.74
167_L170_F0.8260.73
372_E379_K0.8230.73
149_L152_R0.8220.73
310_I314_K0.8220.73
240_S357_D0.8220.73
183_F198_F0.8210.73
217_I292_T0.8200.73
152_R364_K0.8190.73
356_G361_G0.8150.72
334_V342_V0.8120.72
100_F131_L0.8120.72
105_K108_E0.8110.72
82_D89_Y0.8100.72
167_L177_A0.8090.72
350_V384_D0.8070.71
39_T181_Y0.8030.71
33_R187_V0.8030.71
137_S323_G0.8010.71
27_L118_V0.8010.71
374_V377_E0.7980.71
333_Y337_V0.7960.70
119_D148_P0.7940.70
165_K336_D0.7930.70
110_I114_F0.7900.70
9_R37_G0.7900.70
58_E105_K0.7900.70
147_S153_R0.7880.70
172_F201_W0.7880.70
369_I389_V0.7860.69
52_I72_K0.7850.69
182_G321_Y0.7830.69
162_L167_L0.7830.69
370_N379_K0.7800.69
130_I234_I0.7780.69
99_E327_E0.7770.69
277_Y355_Y0.7760.68
32_G36_I0.7750.68
176_D179_H0.7740.68
254_I258_V0.7710.68
327_E362_E0.7710.68
350_V388_D0.7700.68
55_L58_E0.7620.67
39_T291_F0.7600.67
178_I182_G0.7590.67
110_I135_S0.7590.67
99_E323_G0.7580.67
198_F201_W0.7570.67
101_P104_I0.7560.66
270_I292_T0.7560.66
368_G389_V0.7550.66
36_I40_F0.7500.66
213_I216_E0.7490.66
164_F170_F0.7480.66
134_S327_E0.7470.65
235_L296_F0.7450.65
381_K384_D0.7440.65
185_G294_F0.7430.65
29_I131_L0.7400.65
304_S307_E0.7380.65
18_K71_S0.7370.64
43_I239_S0.7360.64
33_R99_E0.7340.64
249_K253_R0.7330.64
355_Y360_A0.7310.64
357_D370_N0.7310.64
28_I157_I0.7300.64
152_R327_E0.7280.63
101_P133_G0.7250.63
371_G375_L0.7240.63
104_I138_M0.7230.63
76_I86_I0.7230.63
33_R327_E0.7200.63
141_D342_V0.7200.63
51_F56_A0.7190.63
342_V345_L0.7190.63
35_R139_M0.7180.62
34_R152_R0.7160.62
119_D133_G0.7160.62
142_A147_S0.7150.62
371_G377_E0.7150.62
145_Y150_Y0.7140.62
303_L307_E0.7140.62
323_G327_E0.7110.62
128_K134_S0.7080.61
111_L147_S0.7070.61
374_V384_D0.7070.61
193_K205_E0.7060.61
347_F363_C0.7060.61
139_M148_P0.7030.61
18_K204_A0.7010.61
370_N376_Y0.7000.60
372_E384_D0.7000.60
382_V385_L0.7000.60
361_G370_N0.6980.60
353_D364_K0.6970.60
34_R362_E0.6960.60
68_L72_K0.6950.60
366_S372_E0.6940.60
384_D387_L0.6930.60
69_T73_Y0.6920.60
275_F283_A0.6920.60
372_E386_G0.6890.59
164_F177_A0.6870.59
244_T248_I0.6840.59
130_I185_G0.6830.59
151_G364_K0.6830.59
275_F280_K0.6800.58
172_F176_D0.6780.58
118_V333_Y0.6780.58
231_Y265_L0.6760.58
63_R67_E0.6760.58
368_G374_V0.6760.58
361_G381_K0.6740.58
255_S358_G0.6730.57
148_P151_G0.6730.57
34_R353_D0.6720.57
379_K384_D0.6720.57
92_D267_K0.6690.57
115_Q221_L0.6680.57
51_F54_Y0.6680.57
299_I307_E0.6660.57
380_R386_G0.6650.57
355_Y384_D0.6630.56
231_Y234_I0.6630.56
353_D362_E0.6620.56
35_R190_Y0.6620.56
30_I258_V0.6620.56
294_F321_Y0.6570.56
124_G389_V0.6570.56
110_I187_V0.6550.55
358_G380_R0.6530.55
287_I296_F0.6530.55
7_V104_I0.6520.55
106_E217_I0.6520.55
39_T103_M0.6500.55
340_V386_G0.6490.55
338_Y342_V0.6480.55
67_E88_H0.6480.55
96_I286_Y0.6420.54
43_I184_A0.6400.54
361_G371_G0.6380.53
21_S97_I0.6360.53
345_L385_L0.6350.53
100_F283_A0.6350.53
266_E273_K0.6350.53
227_E231_Y0.6320.53
94_I157_I0.6280.52
329_I333_Y0.6260.52
32_G37_G0.6250.52
121_T130_I0.6250.52
12_E41_L0.6240.52
152_R362_E0.6240.52
102_Y112_S0.6230.52
71_S173_S0.6230.52
131_L144_S0.6200.51
27_L220_M0.6190.51
13_L48_G0.6190.51
379_K383_E0.6190.51
52_I82_D0.6180.51
34_R151_G0.6170.51
102_Y143_I0.6170.51
198_F318_Y0.6150.51
34_R289_D0.6140.51
119_D151_G0.6130.51
57_T131_L0.6130.51
365_W378_L0.6130.51
148_P224_E0.6120.50
