GREMLIN Database
Q97X29 - Transposase ISC1229
UniProt: Q97X29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (312)
Sequences: 4316 (3302)
Seq/√Len: 186.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_V131_V4.8441.00
324_K329_G3.1111.00
237_V353_P2.9691.00
268_F341_A2.7441.00
205_E227_M2.6021.00
108_L127_I2.5431.00
256_V268_F2.4991.00
155_I158_K2.4801.00
156_E218_Q2.3741.00
78_V127_I2.3311.00
240_T353_P2.3221.00
290_I334_A2.3041.00
272_C298_L2.2941.00
328_H331_K2.2851.00
327_L331_K2.2841.00
252_I344_V2.2401.00
77_I98_I2.2311.00
149_Y153_K2.2301.00
209_V220_K2.1991.00
317_L321_E2.1871.00
51_T69_I2.1411.00
48_Y58_K2.1151.00
263_P267_S2.0691.00
157_V161_N2.0581.00
119_T278_V2.0321.00
212_K220_K2.0061.00
155_I162_R1.9931.00
280_R285_V1.9881.00
237_V347_V1.9461.00
216_E220_K1.9381.00
241_I344_V1.9291.00
338_R342_R1.8961.00
42_I49_L1.8751.00
62_N65_G1.8701.00
238_L344_V1.8461.00
272_C341_A1.8231.00
76_T101_L1.8221.00
352_K355_E1.8151.00
274_L337_A1.8141.00
147_T255_I1.8011.00
262_F271_Y1.7501.00
244_I249_A1.7401.00
163_L214_L1.7351.00
248_A301_L1.7251.00
251_I301_L1.7251.00
156_E221_L1.7201.00
264_K267_S1.6981.00
150_L300_S1.6931.00
346_S350_N1.6931.00
184_L187_G1.6611.00
91_Q140_N1.6321.00
241_I347_V1.6271.00
213_T216_E1.6121.00
237_V240_T1.6111.00
42_I89_P1.6051.00
155_I213_T1.5941.00
149_Y225_R1.5941.00
45_S50_I1.5941.00
153_K156_E1.5911.00
180_R183_K1.5841.00
184_L188_D1.5751.00
347_V353_P1.5651.00
47_D283_K1.5581.00
310_Y320_Y1.5481.00
156_E214_L1.5451.00
304_F307_G1.5391.00
79_L100_V1.5281.00
227_M230_E1.5111.00
92_Y95_E1.5071.00
232_V239_L1.4971.00
92_Y96_K1.4871.00
316_L336_L1.4761.00
163_L207_I1.4701.00
316_L343_V1.4581.00
50_I58_K1.4561.00
209_V223_E1.4391.00
322_T325_D1.4231.00
320_Y336_L1.4221.00
306_A337_A1.4141.00
239_L246_R1.4091.00
255_I295_N1.4001.00
212_K219_E1.3991.00
153_K221_L1.3881.00
314_P318_K1.3741.00
149_Y247_L1.3721.00
211_A215_L1.3701.00
306_A340_L1.3661.00
117_K278_V1.3611.00
319_F339_K1.3591.00
269_V338_R1.3471.00
213_T220_K1.3281.00
79_L90_S1.3251.00
212_K216_E1.3181.00
225_R228_I1.3121.00
214_L218_Q1.3021.00
300_S304_F1.2961.00
77_I93_F1.2961.00
181_L184_L1.2891.00
176_I180_R1.2841.00
41_G128_E1.2811.00
42_I51_T1.2801.00
345_W349_Y1.2771.00
183_K187_G1.2751.00
225_R229_E1.2741.00
156_E160_K1.2601.00
152_L221_L1.2531.00
78_V103_V1.2531.00
155_I159_Y1.2511.00
57_R72_M1.2481.00
151_F162_R1.2461.00
269_V275_D1.2371.00
244_I248_A1.2371.00
150_L297_Y1.2341.00
222_K225_R1.2051.00
323_H327_L1.2041.00
