GREMLIN Database
Q97X30 - dTDP-4-dehydrorhamnose 3,5 epimerase (RfbC-2)
UniProt: Q97X30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (166)
Sequences: 4407 (2824)
Seq/√Len: 219.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_C166_C3.4001.00
79_K101_E3.2451.00
33_S43_N3.2381.00
124_E127_I2.8371.00
16_K108_Y2.5671.00
80_I129_V2.5651.00
6_E13_V2.4151.00
8_L98_V2.4071.00
138_S141_D2.3691.00
60_L117_A2.3471.00
70_G111_W2.3331.00
64_I143_R2.3191.00
81_L99_K2.2211.00
50_S120_F2.1961.00
37_T42_P2.1801.00
47_T132_L2.1761.00
57_V121_Q2.1031.00
77_K104_D2.0601.00
54_K125_D2.0211.00
70_G134_H2.0071.00
34_E136_E2.0001.00
8_L96_K1.9711.00
33_S37_T1.9601.00
76_P130_Y1.9041.00
114_P134_H1.8831.00
77_K126_S1.8701.00
146_N168_P1.8581.00
67_K138_S1.8331.00
14_L108_Y1.8081.00
77_K128_V1.7701.00
168_P171_K1.7491.00
161_D165_Q1.7351.00
79_K124_E1.7221.00
51_F128_V1.7071.00
103_N106_N1.6501.00
49_M128_V1.6411.00
161_D164_S1.6401.00
9_G116_F1.6311.00
81_L153_P1.6161.00
70_G114_P1.6141.00
87_L117_A1.5971.00
14_L100_V1.5761.00
67_K135_N1.5351.00
60_L119_G1.5071.00
62_Y143_R1.4981.00
34_E38_K1.4941.00
12_I84_A1.4851.00
49_M74_F1.4851.00
79_K103_N1.4611.00
7_N14_L1.4351.00
19_V107_H1.3711.00
122_A127_I1.3651.00
6_E10_M1.3621.00
62_Y172_A1.3021.00
80_I127_I1.2901.00
26_F51_F1.2501.00
67_K141_D1.2461.00
32_K35_D1.2281.00
57_V157_F1.2221.00
12_I98_V1.2221.00
114_P135_N1.2181.00
121_Q154_I1.1831.00
117_A145_V1.1461.00
65_T68_E1.1391.00
83_V152_W1.1301.00
84_A98_V1.1171.00
29_E32_K1.0901.00
51_F126_S1.0831.00
121_Q153_P1.0781.00
62_Y117_A1.0691.00
113_P116_F1.0401.00
9_G12_I1.0141.00
100_V110_L1.0111.00
26_F49_M1.0111.00
27_F50_S1.0071.00
147_Y157_F1.0031.00
60_L85_L0.9971.00
32_K136_E0.9951.00
167_P171_K0.9881.00
49_M130_Y0.9881.00
23_K161_D0.9831.00
82_D118_H0.9771.00
154_I157_F0.9711.00
65_T141_D0.9621.00
121_Q157_F0.9601.00
64_I141_D0.9521.00
87_L145_V0.9471.00
15_I35_D0.9431.00
35_D38_K0.9401.00
60_L150_V0.9401.00
81_L97_Y0.9331.00
101_E123_L0.9240.99
145_V172_A0.9220.99
9_G98_V0.9160.99
35_D39_A0.9090.99
30_V47_T0.9090.99
54_K124_E0.9030.99
142_E166_C0.9010.99
68_E141_D0.8980.99
44_I47_T0.8890.99
18_K35_D0.8880.99
62_Y87_L0.8860.99
53_F126_S0.8860.99
29_E69_Q0.8820.99
100_V108_Y0.8770.99
37_T41_I0.8710.99
122_A126_S0.8550.99
29_E46_Q0.8470.99
45_V136_E0.8400.99
21_P53_F0.8400.99
48_N133_T0.8400.99
9_G93_T0.8400.99
26_F128_V0.8380.99
26_F107_H0.8310.99
11_G93_T0.8280.99
146_N166_C0.8270.99
7_N12_I0.8140.99
15_I39_A0.8130.99
84_A116_F0.8020.99
76_P128_V0.7960.98
158_I161_D0.7930.98
41_I111_W0.7890.98
130_Y133_T0.7790.98
49_M76_P0.7770.98
44_I134_H0.7760.98
10_M92_P0.7740.98
102_L110_L0.7630.98
14_L110_L0.7620.98
83_V150_V0.7610.98
88_R116_F0.7610.98
84_A112_I0.7550.98