323_G364_K0.6100.50
148_P327_E0.6100.50
19_R157_I0.6100.50
38_K41_L0.6090.50
304_S308_E0.6090.50
6_M13_L0.6090.50
133_G190_Y0.6080.50
372_E377_E0.6070.50
79_V85_A0.6060.50
352_I381_K0.6040.50
31_Y143_I0.6030.49
33_R134_S0.6020.49
150_Y219_F0.6010.49
38_K188_P0.5980.49
311_Y332_E0.5980.49
368_G382_V0.5970.49
153_R248_I0.5970.49
366_S376_Y0.5960.49
11_R67_E0.5960.49
343_E346_W0.5950.49
378_L381_K0.5940.48
302_N305_L0.5940.48
249_K258_V0.5930.48
230_T261_Y0.5920.48
348_K371_G0.5910.48
8_N177_A0.5900.48
367_E384_D0.5890.48
258_V281_K0.5870.48
219_F222_R0.5870.48
246_G249_K0.5860.47
36_I352_I0.5840.47
82_D97_I0.5830.47
163_K338_Y0.5820.47
90_L331_R0.5800.47
143_I170_F0.5790.47
256_G330_A0.5790.47
383_E389_V0.5790.47
366_S369_I0.5790.47
80_K83_W0.5760.46
141_D267_K0.5740.46
244_T251_F0.5730.46
34_R327_E0.5730.46
125_S375_L0.5730.46
370_N375_L0.5720.46
223_Y292_T0.5720.46
359_I365_W0.5720.46
198_F202_I0.5700.46
39_T183_F0.5690.46
59_K63_R0.5690.46
196_T200_K0.5670.45
185_G289_D0.5660.45
8_N232_K0.5660.45
147_S156_S0.5660.45
35_R362_E0.5660.45
35_R38_K0.5650.45
53_Y57_T0.5630.45
101_P106_E0.5620.45
17_K30_I0.5620.45
115_Q153_R0.5620.45
270_I359_I0.5620.45
61_N64_K0.5610.45
81_E90_L0.5600.45
205_E212_F0.5590.44
162_L179_H0.5580.44
11_R209_V0.5570.44
184_A290_N0.5560.44
119_D327_E0.5560.44
321_Y326_F0.5540.44
204_A235_L0.5530.44
183_F218_D0.5530.44
139_M143_I0.5510.43
98_D364_K0.5500.43
216_E220_M0.5500.43
377_E388_D0.5490.43
360_A389_V0.5480.43
187_V192_T0.5470.43
86_I160_K0.5460.43
11_R303_L0.5460.43
162_L188_P0.5450.43
304_S317_E0.5440.43
69_T226_S0.5430.43
363_C367_E0.5430.43
358_G386_G0.5430.43
69_T116_K0.5410.42
315_E336_D0.5390.42
293_L321_Y0.5380.42
166_D197_P0.5370.42
233_E237_A0.5370.42
377_E385_L0.5360.42
42_I239_S0.5340.42
35_R187_V0.5340.42
247_E285_Y0.5330.41
187_V340_V0.5330.41
119_D134_S0.5320.41
80_K85_A0.5320.41
170_F365_W0.5310.41
123_K363_C0.5300.41
272_G286_Y0.5290.41
192_T291_F0.5290.41
138_M148_P0.5290.41
103_M238_I0.5280.41
376_Y389_V0.5280.41
42_I243_N0.5280.41
355_Y381_K0.5280.41
111_L189_F0.5260.41
341_K344_R0.5260.41
60_N252_V0.5260.41
322_L330_A0.5250.41
32_G38_K0.5230.40
341_K348_K0.5230.40
179_H322_L0.5230.40
221_L270_I0.5200.40
254_I257_D0.5190.40
244_T253_R0.5180.40
245_L258_V0.5170.40
134_S148_P0.5160.40
332_E358_G0.5150.39
99_E238_I0.5150.39
189_F193_K0.5140.39
358_G377_E0.5130.39
37_G98_D0.5130.39
235_L355_Y0.5110.39
81_E85_A0.5100.39
118_V289_D0.5100.39
134_S353_D0.5100.39
151_G327_E0.5100.39
66_K70_E0.5090.39
112_S148_P0.5090.39
226_S232_K0.5090.39
68_L124_G0.5080.39
348_K384_D0.5080.39
239_S322_L0.5070.39
326_F330_A0.5060.38
63_R79_V0.5060.38
211_S214_K0.5050.38
39_T325_I0.5040.38
134_S323_G0.5030.38
274_E331_R0.5020.38
275_F380_R0.5020.38
96_I121_T0.5020.38
385_L388_D0.5010.38
10_E13_L0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qenA 1 0.6714 100 0.596 Contact Map
2fnaA 1 0.6571 100 0.6 Contact Map
1z6tA 1 0.8905 100 0.71 Contact Map
1w5sA 1 0.7167 99.9 0.715 Contact Map
1fnnA 1 0.6976 99.9 0.749 Contact Map
2a5yB 2 0.7405 99.9 0.75 Contact Map
2v1uA 1 0.7119 99.8 0.77 Contact Map
2qbyA 1 0.7024 99.8 0.771 Contact Map
4xgcA 1 0.6286 99.8 0.775 Contact Map
3pfiA 3 0.631 99.8 0.776 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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