45_S48_Y1.2001.00
303_Y337_A1.1981.00
238_L249_A1.1931.00
65_G68_E1.1791.00
241_I340_L1.1791.00
154_D158_K1.1781.00
132_D136_E1.1691.00
39_V131_V1.1641.00
44_V49_L1.1601.00
146_V297_Y1.1531.00
56_V125_E1.1501.00
158_K161_N1.1451.00
159_Y162_R1.1401.00
238_L348_W1.1391.00
76_T99_K1.1351.00
179_E183_K1.1321.00
70_L96_K1.1301.00
40_I77_I1.1291.00
248_A305_L1.1211.00
46_K168_F1.1191.00
290_I299_R1.1171.00
173_N181_L1.1161.00
106_N110_R1.1131.00
343_V347_V1.1131.00
177_S180_R1.1101.00
59_Y72_M1.1091.00
306_A336_L1.1071.00
346_S349_Y1.1021.00
148_L152_L1.1011.00
40_I51_T1.0971.00
244_I344_V1.0961.00
323_H332_L1.0931.00
186_K189_F1.0921.00
305_L340_L1.0921.00
307_G329_G1.0881.00
103_V108_L1.0861.00
324_K332_L1.0781.00
320_Y332_L1.0741.00
178_K182_E1.0631.00
292_K299_R1.0621.00
81_P105_P1.0521.00
319_F336_L1.0471.00
89_P93_F1.0461.00
316_L340_L1.0401.00
319_F323_H1.0361.00
66_Y92_Y1.0351.00
230_E234_D1.0341.00
219_E223_E1.0301.00
177_S184_L1.0301.00
133_K136_E1.0291.00
319_F335_A1.0271.00
244_I340_L1.0271.00
181_L188_D1.0231.00
86_A102_Q1.0221.00
66_Y88_R1.0191.00
145_L224_V1.0181.00
303_Y334_A1.0151.00
60_E65_G1.0070.99
132_D135_K1.0070.99
118_K123_D1.0050.99
90_S100_V1.0030.99
303_Y307_G0.9980.99
259_I348_W0.9940.99
218_Q222_K0.9930.99
306_A333_Y0.9830.99
204_V208_K0.9820.99
132_D137_Y0.9770.99
313_N317_L0.9730.99
227_M231_Q0.9650.99
61_N69_I0.9630.99
180_R188_D0.9580.99
181_L187_G0.9570.99
177_S181_L0.9560.99
70_L93_F0.9530.99
281_S285_V0.9510.99
173_N177_S0.9450.99
347_V352_K0.9450.99
59_Y65_G0.9330.99
101_L131_V0.9320.99
232_V235_N0.9290.99
149_Y221_L0.9280.99
320_Y329_G0.9260.99
264_K345_W0.9230.99
159_Y163_L0.9190.99
185_A188_D0.9180.99
160_K178_K0.9170.99
125_E129_N0.9170.99
146_V250_G0.9160.99
256_V259_I0.9140.99
307_G310_Y0.9110.99
40_I75_C0.9110.99
51_T59_Y0.9060.99
65_G69_I0.9050.99
314_P317_L0.9050.99
174_N184_L0.9040.99
323_H326_R0.9030.99
302_L341_A0.9000.99
329_G333_Y0.8940.99
146_V228_I0.8900.99
223_E227_M0.8870.99
172_D176_I0.8810.99
216_E219_E0.8790.99
152_L224_V0.8780.99
185_A189_F0.8750.99
153_K157_V0.8710.99
42_I69_I0.8630.98
271_Y295_N0.8610.98
143_R255_I0.8580.98
255_I297_Y0.8580.98
127_I130_M0.8560.98
42_I66_Y0.8510.98
209_V213_T0.8500.98
173_N185_A0.8500.98
252_I298_L0.8470.98
209_V227_M0.8460.98
44_V79_L0.8440.98
90_S102_Q0.8420.98
220_K223_E0.8390.98
116_G270_A0.8360.98
146_V251_I0.8360.98
171_S177_S0.8360.98
50_I56_V0.8310.98
318_K322_T0.8310.98
182_E186_K0.8280.98
81_P102_Q0.8280.98
63_K67_E0.8270.98
150_L154_D0.8260.98