12_I110_L0.7540.98
14_L98_V0.7500.98
95_G169_L0.7420.98
167_P172_A0.7410.98
99_K153_P0.7350.97
36_F109_I0.7330.97
147_Y159_I0.7330.97
64_I172_A0.7330.97
111_W134_H0.7290.97
10_M93_T0.7280.97
143_R167_P0.7200.97
84_A110_L0.7190.97
123_L153_P0.7190.97
6_E11_G0.7050.97
9_G84_A0.7000.96
14_L106_N0.6970.96
41_I114_P0.6960.96
79_K127_I0.6930.96
75_V80_I0.6910.96
21_P107_H0.6870.96
73_V129_V0.6860.96
144_C167_P0.6820.96
15_I72_L0.6810.96
71_K82_D0.6750.96
107_H128_V0.6740.96
29_E48_N0.6730.96
30_V49_M0.6690.95
162_K166_C0.6600.95
93_T96_K0.6600.95
104_D128_V0.6580.95
19_V28_L0.6570.95
27_F48_N0.6570.95
7_N98_V0.6480.95
36_F41_I0.6450.95
74_F130_Y0.6390.94
75_V127_I0.6320.94
32_K36_F0.6310.94
68_E114_P0.6310.94
12_I116_F0.6250.94
30_V74_F0.6210.93
44_I132_L0.6200.93
8_L12_I0.6200.93
101_E153_P0.6180.93
54_K155_K0.6180.93
98_V110_L0.6160.93
52_S56_V0.6150.93
22_D25_G0.6130.93
7_N100_V0.6110.93
85_L145_V0.6090.93
33_S42_P0.6080.93
23_K158_I0.6070.93
89_K92_P0.6050.92
122_A125_D0.6020.92
34_E37_T0.6020.92
19_V26_F0.6010.92
60_L145_V0.5980.92
143_R166_C0.5960.92
137_Y142_E0.5960.92
27_F131_F0.5940.92
62_Y145_V0.5940.92
30_V130_Y0.5920.92
28_L107_H0.5870.91
53_F158_I0.5850.91
81_L123_L0.5840.91
54_K156_E0.5840.91
45_V135_N0.5820.91
89_K95_G0.5820.91
168_P172_A0.5810.91
143_R172_A0.5800.91
97_Y150_V0.5750.90
69_Q133_T0.5720.90
80_I120_F0.5710.90
16_K106_N0.5700.90
74_F128_V0.5690.90
18_K21_P0.5680.90
13_V111_W0.5670.90
56_V158_I0.5640.90
111_W114_P0.5640.90
156_E164_S0.5620.89
142_E162_K0.5610.89
77_K124_E0.5580.89
104_D107_H0.5560.89
51_F77_K0.5560.89
13_V113_P0.5470.88
79_K123_L0.5450.88
83_V99_K0.5440.88
73_V82_D0.5440.88
6_E39_A0.5440.88
139_K165_Q0.5430.88
85_L117_A0.5410.88
7_N110_L0.5410.88
64_I67_K0.5390.87
30_V132_L0.5340.87
133_T162_K0.5320.87
89_K172_A0.5300.86
15_I36_F0.5280.86
135_N141_D0.5280.86
57_V152_W0.5280.86
52_S58_R0.5280.86
44_I72_L0.5250.86
104_D124_E0.5240.86
101_E106_N0.5210.86
98_V101_E0.5190.85
31_F56_V0.5180.85
53_F56_V0.5150.85
65_T172_A0.5100.84
9_G110_L0.5100.84
81_L151_D0.5090.84
72_L111_W0.5090.84
72_L109_I0.5090.84
13_V39_A0.5080.84
11_G116_F0.5080.84
146_N164_S0.5080.84
44_I109_I0.5070.84
33_S136_E0.5060.84
159_I164_S0.5030.84
140_S143_R0.5000.83
80_I122_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rykA 2 0.9602 100 0.19 Contact Map
1upiA 2 0.9886 100 0.19 Contact Map
1wltA 2 0.9886 100 0.19 Contact Map
2c0zA 2 1 100 0.192 Contact Map
1oi6A 2 0.9943 100 0.193 Contact Map
2ixkA 2 0.9943 100 0.194 Contact Map
4hn1A 3 0.983 100 0.195 Contact Map
1ep0A 2 0.9886 100 0.201 Contact Map
1dzrA 2 1 100 0.201 Contact Map
5buvA 2 0.9602 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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