229_E246_R0.8260.98
176_I184_L0.8170.98
76_T131_V0.8170.98
181_L185_A0.8160.98
49_L59_Y0.8100.98
206_E209_V0.8080.98
146_V254_G0.8050.98
267_S270_A0.8030.97
172_D177_S0.8000.97
176_I182_E0.7980.97
307_G337_A0.7970.97
51_T72_M0.7950.97
334_A337_A0.7950.97
116_G293_R0.7920.97
180_R184_L0.7910.97
41_G124_A0.7910.97
275_D291_S0.7830.97
303_Y330_R0.7800.97
104_S107_M0.7760.97
237_V351_N0.7760.97
170_V181_L0.7750.97
315_N354_Y0.7750.97
307_G330_R0.7750.97
156_E211_A0.7730.97
175_K180_R0.7700.97
64_E68_E0.7630.97
173_N176_I0.7560.96
138_E234_D0.7530.96
172_D181_L0.7520.96
68_E71_E0.7510.96
174_N180_R0.7430.96
61_N66_Y0.7390.96
330_R333_Y0.7380.96
148_L206_E0.7340.96
278_V285_V0.7340.96
344_V347_V0.7310.96
180_R187_G0.7300.96
280_R286_V0.7300.96
50_I121_F0.7260.95
45_S282_G0.7260.95
70_L98_I0.7250.95
159_Y217_T0.7220.95
133_K137_Y0.7220.95
74_P99_K0.7220.95
160_K214_L0.7210.95
258_D261_R0.7190.95
103_V130_M0.7180.95
111_E130_M0.7170.95
45_S49_L0.7130.95
218_Q221_L0.7090.95
277_V291_S0.7090.95
171_S174_N0.7090.95
67_E92_Y0.7070.95
290_I335_A0.7070.95
275_D292_K0.7060.95
210_L213_T0.7040.95
170_V173_N0.7040.95
117_K122_Y0.6990.94
152_L217_T0.6970.94
173_N184_L0.6960.94
322_T326_R0.6960.94
176_I186_K0.6950.94
205_E208_K0.6920.94
176_I181_L0.6910.94
205_E216_E0.6910.94
109_S114_F0.6900.94
49_L61_N0.6900.94
308_R312_R0.6880.94
82_M85_Y0.6880.94
141_P200_T0.6870.94
241_I244_I0.6790.94
178_K181_L0.6780.94
176_I179_E0.6770.93
176_I185_A0.6760.93
310_Y333_Y0.6720.93
265_P345_W0.6710.93
310_Y324_K0.6700.93
304_F330_R0.6690.93
275_D278_V0.6690.93
120_D281_S0.6670.93
65_G72_M0.6650.93
66_Y93_F0.6650.93
328_H332_L0.6630.93
174_N181_L0.6600.93
70_L92_Y0.6600.93
307_G333_Y0.6590.93
136_E139_Y0.6560.92
151_F158_K0.6520.92
251_I255_I0.6520.92
161_N165_R0.6500.92
147_T297_Y0.6500.92
184_L189_F0.6490.92
215_L219_E0.6460.92
134_A138_E0.6460.92
239_L249_A0.6450.92
275_D299_R0.6440.92
79_L127_I0.6440.92
183_K188_D0.6430.92
323_H335_A0.6420.92
195_Y199_Y0.6400.91
244_I252_I0.6400.91
176_I187_G0.6400.91
108_L130_M0.6370.91
105_P255_I0.6340.91
251_I297_Y0.6320.91
313_N318_K0.6310.91
265_P342_R0.6300.91
233_P246_R0.6290.91
93_F340_L0.6280.91
309_N316_L0.6270.91
147_T295_N0.6260.91
174_N177_S0.6260.91
79_L102_Q0.6260.91
106_N293_R0.6260.91
119_T280_R0.6250.90
175_K181_L0.6240.90
37_V52_S0.6240.90
331_K335_A0.6230.90
179_E182_E0.6210.90
41_G93_F0.6190.90
84_V168_F0.6190.90
152_L220_K0.6180.90
145_L149_Y0.6170.90
140_N144_E0.6160.90
176_I183_K0.6160.90
56_V121_F0.6160.90
229_E233_P0.6150.90
174_N178_K0.6120.90
269_V342_R0.6120.90
49_L69_I0.6120.90
266_E338_R0.6110.89
274_L338_R0.6100.89
221_L225_R0.6090.89
313_N354_Y0.6090.89
225_R247_L0.6080.89
208_K212_K0.6080.89
259_I345_W0.6070.89
203_V206_E0.6070.89
235_N239_L0.6060.89
294_G299_R0.6060.89
270_A275_D0.6050.89
50_I281_S0.6050.89
174_N188_D0.6050.89
301_L305_L0.6040.89
304_F308_R0.6040.89
151_F155_I0.6020.89
226_R229_E0.5990.89
159_Y213_T0.5980.88
342_R345_W0.5980.88
40_I93_F0.5970.88
310_Y336_L0.5960.88
319_F322_T0.5870.88
290_I294_G0.5850.87
217_T221_L0.5830.87
37_V75_C0.5820.87
163_L204_V0.5810.87
133_K138_E0.5800.87
162_R165_R0.5790.87
170_V179_E0.5790.87
78_V108_L0.5780.87
57_R68_E0.5780.87
74_P98_I0.5780.87
152_L156_E0.5760.87
49_L89_P0.5710.86
309_N313_N0.5710.86
330_R334_A0.5710.86
148_L224_V0.5710.86
205_E209_V0.5670.86
111_E129_N0.5650.85
275_D293_R0.5640.85
148_L151_F0.5630.85
187_G195_Y0.5620.85
159_Y214_L0.5620.85
171_S180_R0.5600.85
182_E189_F0.5600.85
307_G311_S0.5570.85
148_L209_V0.5560.85
172_D175_K0.5540.84
132_D138_E0.5530.84
44_V85_Y0.5520.84
202_I227_M0.5480.84
157_V160_K0.5460.84
257_G261_R0.5450.83
265_P270_A0.5430.83
321_E324_K0.5420.83
148_L162_R0.5400.83
320_Y333_Y0.5380.83
256_V272_C0.5370.83
349_Y352_K0.5360.82
40_I69_I0.5360.82
309_N340_L0.5340.82
186_K196_Q0.5300.82
67_E71_E0.5290.82
115_R275_D0.5290.82
150_L251_I0.5280.81
173_N187_G0.5270.81
171_S175_K0.5270.81
305_L337_A0.5260.81
197_L201_P0.5250.81
320_Y324_K0.5240.81
108_L126_K0.5200.80
273_G299_R0.5190.80
69_I72_M0.5180.80
75_C98_I0.5140.80
291_S299_R0.5120.79
116_G277_V0.5110.79
237_V241_I0.5110.79
343_V346_S0.5090.79
195_Y200_T0.5090.79
182_E185_A0.5080.79
279_E288_K0.5070.79
181_L189_F0.5060.79
175_K182_E0.5060.79
219_E222_K0.5050.79
217_T220_K0.5050.79
302_L337_A0.5040.78
195_Y198_E0.5040.78
172_D187_G0.5030.78
144_E203_V0.5030.78
278_V287_S0.5030.78
183_K186_K0.5020.78
244_I305_L0.5020.78
45_S89_P0.5020.78
156_E217_T0.5010.78
253_I348_W0.5000.78
68_E72_M0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1keaA 2 0.5406 89.6 0.943 Contact Map
1hjrA 2 0.2885 87.5 0.945 Contact Map
3fhfA 1 0.5686 87.5 0.945 Contact Map
3n0uA 1 0.5406 86.7 0.946 Contact Map
2a1jB 2 0.2157 86 0.947 Contact Map
1pu6A 1 0.5462 84.7 0.947 Contact Map
2duyA 1 0.1821 79.5 0.95 Contact Map
4ep4A 2 0.2997 79 0.951 Contact Map
2a1jA 1 0.1653 79 0.951 Contact Map
1kftA 1 0.1513 79 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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